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The map label for this gene is cysM [H]

Identifier: 39998248

GI number: 39998248

Start: 3465190

End: 3466116

Strand: Reverse

Name: cysM [H]

Synonym: GSU3158

Alternate gene names: 39998248

Gene position: 3466116-3465190 (Counterclockwise)

Preceding gene: 39998279

Following gene: 39998245

Centisome position: 90.88

GC content: 66.02

Gene sequence:

>927_bases
ATGGAGCATCCCCCTTTTTCGCTTGCCGGCAGCATCGGCGCCACCCCCCTCGTTGAGCTGCGACACCTGAACCCGAATCC
GCGGGTTCGCATCCTGGCCAAATTGGAGGGGAATAACGTGGGCGGTTCCGTCAAGGACCGTCCGGCTCTCTACATGCTGG
CCAAGGCGGAGGAGTCCGGCGAGTTGGTGCCGGAGAAGACCATCCTCGAGCCGACCTCCGGCAATACCGGCATCGCTCTG
GCCATGCTCGGCACGGTCAAGGGATACCGGGTCAAGCTCGTGATGCCCGCCTGCGTAAGCCTTGAACGGCGCGCCGTGCT
GGAGGCCTATGGCGCCGAGTTGGTCCTCTCTCCCCACGACGAGGCCACCGACGGAGCCATCCGGCTGGCCCACCGCATCC
TGGAAGAGGAGCCGGACCGCTACTACATGCCCAACCAGTACGCCAATCCCAACAATCCCCTGGCTCACTATGAGACCACT
GCGCCTGAGATTTTCCGGGACACCGGCGGTGCCGTCGACTTCTTCGTGGCCGGCATGGGGACGGGCGGCACCTTGATGGG
AACGAGCCGCTATTTCCGGGAGAAGAAGCCTTCCGTGCGCATCGTGGGCGTGGAGCCGCGATTGGGGCACAAGGTGCAGG
GGCTCAAGAACATGCAGGAAGCCATCGTGCCTCCCATCTACCACCCCGAGGCCCTGGACCTGAAGCTGACGGTCCATGAC
GAGCCGGCCTTCGACACGGCCCGTGAGCTGGCCGCCCGCGAGGGCCTTTTCGTGGGGATGTCCAGCGGCGCCGCCGTGGC
GGGTGCCGTCCAGGTGGCACGGGATGCCCCGGCAGGCAGCACCATCGTAGTGCTCCTGCCGGACCGGGGGGACCGCTATC
TCAGCACGGTCCTGTTCCGGTCGGTTTGCGGCAAGTGCCCTCCCTGA

Upstream 100 bases:

>100_bases
CGGCAAAAGCCGAGGTGGCTCGCGAATGTTGTTTTTTGCGGCATGTTCGTATAGCATGAGGGGGCATTAAGCACCTTTTT
CCGTTTAGAGGAATCCTGCC

Downstream 100 bases:

>100_bases
GAGGCGCATGTGCCTGACGTTGCACCACCAGCCCGCATCCCGCGGGCTTTTTCATGTCCGCTACCAGCTGCCGAGCGAGG
TGAGGAATTCCAGCAGGCAG

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MEHPPFSLAGSIGATPLVELRHLNPNPRVRILAKLEGNNVGGSVKDRPALYMLAKAEESGELVPEKTILEPTSGNTGIAL
AMLGTVKGYRVKLVMPACVSLERRAVLEAYGAELVLSPHDEATDGAIRLAHRILEEEPDRYYMPNQYANPNNPLAHYETT
APEIFRDTGGAVDFFVAGMGTGGTLMGTSRYFREKKPSVRIVGVEPRLGHKVQGLKNMQEAIVPPIYHPEALDLKLTVHD
EPAFDTARELAAREGLFVGMSSGAAVAGAVQVARDAPAGSTIVVLLPDRGDRYLSTVLFRSVCGKCPP

Sequences:

>Translated_308_residues
MEHPPFSLAGSIGATPLVELRHLNPNPRVRILAKLEGNNVGGSVKDRPALYMLAKAEESGELVPEKTILEPTSGNTGIAL
AMLGTVKGYRVKLVMPACVSLERRAVLEAYGAELVLSPHDEATDGAIRLAHRILEEEPDRYYMPNQYANPNNPLAHYETT
APEIFRDTGGAVDFFVAGMGTGGTLMGTSRYFREKKPSVRIVGVEPRLGHKVQGLKNMQEAIVPPIYHPEALDLKLTVHD
EPAFDTARELAAREGLFVGMSSGAAVAGAVQVARDAPAGSTIVVLLPDRGDRYLSTVLFRSVCGKCPP
>Mature_308_residues
MEHPPFSLAGSIGATPLVELRHLNPNPRVRILAKLEGNNVGGSVKDRPALYMLAKAEESGELVPEKTILEPTSGNTGIAL
AMLGTVKGYRVKLVMPACVSLERRAVLEAYGAELVLSPHDEATDGAIRLAHRILEEEPDRYYMPNQYANPNNPLAHYETT
APEIFRDTGGAVDFFVAGMGTGGTLMGTSRYFREKKPSVRIVGVEPRLGHKVQGLKNMQEAIVPPIYHPEALDLKLTVHD
EPAFDTARELAAREGLFVGMSSGAAVAGAVQVARDAPAGSTIVVLLPDRGDRYLSTVLFRSVCGKCPP

Specific function: Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=307, Percent_Identity=39.7394136807818, Blast_Score=207, Evalue=9e-54,
Organism=Homo sapiens, GI295821200, Length=307, Percent_Identity=39.7394136807818, Blast_Score=207, Evalue=9e-54,
Organism=Homo sapiens, GI4557415, Length=307, Percent_Identity=39.7394136807818, Blast_Score=207, Evalue=9e-54,
Organism=Escherichia coli, GI2367138, Length=293, Percent_Identity=47.098976109215, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI1788754, Length=313, Percent_Identity=42.8115015974441, Blast_Score=200, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17535051, Length=297, Percent_Identity=43.0976430976431, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17562970, Length=304, Percent_Identity=42.4342105263158, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI32566674, Length=296, Percent_Identity=42.9054054054054, Blast_Score=206, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI115535073, Length=306, Percent_Identity=42.156862745098, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17561720, Length=304, Percent_Identity=40.4605263157895, Blast_Score=184, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI25147552, Length=309, Percent_Identity=37.5404530744337, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17534315, Length=315, Percent_Identity=38.0952380952381, Blast_Score=160, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI32566672, Length=223, Percent_Identity=38.1165919282511, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6321594, Length=316, Percent_Identity=37.0253164556962, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6321449, Length=322, Percent_Identity=35.0931677018634, Blast_Score=140, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24643623, Length=301, Percent_Identity=37.8737541528239, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI20129101, Length=301, Percent_Identity=37.8737541528239, Blast_Score=169, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33174; Mature: 33174

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHPPFSLAGSIGATPLVELRHLNPNPRVRILAKLEGNNVGGSVKDRPALYMLAKAEESG
CCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCEEEEEEECCCCC
ELVPEKTILEPTSGNTGIALAMLGTVKGYRVKLVMPACVSLERRAVLEAYGAELVLSPHD
CCCCCCEEECCCCCCCCEEEEEEECCCCEEEEEEEHHHHHHHHHHHHHHCCCEEEECCCC
EATDGAIRLAHRILEEEPDRYYMPNQYANPNNPLAHYETTAPEIFRDTGGAVDFFVAGMG
CCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCEEECCCHHHHHCCCCEEEEEEEECC
TGGTLMGTSRYFREKKPSVRIVGVEPRLGHKVQGLKNMQEAIVPPIYHPEALDLKLTVHD
CCCEEECCHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECC
EPAFDTARELAAREGLFVGMSSGAAVAGAVQVARDAPAGSTIVVLLPDRGDRYLSTVLFR
CCCHHHHHHHHHHCCEEEEECCCCCHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHH
SVCGKCPP
HHHCCCCC
>Mature Secondary Structure
MEHPPFSLAGSIGATPLVELRHLNPNPRVRILAKLEGNNVGGSVKDRPALYMLAKAEESG
CCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCEEEEEEECCCCC
ELVPEKTILEPTSGNTGIALAMLGTVKGYRVKLVMPACVSLERRAVLEAYGAELVLSPHD
CCCCCCEEECCCCCCCCEEEEEEECCCCEEEEEEEHHHHHHHHHHHHHHCCCEEEECCCC
EATDGAIRLAHRILEEEPDRYYMPNQYANPNNPLAHYETTAPEIFRDTGGAVDFFVAGMG
CCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCEEECCCHHHHHCCCCEEEEEEEECC
TGGTLMGTSRYFREKKPSVRIVGVEPRLGHKVQGLKNMQEAIVPPIYHPEALDLKLTVHD
CCCEEECCHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECC
EPAFDTARELAAREGLFVGMSSGAAVAGAVQVARDAPAGSTIVVLLPDRGDRYLSTVLFR
CCCHHHHHHHHHHCCEEEEECCCCCHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHH
SVCGKCPP
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2188958; 9205837; 9278503 [H]