Click here to switch to the map view.

The map label for this gene is ddn [H]

Identifier: 41407163

GI number: 41407163

Start: 1118362

End: 1118793

Strand: Direct

Name: ddn [H]

Synonym: MAP1065

Alternate gene names: 41407163

Gene position: 1118362-1118793 (Clockwise)

Preceding gene: 41407162

Following gene: 41407164

Centisome position: 23.16

GC content: 68.98

Gene sequence:

>432_bases
ATGACTGATATTCCGGACACCGGCACCATCAACGCGTTCAACCAGAGCATCATCGACGAATTCCGGGCCAACGACGGCAA
AGTGGGCGGCCAGTTCGAGGGTGCCGACCTGCTGCTGCTGCACACCACCGGCGCCAAGTCGGGTCAGCCCCGGGTGTCGC
CGCTGGCCTACTTCCGCATCGACGGCAAGCTCCTGGTGATCGGCTCGTTCGCCGGCGCCCCGGTCAGCCCGGCCTGGGTG
CACAACCTGCGGGCCAACCCCGCCGCGCGGGTGGAGATCGGCACCGACAGCTTCGACGTGACCGCGCGCGAGCTGCCCCG
CGAGGAGCGCGACGCGCTGTTCGCCCAGGTCGCCGCGGCCGCCTCCGGCTTTGCCGAGTACCAGGCTAAGACCAGCCGGG
TGATCCCCCTGTTCGAGCTGATCCGGACCTGA

Upstream 100 bases:

>100_bases
CCTGACCAGGGTGTTTCTTGCGCAGCCATCACAGCTAACAGCAACAAACGAGCAGCACGAAGTCCGGAATAGATGTCAAG
CCGGACCGGGTTGAGCAGGC

Downstream 100 bases:

>100_bases
CCGATGCGCGGCTCGGCGGTGCCCTCGTTGGTGCGCACCGCCGTGCGGGCGGGCGGCAAGCGGCTGGGTGCGGTGTGGTT
CAACCTGCTGCAGACGTCGC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 143; Mature: 142

Protein sequence:

>143_residues
MTDIPDTGTINAFNQSIIDEFRANDGKVGGQFEGADLLLLHTTGAKSGQPRVSPLAYFRIDGKLLVIGSFAGAPVSPAWV
HNLRANPAARVEIGTDSFDVTARELPREERDALFAQVAAAASGFAEYQAKTSRVIPLFELIRT

Sequences:

>Translated_143_residues
MTDIPDTGTINAFNQSIIDEFRANDGKVGGQFEGADLLLLHTTGAKSGQPRVSPLAYFRIDGKLLVIGSFAGAPVSPAWV
HNLRANPAARVEIGTDSFDVTARELPREERDALFAQVAAAASGFAEYQAKTSRVIPLFELIRT
>Mature_142_residues
TDIPDTGTINAFNQSIIDEFRANDGKVGGQFEGADLLLLHTTGAKSGQPRVSPLAYFRIDGKLLVIGSFAGAPVSPAWVH
NLRANPAARVEIGTDSFDVTARELPREERDALFAQVAAAASGFAEYQAKTSRVIPLFELIRT

Specific function: Nitroreductase involved in the bioreductive activation of the antitubercular prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It converts PA-824 into three primary metabolites;

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deazaflavin-dependent nitroreductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012349
- InterPro:   IPR009002
- InterPro:   IPR004378 [H]

Pfam domain/function: PF04075 DUF385 [H]

EC number: NA

Molecular weight: Translated: 15373; Mature: 15242

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIPDTGTINAFNQSIIDEFRANDGKVGGQFEGADLLLLHTTGAKSGQPRVSPLAYFRI
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCEEEEEECCCCCCCCCCCEEEEEEE
DGKLLVIGSFAGAPVSPAWVHNLRANPAARVEIGTDSFDVTARELPREERDALFAQVAAA
CCEEEEEECCCCCCCCHHHHHHCCCCCCEEEEECCCCCCCCHHHCCCHHHHHHHHHHHHH
ASGFAEYQAKTSRVIPLFELIRT
HHHHHHHHHHCCCCCHHHHHHCC
>Mature Secondary Structure 
TDIPDTGTINAFNQSIIDEFRANDGKVGGQFEGADLLLLHTTGAKSGQPRVSPLAYFRI
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCEEEEEECCCCCCCCCCCEEEEEEE
DGKLLVIGSFAGAPVSPAWVHNLRANPAARVEIGTDSFDVTARELPREERDALFAQVAAA
CCEEEEEECCCCCCCCHHHHHHCCCCCCEEEEECCCCCCCCHHHCCCHHHHHHHHHHHHH
ASGFAEYQAKTSRVIPLFELIRT
HHHHHHHHHHCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]