Click here to switch to the map view.

The map label for this gene is pdhB [H]

Identifier: 39997531

GI number: 39997531

Start: 2671953

End: 2672939

Strand: Reverse

Name: pdhB [H]

Synonym: GSU2436

Alternate gene names: 39997531

Gene position: 2672939-2671953 (Counterclockwise)

Preceding gene: 39997532

Following gene: 39997530

Centisome position: 70.08

GC content: 66.36

Gene sequence:

>987_bases
ATGCCTGAAATGAACTACCGCGATGCCCTGAACCTGGCCCTGAAGGAAGAGATGCGCCGCGATCCGTCGGTGGTGGTCTG
GGGGGAAGACGTGGCCCTGTACGAGGGGTCCTTCAAGGTGACCCGCGGGCTGCTGGCCGAGTTCGGCGAGGAGCGGGTGA
AGGATACCCCCATTTCGGAGAACTCCATCGTGGGGGTGGCCGTGGGCGCTGCCATGGGGGGCTTGAGGCCCGTGGCGGAG
CTGATGACGGTGAATTTCGCGCTCCTGGCCATGGACCAGATCGTGAACCACATGGCCAAGATCCGCTCCATGTTCGGGGG
CCAGACCTATCTCCCCATGGTGGTCAGGGCGCCGGGGGGCGGGGGGAGCCAGTTGGGCGCCCAGCATTCCCAGAGCCTGG
AAACCTATTTCATGCACTGCCCCGGCATCCATGTGGCGGTGCCGGCCACACCGGCGGATGCCCGGGGGCTGCTCAAGGCG
GCCATCCGCGACGACAACCCGGTCATGTTCCTGGAGCACGAGCTGCTCTACAACAGCAAGGGCGAGGTGCCCGACGACCC
GGAGTCCGTCATTCCCTTCGGAAAGGCGGATGTGAAGCGTGAGGGGAAGGACCTGACCATTGTCGCCTATTCGCGCATGA
CCATCCTGGCGCTCCAGGCGGCGGAGGAGCTGGCAAAGGAGGGGATATCCTGCGAGGTGGTGGACCTGCGGACCCTGACC
CCCCTCGATACGGCGACCTTTACGGCGTCGGTGAAGAAGACCGGCCGGGCCGTGGTGGTGGAGGAGTGCTGGCGGAGCGC
CGGACTGGGCGGGCACCTGGCCGCGATCATCGCGGAGGAGTGCTTTGACCGGCTCCTGGCGCCGGTGCGGCGGGTGTCGG
GGCTCGACGTGCCCATGCCCTATTCGCGCAAGATTGAGAAGCTCTGCATTCCGCAACCGGAGACGATCGCCGCGGCGGTG
CGGGAGACGCTGAGCGGAACGTACTGA

Upstream 100 bases:

>100_bases
GCGATGATGCAGATGAAAAAGATCGACATCGCCGCAATTGAGGCTGCGTACCGCGGGTGAGATTGCATTCCTCGCACCAT
CATGAACCCGGAGGCTTCCG

Downstream 100 bases:

>100_bases
GAAAGGGATATCCTCATGGCAACCGACATCACCATGCCCAAGCTCTCCGACACCATGACCGAAGGCCGTCTCGTCGCCTG
GAAGAAAGGGGTGGGCGACC

Product: dehydrogenase complex, E1 component subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MPEMNYRDALNLALKEEMRRDPSVVVWGEDVALYEGSFKVTRGLLAEFGEERVKDTPISENSIVGVAVGAAMGGLRPVAE
LMTVNFALLAMDQIVNHMAKIRSMFGGQTYLPMVVRAPGGGGSQLGAQHSQSLETYFMHCPGIHVAVPATPADARGLLKA
AIRDDNPVMFLEHELLYNSKGEVPDDPESVIPFGKADVKREGKDLTIVAYSRMTILALQAAEELAKEGISCEVVDLRTLT
PLDTATFTASVKKTGRAVVVEECWRSAGLGGHLAAIIAEECFDRLLAPVRRVSGLDVPMPYSRKIEKLCIPQPETIAAAV
RETLSGTY

Sequences:

>Translated_328_residues
MPEMNYRDALNLALKEEMRRDPSVVVWGEDVALYEGSFKVTRGLLAEFGEERVKDTPISENSIVGVAVGAAMGGLRPVAE
LMTVNFALLAMDQIVNHMAKIRSMFGGQTYLPMVVRAPGGGGSQLGAQHSQSLETYFMHCPGIHVAVPATPADARGLLKA
AIRDDNPVMFLEHELLYNSKGEVPDDPESVIPFGKADVKREGKDLTIVAYSRMTILALQAAEELAKEGISCEVVDLRTLT
PLDTATFTASVKKTGRAVVVEECWRSAGLGGHLAAIIAEECFDRLLAPVRRVSGLDVPMPYSRKIEKLCIPQPETIAAAV
RETLSGTY
>Mature_327_residues
PEMNYRDALNLALKEEMRRDPSVVVWGEDVALYEGSFKVTRGLLAEFGEERVKDTPISENSIVGVAVGAAMGGLRPVAEL
MTVNFALLAMDQIVNHMAKIRSMFGGQTYLPMVVRAPGGGGSQLGAQHSQSLETYFMHCPGIHVAVPATPADARGLLKAA
IRDDNPVMFLEHELLYNSKGEVPDDPESVIPFGKADVKREGKDLTIVAYSRMTILALQAAEELAKEGISCEVVDLRTLTP
LDTATFTASVKKTGRAVVVEECWRSAGLGGHLAAIIAEECFDRLLAPVRRVSGLDVPMPYSRKIEKLCIPQPETIAAAVR
ETLSGTY

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI156564403, Length=327, Percent_Identity=45.8715596330275, Blast_Score=305, Evalue=5e-83,
Organism=Homo sapiens, GI291084858, Length=327, Percent_Identity=44.0366972477064, Blast_Score=282, Evalue=3e-76,
Organism=Homo sapiens, GI4557353, Length=327, Percent_Identity=38.2262996941896, Blast_Score=225, Evalue=4e-59,
Organism=Homo sapiens, GI34101272, Length=327, Percent_Identity=38.2262996941896, Blast_Score=225, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17538422, Length=326, Percent_Identity=46.9325153374233, Blast_Score=312, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI17506935, Length=326, Percent_Identity=37.1165644171779, Blast_Score=192, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6319698, Length=327, Percent_Identity=47.7064220183486, Blast_Score=306, Evalue=2e-84,
Organism=Drosophila melanogaster, GI21358145, Length=328, Percent_Identity=48.1707317073171, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24650940, Length=328, Percent_Identity=48.1707317073171, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI160714832, Length=325, Percent_Identity=36.3076923076923, Blast_Score=204, Evalue=5e-53,
Organism=Drosophila melanogaster, GI160714828, Length=326, Percent_Identity=36.1963190184049, Blast_Score=204, Evalue=5e-53,
Organism=Drosophila melanogaster, GI24650943, Length=91, Percent_Identity=54.9450549450549, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24650945, Length=91, Percent_Identity=54.9450549450549, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35541; Mature: 35410

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEMNYRDALNLALKEEMRRDPSVVVWGEDVALYEGSFKVTRGLLAEFGEERVKDTPISE
CCCCCHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCC
NSIVGVAVGAAMGGLRPVAELMTVNFALLAMDQIVNHMAKIRSMFGGQTYLPMVVRAPGG
CCEEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCC
GGSQLGAQHSQSLETYFMHCPGIHVAVPATPADARGLLKAAIRDDNPVMFLEHELLYNSK
CCCCCCCHHHHHHHHHHEECCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEEHHHHCCCC
GEVPDDPESVIPFGKADVKREGKDLTIVAYSRMTILALQAAEELAKEGISCEVVDLRTLT
CCCCCCHHHCCCCCCHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEEECC
PLDTATFTASVKKTGRAVVVEECWRSAGLGGHLAAIIAEECFDRLLAPVRRVSGLDVPMP
CCCHHHHHHHHHHCCCEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
YSRKIEKLCIPQPETIAAAVRETLSGTY
HHHHHHHHCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PEMNYRDALNLALKEEMRRDPSVVVWGEDVALYEGSFKVTRGLLAEFGEERVKDTPISE
CCCCHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCC
NSIVGVAVGAAMGGLRPVAELMTVNFALLAMDQIVNHMAKIRSMFGGQTYLPMVVRAPGG
CCEEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCC
GGSQLGAQHSQSLETYFMHCPGIHVAVPATPADARGLLKAAIRDDNPVMFLEHELLYNSK
CCCCCCCHHHHHHHHHHEECCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEEHHHHCCCC
GEVPDDPESVIPFGKADVKREGKDLTIVAYSRMTILALQAAEELAKEGISCEVVDLRTLT
CCCCCCHHHCCCCCCHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEEECC
PLDTATFTASVKKTGRAVVVEECWRSAGLGGHLAAIIAEECFDRLLAPVRRVSGLDVPMP
CCCHHHHHHHHHHCCCEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
YSRKIEKLCIPQPETIAAAVRETLSGTY
HHHHHHHHCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA