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The map label for this gene is lytB

Identifier: 39997698

GI number: 39997698

Start: 2872104

End: 2872952

Strand: Reverse

Name: lytB

Synonym: GSU2604

Alternate gene names: 39997698

Gene position: 2872952-2872104 (Counterclockwise)

Preceding gene: 39997699

Following gene: 39997697

Centisome position: 75.32

GC content: 62.54

Gene sequence:

>849_bases
ATGGAGATCGTACTGGCAAAGCGGGCCGGCTTCTGCTTCGGCGTGAAGCGGGCAACCCAGATGGCCTTCGAGGCCGCCGA
AAAGGAAGGGGAAACCTTCACCCTCGGCCCCATCATCCATTCGCCCCAGGTCGTGCAGCGCCTGGAGGGGATGGGAGTGA
AGGTGCTGAGCGACCTGGAAGGGATCGGTAACGGCACCGTCATCATCCGGTCCCACGGGGTGACCTCCGCGGAACTGGAA
GACGCGGTCCGCCGGCAGCTTGAGGTGGTGGACGCCACCTGTCCCTTTGTCAAGAAGGCCCAGGAGCACGTGAAGCGTCT
GTCCCACGACGGCTATACCGTGGTGGTGGTGGGCGATGCCGACCACCCCGAGGTGCAGGGCATCGTATCCTACGCCGAGG
GGCCGGTCCACGTGGTCGGTTCCGGCGAGGAGGCCGCCAGGCTCCCCAACATGAAGAAGGTCGGCGTTGTGGCCCAGACC
ACCCAATCCTTCGAAACCCTCAAGAACGTGGTGAAGGAATGCCTCCTCAAGGGGGGGGAGATCCGGGTCTTCAACACCAT
CTGCGACGCCACCGCCGTCCGCCAGGACGAAGCCAAGGCCCTGGCCCGGGAGGTGGACTGCATGATCGTCATCGGTGGCT
TCAACAGCGCCAACACCAAGCGGCTCGCCGAGGTCTGCTCCGAACTGCAGCCGCGTACCTACCACATAGAGACGGCCCAG
GAGCTGGATGCATCATGGTTTCAAGGGGTTGAGCGGGTAGGGGTCACTGCGGGCGCATCCACGCCCAAGTGGCTTATCGA
CGAGGTAATAGAACGGATACAAGAGTTTGACAATAAGAAAAAAGGTTGA

Upstream 100 bases:

>100_bases
GAGGTCCTGGACCGCATGGAATCCATCGTGCGGGAGCGGGAACGGGCCACTCCGGGCGCGTAGTCCGGGACGGCAACAGA
GCAGCTTCGGGAGCAACGCA

Downstream 100 bases:

>100_bases
GTTTTTCGATAGATATTGCTACGTTTACTCATCCTAATCCACGACGTGTAGGGAGGCCAGCTTTAAATGAGTGATGACAA
GGACTATAACAGCCGCACCG

Product: penicillin tolerance protein LytB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MEIVLAKRAGFCFGVKRATQMAFEAAEKEGETFTLGPIIHSPQVVQRLEGMGVKVLSDLEGIGNGTVIIRSHGVTSAELE
DAVRRQLEVVDATCPFVKKAQEHVKRLSHDGYTVVVVGDADHPEVQGIVSYAEGPVHVVGSGEEAARLPNMKKVGVVAQT
TQSFETLKNVVKECLLKGGEIRVFNTICDATAVRQDEAKALAREVDCMIVIGGFNSANTKRLAEVCSELQPRTYHIETAQ
ELDASWFQGVERVGVTAGASTPKWLIDEVIERIQEFDNKKKG

Sequences:

>Translated_282_residues
MEIVLAKRAGFCFGVKRATQMAFEAAEKEGETFTLGPIIHSPQVVQRLEGMGVKVLSDLEGIGNGTVIIRSHGVTSAELE
DAVRRQLEVVDATCPFVKKAQEHVKRLSHDGYTVVVVGDADHPEVQGIVSYAEGPVHVVGSGEEAARLPNMKKVGVVAQT
TQSFETLKNVVKECLLKGGEIRVFNTICDATAVRQDEAKALAREVDCMIVIGGFNSANTKRLAEVCSELQPRTYHIETAQ
ELDASWFQGVERVGVTAGASTPKWLIDEVIERIQEFDNKKKG
>Mature_282_residues
MEIVLAKRAGFCFGVKRATQMAFEAAEKEGETFTLGPIIHSPQVVQRLEGMGVKVLSDLEGIGNGTVIIRSHGVTSAELE
DAVRRQLEVVDATCPFVKKAQEHVKRLSHDGYTVVVVGDADHPEVQGIVSYAEGPVHVVGSGEEAARLPNMKKVGVVAQT
TQSFETLKNVVKECLLKGGEIRVFNTICDATAVRQDEAKALAREVDCMIVIGGFNSANTKRLAEVCSELQPRTYHIETAQ
ELDASWFQGVERVGVTAGASTPKWLIDEVIERIQEFDNKKKG

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP)

COG id: COG0761

COG function: function code IM; Penicillin tolerance protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispH family

Homologues:

Organism=Escherichia coli, GI1786212, Length=285, Percent_Identity=34.0350877192982, Blast_Score=152, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPH_GEOSL (Q749Y8)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_953649.1
- GeneID:   2686313
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU2604
- NMPDR:   fig|243231.1.peg.2587
- TIGR:   GSU2604
- HOGENOM:   HBG335228
- OMA:   HMQVARA
- ProtClustDB:   CLSK790176
- BioCyc:   GSUL243231:GSU_2604-MONOMER
- BRENDA:   1.17.1.2
- HAMAP:   MF_00191
- InterPro:   IPR003451
- TIGRFAMs:   TIGR00216

Pfam domain/function: PF02401 LYTB

EC number: =1.17.1.2

Molecular weight: Translated: 30702; Mature: 30702

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIVLAKRAGFCFGVKRATQMAFEAAEKEGETFTLGPIIHSPQVVQRLEGMGVKVLSDLE
CCEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCCCHHHHHHHC
GIGNGTVIIRSHGVTSAELEDAVRRQLEVVDATCPFVKKAQEHVKRLSHDGYTVVVVGDA
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECCC
DHPEVQGIVSYAEGPVHVVGSGEEAARLPNMKKVGVVAQTTQSFETLKNVVKECLLKGGE
CCCHHHHHHHHCCCCEEEEECCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
IRVFNTICDATAVRQDEAKALAREVDCMIVIGGFNSANTKRLAEVCSELQPRTYHIETAQ
EEEEHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEECCHH
ELDASWFQGVERVGVTAGASTPKWLIDEVIERIQEFDNKKKG
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEIVLAKRAGFCFGVKRATQMAFEAAEKEGETFTLGPIIHSPQVVQRLEGMGVKVLSDLE
CCEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCCCHHHHHHHC
GIGNGTVIIRSHGVTSAELEDAVRRQLEVVDATCPFVKKAQEHVKRLSHDGYTVVVVGDA
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECCC
DHPEVQGIVSYAEGPVHVVGSGEEAARLPNMKKVGVVAQTTQSFETLKNVVKECLLKGGE
CCCHHHHHHHHCCCCEEEEECCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
IRVFNTICDATAVRQDEAKALAREVDCMIVIGGFNSANTKRLAEVCSELQPRTYHIETAQ
EEEEHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEECCHH
ELDASWFQGVERVGVTAGASTPKWLIDEVIERIQEFDNKKKG
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA