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The map label for this gene is ziaR [H]

Identifier: 39997247

GI number: 39997247

Start: 2366388

End: 2366762

Strand: Reverse

Name: ziaR [H]

Synonym: GSU2149

Alternate gene names: 39997247

Gene position: 2366762-2366388 (Counterclockwise)

Preceding gene: 39997267

Following gene: 39997246

Centisome position: 62.05

GC content: 50.4

Gene sequence:

>375_bases
ATGTCCGAATTTGCAACATGCCGAATCAACTTGATCAACGAAGCTAAGGTCATGAGCGCCAAAAAAGCCATGCCTTCAGA
TGACATTACGAACCGCCTGGCAGAAACATTCAAAGTTTTGGGCGATCCCACCCGACTCAAAATTCTTCTCGCCGTTTCAT
TGGATGAGCTTTGCGTGTGCGACATCGCCAGTCTTCTCGGGACGACCAAATCCGCAGTCTCCCATCAATTGCGCCTGCTT
CGTTCACTGAGAGTGGTCAAATACCGTAAGGATGGCAGAATCGTCTACTATTCGCTTGACGACAGTCATGTGGGGAATCT
GCTCAGTGAAGGTCTTGACCACATCACCGCCCAAGGGGGGCACCATGATTCGTAG

Upstream 100 bases:

>100_bases
CCGCATCGTTAACGCAATTTACGAACAATCCTCATTGACACGTTGGACAAAAGACAATATCTTTATTGTTGAAAGGTTGC
TCAACTATTGAGGTGATACC

Downstream 100 bases:

>100_bases
GATCAGCGCTGCGTTTGCAGGAGGTGCCCTGGGCGCCTTCATCGATAGCTTCAATATCTGGTTTATGGGCAAGGCCGGCA
TCAGTGATCTGATCGGATTA

Product: ArsR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 124; Mature: 123

Protein sequence:

>124_residues
MSEFATCRINLINEAKVMSAKKAMPSDDITNRLAETFKVLGDPTRLKILLAVSLDELCVCDIASLLGTTKSAVSHQLRLL
RSLRVVKYRKDGRIVYYSLDDSHVGNLLSEGLDHITAQGGHHDS

Sequences:

>Translated_124_residues
MSEFATCRINLINEAKVMSAKKAMPSDDITNRLAETFKVLGDPTRLKILLAVSLDELCVCDIASLLGTTKSAVSHQLRLL
RSLRVVKYRKDGRIVYYSLDDSHVGNLLSEGLDHITAQGGHHDS
>Mature_123_residues
SEFATCRINLINEAKVMSAKKAMPSDDITNRLAETFKVLGDPTRLKILLAVSLDELCVCDIASLLGTTKSAVSHQLRLLR
SLRVVKYRKDGRIVYYSLDDSHVGNLLSEGLDHITAQGGHHDS

Specific function: Transcriptional repressor of the expression of the ziaA gene. Controls zinc homeostasis by triggering ziaA-mediated efflux of excess zinc into the periplasm [H]

COG id: COG0640

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH arsR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001845
- InterPro:   IPR018334
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01022 HTH_5 [H]

EC number: NA

Molecular weight: Translated: 13682; Mature: 13551

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: PS00846 HTH_ARSR_1 ; PS50987 HTH_ARSR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFATCRINLINEAKVMSAKKAMPSDDITNRLAETFKVLGDPTRLKILLAVSLDELCVC
CCCCCEEEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHH
DIASLLGTTKSAVSHQLRLLRSLRVVKYRKDGRIVYYSLDDSHVGNLLSEGLDHITAQGG
HHHHHHCCHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCHHHHHHHHHHHHHHHCCCC
HHDS
CCCC
>Mature Secondary Structure 
SEFATCRINLINEAKVMSAKKAMPSDDITNRLAETFKVLGDPTRLKILLAVSLDELCVC
CCCCEEEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHH
DIASLLGTTKSAVSHQLRLLRSLRVVKYRKDGRIVYYSLDDSHVGNLLSEGLDHITAQGG
HHHHHHCCHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCHHHHHHHHHHHHHHHCCCC
HHDS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231; 9724772 [H]