Click here to switch to the map view.

The map label for this gene is accD4_1

Identifier: 41406319

GI number: 41406319

Start: 233842

End: 235416

Strand: Direct

Name: accD4_1

Synonym: MAP0221

Alternate gene names: 41406319

Gene position: 233842-235416 (Clockwise)

Preceding gene: 41406318

Following gene: 41406324

Centisome position: 4.84

GC content: 68.44

Gene sequence:

>1575_bases
GTGACGGAGATGGCGCCGGCCCCCATCCAGCACACCACCGCCGAGAAGCTGGCCGAGCTGTACCTCCGGCTGGAGTTGGC
CAAGGAGCCCGGAGGCGAGAAGGCCGCCGCCAAGCGGGACAAGAAGGGCATCCCCAGCGCCCGGGCCCGCATCCACGCGC
TCGTCGATCCGGGCACCTTCCTGGAGACCGGGGCGCTGGCCAAGACACCCAACGACCCCAACGCCCTCTACGGCGACGGC
TGCGTCACCGGCCACGCCATGATCGACGGCCGGCCGGTCGGGGTGTTCTCCCACGACCAGACGGTGTTCCAGGGCACGGT
CGGCGAGATGTTCGGCCGCAAGGTGGCCCGGCTGATGGAGTGGTGCGCCATGGTCGGCTGCCCGATCATCGGCATCCAAG
ACTCCGGCGGCGCCCGCATCCAGGACGCGGTCACCTCGCTGGCCTGGTACGCCGAGCTGGGCCGCCGGCACGAGGCATTG
AGCGGGCTGGTGCCGCAGATCTCGCTGATCTTCGGCAAATGCGCTGGGGGAGCGGTGTATTCGCCGATCCAGGACGACCT
GCTGGTCTCGGTGCGCGATCAGGGCTACTTCTTCGTCACCGGCCCGGACGTGATCCGGGAGGTCACCGGCGAGGAGGTCA
CCCTCGACGAGCTCGGCGGCTCCGACGCGCAGGCCCGCTACGGCAACATCCACCACGTGGTCAACACCGAGGCCGAGGCG
TTCCAGTACGTGCGGGAGTACCTGTCCTTCCTGCCGTCCAACTGCTTCGACCAGCCGCCGATCGTCAACCCCGGGCTGGA
GCCCGAGATCACGCCGACCGACCTCGAGCTCGACTCGATCGTGCCGGACTCGGACAACATGTCCTACGACATGCACGAGA
TCCTGCTGCGGATCTTCGACGACGGCGACTTCCTCGAGGTGGCCGCCCAGCACGGCCCGGCCATCATTACCGGCTACGCC
CGCGTCGACGGCCACCCCGTGGGCGTGATCGCCAACCAGCCCATGCACCTGTCCGGGTCGATCGACAACGAGGCCTCGGA
CAAGGCCGCGCGGTTCATCCGGTTCTGCGACGCGTTCAACATCCCGCTGGTCTTCGTGGTGGACACGCCCGGCTTTCTGC
CCGGGGCCGAGGAGGAGAAGCGGGGCATCATCAAGCGCGGCGGCCGGTTCCTCTACTCGGTGGTGGAGGCCGACGTGCCG
AAGGTGACGATCACCGTCCGCAAGTCCTACGGCGGCGCCTACGCCGTGATGGGCTCGCGGCAGCTGACCGCCGACTTCAA
CTTCGCCTGGCCGACCGCGCGGATCGCGGTGATCGGCGCCGAGGGGGCGGCGCAGCTGCTGATGAAGCGGTTCCCCGACC
CGACCACGCCCGAGGCGCAGCAGATCAAGAAGGACTTCATCGAGGGCTACAACCTCAACATGGCGATCCCGTGGACGGCG
GCCGAACGCGGCTTCATCGACGCGGTCATCGACCCGCATGAGACGCGGCTGCTGCTGCGCAAGTCGCTGAAGTTGTTGCG
GGACAAGCAGTTGTGGTTCCGCGTCGCCCGCAAGCACGGGCTGATCCCGGTCTAG

Upstream 100 bases:

>100_bases
TCATCGACGAACCGATCATCGGCAAGGTCGGCGCCCACCTCACCGACGTGCTGAATAAGGTGGAGGCGCAAACCAGTCAG
ACAAGTGAGGTAGGCAAGTA

Downstream 100 bases:

>100_bases
TCGCCCACGGCCTGCTTGGTCGCCTGCACGAAATAACCGCGCGGCGCCCCCGCGACGTCCATCGGGACCGCGGGCGCATA
CCAGCGCTGGTACCGGTTGC

Product: AccD4_1

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 524; Mature: 523

Protein sequence:

>524_residues
MTEMAPAPIQHTTAEKLAELYLRLELAKEPGGEKAAAKRDKKGIPSARARIHALVDPGTFLETGALAKTPNDPNALYGDG
CVTGHAMIDGRPVGVFSHDQTVFQGTVGEMFGRKVARLMEWCAMVGCPIIGIQDSGGARIQDAVTSLAWYAELGRRHEAL
SGLVPQISLIFGKCAGGAVYSPIQDDLLVSVRDQGYFFVTGPDVIREVTGEEVTLDELGGSDAQARYGNIHHVVNTEAEA
FQYVREYLSFLPSNCFDQPPIVNPGLEPEITPTDLELDSIVPDSDNMSYDMHEILLRIFDDGDFLEVAAQHGPAIITGYA
RVDGHPVGVIANQPMHLSGSIDNEASDKAARFIRFCDAFNIPLVFVVDTPGFLPGAEEEKRGIIKRGGRFLYSVVEADVP
KVTITVRKSYGGAYAVMGSRQLTADFNFAWPTARIAVIGAEGAAQLLMKRFPDPTTPEAQQIKKDFIEGYNLNMAIPWTA
AERGFIDAVIDPHETRLLLRKSLKLLRDKQLWFRVARKHGLIPV

Sequences:

>Translated_524_residues
MTEMAPAPIQHTTAEKLAELYLRLELAKEPGGEKAAAKRDKKGIPSARARIHALVDPGTFLETGALAKTPNDPNALYGDG
CVTGHAMIDGRPVGVFSHDQTVFQGTVGEMFGRKVARLMEWCAMVGCPIIGIQDSGGARIQDAVTSLAWYAELGRRHEAL
SGLVPQISLIFGKCAGGAVYSPIQDDLLVSVRDQGYFFVTGPDVIREVTGEEVTLDELGGSDAQARYGNIHHVVNTEAEA
FQYVREYLSFLPSNCFDQPPIVNPGLEPEITPTDLELDSIVPDSDNMSYDMHEILLRIFDDGDFLEVAAQHGPAIITGYA
RVDGHPVGVIANQPMHLSGSIDNEASDKAARFIRFCDAFNIPLVFVVDTPGFLPGAEEEKRGIIKRGGRFLYSVVEADVP
KVTITVRKSYGGAYAVMGSRQLTADFNFAWPTARIAVIGAEGAAQLLMKRFPDPTTPEAQQIKKDFIEGYNLNMAIPWTA
AERGFIDAVIDPHETRLLLRKSLKLLRDKQLWFRVARKHGLIPV
>Mature_523_residues
TEMAPAPIQHTTAEKLAELYLRLELAKEPGGEKAAAKRDKKGIPSARARIHALVDPGTFLETGALAKTPNDPNALYGDGC
VTGHAMIDGRPVGVFSHDQTVFQGTVGEMFGRKVARLMEWCAMVGCPIIGIQDSGGARIQDAVTSLAWYAELGRRHEALS
GLVPQISLIFGKCAGGAVYSPIQDDLLVSVRDQGYFFVTGPDVIREVTGEEVTLDELGGSDAQARYGNIHHVVNTEAEAF
QYVREYLSFLPSNCFDQPPIVNPGLEPEITPTDLELDSIVPDSDNMSYDMHEILLRIFDDGDFLEVAAQHGPAIITGYAR
VDGHPVGVIANQPMHLSGSIDNEASDKAARFIRFCDAFNIPLVFVVDTPGFLPGAEEEKRGIIKRGGRFLYSVVEADVPK
VTITVRKSYGGAYAVMGSRQLTADFNFAWPTARIAVIGAEGAAQLLMKRFPDPTTPEAQQIKKDFIEGYNLNMAIPWTAA
ERGFIDAVIDPHETRLLLRKSLKLLRDKQLWFRVARKHGLIPV

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=505, Percent_Identity=42.3762376237624, Blast_Score=401, Evalue=1e-111,
Organism=Homo sapiens, GI295821216, Length=525, Percent_Identity=40.7619047619048, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI11545863, Length=501, Percent_Identity=32.7345309381238, Blast_Score=215, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI25147362, Length=533, Percent_Identity=41.2757973733583, Blast_Score=392, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI25147359, Length=533, Percent_Identity=41.2757973733583, Blast_Score=391, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17552936, Length=501, Percent_Identity=29.940119760479, Blast_Score=212, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI71997163, Length=291, Percent_Identity=22.3367697594502, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24586065, Length=508, Percent_Identity=30.7086614173228, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 57286; Mature: 57155

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEMAPAPIQHTTAEKLAELYLRLELAKEPGGEKAAAKRDKKGIPSARARIHALVDPGTF
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHEEEEEECCCCH
LETGALAKTPNDPNALYGDGCVTGHAMIDGRPVGVFSHDQTVFQGTVGEMFGRKVARLME
HCCCCCCCCCCCCCCEECCCEEECCEEECCEEEEEECCCCHHHHCHHHHHHHHHHHHHHH
WCAMVGCPIIGIQDSGGARIQDAVTSLAWYAELGRRHEALSGLVPQISLIFGKCAGGAVY
HHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SPIQDDLLVSVRDQGYFFVTGPDVIREVTGEEVTLDELGGSDAQARYGNIHHVVNTEAEA
CCCCCCEEEEEECCCEEEEECHHHHHHHCCCEEEHHHCCCCCCHHHCCCEEEEECCHHHH
FQYVREYLSFLPSNCFDQPPIVNPGLEPEITPTDLELDSIVPDSDNMSYDMHEILLRIFD
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHCC
DGDFLEVAAQHGPAIITGYARVDGHPVGVIANQPMHLSGSIDNEASDKAARFIRFCDAFN
CCCHHHHHHCCCCEEEEEEEEECCCEEEEEECCCEEECCCCCCCCHHHHHHHHHHHHCCC
IPLVFVVDTPGFLPGAEEEKRGIIKRGGRFLYSVVEADVPKVTITVRKSYGGAYAVMGSR
CCEEEEECCCCCCCCCCHHHCCHHHHCCHHHHHHHHCCCCEEEEEEEECCCCEEEEECCE
QLTADFNFAWPTARIAVIGAEGAAQLLMKRFPDPTTPEAQQIKKDFIEGYNLNMAIPWTA
EEEECCCEECCCEEEEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCC
AERGFIDAVIDPHETRLLLRKSLKLLRDKQLWFRVARKHGLIPV
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TEMAPAPIQHTTAEKLAELYLRLELAKEPGGEKAAAKRDKKGIPSARARIHALVDPGTF
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHEEEEEECCCCH
LETGALAKTPNDPNALYGDGCVTGHAMIDGRPVGVFSHDQTVFQGTVGEMFGRKVARLME
HCCCCCCCCCCCCCCEECCCEEECCEEECCEEEEEECCCCHHHHCHHHHHHHHHHHHHHH
WCAMVGCPIIGIQDSGGARIQDAVTSLAWYAELGRRHEALSGLVPQISLIFGKCAGGAVY
HHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SPIQDDLLVSVRDQGYFFVTGPDVIREVTGEEVTLDELGGSDAQARYGNIHHVVNTEAEA
CCCCCCEEEEEECCCEEEEECHHHHHHHCCCEEEHHHCCCCCCHHHCCCEEEEECCHHHH
FQYVREYLSFLPSNCFDQPPIVNPGLEPEITPTDLELDSIVPDSDNMSYDMHEILLRIFD
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHCC
DGDFLEVAAQHGPAIITGYARVDGHPVGVIANQPMHLSGSIDNEASDKAARFIRFCDAFN
CCCHHHHHHCCCCEEEEEEEEECCCEEEEEECCCEEECCCCCCCCHHHHHHHHHHHHCCC
IPLVFVVDTPGFLPGAEEEKRGIIKRGGRFLYSVVEADVPKVTITVRKSYGGAYAVMGSR
CCEEEEECCCCCCCCCCHHHCCHHHHCCHHHHHHHHCCCCEEEEEEEECCCCEEEEECCE
QLTADFNFAWPTARIAVIGAEGAAQLLMKRFPDPTTPEAQQIKKDFIEGYNLNMAIPWTA
EEEECCCEECCCEEEEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCC
AERGFIDAVIDPHETRLLLRKSLKLLRDKQLWFRVARKHGLIPV
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]