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The map label for this gene is murC

Identifier: 39998159

GI number: 39998159

Start: 3373685

End: 3375073

Strand: Reverse

Name: murC

Synonym: GSU3068

Alternate gene names: 39998159

Gene position: 3375073-3373685 (Counterclockwise)

Preceding gene: 39998160

Following gene: 39998158

Centisome position: 88.49

GC content: 62.2

Gene sequence:

>1389_bases
ATGTACGGTAAAATAGAGAAAATTCACTTCGTCGGCATCGGCGGCATCGGCATGAGCGGCATTGCCGAGGTTCTCCTCAA
CCTGGGATATAAGGTGTCGGGCTCCGATCTGAAACAGTCCGATACCACCGACCGCCTCGCCTCGCTCGGGGGAGAAATCC
GCTTCGGGCATGGCCGGGAGAATGTGGCCGATGTGGACGTGGTGGTAACCTCTACGGCGGTCCGTGATGACAATCCTGAG
GTGGTCGAGGCCAAGCGGCGGATGATTCCGGTTATCCCCCGGGCCGAGATGCTGGCGGAACTGATGCGGATGAAGTACGG
CATCGCCATCGCGGGCACCCACGGCAAGACCACCACCACTTCCATGGTGGCGACGGTTCTTACCCACGGCGGCATCGACC
CTACCATCGTGATCGGCGGCAAGCTCAACACCCTCGGCACCAACGCCAAGCTCGGCCAGGGTCAGTTCCTGGTGGCGGAA
GCCGACGAGTCGGACGGTTCGTTCCTGAAGCTTTCGCCCACCATTGCGGTGGTGACCAATATCGACGCCGACCACCTCGA
CTTCTATACCGGCGGGATCGAACAGATCAAAGACACCTTTGTCGACTTCATAAACAAGATTCCCTTCTACGGACTGGCGG
TGCTCTGCCTGGAAGACCGCAACATCGCCGAGATCCTCCCGCGGGTGAAGAAGCGTTTCGTCACCTACGGCCTTTCGTCC
CAGGCCGACATCCGTGCGACGCATATCCGGCTCGAAGGGGGCACCACCTCTTTTGTGGCCCATTACAAGGGATACCGCAT
GGGTGAGGTGTCCTTTTCCATGCCCGGCGCCCACAACGTGCTGAATGCCCTTGCCTGTATCGCAGTGGCCATGGAACTGG
ATGTCCCCTTCTCCCAGATCCAGGAAGGGTTCGCCACGTTCGGCGGGGTAGGACGGCGTTTCCAGGTGAAGGGAGAGGTG
AACGGCATCACCGTGGTGGATGACTACGGCCACCATCCGGCGGAGATCCGGGCCACCCTGGCCGCCGGCAAGAGCGGCTG
GCCCGAGAGGCGGCTCGTGGTGGCGTTCCAGCCCCACCGGTTCAGCCGGACCAGGGAACTGTTCGCCGAGTTCGTCACCT
GCTTCTACGACGCAGATGTGCTGGTACTGACGGATATCTATCCGGCCGGCGAGGCCCCCATTGAAGGTGTGTCGGCCGAG
CGGCTGGCCGAGGAGATCCGTAAGCACGGCCAGCGCGACGTGACCTACGTGGCCGATCGGGAGGCGCTTCCCGAGCACCT
GCTGACGATCGTGCAGCCCGGGGACATCGTGCTGACCCTTGGAGCGGGAAATATCTGGCAGTCAGGCGAGGCGTTCCTCG
CGAAGCTGGAAGAAGCCCGGCAGGCCTAG

Upstream 100 bases:

>100_bases
TCAAGGCTGTCGGCGAGGCGGCCCAGGAGCTTGCCCGGCTTGATGCGGCCCAGGCCATCGTCGACGAGATGGTGGCAAGC
ACAAGGAAAGAAGAGTAACC

Downstream 100 bases:

>100_bases
CGGGCACGGGACGGTTCTTTGAACGATCGGTTGGCGGCACGGCTTGAGGCGGAAGTGCGGGGGGAGATCCTCCGGGACGA
GCCCATGGCGCGCCATACGT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MYGKIEKIHFVGIGGIGMSGIAEVLLNLGYKVSGSDLKQSDTTDRLASLGGEIRFGHGRENVADVDVVVTSTAVRDDNPE
VVEAKRRMIPVIPRAEMLAELMRMKYGIAIAGTHGKTTTTSMVATVLTHGGIDPTIVIGGKLNTLGTNAKLGQGQFLVAE
ADESDGSFLKLSPTIAVVTNIDADHLDFYTGGIEQIKDTFVDFINKIPFYGLAVLCLEDRNIAEILPRVKKRFVTYGLSS
QADIRATHIRLEGGTTSFVAHYKGYRMGEVSFSMPGAHNVLNALACIAVAMELDVPFSQIQEGFATFGGVGRRFQVKGEV
NGITVVDDYGHHPAEIRATLAAGKSGWPERRLVVAFQPHRFSRTRELFAEFVTCFYDADVLVLTDIYPAGEAPIEGVSAE
RLAEEIRKHGQRDVTYVADREALPEHLLTIVQPGDIVLTLGAGNIWQSGEAFLAKLEEARQA

Sequences:

>Translated_462_residues
MYGKIEKIHFVGIGGIGMSGIAEVLLNLGYKVSGSDLKQSDTTDRLASLGGEIRFGHGRENVADVDVVVTSTAVRDDNPE
VVEAKRRMIPVIPRAEMLAELMRMKYGIAIAGTHGKTTTTSMVATVLTHGGIDPTIVIGGKLNTLGTNAKLGQGQFLVAE
ADESDGSFLKLSPTIAVVTNIDADHLDFYTGGIEQIKDTFVDFINKIPFYGLAVLCLEDRNIAEILPRVKKRFVTYGLSS
QADIRATHIRLEGGTTSFVAHYKGYRMGEVSFSMPGAHNVLNALACIAVAMELDVPFSQIQEGFATFGGVGRRFQVKGEV
NGITVVDDYGHHPAEIRATLAAGKSGWPERRLVVAFQPHRFSRTRELFAEFVTCFYDADVLVLTDIYPAGEAPIEGVSAE
RLAEEIRKHGQRDVTYVADREALPEHLLTIVQPGDIVLTLGAGNIWQSGEAFLAKLEEARQA
>Mature_462_residues
MYGKIEKIHFVGIGGIGMSGIAEVLLNLGYKVSGSDLKQSDTTDRLASLGGEIRFGHGRENVADVDVVVTSTAVRDDNPE
VVEAKRRMIPVIPRAEMLAELMRMKYGIAIAGTHGKTTTTSMVATVLTHGGIDPTIVIGGKLNTLGTNAKLGQGQFLVAE
ADESDGSFLKLSPTIAVVTNIDADHLDFYTGGIEQIKDTFVDFINKIPFYGLAVLCLEDRNIAEILPRVKKRFVTYGLSS
QADIRATHIRLEGGTTSFVAHYKGYRMGEVSFSMPGAHNVLNALACIAVAMELDVPFSQIQEGFATFGGVGRRFQVKGEV
NGITVVDDYGHHPAEIRATLAAGKSGWPERRLVVAFQPHRFSRTRELFAEFVTCFYDADVLVLTDIYPAGEAPIEGVSAE
RLAEEIRKHGQRDVTYVADREALPEHLLTIVQPGDIVLTLGAGNIWQSGEAFLAKLEEARQA

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=451, Percent_Identity=48.780487804878, Blast_Score=387, Evalue=1e-109,
Organism=Escherichia coli, GI1790680, Length=476, Percent_Identity=28.781512605042, Blast_Score=160, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_GEOSL (P61679)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_954110.1
- ProteinModelPortal:   P61679
- SMR:   P61679
- GeneID:   2686325
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU3068
- NMPDR:   fig|243231.1.peg.3048
- TIGR:   GSU3068
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- BioCyc:   GSUL243231:GSU_3068-MONOMER
- BRENDA:   6.3.2.8
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 50149; Mature: 50149

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYGKIEKIHFVGIGGIGMSGIAEVLLNLGYKVSGSDLKQSDTTDRLASLGGEIRFGHGRE
CCCCEEEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHCCCCEEECCCCC
NVADVDVVVTSTAVRDDNPEVVEAKRRMIPVIPRAEMLAELMRMKYGIAIAGTHGKTTTT
CCCEEEEEEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEECCCCCHHH
SMVATVLTHGGIDPTIVIGGKLNTLGTNAKLGQGQFLVAEADESDGSFLKLSPTIAVVTN
HHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEECCEEEEEEE
IDADHLDFYTGGIEQIKDTFVDFINKIPFYGLAVLCLEDRNIAEILPRVKKRFVTYGLSS
CCCHHHHHHCCCHHHHHHHHHHHHHCCCHHCEEEEEECCCCHHHHHHHHHHHHHHCCCCC
QADIRATHIRLEGGTTSFVAHYKGYRMGEVSFSMPGAHNVLNALACIAVAMELDVPFSQI
CCCEEEEEEEEECCCEEEEHHCCCCEECEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHH
QEGFATFGGVGRRFQVKGEVNGITVVDDYGHHPAEIRATLAAGKSGWPERRLVVAFQPHR
HHHHHHHCCCCCEEEEEECCCCEEEEECCCCCHHHHHEEECCCCCCCCCCEEEEEECCCH
FSRTRELFAEFVTCFYDADVLVLTDIYPAGEAPIEGVSAERLAEEIRKHGQRDVTYVADR
HHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECH
EALPEHLLTIVQPGDIVLTLGAGNIWQSGEAFLAKLEEARQA
HHHHHHHHEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MYGKIEKIHFVGIGGIGMSGIAEVLLNLGYKVSGSDLKQSDTTDRLASLGGEIRFGHGRE
CCCCEEEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHCCCCEEECCCCC
NVADVDVVVTSTAVRDDNPEVVEAKRRMIPVIPRAEMLAELMRMKYGIAIAGTHGKTTTT
CCCEEEEEEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEECCCCCHHH
SMVATVLTHGGIDPTIVIGGKLNTLGTNAKLGQGQFLVAEADESDGSFLKLSPTIAVVTN
HHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEECCEEEEEEE
IDADHLDFYTGGIEQIKDTFVDFINKIPFYGLAVLCLEDRNIAEILPRVKKRFVTYGLSS
CCCHHHHHHCCCHHHHHHHHHHHHHCCCHHCEEEEEECCCCHHHHHHHHHHHHHHCCCCC
QADIRATHIRLEGGTTSFVAHYKGYRMGEVSFSMPGAHNVLNALACIAVAMELDVPFSQI
CCCEEEEEEEEECCCEEEEHHCCCCEECEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHH
QEGFATFGGVGRRFQVKGEVNGITVVDDYGHHPAEIRATLAAGKSGWPERRLVVAFQPHR
HHHHHHHCCCCCEEEEEECCCCEEEEECCCCCHHHHHEEECCCCCCCCCCEEEEEECCCH
FSRTRELFAEFVTCFYDADVLVLTDIYPAGEAPIEGVSAERLAEEIRKHGQRDVTYVADR
HHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECH
EALPEHLLTIVQPGDIVLTLGAGNIWQSGEAFLAKLEEARQA
HHHHHHHHEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA