Click here to switch to the map view.

The map label for this gene is ltaE [H]

Identifier: 39998497

GI number: 39998497

Start: 3749852

End: 3750907

Strand: Direct

Name: ltaE [H]

Synonym: GSU3408

Alternate gene names: 39998497

Gene position: 3749852-3750907 (Clockwise)

Preceding gene: 39998496

Following gene: 39998498

Centisome position: 98.31

GC content: 61.36

Gene sequence:

>1056_bases
ATGAACAACTGCACGACCACCGAGCGCCGCAACCAGTTTGCCAGTGACAACTACGCCGGAATCTGCCCCGAGGCATGGCA
GGCCATGGAAGAGGCCAACCGTGGGTATGCCTGTTCCTACGGCGACGACACCTGGACGGAGAGGGCGTGCCGCCTGCTGC
GCGACACCTTTGAAACCGACTGCGAGGTGTTCTTCGTCTTCAACGGCACGGCGGCCAACTCACTGGCCCTGGCATCCCTC
TGCCAGTCGTACCACAGCATCATCTGCCACGAGACATCCCATATCGAAACCGACGAATGCGGGGCCGCCGAATTTTTTTC
CAACGGCACAAAAATACTTCTGGTTCCCGGCCCCCACGGCAAGGTCGACCCGGACGCAGTTGAGCACACGGTCAAACGGC
GCCTCGACATTCATTACCCCAAGCCCAAGGTCCTCAGCATCACCCAGGCAACGGAATTGGGGACCCTCTATTCGGTGGAT
GAACTGCGCGAGCTGGGCCATCTTGCTCGACGCCTGGATCTACGCGTCCACATGGACGGGGCCCGTTTTGCAAATGCCGT
TGCCGCCCTCGGTGTCCACCCGAGCGAGATCACCTGGAAGGCCGGGGTCGACGTGCTCTGTTTCGGCGGGACCAAGAACG
GCATGGCCGTAGGTGAAGCAGTCGTGTTTTTCAACCGGGAGCTTGCCCGCGAGTTCGACTACCGCTGCAAGCAGGCAGGA
CAGCTTGCCTCGAAGATGCGCTTTCTGGCCGCTCCCTGGATCGGCATGCTGGAAAGCGGTGCCTGGTTGACCCGCTCAGC
CCATGCGAATGCCTGCGCAGCCAGACTTGAAGCCCGGCTTCGCGATATTCCCGGCGTCGGCATCCGCTTTCCCCGCCAGG
CAAACTCGGTCTTTGCCGATCTCCCGCCGGGGGTCGTCGACGCCCTCCATGGGCTTGGTTGGCATTTCTACACCTTCATC
GGCTCCGGCGGAGCGCGCTTCATGTGCTCCTGGGAGACGAGCGATCAGGACATCGACCTACTGGCGACTGACATAGCAGG
TTGCTGTAATAGGTAA

Upstream 100 bases:

>100_bases
GTAATTTCGGAGCTTGCACCCAGCGGCGAATCCCCTGAAGCGTCAACGGCGACCTGACCCGGATGCGTCGTCATACTCTT
TGCCAAAGGACATCGTGAAC

Downstream 100 bases:

>100_bases
CAAAGAGGGCGGGAGATAAGGCAACACCCAAGGCATATCAGTAAGATAAGCAGGGGGCTGAGCACCACGCGACGGAGCAA
ATGTGCTCCGCAGTAGTATT

Product: L-threonine aldolase, low-specificity

Products: NA

Alternate protein names: Low specificity L-TA [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MNNCTTTERRNQFASDNYAGICPEAWQAMEEANRGYACSYGDDTWTERACRLLRDTFETDCEVFFVFNGTAANSLALASL
CQSYHSIICHETSHIETDECGAAEFFSNGTKILLVPGPHGKVDPDAVEHTVKRRLDIHYPKPKVLSITQATELGTLYSVD
ELRELGHLARRLDLRVHMDGARFANAVAALGVHPSEITWKAGVDVLCFGGTKNGMAVGEAVVFFNRELAREFDYRCKQAG
QLASKMRFLAAPWIGMLESGAWLTRSAHANACAARLEARLRDIPGVGIRFPRQANSVFADLPPGVVDALHGLGWHFYTFI
GSGGARFMCSWETSDQDIDLLATDIAGCCNR

Sequences:

>Translated_351_residues
MNNCTTTERRNQFASDNYAGICPEAWQAMEEANRGYACSYGDDTWTERACRLLRDTFETDCEVFFVFNGTAANSLALASL
CQSYHSIICHETSHIETDECGAAEFFSNGTKILLVPGPHGKVDPDAVEHTVKRRLDIHYPKPKVLSITQATELGTLYSVD
ELRELGHLARRLDLRVHMDGARFANAVAALGVHPSEITWKAGVDVLCFGGTKNGMAVGEAVVFFNRELAREFDYRCKQAG
QLASKMRFLAAPWIGMLESGAWLTRSAHANACAARLEARLRDIPGVGIRFPRQANSVFADLPPGVVDALHGLGWHFYTFI
GSGGARFMCSWETSDQDIDLLATDIAGCCNR
>Mature_351_residues
MNNCTTTERRNQFASDNYAGICPEAWQAMEEANRGYACSYGDDTWTERACRLLRDTFETDCEVFFVFNGTAANSLALASL
CQSYHSIICHETSHIETDECGAAEFFSNGTKILLVPGPHGKVDPDAVEHTVKRRLDIHYPKPKVLSITQATELGTLYSVD
ELRELGHLARRLDLRVHMDGARFANAVAALGVHPSEITWKAGVDVLCFGGTKNGMAVGEAVVFFNRELAREFDYRCKQAG
QLASKMRFLAAPWIGMLESGAWLTRSAHANACAARLEARLRDIPGVGIRFPRQANSVFADLPPGVVDALHGLGWHFYTFI
GSGGARFMCSWETSDQDIDLLATDIAGCCNR

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. Can also act on L-erythro- phenylserine, L-threo-phenylserine, L-beta-3,4- methylenedioxyphenylserine and L-beta-3,4-dihydroxyphenylserine [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=233, Percent_Identity=28.3261802575107, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193206520, Length=210, Percent_Identity=32.8571428571429, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI193206522, Length=210, Percent_Identity=32.8571428571429, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI193206524, Length=210, Percent_Identity=32.8571428571429, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320789, Length=300, Percent_Identity=24.3333333333333, Blast_Score=66, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 38680; Mature: 38680

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
4.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNCTTTERRNQFASDNYAGICPEAWQAMEEANRGYACSYGDDTWTERACRLLRDTFETD
CCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCC
CEVFFVFNGTAANSLALASLCQSYHSIICHETSHIETDECGAAEFFSNGTKILLVPGPHG
CEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCEEEEEECCCC
KVDPDAVEHTVKRRLDIHYPKPKVLSITQATELGTLYSVDELRELGHLARRLDLRVHMDG
CCCHHHHHHHHHHHHCCCCCCCCEEEEECHHHCCCCCCHHHHHHHHHHHHHHHEEEEECH
ARFANAVAALGVHPSEITWKAGVDVLCFGGTKNGMAVGEAVVFFNRELAREFDYRCKQAG
HHHHHHHHHHCCCCCCEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QLASKMRFLAAPWIGMLESGAWLTRSAHANACAARLEARLRDIPGVGIRFPRQANSVFAD
HHHHHHHHHHCCHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCCCEECCCHHCCEECC
LPPGVVDALHGLGWHFYTFIGSGGARFMCSWETSDQDIDLLATDIAGCCNR
CCCHHHHHHHHCCCEEEHEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNCTTTERRNQFASDNYAGICPEAWQAMEEANRGYACSYGDDTWTERACRLLRDTFETD
CCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCC
CEVFFVFNGTAANSLALASLCQSYHSIICHETSHIETDECGAAEFFSNGTKILLVPGPHG
CEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCEEEEEECCCC
KVDPDAVEHTVKRRLDIHYPKPKVLSITQATELGTLYSVDELRELGHLARRLDLRVHMDG
CCCHHHHHHHHHHHHCCCCCCCCEEEEECHHHCCCCCCHHHHHHHHHHHHHHHEEEEECH
ARFANAVAALGVHPSEITWKAGVDVLCFGGTKNGMAVGEAVVFFNRELAREFDYRCKQAG
HHHHHHHHHHCCCCCCEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QLASKMRFLAAPWIGMLESGAWLTRSAHANACAARLEARLRDIPGVGIRFPRQANSVFAD
HHHHHHHHHHCCHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCCCEECCCHHCCEECC
LPPGVVDALHGLGWHFYTFIGSGGARFMCSWETSDQDIDLLATDIAGCCNR
CCCHHHHHHHHCCCEEEHEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9464392 [H]