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The map label for this gene is loN-2 [H]

Identifier: 39996889

GI number: 39996889

Start: 1954021

End: 1956444

Strand: Reverse

Name: loN-2 [H]

Synonym: GSU1790

Alternate gene names: 39996889

Gene position: 1956444-1954021 (Counterclockwise)

Preceding gene: 39996890

Following gene: 39996888

Centisome position: 51.29

GC content: 53.84

Gene sequence:

>2424_bases
ATGAGCGTCGACCATAGTATAGAAAGCCTGGAAAGAGGGGATCTGCAAAGATTCCCTCTTTTACCGTTAAGGGACATTGT
TGTTTTTCCGCACATGGTAGTTCCTCTTTTTGTGGGGCGAGAGCGTTCGATCTCTGCCCTTGAGGCGGCCATGAACGGCA
ACAGGATGATTTTTCTCGCCGCACAGAGAAATGCCAAAACGGAAGATCCCCGCCAGGAGGATATCTACACAACTGGTACC
ATCTCACAGATCATACAACTGCTGAAGCTCCCCGACGGTACAGTCAAGGTGTTGGTGGAGGGCAAGCAGCGGGGCAGTCT
TGTCTCCTTTCTACCTAACCCCGACTACTTCATGGCTGAAATACAGCCGTATCTTGAGTCTCTTGAAGCAAACCCCGAAC
TTGAAGCCCTTATTCGGAGCACCAAATCGGTGTTTGAAGGCTATGTGAAGCTGACCAAGGGCATTCCGCAGGAAGTGGTC
AGTGCTGTTGGGGGAATTGTTGAGCCCGGCAAGCTTGCCGATACGCTGGCACCCCATCTTAATCTCAAGCTTTCCGACAA
GCAGCTGCTACTTGGTATAATGACTCCCCATGAGCGACTGGAGAAGCTCTTGTCTTTCATGGAGGCCGAATTGGAGATTC
TCCAACTGGAGAATAAAATCCGGACCCGTGTCAAGAAGCAGATGGAGAAGAACCAGAAAGAATATTATCTGAACGAGCAG
ATGCGAGCCATCCAGAAGGAGTTGGGAACCAAAGACGACTTCAGGCAGGAACTCCTTGAACTGGAGAACAAGGCAACCAA
AGGGAAGTTGTCCAAGGAAGCCCGACAAAAGGCCCTTGCAGAACTCAAAAAACTGAAGCTCATGTCGCCTGCGTCTGCCG
AAGCTGCTGTGGTGAGAAACTACGTCGACTGGCTTGTATCACTTCCGTGGGCGAAGATGACTCGCGAAAAGCATGACATC
ATCGGCGCTGAAGAGGTTTTGAACGCTGACCATTACGGTCTTGAAAAGGTCAAGGAGCGTATATTGGAGTATCTCTCCGT
CCAGGCGCTCGTTAAGAAGTTGAAGGGACCTATTCTCTGTCTGGTTGGTCCCCCCGGGGTGGGTAAAACTTCACTTGCCC
GATCAATCGCCACGGCAACCGGTCGTCATTTTGTCAAAATGTCGCTCGGTGGAATGCGTGACGAAGCGGAGATCCGGGGC
CACCGCCGTACCTATGTTGGAGCCATGCCCGGCAAGATCATCCAGAACCTCAAAAAGGCGGGAAGTAACAACCCTGTATT
TTTGCTGGACGAGATTGACAAAATGAGCTCCGATTTCAGGGGTGATCCGGCGTCGGCACTGCTTGAGGTTCTCGACCCGG
AGCAGAATGCCCATTTCAGCGATCATTTTCTTGATGTGGAGTATGATCTTTCCCACGTCATGTTCATTGCCACGGCCAAC
TCGACGCATTCGATTCCCCGTCCCCTGCTCGACCGGATGGAGGTGATTCGCCTTGAGGGCTACACCGAGCATGAAAAACT
TGCTATTGCCGAGCGCTATCTCGTTGGTAAACAGATGGCAGCCAATGGGCTTTCTGAACAACAGATCAGCATCTCCGGAA
AGGCGGTCAGTGAAATAATTCGCTATTACACCCGCGAGGCTGGCGTGCGCAATCTGGAGCGCGATATTGCGACGCTCTGT
CGCAAGGCGGCTCATCGTGTGGTCAAGGGCGAGAAAAAGAAGATTGTAATTCAGCCCAAGAATCTGTCTGGGTTCCTGGG
GCCTCGCAAGTACCGGATCGGGACGGCAGAGGACAAAGATGCTCCCGGCTACGCAACGGGTCTTGCCTGGACCGAAGTCG
GCGGGGACCTGCTTACCATTGAGGTGGCGATTGTGCCCGGCACCGGAAAGCTCCTCATTACCGGGAAGCTGGGGGAGGTC
ATGCAGGAGTCGGCACAGGCGGCCATGACCTATGTGCGTTCGCGGGCGCAGATCCTGGGTATTGATAAAGAGTTTCACAA
GAAGGCGGACATACATATTCACGTGCCGGAAGGAGCAATCCCCAAGGATGGCCCCTCGGCCGGCATTACCATGGCTACGG
CGATAGTGTCTGCTCTAACTGGCCGGCCGGTTCGGCACGATCTTGCCATGACGGGTGAGATTACTCTCCGCGGTAATGTG
CTTGCCATCGGGGGCCTCAAGGAAAAACTCCTGGCCGCGGGGCGAGGTGGAATTTCCACGGTTGTCATCCCAGAGGAAAA
TAAAAAGGATCTGGCGGAAATCCCACGGGAGGTTACGGTGGGGCTTACTATCGTTCCAGCCCGTCATATGGACGAAGTGC
TTTCCCGGGCGCTCTTGGCTGAAGGCGTTTCAAGTGGAGCTCCCTACCTCGCCTCGGAGGGGCATCCGGCGATATCTGAA
CAGGAAACCGTTACTGCCCACTGA

Upstream 100 bases:

>100_bases
TTAAAGAAGTGGTCATCAACGAAGATGTCATCTACAACAAGGAAAAGCCGATCATTGTTTATGAAAATGTGGCTGAGTCA
GCCTGACTGCAAAGGACCCA

Downstream 100 bases:

>100_bases
CGCGTGGAAAAAAGCGCTTGACACCTCTGTGAGGTCTCTGTTATAAGTTATGTCTCGTTTCGAGGCGGCAATAAGTCAAT
ATTTGGCTGTAAAATTGATA

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La 1 [H]

Number of amino acids: Translated: 807; Mature: 806

Protein sequence:

>807_residues
MSVDHSIESLERGDLQRFPLLPLRDIVVFPHMVVPLFVGRERSISALEAAMNGNRMIFLAAQRNAKTEDPRQEDIYTTGT
ISQIIQLLKLPDGTVKVLVEGKQRGSLVSFLPNPDYFMAEIQPYLESLEANPELEALIRSTKSVFEGYVKLTKGIPQEVV
SAVGGIVEPGKLADTLAPHLNLKLSDKQLLLGIMTPHERLEKLLSFMEAELEILQLENKIRTRVKKQMEKNQKEYYLNEQ
MRAIQKELGTKDDFRQELLELENKATKGKLSKEARQKALAELKKLKLMSPASAEAAVVRNYVDWLVSLPWAKMTREKHDI
IGAEEVLNADHYGLEKVKERILEYLSVQALVKKLKGPILCLVGPPGVGKTSLARSIATATGRHFVKMSLGGMRDEAEIRG
HRRTYVGAMPGKIIQNLKKAGSNNPVFLLDEIDKMSSDFRGDPASALLEVLDPEQNAHFSDHFLDVEYDLSHVMFIATAN
STHSIPRPLLDRMEVIRLEGYTEHEKLAIAERYLVGKQMAANGLSEQQISISGKAVSEIIRYYTREAGVRNLERDIATLC
RKAAHRVVKGEKKKIVIQPKNLSGFLGPRKYRIGTAEDKDAPGYATGLAWTEVGGDLLTIEVAIVPGTGKLLITGKLGEV
MQESAQAAMTYVRSRAQILGIDKEFHKKADIHIHVPEGAIPKDGPSAGITMATAIVSALTGRPVRHDLAMTGEITLRGNV
LAIGGLKEKLLAAGRGGISTVVIPEENKKDLAEIPREVTVGLTIVPARHMDEVLSRALLAEGVSSGAPYLASEGHPAISE
QETVTAH

Sequences:

>Translated_807_residues
MSVDHSIESLERGDLQRFPLLPLRDIVVFPHMVVPLFVGRERSISALEAAMNGNRMIFLAAQRNAKTEDPRQEDIYTTGT
ISQIIQLLKLPDGTVKVLVEGKQRGSLVSFLPNPDYFMAEIQPYLESLEANPELEALIRSTKSVFEGYVKLTKGIPQEVV
SAVGGIVEPGKLADTLAPHLNLKLSDKQLLLGIMTPHERLEKLLSFMEAELEILQLENKIRTRVKKQMEKNQKEYYLNEQ
MRAIQKELGTKDDFRQELLELENKATKGKLSKEARQKALAELKKLKLMSPASAEAAVVRNYVDWLVSLPWAKMTREKHDI
IGAEEVLNADHYGLEKVKERILEYLSVQALVKKLKGPILCLVGPPGVGKTSLARSIATATGRHFVKMSLGGMRDEAEIRG
HRRTYVGAMPGKIIQNLKKAGSNNPVFLLDEIDKMSSDFRGDPASALLEVLDPEQNAHFSDHFLDVEYDLSHVMFIATAN
STHSIPRPLLDRMEVIRLEGYTEHEKLAIAERYLVGKQMAANGLSEQQISISGKAVSEIIRYYTREAGVRNLERDIATLC
RKAAHRVVKGEKKKIVIQPKNLSGFLGPRKYRIGTAEDKDAPGYATGLAWTEVGGDLLTIEVAIVPGTGKLLITGKLGEV
MQESAQAAMTYVRSRAQILGIDKEFHKKADIHIHVPEGAIPKDGPSAGITMATAIVSALTGRPVRHDLAMTGEITLRGNV
LAIGGLKEKLLAAGRGGISTVVIPEENKKDLAEIPREVTVGLTIVPARHMDEVLSRALLAEGVSSGAPYLASEGHPAISE
QETVTAH
>Mature_806_residues
SVDHSIESLERGDLQRFPLLPLRDIVVFPHMVVPLFVGRERSISALEAAMNGNRMIFLAAQRNAKTEDPRQEDIYTTGTI
SQIIQLLKLPDGTVKVLVEGKQRGSLVSFLPNPDYFMAEIQPYLESLEANPELEALIRSTKSVFEGYVKLTKGIPQEVVS
AVGGIVEPGKLADTLAPHLNLKLSDKQLLLGIMTPHERLEKLLSFMEAELEILQLENKIRTRVKKQMEKNQKEYYLNEQM
RAIQKELGTKDDFRQELLELENKATKGKLSKEARQKALAELKKLKLMSPASAEAAVVRNYVDWLVSLPWAKMTREKHDII
GAEEVLNADHYGLEKVKERILEYLSVQALVKKLKGPILCLVGPPGVGKTSLARSIATATGRHFVKMSLGGMRDEAEIRGH
RRTYVGAMPGKIIQNLKKAGSNNPVFLLDEIDKMSSDFRGDPASALLEVLDPEQNAHFSDHFLDVEYDLSHVMFIATANS
THSIPRPLLDRMEVIRLEGYTEHEKLAIAERYLVGKQMAANGLSEQQISISGKAVSEIIRYYTREAGVRNLERDIATLCR
KAAHRVVKGEKKKIVIQPKNLSGFLGPRKYRIGTAEDKDAPGYATGLAWTEVGGDLLTIEVAIVPGTGKLLITGKLGEVM
QESAQAAMTYVRSRAQILGIDKEFHKKADIHIHVPEGAIPKDGPSAGITMATAIVSALTGRPVRHDLAMTGEITLRGNVL
AIGGLKEKLLAAGRGGISTVVIPEENKKDLAEIPREVTVGLTIVPARHMDEVLSRALLAEGVSSGAPYLASEGHPAISEQ
ETVTAH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=598, Percent_Identity=46.4882943143813, Blast_Score=545, Evalue=1e-155,
Organism=Homo sapiens, GI31377667, Length=829, Percent_Identity=38.2388419782871, Blast_Score=533, Evalue=1e-151,
Organism=Escherichia coli, GI1786643, Length=773, Percent_Identity=61.1901681759379, Blast_Score=937, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=653, Percent_Identity=41.04134762634, Blast_Score=484, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17556486, Length=722, Percent_Identity=35.0415512465374, Blast_Score=427, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6319449, Length=715, Percent_Identity=39.3006993006993, Blast_Score=501, Evalue=1e-142,
Organism=Drosophila melanogaster, GI221513036, Length=576, Percent_Identity=47.5694444444444, Blast_Score=530, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24666867, Length=576, Percent_Identity=47.5694444444444, Blast_Score=530, Evalue=1e-150,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 88928; Mature: 88797

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVDHSIESLERGDLQRFPLLPLRDIVVFPHMVVPLFVGRERSISALEAAMNGNRMIFLA
CCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEE
AQRNAKTEDPRQEDIYTTGTISQIIQLLKLPDGTVKVLVEGKQRGSLVSFLPNPDYFMAE
ECCCCCCCCCCHHCCEECHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEECCCCCHHHHH
IQPYLESLEANPELEALIRSTKSVFEGYVKLTKGIPQEVVSAVGGIVEPGKLADTLAPHL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHCCCC
NLKLSDKQLLLGIMTPHERLEKLLSFMEAELEILQLENKIRTRVKKQMEKNQKEYYLNEQ
CEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MRAIQKELGTKDDFRQELLELENKATKGKLSKEARQKALAELKKLKLMSPASAEAAVVRN
HHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
YVDWLVSLPWAKMTREKHDIIGAEEVLNADHYGLEKVKERILEYLSVQALVKKLKGPILC
HHHHHHHCCHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEE
LVGPPGVGKTSLARSIATATGRHFVKMSLGGMRDEAEIRGHRRTYVGAMPGKIIQNLKKA
EECCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCHHHHCCCCCEEECCCCHHHHHHHHHC
GSNNPVFLLDEIDKMSSDFRGDPASALLEVLDPEQNAHFSDHFLDVEYDLSHVMFIATAN
CCCCCEEEEECHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCEEEEEEECC
STHSIPRPLLDRMEVIRLEGYTEHEKLAIAERYLVGKQMAANGLSEQQISISGKAVSEII
CCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHH
RYYTREAGVRNLERDIATLCRKAAHRVVKGEKKKIVIQPKNLSGFLGPRKYRIGTAEDKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEECCCCCCCC
APGYATGLAWTEVGGDLLTIEVAIVPGTGKLLITGKLGEVMQESAQAAMTYVRSRAQILG
CCCCCCCCCHHHCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCC
IDKEFHKKADIHIHVPEGAIPKDGPSAGITMATAIVSALTGRPVRHDLAMTGEITLRGNV
CCHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHCCEEEEEEEEECCE
LAIGGLKEKLLAAGRGGISTVVIPEENKKDLAEIPREVTVGLTIVPARHMDEVLSRALLA
EEECCHHHHHHHCCCCCCEEEEECCCCCHHHHHCCHHHEECEEEECHHHHHHHHHHHHHH
EGVSSGAPYLASEGHPAISEQETVTAH
HHHCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SVDHSIESLERGDLQRFPLLPLRDIVVFPHMVVPLFVGRERSISALEAAMNGNRMIFLA
CCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEE
AQRNAKTEDPRQEDIYTTGTISQIIQLLKLPDGTVKVLVEGKQRGSLVSFLPNPDYFMAE
ECCCCCCCCCCHHCCEECHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEECCCCCHHHHH
IQPYLESLEANPELEALIRSTKSVFEGYVKLTKGIPQEVVSAVGGIVEPGKLADTLAPHL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHCCCC
NLKLSDKQLLLGIMTPHERLEKLLSFMEAELEILQLENKIRTRVKKQMEKNQKEYYLNEQ
CEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MRAIQKELGTKDDFRQELLELENKATKGKLSKEARQKALAELKKLKLMSPASAEAAVVRN
HHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
YVDWLVSLPWAKMTREKHDIIGAEEVLNADHYGLEKVKERILEYLSVQALVKKLKGPILC
HHHHHHHCCHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEE
LVGPPGVGKTSLARSIATATGRHFVKMSLGGMRDEAEIRGHRRTYVGAMPGKIIQNLKKA
EECCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCHHHHCCCCCEEECCCCHHHHHHHHHC
GSNNPVFLLDEIDKMSSDFRGDPASALLEVLDPEQNAHFSDHFLDVEYDLSHVMFIATAN
CCCCCEEEEECHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCEEEEEEECC
STHSIPRPLLDRMEVIRLEGYTEHEKLAIAERYLVGKQMAANGLSEQQISISGKAVSEII
CCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHH
RYYTREAGVRNLERDIATLCRKAAHRVVKGEKKKIVIQPKNLSGFLGPRKYRIGTAEDKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEECCCCCCCC
APGYATGLAWTEVGGDLLTIEVAIVPGTGKLLITGKLGEVMQESAQAAMTYVRSRAQILG
CCCCCCCCCHHHCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCC
IDKEFHKKADIHIHVPEGAIPKDGPSAGITMATAIVSALTGRPVRHDLAMTGEITLRGNV
CCHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHCCEEEEEEEEECCE
LAIGGLKEKLLAAGRGGISTVVIPEENKKDLAEIPREVTVGLTIVPARHMDEVLSRALLA
EEECCHHHHHHHCCCCCCEEEEECCCCCHHHHHCCHHHEECEEEECHHHHHHHHHHHHHH
EGVSSGAPYLASEGHPAISEQETVTAH
HHHCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8468287 [H]