Click here to switch to the map view.

The map label for this gene is LYS1

Identifier: 39997634

GI number: 39997634

Start: 2802886

End: 2804082

Strand: Reverse

Name: LYS1

Synonym: GSU2539

Alternate gene names: NA

Gene position: 2804082-2802886 (Counterclockwise)

Preceding gene: 39997635

Following gene: 39997633

Centisome position: 73.52

GC content: 62.74

Gene sequence:

>1197_bases
ATGAGCAAGGTACTGATAATCGGAGCCGGCGGCGTCGGCCAGGTCGTTGCCCACAAGTGCGCCCAGCGCAGGGACATCTT
CAGCGGGATCACCCTCGCCTCCCGGACCAAGTCCAAGTGCGACGCCATCGCCGCCCAGCTGAACAACAGCATCGCCACTG
CCCAGGTGGACGCGGACAATGTTCCCGAGCTGGTGGCGCTCATCAAGAAAGAGCAGCCGAAGCTCGTCATCAACGTGGCC
CTGCCGTACCAGGACCTGACCATCATGGATGCCTGCCTGGAGACCGGCGTGGACTACCTGGACACCGCCAACTACGAGCC
CCTGGACACCGCCAAGTTCGAGTACTCCTGGCAGTGGGCCTATCAGGACCGTTTCAAGAGCGCTGGGCTCATGGCGCTGC
TCGGTTCCGGCTTCGACCCCGGCGTGACCAACGTCTACACCGCCCTGGCCGCCAAGAAGTACCTGGACGAGGTGCAGGAG
ATCGATATCATCGATGCCAACGCCGGGAGCCACGGCCAGCCCTTTGCCACCAACTTCAACCCGGAGATCAACATCCGCGA
GGTGACCGCTCCGTGCCGCCACTGGGAGAACGGCGAGTTCGTCGAGACGCCCCCCCTTTCGACCAAGCAGGTCTTCGATT
TCCCCGAGGGGATCGGCCCCATGAACATCTATCGTCTCTATCACGAGGAGATGGAGTCCATCGTCAAGCATATCCCGACC
ATCAGGAAGGCCCAGTTCTGGATGACCTTCTCCGACAACTACCTGAAGCACCTGGAGGTGCTGCAGAACGTGGGCATGAC
CCGTATCGACGAGGTGGAGTTCCAGGGGCAGAAGATCGTGCCGATCCAGTTCCTGAAGGCGCTCCTCCCCGATCCGGGTT
CCCTCGGCCCCCTCACCAAGGGGAAGACCTGCATCGGCGTCATCGCCCGCGGTCTCAAGGACGGCAAGCGGAAACAGGTC
TACATCTACAACATCTGCGACCACGAGGCCTGCTACAAAGAGGTTGGCTCCCAGGCCATCAGCTACACCACCGGCGTACC
GGCGGTGGTGGGCGGGATCATGATGCTGACCGGCAAATGGCACGCCCCCGGTGTCTGGAACATGGAACAGTTCGATCCCG
AGCCGTTCCTGGCGGAGCTTGGGCCCATGGGGCTGCCGACGGTGGTGGTGGACGGCGGCGAGTGGCCGGAGCTGTAA

Upstream 100 bases:

>100_bases
CATACGGTGAAAAATATCGGCAAGGGGCCGGCCAAGATATTGTGGGTCGTGACCCCGCCGACATTTGATTACTGATAACG
CAATCGAAGGAGATCAACCA

Downstream 100 bases:

>100_bases
GAGGAGCGCAATCTTCCGACCATCTCACCGCCGTCCTCGGAATGCTCGTTGTGCGGCGTAGCGCTGCTACGCCTCCGCCG
GCATCCCTGCGGGTGCGAGG

Product: saccharopine dehydrogenase

Products: L-lysine; 2-oxoglutarate; NADH; H+

Alternate protein names: Carboxynorspermidine Dehydrogenase; Saccharopine Dehydrogenase-Like Protein; Carboxynorspermide Hydratase; Saccharopine Dehydrogenase Family Protein; Acyl Carrier Protein

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MSKVLIIGAGGVGQVVAHKCAQRRDIFSGITLASRTKSKCDAIAAQLNNSIATAQVDADNVPELVALIKKEQPKLVINVA
LPYQDLTIMDACLETGVDYLDTANYEPLDTAKFEYSWQWAYQDRFKSAGLMALLGSGFDPGVTNVYTALAAKKYLDEVQE
IDIIDANAGSHGQPFATNFNPEINIREVTAPCRHWENGEFVETPPLSTKQVFDFPEGIGPMNIYRLYHEEMESIVKHIPT
IRKAQFWMTFSDNYLKHLEVLQNVGMTRIDEVEFQGQKIVPIQFLKALLPDPGSLGPLTKGKTCIGVIARGLKDGKRKQV
YIYNICDHEACYKEVGSQAISYTTGVPAVVGGIMMLTGKWHAPGVWNMEQFDPEPFLAELGPMGLPTVVVDGGEWPEL

Sequences:

>Translated_398_residues
MSKVLIIGAGGVGQVVAHKCAQRRDIFSGITLASRTKSKCDAIAAQLNNSIATAQVDADNVPELVALIKKEQPKLVINVA
LPYQDLTIMDACLETGVDYLDTANYEPLDTAKFEYSWQWAYQDRFKSAGLMALLGSGFDPGVTNVYTALAAKKYLDEVQE
IDIIDANAGSHGQPFATNFNPEINIREVTAPCRHWENGEFVETPPLSTKQVFDFPEGIGPMNIYRLYHEEMESIVKHIPT
IRKAQFWMTFSDNYLKHLEVLQNVGMTRIDEVEFQGQKIVPIQFLKALLPDPGSLGPLTKGKTCIGVIARGLKDGKRKQV
YIYNICDHEACYKEVGSQAISYTTGVPAVVGGIMMLTGKWHAPGVWNMEQFDPEPFLAELGPMGLPTVVVDGGEWPEL
>Mature_397_residues
SKVLIIGAGGVGQVVAHKCAQRRDIFSGITLASRTKSKCDAIAAQLNNSIATAQVDADNVPELVALIKKEQPKLVINVAL
PYQDLTIMDACLETGVDYLDTANYEPLDTAKFEYSWQWAYQDRFKSAGLMALLGSGFDPGVTNVYTALAAKKYLDEVQEI
DIIDANAGSHGQPFATNFNPEINIREVTAPCRHWENGEFVETPPLSTKQVFDFPEGIGPMNIYRLYHEEMESIVKHIPTI
RKAQFWMTFSDNYLKHLEVLQNVGMTRIDEVEFQGQKIVPIQFLKALLPDPGSLGPLTKGKTCIGVIARGLKDGKRKQVY
IYNICDHEACYKEVGSQAISYTTGVPAVVGGIMMLTGKWHAPGVWNMEQFDPEPFLAELGPMGLPTVVVDGGEWPEL

Specific function: Unknown

COG id: COG1748

COG function: function code E; Saccharopine dehydrogenase and related proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 1.5.1.7

Molecular weight: Translated: 43972; Mature: 43841

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVLIIGAGGVGQVVAHKCAQRRDIFSGITLASRTKSKCDAIAAQLNNSIATAQVDADN
CCEEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHCCCEEEEEECCCC
VPELVALIKKEQPKLVINVALPYQDLTIMDACLETGVDYLDTANYEPLDTAKFEYSWQWA
HHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCHHHCCCCCCCCCCEEEEEEEEH
YQDRFKSAGLMALLGSGFDPGVTNVYTALAAKKYLDEVQEIDIIDANAGSHGQPFATNFN
HHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCCC
PEINIREVTAPCRHWENGEFVETPPLSTKQVFDFPEGIGPMNIYRLYHEEMESIVKHIPT
CCEEEEEECHHHHCCCCCCEEECCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCC
IRKAQFWMTFSDNYLKHLEVLQNVGMTRIDEVEFQGQKIVPIQFLKALLPDPGSLGPLTK
HHHEEEEEEECHHHHHHHHHHHHCCCCEEEHHHCCCCEECHHHHHHHHCCCCCCCCCCCC
GKTCIGVIARGLKDGKRKQVYIYNICDHEACYKEVGSQAISYTTGVPAVVGGIMMLTGKW
CCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHEEECCC
HAPGVWNMEQFDPEPFLAELGPMGLPTVVVDGGEWPEL
CCCCCCCHHHCCCCCHHHHHCCCCCCEEEECCCCCCCC
>Mature Secondary Structure 
SKVLIIGAGGVGQVVAHKCAQRRDIFSGITLASRTKSKCDAIAAQLNNSIATAQVDADN
CEEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHCCCEEEEEECCCC
VPELVALIKKEQPKLVINVALPYQDLTIMDACLETGVDYLDTANYEPLDTAKFEYSWQWA
HHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCHHHCCCCCCCCCCEEEEEEEEH
YQDRFKSAGLMALLGSGFDPGVTNVYTALAAKKYLDEVQEIDIIDANAGSHGQPFATNFN
HHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCCC
PEINIREVTAPCRHWENGEFVETPPLSTKQVFDFPEGIGPMNIYRLYHEEMESIVKHIPT
CCEEEEEECHHHHCCCCCCEEECCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCC
IRKAQFWMTFSDNYLKHLEVLQNVGMTRIDEVEFQGQKIVPIQFLKALLPDPGSLGPLTK
HHHEEEEEEECHHHHHHHHHHHHCCCCEEEHHHCCCCEECHHHHHHHHCCCCCCCCCCCC
GKTCIGVIARGLKDGKRKQVYIYNICDHEACYKEVGSQAISYTTGVPAVVGGIMMLTGKW
CCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHEEECCC
HAPGVWNMEQFDPEPFLAELGPMGLPTVVVDGGEWPEL
CCCCCCCHHHCCCCCHHHHHCCCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N6-(L-1,3-dicarboxypropyl)-L-lysine; NAD+; H2O

Specific reaction: N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA