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The map label for this gene is ymxG [H]

Identifier: 39998449

GI number: 39998449

Start: 3691369

End: 3692688

Strand: Direct

Name: ymxG [H]

Synonym: GSU3360

Alternate gene names: 39998449

Gene position: 3691369-3692688 (Clockwise)

Preceding gene: 39998448

Following gene: 39998452

Centisome position: 96.78

GC content: 64.92

Gene sequence:

>1320_bases
ATGACAGCAACCGCCCACCGGAAAACTCTCCCCAACGGCCTGCGTGTGGTGGCGGTGGAAATGCCCCACCTCCACAGTAC
CGAGATCGCGGTCTACGTACGCGTTGGCGGTCGCGACGACAGCCGCGCCACGGCCGGCCTCGCTCATTTCCTGGAGCACA
TGCTCTTTCGGGGCACCGCCGAGCACCCGACCAACCTGGAGCTGGAAGCCGCTTTCGAGGCCATCGGCGGCTGCGTAAAT
GCCGCGACCGACGCCGAATCCACCAGCTACTATTCCCGCGTCCACCCCGATCACGTGGCCGAAGGGCTGCGCCTGTTGGC
AGCCATGGTCCTCACGCCGACCTTTCCGGGCATTGATATCGAAAAGCGGATCATCACCGAGGAAGCCCTGGAAGACATCA
ACGACCACGGCGACGACATCAACCCCGACAACCTCTCCAGCAGCATGCTCTGGCCCGACCACCCCCTCGGCATGCCGACC
ATCGGCTACCTCGACACCATCTCGGCTATCACCGAGGCCGACCTGAAGGGTCACATGACCCGCTACTACGTGCCCACCAA
CGCAGTGGTCGTAGCCGCCGGACGGGTCAGGGCCGACGACGTATTCGGGGCCGTCGCCGACGCTTTCGGCACCTGGGCGG
GACCGTCCGCCCCCGGCCGGCTGCCGCCGCCGTCAAACCAGGACGAACCCCGCTGCCTCTTTGTGAAGGACGCAGACAGC
CAGGTGGATCTCCAGATAACCTTTCGCGGATTCTCCCGCCCGGACCCGCAGCTGGCGGCAAGCCGGCTCCTCCGGCGCGT
TCTGGCGGGAGGCGGCTGTTCGCGCCTTCACCTGAACCTGCGGGAACGGCTCGGCATCGTCTACTCCGTGGACGCTCAGG
TTGCCGCCTACGATGAGACCGGCTGCTTTTCCATCGAACTGTCCACTGCACCGGAAAATCTGCTCACTGCCGTGGAGGAA
GTCCTTGGGGAGACCCGGAAACTCGCGGCGGAGCCGGTTGGCGCCGAGGAGCTGCGCCGGGTTCGGCAGGGATATTTCTT
CGACCTTGCCTACAGCGAAGATTCCACCTTTGAAATGCAGGTGCGTTACGGGTGGGGCGAACTAATGGGAATGGTCAAGG
GGATCGACGAGGAACGGGCCGAGGTTGAGGCCGTGGATGAGGGCACCCTGCAGGCCGTCGCACGGCGGCTTTTTGCTCCG
GCAGCCCTCAACCTCGTGGCCGTCGGGCCGGTCACCGCGACTGCAAAGCGGCGGATTGAGCAGTTGCTGCGGCGCTACGC
CAAGGAATTTCCTACCTCATCTCAACCACCCGGGCCTTGA

Upstream 100 bases:

>100_bases
AGTCGTTGCTGCGCATTCCCCCCGTGGCCATGGCCCTCTCCCGCGACAAGTACGACGGGGTAGTATTAGACGCCATCCAG
GCCATCAGCGCCGAGGCCCG

Downstream 100 bases:

>100_bases
TCCTGCCGACCACGGCGGCAATGGCCGCCAGCCGGTCGGGGCTTTCCCCCTCAACCAGTTTCACATGCGAGGCATCGGCA
GGAACCTGATCAAAAGTGGG

Product: M16 family peptidase

Products: NA

Alternate protein names: ORFP [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MTATAHRKTLPNGLRVVAVEMPHLHSTEIAVYVRVGGRDDSRATAGLAHFLEHMLFRGTAEHPTNLELEAAFEAIGGCVN
AATDAESTSYYSRVHPDHVAEGLRLLAAMVLTPTFPGIDIEKRIITEEALEDINDHGDDINPDNLSSSMLWPDHPLGMPT
IGYLDTISAITEADLKGHMTRYYVPTNAVVVAAGRVRADDVFGAVADAFGTWAGPSAPGRLPPPSNQDEPRCLFVKDADS
QVDLQITFRGFSRPDPQLAASRLLRRVLAGGGCSRLHLNLRERLGIVYSVDAQVAAYDETGCFSIELSTAPENLLTAVEE
VLGETRKLAAEPVGAEELRRVRQGYFFDLAYSEDSTFEMQVRYGWGELMGMVKGIDEERAEVEAVDEGTLQAVARRLFAP
AALNLVAVGPVTATAKRRIEQLLRRYAKEFPTSSQPPGP

Sequences:

>Translated_439_residues
MTATAHRKTLPNGLRVVAVEMPHLHSTEIAVYVRVGGRDDSRATAGLAHFLEHMLFRGTAEHPTNLELEAAFEAIGGCVN
AATDAESTSYYSRVHPDHVAEGLRLLAAMVLTPTFPGIDIEKRIITEEALEDINDHGDDINPDNLSSSMLWPDHPLGMPT
IGYLDTISAITEADLKGHMTRYYVPTNAVVVAAGRVRADDVFGAVADAFGTWAGPSAPGRLPPPSNQDEPRCLFVKDADS
QVDLQITFRGFSRPDPQLAASRLLRRVLAGGGCSRLHLNLRERLGIVYSVDAQVAAYDETGCFSIELSTAPENLLTAVEE
VLGETRKLAAEPVGAEELRRVRQGYFFDLAYSEDSTFEMQVRYGWGELMGMVKGIDEERAEVEAVDEGTLQAVARRLFAP
AALNLVAVGPVTATAKRRIEQLLRRYAKEFPTSSQPPGP
>Mature_438_residues
TATAHRKTLPNGLRVVAVEMPHLHSTEIAVYVRVGGRDDSRATAGLAHFLEHMLFRGTAEHPTNLELEAAFEAIGGCVNA
ATDAESTSYYSRVHPDHVAEGLRLLAAMVLTPTFPGIDIEKRIITEEALEDINDHGDDINPDNLSSSMLWPDHPLGMPTI
GYLDTISAITEADLKGHMTRYYVPTNAVVVAAGRVRADDVFGAVADAFGTWAGPSAPGRLPPPSNQDEPRCLFVKDADSQ
VDLQITFRGFSRPDPQLAASRLLRRVLAGGGCSRLHLNLRERLGIVYSVDAQVAAYDETGCFSIELSTAPENLLTAVEEV
LGETRKLAAEPVGAEELRRVRQGYFFDLAYSEDSTFEMQVRYGWGELMGMVKGIDEERAEVEAVDEGTLQAVARRLFAPA
ALNLVAVGPVTATAKRRIEQLLRRYAKEFPTSSQPPGP

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=421, Percent_Identity=23.9904988123515, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI155969707, Length=217, Percent_Identity=27.1889400921659, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI46593007, Length=219, Percent_Identity=26.9406392694064, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI24308013, Length=191, Percent_Identity=26.1780104712042, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1787770, Length=249, Percent_Identity=25.3012048192771, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71999683, Length=203, Percent_Identity=31.5270935960591, Blast_Score=101, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71994338, Length=134, Percent_Identity=33.5820895522388, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25146566, Length=134, Percent_Identity=33.5820895522388, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25146563, Length=134, Percent_Identity=33.5820895522388, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI32566665, Length=134, Percent_Identity=33.5820895522388, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17557500, Length=154, Percent_Identity=32.4675324675325, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI72001443, Length=134, Percent_Identity=33.5820895522388, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17553678, Length=434, Percent_Identity=23.5023041474654, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71982342, Length=127, Percent_Identity=33.0708661417323, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI115533970, Length=160, Percent_Identity=32.5, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323192, Length=350, Percent_Identity=24, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321813, Length=329, Percent_Identity=22.4924012158055, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323421, Length=208, Percent_Identity=24.5192307692308, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357875, Length=217, Percent_Identity=29.4930875576037, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24646943, Length=217, Percent_Identity=29.4930875576037, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI221513245, Length=209, Percent_Identity=28.2296650717703, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24667786, Length=211, Percent_Identity=26.5402843601896, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 47834; Mature: 47702

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATAHRKTLPNGLRVVAVEMPHLHSTEIAVYVRVGGRDDSRATAGLAHFLEHMLFRGTA
CCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCC
EHPTNLELEAAFEAIGGCVNAATDAESTSYYSRVHPDHVAEGLRLLAAMVLTPTFPGIDI
CCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCH
EKRIITEEALEDINDHGDDINPDNLSSSMLWPDHPLGMPTIGYLDTISAITEADLKGHMT
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEE
RYYVPTNAVVVAAGRVRADDVFGAVADAFGTWAGPSAPGRLPPPSNQDEPRCLFVKDADS
EEEECCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCC
QVDLQITFRGFSRPDPQLAASRLLRRVLAGGGCSRLHLNLRERLGIVYSVDAQVAAYDET
EEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHHHCCEEEEECCEEEEECCC
GCFSIELSTAPENLLTAVEEVLGETRKLAAEPVGAEELRRVRQGYFFDLAYSEDSTFEMQ
CEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEECCCCCEEEE
VRYGWGELMGMVKGIDEERAEVEAVDEGTLQAVARRLFAPAALNLVAVGPVTATAKRRIE
EECCHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHCHHHHCEEEECCCHHHHHHHHH
QLLRRYAKEFPTSSQPPGP
HHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TATAHRKTLPNGLRVVAVEMPHLHSTEIAVYVRVGGRDDSRATAGLAHFLEHMLFRGTA
CCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCC
EHPTNLELEAAFEAIGGCVNAATDAESTSYYSRVHPDHVAEGLRLLAAMVLTPTFPGIDI
CCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCH
EKRIITEEALEDINDHGDDINPDNLSSSMLWPDHPLGMPTIGYLDTISAITEADLKGHMT
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEE
RYYVPTNAVVVAAGRVRADDVFGAVADAFGTWAGPSAPGRLPPPSNQDEPRCLFVKDADS
EEEECCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCC
QVDLQITFRGFSRPDPQLAASRLLRRVLAGGGCSRLHLNLRERLGIVYSVDAQVAAYDET
EEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHHHCCEEEEECCEEEEECCC
GCFSIELSTAPENLLTAVEEVLGETRKLAAEPVGAEELRRVRQGYFFDLAYSEDSTFEMQ
CEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEECCCCCEEEE
VRYGWGELMGMVKGIDEERAEVEAVDEGTLQAVARRLFAPAALNLVAVGPVTATAKRRIE
EECCHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHCHHHHCEEEECCCHHHHHHHHH
QLLRRYAKEFPTSSQPPGP
HHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 8098035 [H]