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The map label for this gene is rnc

Identifier: 39997326

GI number: 39997326

Start: 2444101

End: 2444847

Strand: Reverse

Name: rnc

Synonym: GSU2228

Alternate gene names: 39997326

Gene position: 2444847-2444101 (Counterclockwise)

Preceding gene: 39997331

Following gene: 39997325

Centisome position: 64.1

GC content: 64.93

Gene sequence:

>747_bases
ATGCGTGAAACGGATGAACAACCAGTCGCCGGCGGCGCGGCATCGACGGAGGGGCTGGAGACCTCGATCGGCTATCGCTT
CACCGACCGCCGTTTTCTGGACGAGGCCCTGACTCACCGTTCCTGGCTGAACGAGGTCCGATCCCCGACGGTTCCCGATA
ATGAGCGGCTCGAATTTTTCGGCGATGCCATCCTTGGTTTCTGCATCGGCAAGATGCTCCTGCGGCACTACCCCGAAAGC
CGTGAGGGAGCGTTGGCACGGATGAAATCGGCTTTGGTGGGCGAAGAGACGCTGGCCGACCTGGCCGCGGCCGTTGAGCT
CGGCAGCTACCTGCGACTCGGGCGCGGCGAGGAGCGCTCCGGAGGCCGCCACCGCAGATCGCTGCTCGCCAATGCCCTGG
AAGCCCTTCTTGCGGCCATGTATCTCGACGGAGGTATGGCTCCGGTGGAGCGTCTCGTGGACGCGTGGTTCGGCCCGCGC
CTGGCCGGTGTTGCTGCCGGGATAAAGGGGCGGGATTTCAAGACTGATTTCCAGGAGCTGGCCCAAGCCCAGTATGGTGG
ATTGCCTCGATATGTCCTGGTCGATACCAGTGGTCCCGCCCATGACCTGCGTTTCACCGTGGCAGCGTACGTGGGTGAGC
GCCTCCTCGGCCAGGGGACGGGCAGGAGTAAGAAGGAGGCGGAGCAGGCTGCGGCGCGGCAATGCCTGGAACGCCTCGAA
ACGGGGCGGTGCAGCGCTGCCCCATGA

Upstream 100 bases:

>100_bases
TGAATTATAGGCGAGAGGTCATGCATTATCAAGCGCAAAATGGCCGTCGGTCCGCATATCTATTGATAAAGACGATGGAA
TCGGGTTATACTTCTCCGCT

Downstream 100 bases:

>100_bases
CGCGGCCCGTTATCGTCCCGTTTTTTATTTCCCATCAGGGATGCCCCCACCGCTGCGTCTTCTGCGACCAGGAACGCATT
GCGGGCCGGGCCGGCCGGCT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MRETDEQPVAGGAASTEGLETSIGYRFTDRRFLDEALTHRSWLNEVRSPTVPDNERLEFFGDAILGFCIGKMLLRHYPES
REGALARMKSALVGEETLADLAAAVELGSYLRLGRGEERSGGRHRRSLLANALEALLAAMYLDGGMAPVERLVDAWFGPR
LAGVAAGIKGRDFKTDFQELAQAQYGGLPRYVLVDTSGPAHDLRFTVAAYVGERLLGQGTGRSKKEAEQAAARQCLERLE
TGRCSAAP

Sequences:

>Translated_248_residues
MRETDEQPVAGGAASTEGLETSIGYRFTDRRFLDEALTHRSWLNEVRSPTVPDNERLEFFGDAILGFCIGKMLLRHYPES
REGALARMKSALVGEETLADLAAAVELGSYLRLGRGEERSGGRHRRSLLANALEALLAAMYLDGGMAPVERLVDAWFGPR
LAGVAAGIKGRDFKTDFQELAQAQYGGLPRYVLVDTSGPAHDLRFTVAAYVGERLLGQGTGRSKKEAEQAAARQCLERLE
TGRCSAAP
>Mature_248_residues
MRETDEQPVAGGAASTEGLETSIGYRFTDRRFLDEALTHRSWLNEVRSPTVPDNERLEFFGDAILGFCIGKMLLRHYPES
REGALARMKSALVGEETLADLAAAVELGSYLRLGRGEERSGGRHRRSLLANALEALLAAMYLDGGMAPVERLVDAWFGPR
LAGVAAGIKGRDFKTDFQELAQAQYGGLPRYVLVDTSGPAHDLRFTVAAYVGERLLGQGTGRSKKEAEQAAARQCLERLE
TGRCSAAP

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=226, Percent_Identity=30.9734513274336, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI155030236, Length=226, Percent_Identity=30.9734513274336, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1788920, Length=209, Percent_Identity=41.1483253588517, Blast_Score=155, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI193202651, Length=234, Percent_Identity=25.2136752136752, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17506883, Length=234, Percent_Identity=25.2136752136752, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137682, Length=225, Percent_Identity=32, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_GEOSL (Q74AX1)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_953277.1
- ProteinModelPortal:   Q74AX1
- SMR:   Q74AX1
- GeneID:   2687587
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU2228
- NMPDR:   fig|243231.1.peg.2215
- TIGR:   GSU2228
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- ProtClustDB:   CLSK828768
- BioCyc:   GSUL243231:GSU_2228-MONOMER
- BRENDA:   3.1.26.3
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 27017; Mature: 27017

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRETDEQPVAGGAASTEGLETSIGYRFTDRRFLDEALTHRSWLNEVRSPTVPDNERLEFF
CCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
GDAILGFCIGKMLLRHYPESREGALARMKSALVGEETLADLAAAVELGSYLRLGRGEERS
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GGRHRRSLLANALEALLAAMYLDGGMAPVERLVDAWFGPRLAGVAAGIKGRDFKTDFQEL
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHH
AQAQYGGLPRYVLVDTSGPAHDLRFTVAAYVGERLLGQGTGRSKKEAEQAAARQCLERLE
HHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
TGRCSAAP
CCCCCCCC
>Mature Secondary Structure
MRETDEQPVAGGAASTEGLETSIGYRFTDRRFLDEALTHRSWLNEVRSPTVPDNERLEFF
CCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
GDAILGFCIGKMLLRHYPESREGALARMKSALVGEETLADLAAAVELGSYLRLGRGEERS
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GGRHRRSLLANALEALLAAMYLDGGMAPVERLVDAWFGPRLAGVAAGIKGRDFKTDFQEL
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHH
AQAQYGGLPRYVLVDTSGPAHDLRFTVAAYVGERLLGQGTGRSKKEAEQAAARQCLERLE
HHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
TGRCSAAP
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA