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The map label for this gene is epsD [H]

Identifier: 39996953

GI number: 39996953

Start: 2026021

End: 2027247

Strand: Reverse

Name: epsD [H]

Synonym: GSU1854

Alternate gene names: 39996953

Gene position: 2027247-2026021 (Counterclockwise)

Preceding gene: 39996954

Following gene: 39996952

Centisome position: 53.15

GC content: 41.48

Gene sequence:

>1227_bases
ATGGAAAGTAAGAAAGTATCTGTAATAGGTTTAGGATATATTGGACTTCCAACTGCGGCGCTATTCGCTTCAAGAAAAAT
AAGAGTAGTTGGCGTTGATATAAATATGGAAGTTGTAGATACAATAAACCGCGGCGAGATACACATAGTCGAACCAGATC
TTGATATGCTCGTAAATGCAGCTGTAGTTGGCGGTTATCTTCGAGCAACTACTTCTCCTGAGGCGTCCGATGCGTTCATA
ATTGCTGTGCCAACGCCTTTCAGGGATGGAAAGAAGCCCGACTTAAGCTATGTGGAGACTGCTACTAGAATGATTGCTGA
TGTACTGAAGAAGGGGGATTTGGTAATTTTGGAATCAACCTCACCAGTCGGAACTACAGAACAAGTGGCAGAATGGCTAG
CCGCAGCAAGACAAGACCTGACCTTTCCGCATCAAGTTGGTGAATCATCAGATATTAGGTTAGCGCATTGCCCGGAGCGG
GTGTTACCTGGACAAATATTGCGTGAATTAGTCCAAAATGATCGAGTAATTGGTGGAATAACTCAGAAATGTTCAGCTGA
AGCAGTTAAATTGTATAAAGCCGTTGTCAATGGTGAATGCATTGTGTCTGACGCACGAACTGCTGAAATGTGCAAATTAA
CAGAAAATAGCTATCGAGATGTGAATATTGCATTTGCGAATGAATTATCACTTATTTGCGATCAGCTTGGTATTAATGTT
TGGGAGCTAATCAGGCTAGCGAATCGACATCCACGGGTCGATATACTTCAGCCTGGTCCTGGTGTAGGTGGTCATTGTAT
TGCTGTCGACCCGTGGTTCATAGTAAGCAAAACCCCCGATAAAGCACGTCTCATCCGAATGGCGAGAGAGGTCAACGATG
ATAAGCCGTATTGGGTTGTTGAAAAGATCAAAACAAAGGCTACCAGATTTAAGCACCCAGTAATTGGTTGTTTAGGCATA
ACTTTCAAAGCAAATATTGATGACCTAAGAGAGTCGCCAGCCTTAGAGATAGTTCGTGACCTTATGGCTTCTGATGTAGG
GCATATACTTGTGTGCGATCCTCATTGCACAAATATGGAGTTGGAATTTCCTATTGTCGAATTAAATGAAGTTGTAGTAT
CTGCAGATATATTAGTTGTTCTTGTTGATCATCAAGAATTCAAAAACATAAGACCAGATACCCTAAAAGAAAAAATTATT
ATTGATACACGAGGTATTTGGAGTTAG

Upstream 100 bases:

>100_bases
ATATGCTATCGAAACTACCAAGTAACGAGCTTGTTGTATGGAACAGGATAAAGTCAAGAGTAGTTAAAAGAATATAAATG
TAGCCACTTAAGGAGTCATA

Downstream 100 bases:

>100_bases
GCTGAAACCAAAGGTGGATTGTGATTAATCTCGAGGCAACTAAACATAAAATAAGAAGTCACGCATCATTTGGTGTAATG
GCTATTGGAGCTATTTCGAT

Product: UDP-N-acetyl-D-mannosamine dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MESKKVSVIGLGYIGLPTAALFASRKIRVVGVDINMEVVDTINRGEIHIVEPDLDMLVNAAVVGGYLRATTSPEASDAFI
IAVPTPFRDGKKPDLSYVETATRMIADVLKKGDLVILESTSPVGTTEQVAEWLAAARQDLTFPHQVGESSDIRLAHCPER
VLPGQILRELVQNDRVIGGITQKCSAEAVKLYKAVVNGECIVSDARTAEMCKLTENSYRDVNIAFANELSLICDQLGINV
WELIRLANRHPRVDILQPGPGVGGHCIAVDPWFIVSKTPDKARLIRMAREVNDDKPYWVVEKIKTKATRFKHPVIGCLGI
TFKANIDDLRESPALEIVRDLMASDVGHILVCDPHCTNMELEFPIVELNEVVVSADILVVLVDHQEFKNIRPDTLKEKII
IDTRGIWS

Sequences:

>Translated_408_residues
MESKKVSVIGLGYIGLPTAALFASRKIRVVGVDINMEVVDTINRGEIHIVEPDLDMLVNAAVVGGYLRATTSPEASDAFI
IAVPTPFRDGKKPDLSYVETATRMIADVLKKGDLVILESTSPVGTTEQVAEWLAAARQDLTFPHQVGESSDIRLAHCPER
VLPGQILRELVQNDRVIGGITQKCSAEAVKLYKAVVNGECIVSDARTAEMCKLTENSYRDVNIAFANELSLICDQLGINV
WELIRLANRHPRVDILQPGPGVGGHCIAVDPWFIVSKTPDKARLIRMAREVNDDKPYWVVEKIKTKATRFKHPVIGCLGI
TFKANIDDLRESPALEIVRDLMASDVGHILVCDPHCTNMELEFPIVELNEVVVSADILVVLVDHQEFKNIRPDTLKEKII
IDTRGIWS
>Mature_408_residues
MESKKVSVIGLGYIGLPTAALFASRKIRVVGVDINMEVVDTINRGEIHIVEPDLDMLVNAAVVGGYLRATTSPEASDAFI
IAVPTPFRDGKKPDLSYVETATRMIADVLKKGDLVILESTSPVGTTEQVAEWLAAARQDLTFPHQVGESSDIRLAHCPER
VLPGQILRELVQNDRVIGGITQKCSAEAVKLYKAVVNGECIVSDARTAEMCKLTENSYRDVNIAFANELSLICDQLGINV
WELIRLANRHPRVDILQPGPGVGGHCIAVDPWFIVSKTPDKARLIRMAREVNDDKPYWVVEKIKTKATRFKHPVIGCLGI
TFKANIDDLRESPALEIVRDLMASDVGHILVCDPHCTNMELEFPIVELNEVVVSADILVVLVDHQEFKNIRPDTLKEKII
IDTRGIWS

Specific function: Probably involved in the synthesis of sugar components of EPS I, by converting NDP-N-acetyl-D-galactosamine into NDP-N- acetyl-D-galactosaminuronic acid [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=400, Percent_Identity=25.75, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI296040438, Length=301, Percent_Identity=24.2524916943522, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI48994968, Length=419, Percent_Identity=60.8591885441527, Blast_Score=536, Evalue=1e-153,
Organism=Escherichia coli, GI1788340, Length=362, Percent_Identity=23.7569060773481, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17560350, Length=381, Percent_Identity=27.5590551181102, Blast_Score=117, Evalue=8e-27,
Organism=Drosophila melanogaster, GI17136908, Length=372, Percent_Identity=28.494623655914, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 45068; Mature: 45068

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESKKVSVIGLGYIGLPTAALFASRKIRVVGVDINMEVVDTINRGEIHIVEPDLDMLVNA
CCCCEEEEEEECCHHHHHHHHHHCCEEEEEEEECCCCEEECCCCCEEEEECCCHHHHHHH
AVVGGYLRATTSPEASDAFIIAVPTPFRDGKKPDLSYVETATRMIADVLKKGDLVILEST
HHHCCEEEECCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECC
SPVGTTEQVAEWLAAARQDLTFPHQVGESSDIRLAHCPERVLPGQILRELVQNDRVIGGI
CCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCEEEECCCCCCCCHHHHHHHHHCCCEEECH
TQKCSAEAVKLYKAVVNGECIVSDARTAEMCKLTENSYRDVNIAFANELSLICDQLGINV
HHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHCCCH
WELIRLANRHPRVDILQPGPGVGGHCIAVDPWFIVSKTPDKARLIRMAREVNDDKPYWVV
HHHHHHHCCCCCEEEECCCCCCCCEEEEECCEEEEECCCCHHHHHHHHHHCCCCCCEEEH
EKIKTKATRFKHPVIGCLGITFKANIDDLRESPALEIVRDLMASDVGHILVCDPHCTNME
HHHHHHHHHHCCCCEEEEEEEEECCHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCEE
LEFPIVELNEVVVSADILVVLVDHQEFKNIRPDTLKEKIIIDTRGIWS
EECCEEEHHHHEEECCEEEEEECCHHHCCCCCCHHCCEEEEECCCCCC
>Mature Secondary Structure
MESKKVSVIGLGYIGLPTAALFASRKIRVVGVDINMEVVDTINRGEIHIVEPDLDMLVNA
CCCCEEEEEEECCHHHHHHHHHHCCEEEEEEEECCCCEEECCCCCEEEEECCCHHHHHHH
AVVGGYLRATTSPEASDAFIIAVPTPFRDGKKPDLSYVETATRMIADVLKKGDLVILEST
HHHCCEEEECCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECC
SPVGTTEQVAEWLAAARQDLTFPHQVGESSDIRLAHCPERVLPGQILRELVQNDRVIGGI
CCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCEEEECCCCCCCCHHHHHHHHHCCCEEECH
TQKCSAEAVKLYKAVVNGECIVSDARTAEMCKLTENSYRDVNIAFANELSLICDQLGINV
HHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHCCCH
WELIRLANRHPRVDILQPGPGVGGHCIAVDPWFIVSKTPDKARLIRMAREVNDDKPYWVV
HHHHHHHCCCCCEEEECCCCCCCCEEEEECCEEEEECCCCHHHHHHHHHHCCCCCCEEEH
EKIKTKATRFKHPVIGCLGITFKANIDDLRESPALEIVRDLMASDVGHILVCDPHCTNME
HHHHHHHHHHCCCCEEEEEEEEECCHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCEE
LEFPIVELNEVVVSADILVVLVDHQEFKNIRPDTLKEKIIIDTRGIWS
EECCEEEHHHHEEECCEEEEEECCHHHCCCCCCHHCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]