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The map label for this gene is gap

Identifier: 41407262

GI number: 41407262

Start: 1221900

End: 1222919

Strand: Direct

Name: gap

Synonym: MAP1164

Alternate gene names: 41407262

Gene position: 1221900-1222919 (Clockwise)

Preceding gene: 41407261

Following gene: 41407263

Centisome position: 25.3

GC content: 66.76

Gene sequence:

>1020_bases
GTGACGGTCCGGGTAGGCATCAACGGCTTCGGTCGAATCGGGCGCAACTTCTACCGGGCCTTGCTGGCTCAACAGGAGCA
GGGCACCGCCGACATCGAGGTGGTCGCGGTCAACGACATCACCGACAACAGCACCCTGGCTCACCTGCTGAAATTCGACT
CCATCCTGGGCCGGCTGCCCTACGACGTCAGCCTGGAGGGCGAGGACACCATCGTGGTGGGCCCGGCCAAGATCAAGGCG
CTGGAGGTGCGCGAGGGCCCGGCCGCGCTGCCCTGGGGCGACCTGGGCGTCGACGTCGTCGTCGAATCCACCGGGCTGTT
CACCAACGCGGCCAAGGCCAAGGGCCACCTGGACGCCGGCGCCAAGAAGGTGATCATCTCCGCGCCGGCCACCGACGAGG
ACATCACCGTGGTGCTGGGCGTCAACGACGACAAGTACGACGGCAGCCAGAACATCATCTCCAACGCGTCGTGCACCACC
AACTGCCTGGCGCCGCTGACCAAGGTGCTCGACGACGAGTTCGGCATCGTCCGCGGCCTGATGACCACGATCCACGCCTA
CACCCAGGACCAGAACCTGCAGGACGGGCCGCACAAGGACCTGCGCCGGGCGCGTGCCGCCGCGCTGAACATCGTCCCCA
CCTCCACCGGCGCGGCCAAGGCGATCGGGCTGGTCATGCCCAACCTCAAGGGCAAGCTGGACGGCTACGCGCTGCGGGTG
CCGATCCCCACCGGCTCGGTCACCGACCTGACCGCCGAGCTGAAGAAGCCGGCCAGCGTCGAGGACATCAACGCGGCGTT
CAAGGCCGCCGCCGAAGGCCGGCTCAAGGGCATCCTGAAGTACTACGACGCGCCGATCGTCTCCAGCGACATCGTCACCG
ACCCGCACAGCTCGATCTTCGACTCCGGGCTGACCAAGGTGATCGACAACCAAGCCAAGGTGGTGTCCTGGTACGACAAC
GAGTGGGGCTACTCCAACCGCCTCGTCGACCTGGTCGCCCTGGTCGGCAAGTCGCTGTAA

Upstream 100 bases:

>100_bases
CACCGGGGCGATACCGGAGCGGCAACCGGCCGCGGCACTGATCTAGGCTGGCGACGAGCGCAAATCAGCCGACACAGGAA
AGAAGACGGAGGAGAGACAA

Downstream 100 bases:

>100_bases
GCCGTGGCTGTCCACAATCTCAAAGACCTTCTCGCCGAAGGTGTTTCCGGACGCGGTGTGCTGGTGCGTTCGGACCTGAA
CGTGCCGCTGGACTCCGATG

Product: glyceraldehyde-3-phosphate dehydrogenase

Products: NA

Alternate protein names: GAPDH

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MTVRVGINGFGRIGRNFYRALLAQQEQGTADIEVVAVNDITDNSTLAHLLKFDSILGRLPYDVSLEGEDTIVVGPAKIKA
LEVREGPAALPWGDLGVDVVVESTGLFTNAAKAKGHLDAGAKKVIISAPATDEDITVVLGVNDDKYDGSQNIISNASCTT
NCLAPLTKVLDDEFGIVRGLMTTIHAYTQDQNLQDGPHKDLRRARAAALNIVPTSTGAAKAIGLVMPNLKGKLDGYALRV
PIPTGSVTDLTAELKKPASVEDINAAFKAAAEGRLKGILKYYDAPIVSSDIVTDPHSSIFDSGLTKVIDNQAKVVSWYDN
EWGYSNRLVDLVALVGKSL

Sequences:

>Translated_339_residues
MTVRVGINGFGRIGRNFYRALLAQQEQGTADIEVVAVNDITDNSTLAHLLKFDSILGRLPYDVSLEGEDTIVVGPAKIKA
LEVREGPAALPWGDLGVDVVVESTGLFTNAAKAKGHLDAGAKKVIISAPATDEDITVVLGVNDDKYDGSQNIISNASCTT
NCLAPLTKVLDDEFGIVRGLMTTIHAYTQDQNLQDGPHKDLRRARAAALNIVPTSTGAAKAIGLVMPNLKGKLDGYALRV
PIPTGSVTDLTAELKKPASVEDINAAFKAAAEGRLKGILKYYDAPIVSSDIVTDPHSSIFDSGLTKVIDNQAKVVSWYDN
EWGYSNRLVDLVALVGKSL
>Mature_338_residues
TVRVGINGFGRIGRNFYRALLAQQEQGTADIEVVAVNDITDNSTLAHLLKFDSILGRLPYDVSLEGEDTIVVGPAKIKAL
EVREGPAALPWGDLGVDVVVESTGLFTNAAKAKGHLDAGAKKVIISAPATDEDITVVLGVNDDKYDGSQNIISNASCTTN
CLAPLTKVLDDEFGIVRGLMTTIHAYTQDQNLQDGPHKDLRRARAAALNIVPTSTGAAKAIGLVMPNLKGKLDGYALRVP
IPTGSVTDLTAELKKPASVEDINAAFKAAAEGRLKGILKYYDAPIVSSDIVTDPHSSIFDSGLTKVIDNQAKVVSWYDNE
WGYSNRLVDLVALVGKSL

Specific function: Second phase of glycolysis; first step. [C]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI7669492, Length=334, Percent_Identity=50.8982035928144, Blast_Score=311, Evalue=7e-85,
Organism=Homo sapiens, GI7657116, Length=333, Percent_Identity=50.1501501501502, Blast_Score=297, Evalue=1e-80,
Organism=Escherichia coli, GI1788079, Length=340, Percent_Identity=52.0588235294118, Blast_Score=330, Evalue=8e-92,
Organism=Escherichia coli, GI1789295, Length=332, Percent_Identity=44.2771084337349, Blast_Score=283, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17534679, Length=339, Percent_Identity=53.0973451327434, Blast_Score=324, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI17534677, Length=339, Percent_Identity=52.8023598820059, Blast_Score=323, Evalue=6e-89,
Organism=Caenorhabditis elegans, GI32566163, Length=339, Percent_Identity=52.8023598820059, Blast_Score=317, Evalue=6e-87,
Organism=Caenorhabditis elegans, GI17568413, Length=339, Percent_Identity=52.8023598820059, Blast_Score=317, Evalue=7e-87,
Organism=Saccharomyces cerevisiae, GI6322409, Length=339, Percent_Identity=51.3274336283186, Blast_Score=315, Evalue=9e-87,
Organism=Saccharomyces cerevisiae, GI6321631, Length=339, Percent_Identity=51.0324483775811, Blast_Score=313, Evalue=3e-86,
Organism=Saccharomyces cerevisiae, GI6322468, Length=339, Percent_Identity=50.1474926253687, Blast_Score=311, Evalue=1e-85,
Organism=Drosophila melanogaster, GI17933600, Length=333, Percent_Identity=51.6516516516517, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI18110149, Length=333, Percent_Identity=51.6516516516517, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI19922412, Length=331, Percent_Identity=48.9425981873112, Blast_Score=298, Evalue=3e-81,
Organism=Drosophila melanogaster, GI85725000, Length=333, Percent_Identity=51.0510510510511, Blast_Score=298, Evalue=5e-81,
Organism=Drosophila melanogaster, GI22023983, Length=333, Percent_Identity=51.0510510510511, Blast_Score=298, Evalue=5e-81,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 740 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Min

Swissprot (AC and ID): G3P_MYCAV (P94915)

Other databases:

- EMBL:   U82749
- ProteinModelPortal:   P94915
- SMR:   P94915
- BRENDA:   1.2.1.12
- GO:   GO:0005737
- GO:   GO:0006096
- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10836
- PIRSF:   PIRSF000149
- PRINTS:   PR00078
- SMART:   SM00846
- TIGRFAMs:   TIGR01534

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N

EC number: =1.2.1.12

Molecular weight: Translated: 36095; Mature: 35964

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00071 GAPDH

Important sites: ACT_SITE 158-158 BINDING 39-39 BINDING 84-84 BINDING 188-188 BINDING 203-203 BINDING 239-239 BINDING 320-320

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVRVGINGFGRIGRNFYRALLAQQEQGTADIEVVAVNDITDNSTLAHLLKFDSILGRLP
CEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCC
YDVSLEGEDTIVVGPAKIKALEVREGPAALPWGDLGVDVVVESTGLFTNAAKAKGHLDAG
CEEEECCCCEEEECCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCEECCHHCCCCCCCC
AKKVIISAPATDEDITVVLGVNDDKYDGSQNIISNASCTTNCLAPLTKVLDDEFGIVRGL
CCEEEEECCCCCCCEEEEEECCCCCCCCCCHHHCCCCCCHHHHHHHHHHHCCHHHHHHHH
MTTIHAYTQDQNLQDGPHKDLRRARAAALNIVPTSTGAAKAIGLVMPNLKGKLDGYALRV
HHHHHHHHCCCCCCCCCHHHHHHHHHHEEEEEECCCCCHHHHHEECCCCCCCCCCEEEEE
PIPTGSVTDLTAELKKPASVEDINAAFKAAAEGRLKGILKYYDAPIVSSDIVTDPHSSIF
ECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
DSGLTKVIDNQAKVVSWYDNEWGYSNRLVDLVALVGKSL
HHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TVRVGINGFGRIGRNFYRALLAQQEQGTADIEVVAVNDITDNSTLAHLLKFDSILGRLP
EEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCC
YDVSLEGEDTIVVGPAKIKALEVREGPAALPWGDLGVDVVVESTGLFTNAAKAKGHLDAG
CEEEECCCCEEEECCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCEECCHHCCCCCCCC
AKKVIISAPATDEDITVVLGVNDDKYDGSQNIISNASCTTNCLAPLTKVLDDEFGIVRGL
CCEEEEECCCCCCCEEEEEECCCCCCCCCCHHHCCCCCCHHHHHHHHHHHCCHHHHHHHH
MTTIHAYTQDQNLQDGPHKDLRRARAAALNIVPTSTGAAKAIGLVMPNLKGKLDGYALRV
HHHHHHHHCCCCCCCCCHHHHHHHHHHEEEEEECCCCCHHHHHEECCCCCCCCCCEEEEE
PIPTGSVTDLTAELKKPASVEDINAAFKAAAEGRLKGILKYYDAPIVSSDIVTDPHSSIF
ECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
DSGLTKVIDNQAKVVSWYDNEWGYSNRLVDLVALVGKSL
HHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10702355