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The map label for this gene is shc-2 [H]

Identifier: 39998152

GI number: 39998152

Start: 3364460

End: 3366652

Strand: Direct

Name: shc-2 [H]

Synonym: GSU3061

Alternate gene names: 39998152

Gene position: 3364460-3366652 (Clockwise)

Preceding gene: 39998151

Following gene: 39998172

Centisome position: 88.21

GC content: 62.43

Gene sequence:

>2193_bases
ATGGCAAAGGGTATACTCAACAAGTTTGCCGTGATAGCCGGCACCAAGAAGGCCGGACCTCCGGCCGGGGAAGAACGCAC
CGTCATCGCACCCATAAAAGAGATATCGGGAAAGGCCGTCCACTGCAGTCAGGCTGTCAAAAAGGCGGAGGAGTATCTCC
TGGCGCTCCAGAACCCGGAGGGGTACTGGGTTTTCGAGCTAGAAGCGGACGTCACGATACCGTCTGAGTACATCATGCTT
CAGCGGTTCCTCGGCAGGGAGATTTCCCCGGAACTGGGGAAGCGGCTGGAGAACTATCTCCTGGACCGGCAACTGCCCGA
CGGCGGCTGGCCCCTCTACGCCGAGGACGGATTCGCCAACATCAGCGCCACGGTCAAGGCGTATCTCGCCCTCAAGGTGC
TGGGGCATTCACCCCAGGCACCCCACATGATACGCGCGCGCCTCATGGTCCTCAGCCTCGGCGGCGCGGCCAGATGCAAT
GTGTTCACGCGCATCCTGCTGGCCCTGTTCGGTCAGATTCCCTGGCATACCCCGCCGGCAATGCCCGTGGAAATCGTGCT
TCTCCCCCAGTGGTTTTTCTTCCATTTGAGCAAAGTCTCCTACTGGTCGAGAACCGTCATTGTCCCTCTGCTGCTGCTCT
ACGCCAAACAGCCCGTGTGTCGGCTGCGGCCCGAGGAGGGGATCCCCGAACTGTTCAGCACGCCGCCCGATAAACTGCGT
CACCTGGATGGCTTTCAACCGGGGTACTGGCGGAAAAACGCCTTCATCATCTTTGACCGCCTGCTCAAGCGCTTCAACCG
ATTCATTCCTTCCGCCCTGCACCGGAAAGCCATTGCCGAAGCAGAACAGTGGACCAGGTCCCACATGCAGGGCAGCGGCG
GGATCGGCGCCATTTTCCCGGCCATGGCCTATGCGGTCATGGCCCTCCGCGTACTCGGCTGCGGAGAAGGGGACCCTGAC
TATATTCGCGGACTGCAGGCCATCGACGACCTGCTCCAGCACCGGACTCCGCAGGAAGCAGACCCCCCCCGCACAGACGG
TACGTGCATTGACAGCGGCATGTCGGCGGCTTTTGCCCTCACCCCCTCTGCCCACGCGGCAGCGGACGGTACAGGGAGCA
GCAGCATCTGCCAGCCGTGCAATTCTCCGATCTGGGACACCTGCCTGAGCCTTTCGGCGCTCATGGAAGCGGGCATGCCC
GCGAGCCACCCCGCGGCGACGCAGGCTGTTGAATGGCTCTTGTCACAGCAGATCCTCTCGCCCGGCGACTGGTCGCTGAA
GGTGCCCGACCTGGAGGGGGGCGGATGGGCGTTCCAGTTCGAGAACACCCTCTACCCCGACCTGGACGACACCTCGAAGG
TCATCATGTCGCTTCTACGGGCCGGCGCGCTGGAGAATGAGCGCTATCGCGACCGGATCGCCCGCGGCGTGAACTGGGTG
CTCGGGATGCAGAGCAGTGACGGCGGGTGGGCCGCCTTTGACATCGACAACAACTACCACTACCTGAACGACATCCCGTT
CGCCGACCATGGGGCGCTCCTCGACCCGAGCACATCTGACCTGACGGGACGCTGCATCGAGCTTCTCTCCATGGTCGGTT
TCGACAGGACGTTTCCGCCCATCGCGCGGGGGATCGGGTTCCTGCGCTCGGAACAGGAAGAAAACGGCGCCTGGTTCGGC
CGCTGGGGGGTGAACTACATCTACGGTACCTGGTCGGTGCTGTCAGGCCTCAGGCAGGCCGGTGAAGATATGCAGCAGCC
CTATATCCGCAAGGCGGTGGGATGGCTGGCGTCATGCCAGAACCACGACGGTGGATGGGGAGAAACCTGCTATTCCTATG
ACGATCCTTCGCTGGCCGGCAAGGGGGCAAGCACCCCGTCCCAGACGGCCTGGAGCCTCCTGGGGCTCATGGCCGCGGGA
GAAGTCAACAGCTTGGCCGTTCGGCGGGGTGTACGCTACCTGCTCGACCACCAGAACCAATGGGGAACCTGGGAGGAAAA
ACATTTTACCGGAACCGGTTTCCCGAGGGTCTTTTACCTGCGCTACCACGGGTACCGCCACTTCTTTCCCCTGTGGGCGC
TCGGCGTCTATTCACGGCTCAGCTCAGGACAAAAGGCCTGTCAGGACGAGCGTCGCCATGCATCCCCCGGCGACCTCCAT
CTGCCTTGGCTGGAGAGGATCAAGAAACGATAA

Upstream 100 bases:

>100_bases
TCGCCGGCTTCGGCACGTAAAATTTTTATCGCATTATTTACACTGTTAATCAAAGATATCGCAGTTAATTTTCTTGCCGC
CTAAGGGAAAGGAGCTACGA

Downstream 100 bases:

>100_bases
CGGCCTCACGGCGGGGGAACGCCTCCAGATATTCCCGCCTGAGCCGGTCGACGCCGGCGCTGCCGATGACGTCCCACGGC
AGCGTTTCGTCAAGGGGAAT

Product: squalene-hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 730; Mature: 729

Protein sequence:

>730_residues
MAKGILNKFAVIAGTKKAGPPAGEERTVIAPIKEISGKAVHCSQAVKKAEEYLLALQNPEGYWVFELEADVTIPSEYIML
QRFLGREISPELGKRLENYLLDRQLPDGGWPLYAEDGFANISATVKAYLALKVLGHSPQAPHMIRARLMVLSLGGAARCN
VFTRILLALFGQIPWHTPPAMPVEIVLLPQWFFFHLSKVSYWSRTVIVPLLLLYAKQPVCRLRPEEGIPELFSTPPDKLR
HLDGFQPGYWRKNAFIIFDRLLKRFNRFIPSALHRKAIAEAEQWTRSHMQGSGGIGAIFPAMAYAVMALRVLGCGEGDPD
YIRGLQAIDDLLQHRTPQEADPPRTDGTCIDSGMSAAFALTPSAHAAADGTGSSSICQPCNSPIWDTCLSLSALMEAGMP
ASHPAATQAVEWLLSQQILSPGDWSLKVPDLEGGGWAFQFENTLYPDLDDTSKVIMSLLRAGALENERYRDRIARGVNWV
LGMQSSDGGWAAFDIDNNYHYLNDIPFADHGALLDPSTSDLTGRCIELLSMVGFDRTFPPIARGIGFLRSEQEENGAWFG
RWGVNYIYGTWSVLSGLRQAGEDMQQPYIRKAVGWLASCQNHDGGWGETCYSYDDPSLAGKGASTPSQTAWSLLGLMAAG
EVNSLAVRRGVRYLLDHQNQWGTWEEKHFTGTGFPRVFYLRYHGYRHFFPLWALGVYSRLSSGQKACQDERRHASPGDLH
LPWLERIKKR

Sequences:

>Translated_730_residues
MAKGILNKFAVIAGTKKAGPPAGEERTVIAPIKEISGKAVHCSQAVKKAEEYLLALQNPEGYWVFELEADVTIPSEYIML
QRFLGREISPELGKRLENYLLDRQLPDGGWPLYAEDGFANISATVKAYLALKVLGHSPQAPHMIRARLMVLSLGGAARCN
VFTRILLALFGQIPWHTPPAMPVEIVLLPQWFFFHLSKVSYWSRTVIVPLLLLYAKQPVCRLRPEEGIPELFSTPPDKLR
HLDGFQPGYWRKNAFIIFDRLLKRFNRFIPSALHRKAIAEAEQWTRSHMQGSGGIGAIFPAMAYAVMALRVLGCGEGDPD
YIRGLQAIDDLLQHRTPQEADPPRTDGTCIDSGMSAAFALTPSAHAAADGTGSSSICQPCNSPIWDTCLSLSALMEAGMP
ASHPAATQAVEWLLSQQILSPGDWSLKVPDLEGGGWAFQFENTLYPDLDDTSKVIMSLLRAGALENERYRDRIARGVNWV
LGMQSSDGGWAAFDIDNNYHYLNDIPFADHGALLDPSTSDLTGRCIELLSMVGFDRTFPPIARGIGFLRSEQEENGAWFG
RWGVNYIYGTWSVLSGLRQAGEDMQQPYIRKAVGWLASCQNHDGGWGETCYSYDDPSLAGKGASTPSQTAWSLLGLMAAG
EVNSLAVRRGVRYLLDHQNQWGTWEEKHFTGTGFPRVFYLRYHGYRHFFPLWALGVYSRLSSGQKACQDERRHASPGDLH
LPWLERIKKR
>Mature_729_residues
AKGILNKFAVIAGTKKAGPPAGEERTVIAPIKEISGKAVHCSQAVKKAEEYLLALQNPEGYWVFELEADVTIPSEYIMLQ
RFLGREISPELGKRLENYLLDRQLPDGGWPLYAEDGFANISATVKAYLALKVLGHSPQAPHMIRARLMVLSLGGAARCNV
FTRILLALFGQIPWHTPPAMPVEIVLLPQWFFFHLSKVSYWSRTVIVPLLLLYAKQPVCRLRPEEGIPELFSTPPDKLRH
LDGFQPGYWRKNAFIIFDRLLKRFNRFIPSALHRKAIAEAEQWTRSHMQGSGGIGAIFPAMAYAVMALRVLGCGEGDPDY
IRGLQAIDDLLQHRTPQEADPPRTDGTCIDSGMSAAFALTPSAHAAADGTGSSSICQPCNSPIWDTCLSLSALMEAGMPA
SHPAATQAVEWLLSQQILSPGDWSLKVPDLEGGGWAFQFENTLYPDLDDTSKVIMSLLRAGALENERYRDRIARGVNWVL
GMQSSDGGWAAFDIDNNYHYLNDIPFADHGALLDPSTSDLTGRCIELLSMVGFDRTFPPIARGIGFLRSEQEENGAWFGR
WGVNYIYGTWSVLSGLRQAGEDMQQPYIRKAVGWLASCQNHDGGWGETCYSYDDPSLAGKGASTPSQTAWSLLGLMAAGE
VNSLAVRRGVRYLLDHQNQWGTWEEKHFTGTGFPRVFYLRYHGYRHFFPLWALGVYSRLSSGQKACQDERRHASPGDLHL
PWLERIKKR

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI224177558, Length=648, Percent_Identity=25.462962962963, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI47933395, Length=648, Percent_Identity=25.6172839506173, Blast_Score=169, Evalue=1e-41,
Organism=Homo sapiens, GI47933397, Length=648, Percent_Identity=25.6172839506173, Blast_Score=169, Evalue=1e-41,
Organism=Homo sapiens, GI224177556, Length=344, Percent_Identity=29.3604651162791, Blast_Score=135, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6321863, Length=696, Percent_Identity=22.9885057471264, Blast_Score=132, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 81227; Mature: 81095

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKGILNKFAVIAGTKKAGPPAGEERTVIAPIKEISGKAVHCSQAVKKAEEYLLALQNPE
CCCHHHHHHHHEECCCCCCCCCCCCCEEEECHHHHCCCEEHHHHHHHHHHHHHEEEECCC
GYWVFELEADVTIPSEYIMLQRFLGREISPELGKRLENYLLDRQLPDGGWPLYAEDGFAN
CEEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCH
ISATVKAYLALKVLGHSPQAPHMIRARLMVLSLGGAARCNVFTRILLALFGQIPWHTPPA
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
MPVEIVLLPQWFFFHLSKVSYWSRTVIVPLLLLYAKQPVCRLRPEEGIPELFSTPPDKLR
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHCCCHHHHH
HLDGFQPGYWRKNAFIIFDRLLKRFNRFIPSALHRKAIAEAEQWTRSHMQGSGGIGAIFP
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AMAYAVMALRVLGCGEGDPDYIRGLQAIDDLLQHRTPQEADPPRTDGTCIDSGMSAAFAL
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCEEEEE
TPSAHAAADGTGSSSICQPCNSPIWDTCLSLSALMEAGMPASHPAATQAVEWLLSQQILS
CCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCC
PGDWSLKVPDLEGGGWAFQFENTLYPDLDDTSKVIMSLLRAGALENERYRDRIARGVNWV
CCCCEEECCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCEE
LGMQSSDGGWAAFDIDNNYHYLNDIPFADHGALLDPSTSDLTGRCIELLSMVGFDRTFPP
EEECCCCCCEEEEEECCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCH
IARGIGFLRSEQEENGAWFGRWGVNYIYGTWSVLSGLRQAGEDMQQPYIRKAVGWLASCQ
HHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NHDGGWGETCYSYDDPSLAGKGASTPSQTAWSLLGLMAAGEVNSLAVRRGVRYLLDHQNQ
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
WGTWEEKHFTGTGFPRVFYLRYHGYRHFFPLWALGVYSRLSSGQKACQDERRHASPGDLH
CCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCC
LPWLERIKKR
CHHHHHHHCC
>Mature Secondary Structure 
AKGILNKFAVIAGTKKAGPPAGEERTVIAPIKEISGKAVHCSQAVKKAEEYLLALQNPE
CCHHHHHHHHEECCCCCCCCCCCCCEEEECHHHHCCCEEHHHHHHHHHHHHHEEEECCC
GYWVFELEADVTIPSEYIMLQRFLGREISPELGKRLENYLLDRQLPDGGWPLYAEDGFAN
CEEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCH
ISATVKAYLALKVLGHSPQAPHMIRARLMVLSLGGAARCNVFTRILLALFGQIPWHTPPA
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
MPVEIVLLPQWFFFHLSKVSYWSRTVIVPLLLLYAKQPVCRLRPEEGIPELFSTPPDKLR
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHCCCHHHHH
HLDGFQPGYWRKNAFIIFDRLLKRFNRFIPSALHRKAIAEAEQWTRSHMQGSGGIGAIFP
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AMAYAVMALRVLGCGEGDPDYIRGLQAIDDLLQHRTPQEADPPRTDGTCIDSGMSAAFAL
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCEEEEE
TPSAHAAADGTGSSSICQPCNSPIWDTCLSLSALMEAGMPASHPAATQAVEWLLSQQILS
CCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCC
PGDWSLKVPDLEGGGWAFQFENTLYPDLDDTSKVIMSLLRAGALENERYRDRIARGVNWV
CCCCEEECCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCEE
LGMQSSDGGWAAFDIDNNYHYLNDIPFADHGALLDPSTSDLTGRCIELLSMVGFDRTFPP
EEECCCCCCEEEEEECCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCH
IARGIGFLRSEQEENGAWFGRWGVNYIYGTWSVLSGLRQAGEDMQQPYIRKAVGWLASCQ
HHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NHDGGWGETCYSYDDPSLAGKGASTPSQTAWSLLGLMAAGEVNSLAVRRGVRYLLDHQNQ
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
WGTWEEKHFTGTGFPRVFYLRYHGYRHFFPLWALGVYSRLSSGQKACQDERRHASPGDLH
CCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCC
LPWLERIKKR
CHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7894707 [H]