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The map label for this gene is panE [C]

Identifier: 39997777

GI number: 39997777

Start: 2961626

End: 2962534

Strand: Reverse

Name: panE [C]

Synonym: GSU2683

Alternate gene names: 39997777

Gene position: 2962534-2961626 (Counterclockwise)

Preceding gene: 39997778

Following gene: 39997776

Centisome position: 77.67

GC content: 64.69

Gene sequence:

>909_bases
ATGAAAATAGCCATTGTCGGCGCCGGAGCCCTGGGGCTCTACTACGGCGCGCTGCTGCAGCGGGCGGGGGAGGACGTGCA
TTTTCTTCTGCGCCGCGATTTCGAGGCAATCGTTCGCAACGGCCTCAAGGTATTCTCCACTGACGGTGACTTTGTCCTCC
CCCACGTGAAAGGATACCGGACCCCTGATGAGATCGGTGCCGCAGATCTGGTTCTGGTGGGGCTGAAGACCTTTGCCAAC
GATCGGTATGAGGAGTTGATCCGTCCGCTGGTGGGGGCTGAGACCCGGATCCTGACCCTTCAGAACGGGTTGGGGAACGA
GGAGGCACTGGCCGCCCTGTTCGGCCCTGAGCGGGTCATCGGCGGGGTGGCCTTTCTCTGTTCCAACCGGGGTGAGCCGG
GAGAGGTGCACCACCTTGGTGCGGGCCGGATCACCCTGGGCGAATTTCTTCCCCGCGACCGGGAATGGACCGAGGCGCTG
GCCGCCCTGTTCGTGCGGGCAGGAGTGGAGTGCCGTGCAACCGGCGACCTGAAGCGGGCCCGCTGGGAGAAGCTGGTCTG
GAACATTCCGTTCAACGGCCTGTGCGCCCTGCTGCAGCAGCCGGTCAACCTGCTCCTGGCGCGGGATGCGAGCCGCACGC
TGGTGCGGGAGATCATGCATGAGGTGATTGCCGCGGCCAATGCCCAGGGGTTGACCGTGCCCATAGCCCCGGCATACGCG
GACAGCATGCTGGAATTCACCGACAGGATGGGCGAATACAAACCCTCCATGCAGATCGACCGGGAAGAGGGGAGGCCCCT
GGAGATCTGGGCCATCTTCCGGACGCCCCTTGCCTACGGCAGCCAACGGGGTATCGCCATGCCCCGGGTGGAGATGCTGG
CAACGCTGCTGGAGCAGTCTGCCGGCTAG

Upstream 100 bases:

>100_bases
ATGTGGCACTCTACCCGATGCCTGACGAGGCACGGATTACTGGCCATCTGCGGACCATTGGCCGCCGTGCCCGGCAAACC
CGTTCCCTGGAGTCGTTCTG

Downstream 100 bases:

>100_bases
TTTTTCCTGGAGCGCTGCCGTCTCTATGGTATCCTTGGAAAGCGTGAATTCTATGTCGAGCCGGGGAGGAAACCATGGAA
CGACGCACGTTTCTGAAGCT

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MKIAIVGAGALGLYYGALLQRAGEDVHFLLRRDFEAIVRNGLKVFSTDGDFVLPHVKGYRTPDEIGAADLVLVGLKTFAN
DRYEELIRPLVGAETRILTLQNGLGNEEALAALFGPERVIGGVAFLCSNRGEPGEVHHLGAGRITLGEFLPRDREWTEAL
AALFVRAGVECRATGDLKRARWEKLVWNIPFNGLCALLQQPVNLLLARDASRTLVREIMHEVIAAANAQGLTVPIAPAYA
DSMLEFTDRMGEYKPSMQIDREEGRPLEIWAIFRTPLAYGSQRGIAMPRVEMLATLLEQSAG

Sequences:

>Translated_302_residues
MKIAIVGAGALGLYYGALLQRAGEDVHFLLRRDFEAIVRNGLKVFSTDGDFVLPHVKGYRTPDEIGAADLVLVGLKTFAN
DRYEELIRPLVGAETRILTLQNGLGNEEALAALFGPERVIGGVAFLCSNRGEPGEVHHLGAGRITLGEFLPRDREWTEAL
AALFVRAGVECRATGDLKRARWEKLVWNIPFNGLCALLQQPVNLLLARDASRTLVREIMHEVIAAANAQGLTVPIAPAYA
DSMLEFTDRMGEYKPSMQIDREEGRPLEIWAIFRTPLAYGSQRGIAMPRVEMLATLLEQSAG
>Mature_302_residues
MKIAIVGAGALGLYYGALLQRAGEDVHFLLRRDFEAIVRNGLKVFSTDGDFVLPHVKGYRTPDEIGAADLVLVGLKTFAN
DRYEELIRPLVGAETRILTLQNGLGNEEALAALFGPERVIGGVAFLCSNRGEPGEVHHLGAGRITLGEFLPRDREWTEAL
AALFVRAGVECRATGDLKRARWEKLVWNIPFNGLCALLQQPVNLLLARDASRTLVREIMHEVIAAANAQGLTVPIAPAYA
DSMLEFTDRMGEYKPSMQIDREEGRPLEIWAIFRTPLAYGSQRGIAMPRVEMLATLLEQSAG

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6320057, Length=333, Percent_Identity=26.1261261261261, Blast_Score=89, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33193; Mature: 33193

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAIVGAGALGLYYGALLQRAGEDVHFLLRRDFEAIVRNGLKVFSTDGDFVLPHVKGYR
CEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEECCCCEEECCCCCCC
TPDEIGAADLVLVGLKTFANDRYEELIRPLVGAETRILTLQNGLGNEEALAALFGPERVI
CHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHCHHHHH
GGVAFLCSNRGEPGEVHHLGAGRITLGEFLPRDREWTEALAALFVRAGVECRATGDLKRA
HHHHHHHCCCCCCCCEEECCCCCEEHHHHCCCCHHHHHHHHHHHHHCCCCEEECCCHHHH
RWEKLVWNIPFNGLCALLQQPVNLLLARDASRTLVREIMHEVIAAANAQGLTVPIAPAYA
HHHHHEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEECCHHHH
DSMLEFTDRMGEYKPSMQIDREEGRPLEIWAIFRTPLAYGSQRGIAMPRVEMLATLLEQS
HHHHHHHHHHCCCCCCCCEECCCCCCEEEEEEEHHHHHCCCCCCCCCCHHHHHHHHHHHC
AG
CC
>Mature Secondary Structure
MKIAIVGAGALGLYYGALLQRAGEDVHFLLRRDFEAIVRNGLKVFSTDGDFVLPHVKGYR
CEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEECCCCEEECCCCCCC
TPDEIGAADLVLVGLKTFANDRYEELIRPLVGAETRILTLQNGLGNEEALAALFGPERVI
CHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHCHHHHH
GGVAFLCSNRGEPGEVHHLGAGRITLGEFLPRDREWTEALAALFVRAGVECRATGDLKRA
HHHHHHHCCCCCCCCEEECCCCCEEHHHHCCCCHHHHHHHHHHHHHCCCCEEECCCHHHH
RWEKLVWNIPFNGLCALLQQPVNLLLARDASRTLVREIMHEVIAAANAQGLTVPIAPAYA
HHHHHEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEECCHHHH
DSMLEFTDRMGEYKPSMQIDREEGRPLEIWAIFRTPLAYGSQRGIAMPRVEMLATLLEQS
HHHHHHHHHHCCCCCCCCEECCCCCCEEEEEEEHHHHHCCCCCCCCCCHHHHHHHHHHHC
AG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]