Click here to switch to the map view.

The map label for this gene is wecB [H]

Identifier: 39997343

GI number: 39997343

Start: 2459963

End: 2461087

Strand: Reverse

Name: wecB [H]

Synonym: GSU2245

Alternate gene names: 39997343

Gene position: 2461087-2459963 (Counterclockwise)

Preceding gene: 39997344

Following gene: 39997342

Centisome position: 64.53

GC content: 50.22

Gene sequence:

>1125_bases
ATGCTTAAAGTCATGACTATAGTCGGCACCAGGCCGGAGATCATCAAGCTTTGCCGCGTGATAGGTGAGCTTGAACAGCA
CGCAAACCATGTACTGGTTCATACTGGTCAGAACTATGATTACGAACTGAACGAGATTTTCTTCAGGGAACTCGGCATCA
AGAAACCTGACCATTTTCTCAATGCCGTGGGCCAAACCACAGCGGAAACCATCGGCAACGTGATTGCCAAATCAGACGTC
GTGATGACAAAGGAAAAACCTGACGCCGTTCTGCTCTATGGCGATACAAACAGTTGTCTCTCCGTCATCTCCGCAAAGCG
TTGCAAGATTCCGGTATTCCACATGGAGGCGGGGAACCGTTGCTTCGACCAGCGAGTTCCCGAGGAGATCAACCGCAAAA
TCGTCGATCACCTGAGTGATATAAATATGCCTCTCACCGAGCATGCACGGCGCTATCTGCTCGATGAGGGAGTACGGCCC
GAAACGATAATCAAGGTCGGGTCGTCCATGAAAGAGGTGTTTGTCTATTACCGTAAAAAAATTGACGGGTCGCGGGTTCT
GAGCGAGATGGACCTCGTACCTGGCGAGTACTTTGTGGTGAGCGCGCATCGAGAGGAAAATATCGACTCCGAACGCAATT
TCAGGGATCTGCTTGCCTCTCTCAATGCTGTGGCCGCCACGTATCGCAAGAAGGTTGTCGTTTCGACCCATCCACGGACC
ATGAAAAGGCTTCAGTCCTCGCCCCCAAACGAATTGAACGGGCTTATTCAGTTCTGTAAGCCCTTCGGCTTCTTCGATTA
TGTAAAATTGCAGACGAACGCCGCGTGCGTTCTCTCTGACAGTGGCACTATCACAGAGGAGTCTTCGATTCTCTGTTTCC
CTGCTGTTACTATTCGGCAAGCACATGAACGTCCCGAGGGGATGGACGAGGGGACGTTGATCATGTGCGGGCTTACGCCT
GGCAGGGTTCTGAACGCCATTGAGATTGCCATGGCCCATTATTCCGACGGCAAGAGACCGTTCAGAATTGTTCAAGACTA
TGACGTTGACAACGTTTCCATGAAAGTTGTGAGGATCATTTTTAGTTACGTTGACTACATTAACAGGACGATATGGTGCA
AATGA

Upstream 100 bases:

>100_bases
TCGCTCAAGGACGACTACACTTCGCACAACACTACGAGATTGGATGTTGAAGGGGTTAAAGAGCTGCTCCTCAAGCTTGA
CTATATTAGAGGCGAACTCA

Downstream 100 bases:

>100_bases
TGGAGCAATTTTATCCAAAGGTGTCTATAGTCATACCTGTATATAATGGCTCTGACTACATGCGTGAGGCTATAGATAGT
GCGCTTGGCCAAACATACGG

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MLKVMTIVGTRPEIIKLCRVIGELEQHANHVLVHTGQNYDYELNEIFFRELGIKKPDHFLNAVGQTTAETIGNVIAKSDV
VMTKEKPDAVLLYGDTNSCLSVISAKRCKIPVFHMEAGNRCFDQRVPEEINRKIVDHLSDINMPLTEHARRYLLDEGVRP
ETIIKVGSSMKEVFVYYRKKIDGSRVLSEMDLVPGEYFVVSAHREENIDSERNFRDLLASLNAVAATYRKKVVVSTHPRT
MKRLQSSPPNELNGLIQFCKPFGFFDYVKLQTNAACVLSDSGTITEESSILCFPAVTIRQAHERPEGMDEGTLIMCGLTP
GRVLNAIEIAMAHYSDGKRPFRIVQDYDVDNVSMKVVRIIFSYVDYINRTIWCK

Sequences:

>Translated_374_residues
MLKVMTIVGTRPEIIKLCRVIGELEQHANHVLVHTGQNYDYELNEIFFRELGIKKPDHFLNAVGQTTAETIGNVIAKSDV
VMTKEKPDAVLLYGDTNSCLSVISAKRCKIPVFHMEAGNRCFDQRVPEEINRKIVDHLSDINMPLTEHARRYLLDEGVRP
ETIIKVGSSMKEVFVYYRKKIDGSRVLSEMDLVPGEYFVVSAHREENIDSERNFRDLLASLNAVAATYRKKVVVSTHPRT
MKRLQSSPPNELNGLIQFCKPFGFFDYVKLQTNAACVLSDSGTITEESSILCFPAVTIRQAHERPEGMDEGTLIMCGLTP
GRVLNAIEIAMAHYSDGKRPFRIVQDYDVDNVSMKVVRIIFSYVDYINRTIWCK
>Mature_374_residues
MLKVMTIVGTRPEIIKLCRVIGELEQHANHVLVHTGQNYDYELNEIFFRELGIKKPDHFLNAVGQTTAETIGNVIAKSDV
VMTKEKPDAVLLYGDTNSCLSVISAKRCKIPVFHMEAGNRCFDQRVPEEINRKIVDHLSDINMPLTEHARRYLLDEGVRP
ETIIKVGSSMKEVFVYYRKKIDGSRVLSEMDLVPGEYFVVSAHREENIDSERNFRDLLASLNAVAATYRKKVVVSTHPRT
MKRLQSSPPNELNGLIQFCKPFGFFDYVKLQTNAACVLSDSGTITEESSILCFPAVTIRQAHERPEGMDEGTLIMCGLTP
GRVLNAIEIAMAHYSDGKRPFRIVQDYDVDNVSMKVVRIIFSYVDYINRTIWCK

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) to produce UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=383, Percent_Identity=27.6762402088773, Blast_Score=112, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 42453; Mature: 42453

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKVMTIVGTRPEIIKLCRVIGELEQHANHVLVHTGQNYDYELNEIFFRELGIKKPDHFL
CEEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCCHHHH
NAVGQTTAETIGNVIAKSDVVMTKEKPDAVLLYGDTNSCLSVISAKRCKIPVFHMEAGNR
HHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEECCCHHHHHHHHHHHCCCEEEEECCCCH
CFDQRVPEEINRKIVDHLSDINMPLTEHARRYLLDEGVRPETIIKVGSSMKEVFVYYRKK
HHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHH
IDGSRVLSEMDLVPGEYFVVSAHREENIDSERNFRDLLASLNAVAATYRKKVVVSTHPRT
CCHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCEEEEECCHHH
MKRLQSSPPNELNGLIQFCKPFGFFDYVKLQTNAACVLSDSGTITEESSILCFPAVTIRQ
HHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECCEEEEEECCCCEECCCCEEEECHHHHHH
AHERPEGMDEGTLIMCGLTPGRVLNAIEIAMAHYSDGKRPFRIVQDYDVDNVSMKVVRII
HHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHH
FSYVDYINRTIWCK
HHHHHHHHHEECCC
>Mature Secondary Structure
MLKVMTIVGTRPEIIKLCRVIGELEQHANHVLVHTGQNYDYELNEIFFRELGIKKPDHFL
CEEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCCHHHH
NAVGQTTAETIGNVIAKSDVVMTKEKPDAVLLYGDTNSCLSVISAKRCKIPVFHMEAGNR
HHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEECCCHHHHHHHHHHHCCCEEEEECCCCH
CFDQRVPEEINRKIVDHLSDINMPLTEHARRYLLDEGVRPETIIKVGSSMKEVFVYYRKK
HHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHH
IDGSRVLSEMDLVPGEYFVVSAHREENIDSERNFRDLLASLNAVAATYRKKVVVSTHPRT
CCHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCEEEEECCHHH
MKRLQSSPPNELNGLIQFCKPFGFFDYVKLQTNAACVLSDSGTITEESSILCFPAVTIRQ
HHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECCEEEEEECCCCEECCCCEEEECHHHHHH
AHERPEGMDEGTLIMCGLTPGRVLNAIEIAMAHYSDGKRPFRIVQDYDVDNVSMKVVRII
HHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHH
FSYVDYINRTIWCK
HHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]