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The map label for this gene is degS [H]

Identifier: 39998320

GI number: 39998320

Start: 3544670

End: 3546226

Strand: Reverse

Name: degS [H]

Synonym: GSU3230

Alternate gene names: 39998320

Gene position: 3546226-3544670 (Counterclockwise)

Preceding gene: 39998321

Following gene: 39998319

Centisome position: 92.98

GC content: 62.24

Gene sequence:

>1557_bases
ATGTCGGTTGATTCGGTGTTATTCGCCGTCACCCCCCGCCCGGGGGATACTCCAAACCTGCGGAGGTATCCGCTCATGCT
CGCGCTTCAGGACGACTCCCTTTTTGCCGCCATTGTCGATAATCTCTCCGACGGTATCTATGTCCTCCAGGACGACCGGG
TGGTCTATCTGAATGAGCGTTTTGCGCAGCTGTTCGGGCATGGTGATGCAGGGTCCCTTCTCATGAGGGAGCTTGATGAC
ATCCTGCCCCACGGCGAGGGCAAGGAGATCGTCGGCAGAATCCACGCGGAGCTGCTGGCGGGTGAGCCGTCATCGGTTGC
CTGGGGCCAGCCCTTTGCCCACATGGACGGTACGCCGGTCTGGCTGGAAATGGAGGCGCGCCGCATCCGCCTGAACGGGC
GACCGGCCATCCTCGGCGTCTGTCATGACCGCACTGACTGCAAACTGATCGGCGAAGCCATGCACATCAGTCAGGAGACA
TTCCGGCTGGTCCTTGACGCCATGCATGACAGCGTGTACGTAGTGGGGCGCGACTACAACGTTATTTACGCCAACCGGGC
CATGCGCGCCGGTGCCTACGGCGATGTGAGCTCTGATCCCTGCTACCGCATCTGCCGCGGCTGCAGTGAGCCATGCCCCG
ACTGCACCCTGGAAGAAGTGCTCTCCTCCGACAAGCCCGTGTGCCGTGAATTCTTTGATGAAAAGCGCAACGCCTGGTAT
TCGACCATTGAACTTGCGGTCCGGATTCCCGGCATGAGTGCCCCCGCCAAGCTGGGCGTACGGCGGGACATTACAGCCCG
CAAGGAGGCGGAACAGCGCAGCCGGATGCTTTCCCAGCGACTCCTGCACGCCCAGGAGAGCGAGCGCAAGCGCCTTTCCC
GGGAACTTCACGACGATCTGGGGCAGCTCCTCAATGCGCTGAAGATCGGATTCGATACGCTGGCCGAAGATCTGCGCCAG
CCGTCGCACGATGTGCAGGATCGCCTCTGGTATCTGAGCGAATCACTGAATAATTCCATCCACACCATTCGCCGCCTCTG
CGCCGGTCTTCATCCCTCGACCCTTGAGCGGCTGGGGCTGGCCGAGACGATCCGGCAGCAGTGCACCCAAGCGGCAACTA
CCCATTCGCTCGACATCGAGCTCAAGTGCGGGACCATGCTCGGCGTGCGGCTTGAGTCGGATACTGAAATCAACCTGTAC
CGGATCTTTCAGGAGGCCCTGCACAACGTGGTGAAACACGCTGACGCCACCCGGGTAATGGTACGGCTGGTGGCATCGCA
TCCCACGGTAAGGCTCCAGATCGAGGATAACGGCGGCGGCTTCTCCATGGAAGACTACGCGGAGCTCTCGGGGCACCACC
TGGGACTCATCAGCATGGCGGAGCGGGTGGAATTGCTGGGTGGCACGTTCCAGATCGCGTCCCTCCCCGGTCTCGGAACG
GCGGTGACCGTGGAGGTCCCGTTCCGCAAGGCCCCGCCGGGCCGAACCACTGCCGCGAAGGGGCGGCCGAGCCTCCCCTA
CCCGGTGCGCGGGAGGAAATCACTCTATGTATGCTAA

Upstream 100 bases:

>100_bases
ATAACCCACCCGGTTTCAGGGGCATTGTGTGTAACATATTGATGTGTCGTCATTTGTCTAGGGGGGCAGTAACGGCAGGT
AAATTGCTATATATTTGTAT

Downstream 100 bases:

>100_bases
GAAGCGGGTCATGATCGTGGATGACCATCCCTTGTTCCGGGATGGTCTCAAGGGGCTCGTCTCACGCAGCGCCGATTACC
AGGCCGTGGGAGAGGCGGGC

Product: sensory box histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 518; Mature: 517

Protein sequence:

>518_residues
MSVDSVLFAVTPRPGDTPNLRRYPLMLALQDDSLFAAIVDNLSDGIYVLQDDRVVYLNERFAQLFGHGDAGSLLMRELDD
ILPHGEGKEIVGRIHAELLAGEPSSVAWGQPFAHMDGTPVWLEMEARRIRLNGRPAILGVCHDRTDCKLIGEAMHISQET
FRLVLDAMHDSVYVVGRDYNVIYANRAMRAGAYGDVSSDPCYRICRGCSEPCPDCTLEEVLSSDKPVCREFFDEKRNAWY
STIELAVRIPGMSAPAKLGVRRDITARKEAEQRSRMLSQRLLHAQESERKRLSRELHDDLGQLLNALKIGFDTLAEDLRQ
PSHDVQDRLWYLSESLNNSIHTIRRLCAGLHPSTLERLGLAETIRQQCTQAATTHSLDIELKCGTMLGVRLESDTEINLY
RIFQEALHNVVKHADATRVMVRLVASHPTVRLQIEDNGGGFSMEDYAELSGHHLGLISMAERVELLGGTFQIASLPGLGT
AVTVEVPFRKAPPGRTTAAKGRPSLPYPVRGRKSLYVC

Sequences:

>Translated_518_residues
MSVDSVLFAVTPRPGDTPNLRRYPLMLALQDDSLFAAIVDNLSDGIYVLQDDRVVYLNERFAQLFGHGDAGSLLMRELDD
ILPHGEGKEIVGRIHAELLAGEPSSVAWGQPFAHMDGTPVWLEMEARRIRLNGRPAILGVCHDRTDCKLIGEAMHISQET
FRLVLDAMHDSVYVVGRDYNVIYANRAMRAGAYGDVSSDPCYRICRGCSEPCPDCTLEEVLSSDKPVCREFFDEKRNAWY
STIELAVRIPGMSAPAKLGVRRDITARKEAEQRSRMLSQRLLHAQESERKRLSRELHDDLGQLLNALKIGFDTLAEDLRQ
PSHDVQDRLWYLSESLNNSIHTIRRLCAGLHPSTLERLGLAETIRQQCTQAATTHSLDIELKCGTMLGVRLESDTEINLY
RIFQEALHNVVKHADATRVMVRLVASHPTVRLQIEDNGGGFSMEDYAELSGHHLGLISMAERVELLGGTFQIASLPGLGT
AVTVEVPFRKAPPGRTTAAKGRPSLPYPVRGRKSLYVC
>Mature_517_residues
SVDSVLFAVTPRPGDTPNLRRYPLMLALQDDSLFAAIVDNLSDGIYVLQDDRVVYLNERFAQLFGHGDAGSLLMRELDDI
LPHGEGKEIVGRIHAELLAGEPSSVAWGQPFAHMDGTPVWLEMEARRIRLNGRPAILGVCHDRTDCKLIGEAMHISQETF
RLVLDAMHDSVYVVGRDYNVIYANRAMRAGAYGDVSSDPCYRICRGCSEPCPDCTLEEVLSSDKPVCREFFDEKRNAWYS
TIELAVRIPGMSAPAKLGVRRDITARKEAEQRSRMLSQRLLHAQESERKRLSRELHDDLGQLLNALKIGFDTLAEDLRQP
SHDVQDRLWYLSESLNNSIHTIRRLCAGLHPSTLERLGLAETIRQQCTQAATTHSLDIELKCGTMLGVRLESDTEINLYR
IFQEALHNVVKHADATRVMVRLVASHPTVRLQIEDNGGGFSMEDYAELSGHHLGLISMAERVELLGGTFQIASLPGLGTA
VTVEVPFRKAPPGRTTAAKGRPSLPYPVRGRKSLYVC

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788812, Length=205, Percent_Identity=31.219512195122, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87082311, Length=229, Percent_Identity=31.0043668122271, Blast_Score=76, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 57775; Mature: 57644

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVDSVLFAVTPRPGDTPNLRRYPLMLALQDDSLFAAIVDNLSDGIYVLQDDRVVYLNER
CCCCCEEEEECCCCCCCCCCCCCEEEEEEECCCHHHHHHHCCCCCEEEEECCCEEEEHHH
FAQLFGHGDAGSLLMRELDDILPHGEGKEIVGRIHAELLAGEPSSVAWGQPFAHMDGTPV
HHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEE
WLEMEARRIRLNGRPAILGVCHDRTDCKLIGEAMHISQETFRLVLDAMHDSVYVVGRDYN
EEEEEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCE
VIYANRAMRAGAYGDVSSDPCYRICRGCSEPCPDCTLEEVLSSDKPVCREFFDEKRNAWY
EEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCHH
STIELAVRIPGMSAPAKLGVRRDITARKEAEQRSRMLSQRLLHAQESERKRLSRELHDDL
EEEEEEEECCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQLLNALKIGFDTLAEDLRQPSHDVQDRLWYLSESLNNSIHTIRRLCAGLHPSTLERLGL
HHHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHCH
AETIRQQCTQAATTHSLDIELKCGTMLGVRLESDTEINLYRIFQEALHNVVKHADATRVM
HHHHHHHHHHHHHCCCEEEEEEECCEEEEEECCCCCCHHHHHHHHHHHHHHHHCHHHHHH
VRLVASHPTVRLQIEDNGGGFSMEDYAELSGHHLGLISMAERVELLGGTFQIASLPGLGT
HHHHHCCCEEEEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEECCCCCE
AVTVEVPFRKAPPGRTTAAKGRPSLPYPVRGRKSLYVC
EEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEECC
>Mature Secondary Structure 
SVDSVLFAVTPRPGDTPNLRRYPLMLALQDDSLFAAIVDNLSDGIYVLQDDRVVYLNER
CCCCEEEEECCCCCCCCCCCCCEEEEEEECCCHHHHHHHCCCCCEEEEECCCEEEEHHH
FAQLFGHGDAGSLLMRELDDILPHGEGKEIVGRIHAELLAGEPSSVAWGQPFAHMDGTPV
HHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEE
WLEMEARRIRLNGRPAILGVCHDRTDCKLIGEAMHISQETFRLVLDAMHDSVYVVGRDYN
EEEEEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCE
VIYANRAMRAGAYGDVSSDPCYRICRGCSEPCPDCTLEEVLSSDKPVCREFFDEKRNAWY
EEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCHH
STIELAVRIPGMSAPAKLGVRRDITARKEAEQRSRMLSQRLLHAQESERKRLSRELHDDL
EEEEEEEECCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQLLNALKIGFDTLAEDLRQPSHDVQDRLWYLSESLNNSIHTIRRLCAGLHPSTLERLGL
HHHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHCH
AETIRQQCTQAATTHSLDIELKCGTMLGVRLESDTEINLYRIFQEALHNVVKHADATRVM
HHHHHHHHHHHHHCCCEEEEEEECCEEEEEECCCCCCHHHHHHHHHHHHHHHHCHHHHHH
VRLVASHPTVRLQIEDNGGGFSMEDYAELSGHHLGLISMAERVELLGGTFQIASLPGLGT
HHHHHCCCEEEEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEECCCCCE
AVTVEVPFRKAPPGRTTAAKGRPSLPYPVRGRKSLYVC
EEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]