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The map label for this gene is ponA_1

Identifier: 41406162

GI number: 41406162

Start: 69679

End: 72312

Strand: Direct

Name: ponA_1

Synonym: MAP0064

Alternate gene names: 41406162

Gene position: 69679-72312 (Clockwise)

Preceding gene: 41406161

Following gene: 41406163

Centisome position: 1.44

GC content: 70.24

Gene sequence:

>2634_bases
ATGAGCTCGAATAACGAAGGACGCCACAGCCAGTCGTCCGGTGATCAACGTGGGCCCGCGGCCGAGCAGGGTGCCGGCGA
ACGCCGGGAGACGGCGCGTCCGGACGCCGACCCGCAGCGGCGCCACGGCCCGTCGACGTCCAGCCGTCGCCGGCAGGCCC
CGCCCGACGATCGGCTCACCACGATCCTGCCGCCGGTCGACGACGACCGGGCGCCCCGGCGCTCCGACCCGATCGAGGAG
GTCAAGGCCGCGCTGGCGGGTCCGCCGTCGACGCCGTTGCGCCGCGACGCGCTCGACGAGGTCAAGGCCGCCCTGGACAG
CCGGGGGCCTGCGTCGGGTCGCCAGCAGCGCGCCGGCCTCGGCGGCCGCCCGCCCGCGGGGCCCCCGCCGCCGCCTCCGA
GCCGCGGCTGGTCCGGTGGGCCCGGCGGCCCGGGCGGCCGGGGGAGCGGACCGTGGCGCGACTGGAGCTGGACCCAGCAG
ATCAACTGGCTGTGGGTGCGCCGCGCCGCCTACCTGTGCGCGGCGGTGCTGGTGTTGTTGCCGATCGTCACGTTCGCGAT
GGCCTACTTCATCGTCGACATCCCCAAGCCGGGTGACCTTCGCACCAACCAGGTTTCGACGATCCTGGCCAGCGACGGCT
CGGAGATCGCGAAACTCATTCCGCCGGAAGGCAATCGGGTCGACGTCAATCTCAACCAGGTGCCCGTGCACGTCCGCCAG
GCGGTGATCGCGGCCGAAGACCGCAACTTCTACTCCAACCCGGGCTTCGACTTCAGCGGTTTCGCGCGCGCGGTGAACAA
CAACCTGTTCGGCAACGGGGATCTGCAGGGCGGGTCGACGATCACCCAGCAGTATGTGAAGAACGCGCTGGTCGGTTCGG
CGCAGCACGGGGTCAGCGGCCTGATGCGCAAGGCCAAGGAATTGGTCATCGCCACCAAGATGTCCGGCGAGTGGTCCAAA
GACGAAGTGCTGCAGTCTTATCTGAACATCATCTATTTCGGCCGGGGCGCCTACGGCATCTCGGCCGCCGCCAAGGCGTA
TTTCGACAAGCCCGTCGAGCAGCTCACCGTGTCCGAGGGTGCGCTGCTGGCGGCGCTGATCCGCCGGCCGTCCACCCTGG
ACCCGGCCGTCGATCCCAAGGGCGCGCTGGCGCGCTGGAACTGGGTGCTCGACGGCATGGTGGAGACCAAGGCGCTGCCC
GCCAAGGACCGTGCCGCGCAGGTCTTCCCGCAGACCGTGCCGCCCGACCAGGCGCGCGCGCAGAACCAGACGACCGGGCC
CAACGGCCTGATCGAGCGTCAGGTGACCAAGGAGCTGATGGAGCTCTTCAACATCGACGAGCGGACGCTGAACACGCAGG
GCCTGCAGGTCACCACCACCATCGACCCCAAGGCCCAGCAGGCCGCCGAGAAGGCGGTGTCGAAATACCTTGACGGGCAA
GACCCCGACATGCGCGCGGCGGTGGTGTCGGTGGATCCGCACGACGGCGCCATCCGCGCCTACTACGGCGGTAGCGACGC
CAACGGTTTCGACTTCGCCCAGGCGGGATTGCAGACCGGCTCGTCGTTCAAGGTGTTCTGCCTGATCGCCGCGCTTGAGC
AGGGCATCGGCCTGGGCTACCAGGTGGACAGCTCGCCGCTGACGGTCGACGGCATCAAGATCACCAACGTCGAGGGCGAG
AGCTGCGGGACGTGCAACATCGCGCAGGCGCTCAAGATGTCGTTGAACACCTCCTATTACCGGCTGATGCTCAAACTCAA
GGGCGGGCCGCAGGCCGTGGCCGATGCCGCGCATCAGGCAGGCGTTGCCACGAGTTTTCCCGGCGTGGACCACACGCTGT
CCGAGGACGGCAAGGGCGGGCCGCCGAACAACGGAATTGTGCTGGGCCAGTACCAAACCCGGGTGATCGACATGGCCTCG
GCGTACGCCACGCTGGCCGCCTCGGGCGTCTACCACCGGCCGCATTTCGTGCAGAAGGTGGTCAACTCGGACGGTCAGGT
GCTCTTCGACGCCGGCAAGTCCGACAACAACGGCGAGCAGCGGATCCCGAAGGCCGTCGCGGACAACGTCACCGCGGCCA
TGGAACCGATCGCGGGCTACTCGCGGGGTCACGCGTTGGCCGGCGGCCGGCCGTCGGCGGCCAAGACCGGCACCACGCAG
CTCGGTGACACCACCTCCAACAAGGACGCCTGGATGGTCGGCTACACGCCGTCGCTGTCGACGGCGGTGTGGCTGGGCAC
GGCCAAGGGCGACCAGCCGCTGGTAACCGCTTCCGGCGGACCGGTTTACGGGTCCGGGCTGCCCTCGGATATCTGGAAGG
CCACCATGGACGGGGCGCTGAAGGGCACCCCCAACGAATCGTTCCCGAAGCCGGCCGAGGTCGGCGGCTACGCCGGTGTG
CCCGCGCCGCCGCCCCCGCCGAAGGCGCCGCCGTCGGAGACCGTCATCCAACCCACCATCGAAGTGGCGCCCGGCATCAC
GATCCCGGTCGGCCCGCCGACGACGGTCACGCTGGCGCCTGCCCCGCCCGCGGGCGGCCCGCCGGGGGGACCCGAGCCGG
GTGGCGGTGTACCGCCGGGGCCGGGCGGCGGTGTTCCGCCGGGTGGTCCCCAAGCACCGCCTCCGCCGCCGTGA

Upstream 100 bases:

>100_bases
TCAAGTCATATGTGCTCGGTGCGGCGCGCCCGGCGCCTCCGCCCCGGGGCACCCGGACGACTACGCGGACGGCGCGCAAC
GGCGCCCGCACGGCCACTGA

Downstream 100 bases:

>100_bases
CCGGCGCTGCCGAGCCCAGCGCCACCATTTCACCGGGGCCGCTGGCCGCGGATCGGCGTAGCGCCGACAATCGAGACTGC
CCGAGCCGCAACGACTTTCT

Product: PonA_1

Products: NA

Alternate protein names: PBP-1F; Penicillin-binding protein F [H]

Number of amino acids: Translated: 877; Mature: 876

Protein sequence:

>877_residues
MSSNNEGRHSQSSGDQRGPAAEQGAGERRETARPDADPQRRHGPSTSSRRRQAPPDDRLTTILPPVDDDRAPRRSDPIEE
VKAALAGPPSTPLRRDALDEVKAALDSRGPASGRQQRAGLGGRPPAGPPPPPPSRGWSGGPGGPGGRGSGPWRDWSWTQQ
INWLWVRRAAYLCAAVLVLLPIVTFAMAYFIVDIPKPGDLRTNQVSTILASDGSEIAKLIPPEGNRVDVNLNQVPVHVRQ
AVIAAEDRNFYSNPGFDFSGFARAVNNNLFGNGDLQGGSTITQQYVKNALVGSAQHGVSGLMRKAKELVIATKMSGEWSK
DEVLQSYLNIIYFGRGAYGISAAAKAYFDKPVEQLTVSEGALLAALIRRPSTLDPAVDPKGALARWNWVLDGMVETKALP
AKDRAAQVFPQTVPPDQARAQNQTTGPNGLIERQVTKELMELFNIDERTLNTQGLQVTTTIDPKAQQAAEKAVSKYLDGQ
DPDMRAAVVSVDPHDGAIRAYYGGSDANGFDFAQAGLQTGSSFKVFCLIAALEQGIGLGYQVDSSPLTVDGIKITNVEGE
SCGTCNIAQALKMSLNTSYYRLMLKLKGGPQAVADAAHQAGVATSFPGVDHTLSEDGKGGPPNNGIVLGQYQTRVIDMAS
AYATLAASGVYHRPHFVQKVVNSDGQVLFDAGKSDNNGEQRIPKAVADNVTAAMEPIAGYSRGHALAGGRPSAAKTGTTQ
LGDTTSNKDAWMVGYTPSLSTAVWLGTAKGDQPLVTASGGPVYGSGLPSDIWKATMDGALKGTPNESFPKPAEVGGYAGV
PAPPPPPKAPPSETVIQPTIEVAPGITIPVGPPTTVTLAPAPPAGGPPGGPEPGGGVPPGPGGGVPPGGPQAPPPPP

Sequences:

>Translated_877_residues
MSSNNEGRHSQSSGDQRGPAAEQGAGERRETARPDADPQRRHGPSTSSRRRQAPPDDRLTTILPPVDDDRAPRRSDPIEE
VKAALAGPPSTPLRRDALDEVKAALDSRGPASGRQQRAGLGGRPPAGPPPPPPSRGWSGGPGGPGGRGSGPWRDWSWTQQ
INWLWVRRAAYLCAAVLVLLPIVTFAMAYFIVDIPKPGDLRTNQVSTILASDGSEIAKLIPPEGNRVDVNLNQVPVHVRQ
AVIAAEDRNFYSNPGFDFSGFARAVNNNLFGNGDLQGGSTITQQYVKNALVGSAQHGVSGLMRKAKELVIATKMSGEWSK
DEVLQSYLNIIYFGRGAYGISAAAKAYFDKPVEQLTVSEGALLAALIRRPSTLDPAVDPKGALARWNWVLDGMVETKALP
AKDRAAQVFPQTVPPDQARAQNQTTGPNGLIERQVTKELMELFNIDERTLNTQGLQVTTTIDPKAQQAAEKAVSKYLDGQ
DPDMRAAVVSVDPHDGAIRAYYGGSDANGFDFAQAGLQTGSSFKVFCLIAALEQGIGLGYQVDSSPLTVDGIKITNVEGE
SCGTCNIAQALKMSLNTSYYRLMLKLKGGPQAVADAAHQAGVATSFPGVDHTLSEDGKGGPPNNGIVLGQYQTRVIDMAS
AYATLAASGVYHRPHFVQKVVNSDGQVLFDAGKSDNNGEQRIPKAVADNVTAAMEPIAGYSRGHALAGGRPSAAKTGTTQ
LGDTTSNKDAWMVGYTPSLSTAVWLGTAKGDQPLVTASGGPVYGSGLPSDIWKATMDGALKGTPNESFPKPAEVGGYAGV
PAPPPPPKAPPSETVIQPTIEVAPGITIPVGPPTTVTLAPAPPAGGPPGGPEPGGGVPPGPGGGVPPGGPQAPPPPP
>Mature_876_residues
SSNNEGRHSQSSGDQRGPAAEQGAGERRETARPDADPQRRHGPSTSSRRRQAPPDDRLTTILPPVDDDRAPRRSDPIEEV
KAALAGPPSTPLRRDALDEVKAALDSRGPASGRQQRAGLGGRPPAGPPPPPPSRGWSGGPGGPGGRGSGPWRDWSWTQQI
NWLWVRRAAYLCAAVLVLLPIVTFAMAYFIVDIPKPGDLRTNQVSTILASDGSEIAKLIPPEGNRVDVNLNQVPVHVRQA
VIAAEDRNFYSNPGFDFSGFARAVNNNLFGNGDLQGGSTITQQYVKNALVGSAQHGVSGLMRKAKELVIATKMSGEWSKD
EVLQSYLNIIYFGRGAYGISAAAKAYFDKPVEQLTVSEGALLAALIRRPSTLDPAVDPKGALARWNWVLDGMVETKALPA
KDRAAQVFPQTVPPDQARAQNQTTGPNGLIERQVTKELMELFNIDERTLNTQGLQVTTTIDPKAQQAAEKAVSKYLDGQD
PDMRAAVVSVDPHDGAIRAYYGGSDANGFDFAQAGLQTGSSFKVFCLIAALEQGIGLGYQVDSSPLTVDGIKITNVEGES
CGTCNIAQALKMSLNTSYYRLMLKLKGGPQAVADAAHQAGVATSFPGVDHTLSEDGKGGPPNNGIVLGQYQTRVIDMASA
YATLAASGVYHRPHFVQKVVNSDGQVLFDAGKSDNNGEQRIPKAVADNVTAAMEPIAGYSRGHALAGGRPSAAKTGTTQL
GDTTSNKDAWMVGYTPSLSTAVWLGTAKGDQPLVTASGGPVYGSGLPSDIWKATMDGALKGTPNESFPKPAEVGGYAGVP
APPPPPKAPPSETVIQPTIEVAPGITIPVGPPTTVTLAPAPPAGGPPGGPEPGGGVPPGPGGGVPPGGPQAPPPPP

Specific function: Cell wall formation. May be involved in outgrowth of the germinated spore or it could function in the synthesis of the germ cell wall [H]

COG id: COG0744

COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI87082258, Length=296, Percent_Identity=36.1486486486487, Blast_Score=150, Evalue=4e-37,
Organism=Escherichia coli, GI1786343, Length=635, Percent_Identity=26.2992125984252, Blast_Score=145, Evalue=1e-35,
Organism=Escherichia coli, GI1788867, Length=589, Percent_Identity=25.6366723259762, Blast_Score=117, Evalue=4e-27,
Organism=Escherichia coli, GI1789601, Length=168, Percent_Identity=36.9047619047619, Blast_Score=97, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-; 3.4.-.- [C]

Molecular weight: Translated: 91679; Mature: 91547

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNNEGRHSQSSGDQRGPAAEQGAGERRETARPDADPQRRHGPSTSSRRRQAPPDDRLT
CCCCCCCCCCCCCCCCCCCCHHCCCCCHHHHCCCCCCHHHHCCCCCCHHCCCCCCCCCCE
TILPPVDDDRAPRRSDPIEEVKAALAGPPSTPLRRDALDEVKAALDSRGPASGRQQRAGL
EECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCC
GGRPPAGPPPPPPSRGWSGGPGGPGGRGSGPWRDWSWTQQINWLWVRRAAYLCAAVLVLL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
PIVTFAMAYFIVDIPKPGDLRTNQVSTILASDGSEIAKLIPPEGNRVDVNLNQVPVHVRQ
HHHHHHHHHHEEECCCCCCCCCCHHHEEEECCCHHHHHHCCCCCCEEEEEHHHCCHHHHH
AVIAAEDRNFYSNPGFDFSGFARAVNNNLFGNGDLQGGSTITQQYVKNALVGSAQHGVSG
HHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHH
LMRKAKELVIATKMSGEWSKDEVLQSYLNIIYFGRGAYGISAAAKAYFDKPVEQLTVSEG
HHHHHHHEEEEEECCCCCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHCHHHHHHHCCC
ALLAALIRRPSTLDPAVDPKGALARWNWVLDGMVETKALPAKDRAAQVFPQTVPPDQARA
HHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHCHHHHCCCCCCCHHHHHCCCCCCCHHHHH
QNQTTGPNGLIERQVTKELMELFNIDERTLNTQGLQVTTTIDPKAQQAAEKAVSKYLDGQ
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCC
DPDMRAAVVSVDPHDGAIRAYYGGSDANGFDFAQAGLQTGSSFKVFCLIAALEQGIGLGY
CCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCE
QVDSSPLTVDGIKITNVEGESCGTCNIAQALKMSLNTSYYRLMLKLKGGPQAVADAAHQA
EECCCCEEECCEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHC
GVATSFPGVDHTLSEDGKGGPPNNGIVLGQYQTRVIDMASAYATLAASGVYHRPHFVQKV
CCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
VNSDGQVLFDAGKSDNNGEQRIPKAVADNVTAAMEPIAGYSRGHALAGGRPSAAKTGTTQ
HCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
LGDTTSNKDAWMVGYTPSLSTAVWLGTAKGDQPLVTASGGPVYGSGLPSDIWKATMDGAL
CCCCCCCCCEEEEEECCCCCCEEEEEECCCCCCEEEECCCCEECCCCCHHHHHHHHCCCC
KGTPNESFPKPAEVGGYAGVPAPPPPPKAPPSETVIQPTIEVAPGITIPVGPPTTVTLAP
CCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCEECCHHHHCCCCEECCCCCCEEEECC
APPAGGPPGGPEPGGGVPPGPGGGVPPGGPQAPPPPP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSNNEGRHSQSSGDQRGPAAEQGAGERRETARPDADPQRRHGPSTSSRRRQAPPDDRLT
CCCCCCCCCCCCCCCCCCCHHCCCCCHHHHCCCCCCHHHHCCCCCCHHCCCCCCCCCCE
TILPPVDDDRAPRRSDPIEEVKAALAGPPSTPLRRDALDEVKAALDSRGPASGRQQRAGL
EECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCC
GGRPPAGPPPPPPSRGWSGGPGGPGGRGSGPWRDWSWTQQINWLWVRRAAYLCAAVLVLL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
PIVTFAMAYFIVDIPKPGDLRTNQVSTILASDGSEIAKLIPPEGNRVDVNLNQVPVHVRQ
HHHHHHHHHHEEECCCCCCCCCCHHHEEEECCCHHHHHHCCCCCCEEEEEHHHCCHHHHH
AVIAAEDRNFYSNPGFDFSGFARAVNNNLFGNGDLQGGSTITQQYVKNALVGSAQHGVSG
HHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHH
LMRKAKELVIATKMSGEWSKDEVLQSYLNIIYFGRGAYGISAAAKAYFDKPVEQLTVSEG
HHHHHHHEEEEEECCCCCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHCHHHHHHHCCC
ALLAALIRRPSTLDPAVDPKGALARWNWVLDGMVETKALPAKDRAAQVFPQTVPPDQARA
HHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHCHHHHCCCCCCCHHHHHCCCCCCCHHHHH
QNQTTGPNGLIERQVTKELMELFNIDERTLNTQGLQVTTTIDPKAQQAAEKAVSKYLDGQ
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCC
DPDMRAAVVSVDPHDGAIRAYYGGSDANGFDFAQAGLQTGSSFKVFCLIAALEQGIGLGY
CCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCE
QVDSSPLTVDGIKITNVEGESCGTCNIAQALKMSLNTSYYRLMLKLKGGPQAVADAAHQA
EECCCCEEECCEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHC
GVATSFPGVDHTLSEDGKGGPPNNGIVLGQYQTRVIDMASAYATLAASGVYHRPHFVQKV
CCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
VNSDGQVLFDAGKSDNNGEQRIPKAVADNVTAAMEPIAGYSRGHALAGGRPSAAKTGTTQ
HCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
LGDTTSNKDAWMVGYTPSLSTAVWLGTAKGDQPLVTASGGPVYGSGLPSDIWKATMDGAL
CCCCCCCCCEEEEEECCCCCCEEEEEECCCCCCEEEECCCCEECCCCCHHHHHHHHCCCC
KGTPNESFPKPAEVGGYAGVPAPPPPPKAPPSETVIQPTIEVAPGITIPVGPPTTVTLAP
CCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCEECCHHHHCCCCEECCCCCCEEEECC
APPAGGPPGGPEPGGGVPPGPGGGVPPGGPQAPPPPP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 8335642; 1459957 [H]