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The map label for this gene is cobD [H]

Identifier: 39998080

GI number: 39998080

Start: 3280633

End: 3281718

Strand: Reverse

Name: cobD [H]

Synonym: GSU2989

Alternate gene names: 39998080

Gene position: 3281718-3280633 (Counterclockwise)

Preceding gene: 39998081

Following gene: 39998078

Centisome position: 86.04

GC content: 69.43

Gene sequence:

>1086_bases
GTGACGAGCACCTTCGATCATGGCGGCACGGTCTTCGCCGTGGCCCGCGAACTCGGTATCCGGCCGGAGGATCTTCTGGA
CTTCTCCGCCAGCATAAATCCTCTGGGGCCGGCCCCTGCGGTGCGGGAGGCGGTGATGGCGGCCTTCGACCGGCTGGTGC
ACTATCCCGATAGCCAGGCGGCCGAGCTGCGAGATTCCCTGGCCCGCCATCACGGGCTGCCGGCAGAGTGCATCTGTGCC
GCCAACGGCTCCACAGAACTCATCTACCTGCTGCCGCGCCTCGTGGGAGGCGGGCGTGGGCTAGTGGTGGCGCCGCCGTT
CTCGGAGTACGCCAGGAGCCTGACCCGCGCCGGCTGGGAAGTGGGCTACCTGGACCTGGCGCCGGAGGAGGGGTTCGCCC
TGGCGCCGGCCCTCCTCGACCAGCGTCTGGCCGAGGGATGGAACCTCGTCGTCCTGGCCAATCCGGGCAATCCCACCGGC
AGTCTGATCCCCCATGACGACATGGTTGCGGTCCACCGGCTGTGCCGTGCCCGCGGGACCTTTCTGGTGGTGGACGAGGC
CTTCATGGATTTCCGGGAAGAGGAGTCGGTGACGGGGTATGTGGCCCGCCAGGGGGGTGGCGTCGTGCTCCGCTCCCTGA
CCAAGTTTCATGCAATTCCCGGTCTGCGCCTCGGCTTTGCCGTGGCGGCTCCGGAGGATGCGGCCCGGCTGGCCGATCTG
CGGGCACCGTGGAGCGTCAACACCCTGGCCCAGGCGGCCGGGCTCGCCACCCTGGTGGATGGGGAGTACGCGGCGCGAAC
GCGGAGACTGATCGAAGAGGAGCGGGCGGTTCTGGCGGCGGGGCTTGCCGCCATTCCGGGGGTGCGGGTCTATCCGTCCG
CGGCCAACTACCTGCTGGCGGAACTGACGACCGGGCCGACGGTGCCGGCGCTGGCCGAGGCCCTGCTGCGGCAGCGGATA
CTGATCCGGGACTGCTCTTTGTTCCGGGGGCTGAACGACCGTTTCTTCCGGGTCGCGGTCCGGTCGCGCGCCGACAATGA
GCGTCTTCTGGCGGCTTGTGCCGCGGTCCTTGCCCGGACCATGTGA

Upstream 100 bases:

>100_bases
TCGATCGCACGGCATGGCGCGGCGCCGTCCGGCTCATGTACGGCTCCGAGATCCTGCTGACGGGGTTCATGTTGTGCTAC
CTTTTTGTCCTGGAGCGTCC

Downstream 100 bases:

>100_bases
GCGGGGGTGGACAGGAAGTGTGGCGGAGGTCAGGCTTTGCCGCCGCTGCGGAGGACCACTACCCGGCAGGCGGGAAGGGA
GAGCTTTAGGCGGTCGATGC

Product: L-threonine-O-3-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MTSTFDHGGTVFAVARELGIRPEDLLDFSASINPLGPAPAVREAVMAAFDRLVHYPDSQAAELRDSLARHHGLPAECICA
ANGSTELIYLLPRLVGGGRGLVVAPPFSEYARSLTRAGWEVGYLDLAPEEGFALAPALLDQRLAEGWNLVVLANPGNPTG
SLIPHDDMVAVHRLCRARGTFLVVDEAFMDFREEESVTGYVARQGGGVVLRSLTKFHAIPGLRLGFAVAAPEDAARLADL
RAPWSVNTLAQAAGLATLVDGEYAARTRRLIEEERAVLAAGLAAIPGVRVYPSAANYLLAELTTGPTVPALAEALLRQRI
LIRDCSLFRGLNDRFFRVAVRSRADNERLLAACAAVLARTM

Sequences:

>Translated_361_residues
MTSTFDHGGTVFAVARELGIRPEDLLDFSASINPLGPAPAVREAVMAAFDRLVHYPDSQAAELRDSLARHHGLPAECICA
ANGSTELIYLLPRLVGGGRGLVVAPPFSEYARSLTRAGWEVGYLDLAPEEGFALAPALLDQRLAEGWNLVVLANPGNPTG
SLIPHDDMVAVHRLCRARGTFLVVDEAFMDFREEESVTGYVARQGGGVVLRSLTKFHAIPGLRLGFAVAAPEDAARLADL
RAPWSVNTLAQAAGLATLVDGEYAARTRRLIEEERAVLAAGLAAIPGVRVYPSAANYLLAELTTGPTVPALAEALLRQRI
LIRDCSLFRGLNDRFFRVAVRSRADNERLLAACAAVLARTM
>Mature_360_residues
TSTFDHGGTVFAVARELGIRPEDLLDFSASINPLGPAPAVREAVMAAFDRLVHYPDSQAAELRDSLARHHGLPAECICAA
NGSTELIYLLPRLVGGGRGLVVAPPFSEYARSLTRAGWEVGYLDLAPEEGFALAPALLDQRLAEGWNLVVLANPGNPTGS
LIPHDDMVAVHRLCRARGTFLVVDEAFMDFREEESVTGYVARQGGGVVLRSLTKFHAIPGLRLGFAVAAPEDAARLADLR
APWSVNTLAQAAGLATLVDGEYAARTRRLIEEERAVLAAGLAAIPGVRVYPSAANYLLAELTTGPTVPALAEALLRQRIL
IRDCSLFRGLNDRFFRVAVRSRADNERLLAACAAVLARTM

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=310, Percent_Identity=30.6451612903226, Blast_Score=99, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6322075, Length=321, Percent_Identity=28.3489096573209, Blast_Score=76, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 38741; Mature: 38610

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTFDHGGTVFAVARELGIRPEDLLDFSASINPLGPAPAVREAVMAAFDRLVHYPDSQA
CCCCCCCCCHHEEEHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHH
AELRDSLARHHGLPAECICAANGSTELIYLLPRLVGGGRGLVVAPPFSEYARSLTRAGWE
HHHHHHHHHHCCCCHHEEEECCCCCHHHHEEHHHHCCCCCEEECCCHHHHHHHHHHCCCE
VGYLDLAPEEGFALAPALLDQRLAEGWNLVVLANPGNPTGSLIPHDDMVAVHRLCRARGT
EEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCC
FLVVDEAFMDFREEESVTGYVARQGGGVVLRSLTKFHAIPGLRLGFAVAAPEDAARLADL
EEEEEHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHC
RAPWSVNTLAQAAGLATLVDGEYAARTRRLIEEERAVLAAGLAAIPGVRVYPSAANYLLA
CCCCCHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHH
ELTTGPTVPALAEALLRQRILIRDCSLFRGLNDRFFRVAVRSRADNERLLAACAAVLART
HHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHC
M
C
>Mature Secondary Structure 
TSTFDHGGTVFAVARELGIRPEDLLDFSASINPLGPAPAVREAVMAAFDRLVHYPDSQA
CCCCCCCCHHEEEHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHH
AELRDSLARHHGLPAECICAANGSTELIYLLPRLVGGGRGLVVAPPFSEYARSLTRAGWE
HHHHHHHHHHCCCCHHEEEECCCCCHHHHEEHHHHCCCCCEEECCCHHHHHHHHHHCCCE
VGYLDLAPEEGFALAPALLDQRLAEGWNLVVLANPGNPTGSLIPHDDMVAVHRLCRARGT
EEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCC
FLVVDEAFMDFREEESVTGYVARQGGGVVLRSLTKFHAIPGLRLGFAVAAPEDAARLADL
EEEEEHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHC
RAPWSVNTLAQAAGLATLVDGEYAARTRRLIEEERAVLAAGLAAIPGVRVYPSAANYLLA
CCCCCHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHH
ELTTGPTVPALAEALLRQRILIRDCSLFRGLNDRFFRVAVRSRADNERLLAACAAVLART
HHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHC
M
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]