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The map label for this gene is trx [H]

Identifier: 39998370

GI number: 39998370

Start: 3600648

End: 3600977

Strand: Reverse

Name: trx [H]

Synonym: GSU3281

Alternate gene names: 39998370

Gene position: 3600977-3600648 (Counterclockwise)

Preceding gene: 39998379

Following gene: 39998369

Centisome position: 94.41

GC content: 55.76

Gene sequence:

>330_bases
ATGGCCAGTGACAAAGTCCTCACATTCAGTGACGATACCTTCGATAGCGAGGTGCTCAAGTCGCCCGTTCCGGTTCTCGT
TGATTTTTGGGCCACCTGGTGCGCCCCCTGCAAGGCCATCGCTCCTGTCATCGATGCCATTGCCGACGAATTTGACGGAA
AAGTGAAGGTCGGCAAGGTTAATGTTGATGATAACCCCGGAACTCCGGGCAAGTACGGCGTGCGCGGCATCCCTACCGTT
ATCCTCTTCAAGGAGGGCAAGGTCGTGGATCAGGTCGTCGGGGCCGTGCCCAAAGCCCAACTTGAGGCGCTTATCAAAAA
AGCGCTGTAA

Upstream 100 bases:

>100_bases
GGAGGGAATCGCGGTGATTGCGACCGATTTCCTCCTTGATGTTTTGAAGTTGCTCGGCTATATTCTAAAAATACTATTCT
TTTCGGCAAAGGAGGCTTTC

Downstream 100 bases:

>100_bases
TCGGCACAAGAGGGAGTCTTATGAAGGTTACCGGAGTCCTTGGGGTCGTCTCAGCAGCGGCCTTCGTTATCGTGAGCGGA
TTCACATCGCCGTCCTTCGC

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1 [H]

Number of amino acids: Translated: 109; Mature: 108

Protein sequence:

>109_residues
MASDKVLTFSDDTFDSEVLKSPVPVLVDFWATWCAPCKAIAPVIDAIADEFDGKVKVGKVNVDDNPGTPGKYGVRGIPTV
ILFKEGKVVDQVVGAVPKAQLEALIKKAL

Sequences:

>Translated_109_residues
MASDKVLTFSDDTFDSEVLKSPVPVLVDFWATWCAPCKAIAPVIDAIADEFDGKVKVGKVNVDDNPGTPGKYGVRGIPTV
ILFKEGKVVDQVVGAVPKAQLEALIKKAL
>Mature_108_residues
ASDKVLTFSDDTFDSEVLKSPVPVLVDFWATWCAPCKAIAPVIDAIADEFDGKVKVGKVNVDDNPGTPGKYGVRGIPTVI
LFKEGKVVDQVVGAVPKAQLEALIKKAL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=96, Percent_Identity=41.6666666666667, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI21361657, Length=84, Percent_Identity=40.4761904761905, Blast_Score=66, Evalue=7e-12,
Organism=Homo sapiens, GI5031973, Length=86, Percent_Identity=38.3720930232558, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082331, Length=107, Percent_Identity=55.1401869158878, Blast_Score=134, Evalue=1e-33,
Organism=Escherichia coli, GI1788936, Length=105, Percent_Identity=40.9523809523809, Blast_Score=98, Evalue=1e-22,
Organism=Escherichia coli, GI87081747, Length=110, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=98, Percent_Identity=35.7142857142857, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17510299, Length=98, Percent_Identity=39.7959183673469, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17554386, Length=108, Percent_Identity=36.1111111111111, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=81, Percent_Identity=35.8024691358025, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71998175, Length=83, Percent_Identity=39.7590361445783, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=98, Percent_Identity=33.6734693877551, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17509965, Length=90, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=95, Percent_Identity=41.0526315789474, Blast_Score=71, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=95, Percent_Identity=40, Blast_Score=70, Evalue=8e-14,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=35.4166666666667, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24639826, Length=84, Percent_Identity=40.4761904761905, Blast_Score=72, Evalue=6e-14,
Organism=Drosophila melanogaster, GI19921434, Length=85, Percent_Identity=40, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21358065, Length=100, Percent_Identity=36, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24639068, Length=103, Percent_Identity=33.0097087378641, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17648013, Length=82, Percent_Identity=39.0243902439024, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24583090, Length=82, Percent_Identity=39.0243902439024, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24664269, Length=71, Percent_Identity=38.0281690140845, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11614; Mature: 11482

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASDKVLTFSDDTFDSEVLKSPVPVLVDFWATWCAPCKAIAPVIDAIADEFDGKVKVGKV
CCCCCEEEECCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
NVDDNPGTPGKYGVRGIPTVILFKEGKVVDQVVGAVPKAQLEALIKKAL
ECCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
ASDKVLTFSDDTFDSEVLKSPVPVLVDFWATWCAPCKAIAPVIDAIADEFDGKVKVGKV
CCCCEEEECCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
NVDDNPGTPGKYGVRGIPTVILFKEGKVVDQVVGAVPKAQLEALIKKAL
ECCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]