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The map label for this gene is lspA

Identifier: 39998225

GI number: 39998225

Start: 3439285

End: 3439767

Strand: Reverse

Name: lspA

Synonym: GSU3135

Alternate gene names: 39998225

Gene position: 3439767-3439285 (Counterclockwise)

Preceding gene: 39998226

Following gene: 39998223

Centisome position: 90.18

GC content: 61.49

Gene sequence:

>483_bases
ATGAAGCCGACCTATCGCATCTTCAATGCAGTGGTGCTGGGCTCCCTCGTTCTCGACCAGGCGACGAAGGTCCTCATCGA
CCGCACCATGGATCTTTACCAGTCGATTCCTGTTATCGACGGATTGTTCAGCATCACCTACCTGCGGAATCGGGGGGCCG
CGTTCAGCTTTCTGGCGGATTTTTCCTACCGGCTCCCCTTCTTCATCCTGGTTTCGGTGGTGGCCCTAGGGGTGATAGCT
GTTACGTTCCGCAAGCTTCGGGACGACCAGCACCTGGCGGCCGCCGCGCTCGCGCTCATCTTCTCGGGCGCCCTCGGCAA
CCTCATCGACCGGGTCAGGCTCGGCGAGGTGATCGATTTCCTGGACGTCTACTGGAAGACGTATCACTGGCCCGCGTTCA
ATGTGGCCGATTCGGCCATCTGCGTGGGGGTGGCGCTCCTTGCCGTCGACATGATCCGGGAGGAGCGGCGCAAGGCCCCC
TGA

Upstream 100 bases:

>100_bases
AGAAGTGTGAGCGCTGCTGGCACTACGACGAGGAGATCGGCGGCGACAGCGAGCATCCGACCCTGTGCCCCAAGTGCGCA
GCGGCGGTCAAGTAGCCTGT

Downstream 100 bases:

>100_bases
GGTTCAGAACCGGTGTGACAGTGCCAGATGGAACACCACGTCCGGCGCCGTCTTGACACTTGCGTCCTCCGCCACCCCGA
TGTCAAGGGCGGTCCGGTCC

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 160; Mature: 160

Protein sequence:

>160_residues
MKPTYRIFNAVVLGSLVLDQATKVLIDRTMDLYQSIPVIDGLFSITYLRNRGAAFSFLADFSYRLPFFILVSVVALGVIA
VTFRKLRDDQHLAAAALALIFSGALGNLIDRVRLGEVIDFLDVYWKTYHWPAFNVADSAICVGVALLAVDMIREERRKAP

Sequences:

>Translated_160_residues
MKPTYRIFNAVVLGSLVLDQATKVLIDRTMDLYQSIPVIDGLFSITYLRNRGAAFSFLADFSYRLPFFILVSVVALGVIA
VTFRKLRDDQHLAAAALALIFSGALGNLIDRVRLGEVIDFLDVYWKTYHWPAFNVADSAICVGVALLAVDMIREERRKAP
>Mature_160_residues
MKPTYRIFNAVVLGSLVLDQATKVLIDRTMDLYQSIPVIDGLFSITYLRNRGAAFSFLADFSYRLPFFILVSVVALGVIA
VTFRKLRDDQHLAAAALALIFSGALGNLIDRVRLGEVIDFLDVYWKTYHWPAFNVADSAICVGVALLAVDMIREERRKAP

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=144, Percent_Identity=39.5833333333333, Blast_Score=95, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_GEOSL (Q747Y0)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_954176.1
- MEROPS:   A08.001
- GeneID:   2688444
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU3135
- NMPDR:   fig|243231.1.peg.3114
- TIGR:   GSU3135
- HOGENOM:   HBG724422
- OMA:   PVIDGLF
- ProtClustDB:   PRK00376
- BioCyc:   GSUL243231:GSU_3135-MONOMER
- BRENDA:   3.4.23.36
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 17899; Mature: 17899

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 110-110 ACT_SITE 137-137

Signals:

None

Transmembrane regions:

HASH(0x1107ccb4)-; HASH(0x114fd638)-; HASH(0x11dd29c4)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPTYRIFNAVVLGSLVLDQATKVLIDRTMDLYQSIPVIDGLFSITYLRNRGAAFSFLAD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHH
FSYRLPFFILVSVVALGVIAVTFRKLRDDQHLAAAALALIFSGALGNLIDRVRLGEVIDF
HHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDVYWKTYHWPAFNVADSAICVGVALLAVDMIREERRKAP
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MKPTYRIFNAVVLGSLVLDQATKVLIDRTMDLYQSIPVIDGLFSITYLRNRGAAFSFLAD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHH
FSYRLPFFILVSVVALGVIAVTFRKLRDDQHLAAAALALIFSGALGNLIDRVRLGEVIDF
HHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDVYWKTYHWPAFNVADSAICVGVALLAVDMIREERRKAP
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA