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The map label for this gene is hsaD [H]

Identifier: 41406596

GI number: 41406596

Start: 526159

End: 527040

Strand: Direct

Name: hsaD [H]

Synonym: MAP0498

Alternate gene names: 41406596

Gene position: 526159-527040 (Clockwise)

Preceding gene: 41406595

Following gene: 41406597

Centisome position: 10.89

GC content: 68.03

Gene sequence:

>882_bases
ATGACCGCGACCGAGGAGTTGACGTTCGAGTCGACCTCGCGCTTCGCCGAAGTCGACGTCGACGGGCCGCTCAAGCTGCA
CTACCACGAGGCCGGTTTGTCCTTCAAGGGCACCGGGCGCACGGTGGTGCTGCTGCACGGCGGCGGCCCGGGCGCGGCCA
GCTGGACCAACTTCGGCCGCAACATCCCGGTGCTGGCCCGGCACTTCCACGTGCTGGCCGTCGACCAGCCCGGCTACGGC
CTGTCCGACAAGCGCGCCGAGCACGGACAGTTCAACCGCTACGCCGCCCGGGCGCTCAACGGGCTGTTCGAGCAGCTGGA
GCTGGGACGCGTTCCGCTGGTGGGCAATTCGCTGGGCGGGGGCACCGCGGTGCGGTTCGCCCTGGACTACCCGGACAAGG
CCGGGCGGCTGGTACTGATGGGCCCCGGCGGGTTGAGCATCAACCTGTTCGCGCCCGACCCCACCGAGGGCGTCAAACGG
CTGGGAAAGTTCTCCGCCGAGCCGACGCGGGAAAACCTCGAGGCGTTCCTGCGGGTGATGGTCTACGACCAGAAGCTGAT
CACCGACGAATTGATCGACGAGCGGTTCGCGCTGGCCAGCACGCCGGAATCGCTGGCGGCCACCCGGGCGATGGGAATGT
CGTTCGCGGGGGCCGACTTCGAGCTGGGCATGATGTGGCGCGAGGTGCACCGGCTGCGGCAACCGGTGCTGCTGATCTGG
GGTCGCGAGGACCGGGTCAACCCGCTCGATGGCGCGCTGGTCGCGCTGAAAACCATTGCCCGCGCCCAGCTTCACGTGTT
CGGGCAGTGTGGGCACTGGGCGCAGGTGGAGAAATTCGACGAGTTCAACAAGCTCACCATCGATTTCCTGGGAGGTGCGT
GA

Upstream 100 bases:

>100_bases
ACGCGCACGCCGGCCGGGTGCACGCGGCCAACGACCCCGAGCGGGCCTACCAGATCTTCGGAAACCACGAGTTCGGGTTG
CCGCCGGGCGACACGATGGT

Downstream 100 bases:

>100_bases
TGAGCAACGGAGCCATCAGGTCGCTGGGCTATCTGCGCATCGAGGCCACCGACATGGCGGCCTGGCGCGACTACGGCCTG
AAGGTTCTCGGCATGGTCGA

Product: hypothetical protein

Products: NA

Alternate protein names: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; HOPDA hydrolase; Meta-cleavage product hydrolase; MCP hydrolase [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MTATEELTFESTSRFAEVDVDGPLKLHYHEAGLSFKGTGRTVVLLHGGGPGAASWTNFGRNIPVLARHFHVLAVDQPGYG
LSDKRAEHGQFNRYAARALNGLFEQLELGRVPLVGNSLGGGTAVRFALDYPDKAGRLVLMGPGGLSINLFAPDPTEGVKR
LGKFSAEPTRENLEAFLRVMVYDQKLITDELIDERFALASTPESLAATRAMGMSFAGADFELGMMWREVHRLRQPVLLIW
GREDRVNPLDGALVALKTIARAQLHVFGQCGHWAQVEKFDEFNKLTIDFLGGA

Sequences:

>Translated_293_residues
MTATEELTFESTSRFAEVDVDGPLKLHYHEAGLSFKGTGRTVVLLHGGGPGAASWTNFGRNIPVLARHFHVLAVDQPGYG
LSDKRAEHGQFNRYAARALNGLFEQLELGRVPLVGNSLGGGTAVRFALDYPDKAGRLVLMGPGGLSINLFAPDPTEGVKR
LGKFSAEPTRENLEAFLRVMVYDQKLITDELIDERFALASTPESLAATRAMGMSFAGADFELGMMWREVHRLRQPVLLIW
GREDRVNPLDGALVALKTIARAQLHVFGQCGHWAQVEKFDEFNKLTIDFLGGA
>Mature_292_residues
TATEELTFESTSRFAEVDVDGPLKLHYHEAGLSFKGTGRTVVLLHGGGPGAASWTNFGRNIPVLARHFHVLAVDQPGYGL
SDKRAEHGQFNRYAARALNGLFEQLELGRVPLVGNSLGGGTAVRFALDYPDKAGRLVLMGPGGLSINLFAPDPTEGVKRL
GKFSAEPTRENLEAFLRVMVYDQKLITDELIDERFALASTPESLAATRAMGMSFAGADFELGMMWREVHRLRQPVLLIWG
REDRVNPLDGALVALKTIARAQLHVFGQCGHWAQVEKFDEFNKLTIDFLGGA

Specific function: Catalyzes the hydrolysis of a carbon-carbon bond in 4,5- 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid (4,9-DSHA) to yield 9,17-dioxo-1,2,3,4,10,19- hexanorandrostan-5-oic acid (DOHNAA) and 2-hydroxy-hexa-2,4- dienoic acid (HHD). Is

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. HsaD family [H]

Homologues:

Organism=Escherichia coli, GI87081721, Length=300, Percent_Identity=37.6666666666667, Blast_Score=203, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.7.1.8 [H]

Molecular weight: Translated: 32120; Mature: 31989

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATEELTFESTSRFAEVDVDGPLKLHYHEAGLSFKGTGRTVVLLHGGGPGAASWTNFGR
CCCCCCCEECCCCCEEEECCCCCEEEEEEECCCEEECCCCEEEEEECCCCCCCCHHHCCC
NIPVLARHFHVLAVDQPGYGLSDKRAEHGQFNRYAARALNGLFEQLELGRVPLVGNSLGG
CCCCEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEECCCCCC
GTAVRFALDYPDKAGRLVLMGPGGLSINLFAPDPTEGVKRLGKFSAEPTRENLEAFLRVM
CEEEEEEEECCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHH
VYDQKLITDELIDERFALASTPESLAATRAMGMSFAGADFELGMMWREVHRLRQPVLLIW
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEECCCCCHHHHHHHHHHHHCCCEEEEE
GREDRVNPLDGALVALKTIARAQLHVFGQCGHWAQVEKFDEFNKLTIDFLGGA
CCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHCCCCEEEEECCCC
>Mature Secondary Structure 
TATEELTFESTSRFAEVDVDGPLKLHYHEAGLSFKGTGRTVVLLHGGGPGAASWTNFGR
CCCCCCEECCCCCEEEECCCCCEEEEEEECCCEEECCCCEEEEEECCCCCCCCHHHCCC
NIPVLARHFHVLAVDQPGYGLSDKRAEHGQFNRYAARALNGLFEQLELGRVPLVGNSLGG
CCCCEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEECCCCCC
GTAVRFALDYPDKAGRLVLMGPGGLSINLFAPDPTEGVKRLGKFSAEPTRENLEAFLRVM
CEEEEEEEECCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHH
VYDQKLITDELIDERFALASTPESLAATRAMGMSFAGADFELGMMWREVHRLRQPVLLIW
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEECCCCCHHHHHHHHHHHHCCCEEEEE
GREDRVNPLDGALVALKTIARAQLHVFGQCGHWAQVEKFDEFNKLTIDFLGGA
CCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]