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The map label for this gene is prsA [H]

Identifier: 39997172

GI number: 39997172

Start: 2278904

End: 2279869

Strand: Reverse

Name: prsA [H]

Synonym: GSU2074

Alternate gene names: 39997172

Gene position: 2279869-2278904 (Counterclockwise)

Preceding gene: 39997173

Following gene: 39997171

Centisome position: 59.77

GC content: 58.07

Gene sequence:

>966_bases
ATGAAGACAGTACGCAACCTCATTATTACCATTCTGTGCTTGCTGGGAAGCGTTCCGTCCGCGCCCGGCGCCGAAACGGC
CGTCGCTCCCTCCGGCAGAGCCGCTGCGGCTGTTGTGAACGGCGCCGTCATCTTCCGGGACGAACTCGATCATTTCGTCG
AATTTGCCTTGAGTCGACGGAGGGGAGCCGGGCGTAAGGTTACCGACGAGCAGAAGAAGAGAGTCGAGCGCCAGGAGCTC
GATAAGCTTATTGCGATGGAGTTGCTGGCCCAGGCGGGCGAAAAGCTGAATCCTGCCGATCTGTCCAAAAAGATTCAGGC
CCGCCGGGAAGCCATCGGTTCGAGCGTATCCCGGGGCGGGAGCGTGGTGGCACCGTCCGAGGACAGACTTAACGACACCG
CTCGCCGCGACGTCCTTGTGGACGCCTATCTGGCCTCGCGCGGCATCGATGCGATCAAGGTTCCCGAAACGGATCTCAGG
GCCTATTACGAAAAGAACAAGTCCGGTTTTAAAAAGCCTGAGACAATCGCTGTCCGGCATATCCTGGTGAAGGTCGAAAA
AGAGGCTTCCCCGGAGACTCAGGCGGAGGCCCGGAAAAAGATCGAGGGCATTCGCGACCGGATTGGCGCCGGCGCCGATT
TTGCCGTTCTTGCCAGCGAGAGCTCCGATTGCGCCAGTGCCGCCAAGGGCGGAGATCTGGGAGAGATTCAGCGGGGCTTC
ATGCCGCGCGAGTTCGACCAGGTCGCCTTTTCCCTCAAACCGGGTGAGACGAGCGGAATCGTCAAGACGCACCATGGGTT
TCACATTATCAGGGTGATGGAACGGCATCCCGAAACGGTCAGGACCTTCGAAGAGATGCGGGATTTCATCGAGCAGTATC
TGGCAAAGGATTACCAACGCAAGAAGGTCGAGGAAATCGTTGAAGAGCTGAAGCGCGCAGCAACAATAGATATTCGTATT
CAATGA

Upstream 100 bases:

>100_bases
CATCCGGCACTGTCAGGCTGGTGCTGATCCCCCACGGCAAACCGGGAACATCGGCGCGGGTGACGGCCGTTCCGGAGCAG
CTGTGAGTCGGGCGGGCACG

Downstream 100 bases:

>100_bases
CGCTATGACGGAGCCTTTTCAGTCGGGAACTGCAAGTACGAGGAGCGTGTGGAAATGAAAACTCTAGCAAGTTTGTGCAG
GGCGGTCGCGGTGGCTGTGC

Product: peptidyl-prolyl cis-trans isomerase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MKTVRNLIITILCLLGSVPSAPGAETAVAPSGRAAAAVVNGAVIFRDELDHFVEFALSRRRGAGRKVTDEQKKRVERQEL
DKLIAMELLAQAGEKLNPADLSKKIQARREAIGSSVSRGGSVVAPSEDRLNDTARRDVLVDAYLASRGIDAIKVPETDLR
AYYEKNKSGFKKPETIAVRHILVKVEKEASPETQAEARKKIEGIRDRIGAGADFAVLASESSDCASAAKGGDLGEIQRGF
MPREFDQVAFSLKPGETSGIVKTHHGFHIIRVMERHPETVRTFEEMRDFIEQYLAKDYQRKKVEEIVEELKRAATIDIRI
Q

Sequences:

>Translated_321_residues
MKTVRNLIITILCLLGSVPSAPGAETAVAPSGRAAAAVVNGAVIFRDELDHFVEFALSRRRGAGRKVTDEQKKRVERQEL
DKLIAMELLAQAGEKLNPADLSKKIQARREAIGSSVSRGGSVVAPSEDRLNDTARRDVLVDAYLASRGIDAIKVPETDLR
AYYEKNKSGFKKPETIAVRHILVKVEKEASPETQAEARKKIEGIRDRIGAGADFAVLASESSDCASAAKGGDLGEIQRGF
MPREFDQVAFSLKPGETSGIVKTHHGFHIIRVMERHPETVRTFEEMRDFIEQYLAKDYQRKKVEEIVEELKRAATIDIRI
Q
>Mature_321_residues
MKTVRNLIITILCLLGSVPSAPGAETAVAPSGRAAAAVVNGAVIFRDELDHFVEFALSRRRGAGRKVTDEQKKRVERQEL
DKLIAMELLAQAGEKLNPADLSKKIQARREAIGSSVSRGGSVVAPSEDRLNDTARRDVLVDAYLASRGIDAIKVPETDLR
AYYEKNKSGFKKPETIAVRHILVKVEKEASPETQAEARKKIEGIRDRIGAGADFAVLASESSDCASAAKGGDLGEIQRGF
MPREFDQVAFSLKPGETSGIVKTHHGFHIIRVMERHPETVRTFEEMRDFIEQYLAKDYQRKKVEEIVEELKRAATIDIRI
Q

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI5453898, Length=114, Percent_Identity=39.4736842105263, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786645, Length=138, Percent_Identity=31.8840579710145, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1790211, Length=103, Percent_Identity=40.7766990291262, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 35505; Mature: 35505

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVRNLIITILCLLGSVPSAPGAETAVAPSGRAAAAVVNGAVIFRDELDHFVEFALSRR
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCHHEEHHHHHHHHHHHHHHH
RGAGRKVTDEQKKRVERQELDKLIAMELLAQAGEKLNPADLSKKIQARREAIGSSVSRGG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
SVVAPSEDRLNDTARRDVLVDAYLASRGIDAIKVPETDLRAYYEKNKSGFKKPETIAVRH
CEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHCCCCCCCCHHHHHHH
ILVKVEKEASPETQAEARKKIEGIRDRIGAGADFAVLASESSDCASAAKGGDLGEIQRGF
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCCHHHHHHCC
MPREFDQVAFSLKPGETSGIVKTHHGFHIIRVMERHPETVRTFEEMRDFIEQYLAKDYQR
CCCHHHHHHEEECCCCCCCEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
KKVEEIVEELKRAATIDIRIQ
HHHHHHHHHHHHHCCEEEEEC
>Mature Secondary Structure
MKTVRNLIITILCLLGSVPSAPGAETAVAPSGRAAAAVVNGAVIFRDELDHFVEFALSRR
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCHHEEHHHHHHHHHHHHHHH
RGAGRKVTDEQKKRVERQELDKLIAMELLAQAGEKLNPADLSKKIQARREAIGSSVSRGG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
SVVAPSEDRLNDTARRDVLVDAYLASRGIDAIKVPETDLRAYYEKNKSGFKKPETIAVRH
CEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHCCCCCCCCHHHHHHH
ILVKVEKEASPETQAEARKKIEGIRDRIGAGADFAVLASESSDCASAAKGGDLGEIQRGF
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCCHHHHHHCC
MPREFDQVAFSLKPGETSGIVKTHHGFHIIRVMERHPETVRTFEEMRDFIEQYLAKDYQR
CCCHHHHHHEEECCCCCCCEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
KKVEEIVEELKRAATIDIRIQ
HHHHHHHHHHHHHCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]