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The map label for this gene is ilvC

Identifier: 39997007

GI number: 39997007

Start: 2087411

End: 2088427

Strand: Reverse

Name: ilvC

Synonym: GSU1909

Alternate gene names: 39997007

Gene position: 2088427-2087411 (Counterclockwise)

Preceding gene: 39997008

Following gene: 39997006

Centisome position: 54.75

GC content: 59.59

Gene sequence:

>1017_bases
ATGAAGATTTATTACGACAAGGACTGCAATCAGAGCGTGCTCAAGGGGAAAAGGGTAGCCGTCATCGGCTACGGCTCCCA
GGGCCACGCCCATGCCAATAACCTGAAGGATTCGGGTGTCGACGTGGTGGTCGGTCTCAAGGCCGACTCTTCCTCCGTGG
CCAAGGCCACCGGCGCTGGTCTGACGGTTCTCCCCACCGCGGATGCGGTAAAGGGTGCCGATGTGGTTATGATTCTCCTG
CCGGACGAGATTCAGGGTGACGTCTACCGCGAGGAAGTCGGCCCCTATCTGAAGCAGGGGGCCTATCTGGCTTTCGGCCA
CGGTTTCAATATCCATTTCGGTCAGATCACTCCGCGCCCGGACATCAACGTCATCATGGCTGCTCCCAAGGGACCCGGTC
ACCTGGTGCGTCACGAATACACGAGAGGAGGCGGGGTTCCCTGCCTTATCGCCATTCACCACGACCCGTCCGGCAACTCC
CGTGATGTGGCTCTGGCCTATGCTTCCGCCATCGGCGGCGGTCGCGCCGGCATCATCGAGACCTCCTTCAAGGAAGAGAC
CGAGACCGACCTGTTCGGTGAGCAGGCCGTGCTGTGCGGCGGCATTTCGGCCCTGATCCAGGCTGGCTTCGAAACCCTGG
TGGAAGCGGGCTATTCTCCGGAGATGGCTTACTTTGAGTGCCTGCACGAGACCAAGCTCATCGTGGACCTGATCTACGAG
GGCGGTATTGCCAACATGCGCTATTCCATCTCCAACACTGCCGAGTACGGCGACCTGACCCGCGGTCCCCGCGTCATCAC
CGACGAGACCAAGAAGGAAATGAAGCAGATCCTCTGGGAAATCCAGAGTGGACAGTTCGCCAAGGAGTGGATGCTGGAGA
ACAAGGCCAACAAGCCGACCTTCAACGCGCTGCGCCGCAAGGGGATGGAACACCCCATCGAGGACGTTGGCGCACGGCTC
CGCTCCATGATGTCGTGGATCGGTTCGTCCAAGATCGTCGATAAATCCAAAAACTGA

Upstream 100 bases:

>100_bases
GGCGGCCATCGGGCGCGGCGCCAAGGGGTGGAAAGGGTAGGACCGATTACATTCACCGTTCGTCTCAGGTGTTGATCGAA
CAAATACAAGGAGGAAAGTG

Downstream 100 bases:

>100_bases
TACACTCGGTTGCACCCACGGTGAGGCCGGATACGGCGGGAGTTCAGGCTCCACGGCCGCATCCGGCCTCATTTGCCGTT
TGACGGGTGGCATCCGGTGT

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKIYYDKDCNQSVLKGKRVAVIGYGSQGHAHANNLKDSGVDVVVGLKADSSSVAKATGAGLTVLPTADAVKGADVVMILL
PDEIQGDVYREEVGPYLKQGAYLAFGHGFNIHFGQITPRPDINVIMAAPKGPGHLVRHEYTRGGGVPCLIAIHHDPSGNS
RDVALAYASAIGGGRAGIIETSFKEETETDLFGEQAVLCGGISALIQAGFETLVEAGYSPEMAYFECLHETKLIVDLIYE
GGIANMRYSISNTAEYGDLTRGPRVITDETKKEMKQILWEIQSGQFAKEWMLENKANKPTFNALRRKGMEHPIEDVGARL
RSMMSWIGSSKIVDKSKN

Sequences:

>Translated_338_residues
MKIYYDKDCNQSVLKGKRVAVIGYGSQGHAHANNLKDSGVDVVVGLKADSSSVAKATGAGLTVLPTADAVKGADVVMILL
PDEIQGDVYREEVGPYLKQGAYLAFGHGFNIHFGQITPRPDINVIMAAPKGPGHLVRHEYTRGGGVPCLIAIHHDPSGNS
RDVALAYASAIGGGRAGIIETSFKEETETDLFGEQAVLCGGISALIQAGFETLVEAGYSPEMAYFECLHETKLIVDLIYE
GGIANMRYSISNTAEYGDLTRGPRVITDETKKEMKQILWEIQSGQFAKEWMLENKANKPTFNALRRKGMEHPIEDVGARL
RSMMSWIGSSKIVDKSKN
>Mature_338_residues
MKIYYDKDCNQSVLKGKRVAVIGYGSQGHAHANNLKDSGVDVVVGLKADSSSVAKATGAGLTVLPTADAVKGADVVMILL
PDEIQGDVYREEVGPYLKQGAYLAFGHGFNIHFGQITPRPDINVIMAAPKGPGHLVRHEYTRGGGVPCLIAIHHDPSGNS
RDVALAYASAIGGGRAGIIETSFKEETETDLFGEQAVLCGGISALIQAGFETLVEAGYSPEMAYFECLHETKLIVDLIYE
GGIANMRYSISNTAEYGDLTRGPRVITDETKKEMKQILWEIQSGQFAKEWMLENKANKPTFNALRRKGMEHPIEDVGARL
RSMMSWIGSSKIVDKSKN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=297, Percent_Identity=39.3939393939394, Blast_Score=166, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6323387, Length=258, Percent_Identity=35.6589147286822, Blast_Score=131, Evalue=2e-31,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_GEOSL (Q74BW9)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_952958.1
- ProteinModelPortal:   Q74BW9
- SMR:   Q74BW9
- GeneID:   2688407
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU1909
- NMPDR:   fig|243231.1.peg.1896
- TIGR:   GSU1909
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- BioCyc:   GSUL243231:GSU_1909-MONOMER
- BRENDA:   1.1.1.86
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36633; Mature: 36633

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIYYDKDCNQSVLKGKRVAVIGYGSQGHAHANNLKDSGVDVVVGLKADSSSVAKATGAG
CEEEECCCCCHHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHCCCC
LTVLPTADAVKGADVVMILLPDEIQGDVYREEVGPYLKQGAYLAFGHGFNIHFGQITPRP
EEEEECCCCCCCCCEEEEEECCCCCCCHHHHHHCHHHHCCCEEEEECCCEEEECCCCCCC
DINVIMAAPKGPGHLVRHEYTRGGGVPCLIAIHHDPSGNSRDVALAYASAIGGGRAGIIE
CCEEEEECCCCCCCCCEEECCCCCCCEEEEEEEECCCCCCCEEEEEEEHHCCCCCCCEEE
TSFKEETETDLFGEQAVLCGGISALIQAGFETLVEAGYSPEMAYFECLHETKLIVDLIYE
CCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
GGIANMRYSISNTAEYGDLTRGPRVITDETKKEMKQILWEIQSGQFAKEWMLENKANKPT
CCCCEEEEECCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCH
FNALRRKGMEHPIEDVGARLRSMMSWIGSSKIVDKSKN
HHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKIYYDKDCNQSVLKGKRVAVIGYGSQGHAHANNLKDSGVDVVVGLKADSSSVAKATGAG
CEEEECCCCCHHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHCCCC
LTVLPTADAVKGADVVMILLPDEIQGDVYREEVGPYLKQGAYLAFGHGFNIHFGQITPRP
EEEEECCCCCCCCCEEEEEECCCCCCCHHHHHHCHHHHCCCEEEEECCCEEEECCCCCCC
DINVIMAAPKGPGHLVRHEYTRGGGVPCLIAIHHDPSGNSRDVALAYASAIGGGRAGIIE
CCEEEEECCCCCCCCCEEECCCCCCCEEEEEEEECCCCCCCEEEEEEEHHCCCCCCCEEE
TSFKEETETDLFGEQAVLCGGISALIQAGFETLVEAGYSPEMAYFECLHETKLIVDLIYE
CCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
GGIANMRYSISNTAEYGDLTRGPRVITDETKKEMKQILWEIQSGQFAKEWMLENKANKPT
CCCCEEEEECCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCH
FNALRRKGMEHPIEDVGARLRSMMSWIGSSKIVDKSKN
HHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA