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The map label for this gene is hprA [C]

Identifier: 39996772

GI number: 39996772

Start: 1832580

End: 1833563

Strand: Direct

Name: hprA [C]

Synonym: GSU1672

Alternate gene names: 39996772

Gene position: 1832580-1833563 (Clockwise)

Preceding gene: 39996770

Following gene: 39996774

Centisome position: 48.05

GC content: 60.37

Gene sequence:

>984_bases
ATGATACAAAAACCCAACATCGTCATCCTGGACGGCTATACCATCAATCCGGGTGACAACCCCTGGACTCCGCTGGAGAA
GTTGGGCGACTGCACTATTTATGACCGGACCCCGCCCGAGTTGCGGGTGGAGCGGGCCAAGGATGCGGATATTGTCCTGA
CCAGCAAGGTCAAGCTCGACGAGGCTACTCTGGCGGCGCTGCCCAAGTTGCGCTATATATCGATGCTGGCCACGGGATAC
AACAACGTTGACGTGGAGGCTGCCGGCAAGCGCGGCATTCCCGTGGCCAATATCCCGGCCTATTCCACCGAATCGGTTGT
GCAGACCACTTTTGCCCTTCTTCTTGAACTGGCTGTACACGTGGGGATCCATGATTCAGCCGTAAAGGCCCGCGAGTGGG
TCCGTTCGCCGGACCACTCATTCTGGAAGACGCCCATTGTCGAGCTTGACGGCCTCACGCTGGGCATTGTCGGGTACGGC
ACCATCGGCCGGGCCGTGGCGCGAGTAGGGGCGGCCTTCGGCATGAAGATAATGGCGTATGCCCCCCGCGTTCCTGCAGA
CCTTGGGCCGGTGCCCGTCCGGTTCGTTTCTCTTGACGAACTGTTCGCCGGTTCCGACGTGGTATCCCTCAACTGTCCCC
AAACTGCTGAGAATACCGGCTTTGTGAACAGCCGACTCCTCTCGCTCATGAAGCCGAGCGCCTTCTTTCTCAATGTGGCG
CGCGGGGGCTTGGTCAATGAAGTCGATTTGGCCGCTGCCCTGCATAGCGGAAAACTTGCCGGCGCGGGGTTGGATGTGGT
CGCCCACGAGCCGATGAGTCCCGACAACCCACTCCTCGGGGCGCCGAACTGTATTTTCACGCCGCATCTGGCATGGGCTT
CCCTGGCAGCCCGCCGTCGACTTATGGGAATCCTGGCGGCCAACGTGGCAACGTTCCTGGCGGGAGAGCCCCAGAACGTG
GTTAACAGCCGGTTCCTGAAATGA

Upstream 100 bases:

>100_bases
CCGGATGGTTTTGAGACCATTGACAGCATCGTTGCCTGCTGCTACTTTCCACACGTATCTTTCTCAACATACCCATATCA
GGAATCGGAGCGTGACATAT

Downstream 100 bases:

>100_bases
AAAAAGCCGTCATCAAAAAAGATGACGGCCCGAGCCGGCAAGAAAGAGTCTTGGATCAGCCTTTGGAGTTTTCGTAGAAC
AGAAATACCAAGAGAACCAC

Product: glycerate dehydrogenase

Products: hydroxypyruvate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MIQKPNIVILDGYTINPGDNPWTPLEKLGDCTIYDRTPPELRVERAKDADIVLTSKVKLDEATLAALPKLRYISMLATGY
NNVDVEAAGKRGIPVANIPAYSTESVVQTTFALLLELAVHVGIHDSAVKAREWVRSPDHSFWKTPIVELDGLTLGIVGYG
TIGRAVARVGAAFGMKIMAYAPRVPADLGPVPVRFVSLDELFAGSDVVSLNCPQTAENTGFVNSRLLSLMKPSAFFLNVA
RGGLVNEVDLAAALHSGKLAGAGLDVVAHEPMSPDNPLLGAPNCIFTPHLAWASLAARRRLMGILAANVATFLAGEPQNV
VNSRFLK

Sequences:

>Translated_327_residues
MIQKPNIVILDGYTINPGDNPWTPLEKLGDCTIYDRTPPELRVERAKDADIVLTSKVKLDEATLAALPKLRYISMLATGY
NNVDVEAAGKRGIPVANIPAYSTESVVQTTFALLLELAVHVGIHDSAVKAREWVRSPDHSFWKTPIVELDGLTLGIVGYG
TIGRAVARVGAAFGMKIMAYAPRVPADLGPVPVRFVSLDELFAGSDVVSLNCPQTAENTGFVNSRLLSLMKPSAFFLNVA
RGGLVNEVDLAAALHSGKLAGAGLDVVAHEPMSPDNPLLGAPNCIFTPHLAWASLAARRRLMGILAANVATFLAGEPQNV
VNSRFLK
>Mature_327_residues
MIQKPNIVILDGYTINPGDNPWTPLEKLGDCTIYDRTPPELRVERAKDADIVLTSKVKLDEATLAALPKLRYISMLATGY
NNVDVEAAGKRGIPVANIPAYSTESVVQTTFALLLELAVHVGIHDSAVKAREWVRSPDHSFWKTPIVELDGLTLGIVGYG
TIGRAVARVGAAFGMKIMAYAPRVPADLGPVPVRFVSLDELFAGSDVVSLNCPQTAENTGFVNSRLLSLMKPSAFFLNVA
RGGLVNEVDLAAALHSGKLAGAGLDVVAHEPMSPDNPLLGAPNCIFTPHLAWASLAARRRLMGILAANVATFLAGEPQNV
VNSRFLK

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI145580578, Length=285, Percent_Identity=34.3859649122807, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI4557499, Length=285, Percent_Identity=34.3859649122807, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI145580575, Length=285, Percent_Identity=34.3859649122807, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI61743967, Length=257, Percent_Identity=35.408560311284, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI4557497, Length=257, Percent_Identity=35.408560311284, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI23308577, Length=292, Percent_Identity=33.2191780821918, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI6912396, Length=258, Percent_Identity=34.4961240310078, Blast_Score=134, Evalue=8e-32,
Organism=Escherichia coli, GI87082289, Length=278, Percent_Identity=36.3309352517986, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1787645, Length=260, Percent_Identity=30, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1789279, Length=265, Percent_Identity=33.5849056603774, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI87081824, Length=156, Percent_Identity=35.8974358974359, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17532191, Length=291, Percent_Identity=31.9587628865979, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI25147481, Length=277, Percent_Identity=32.129963898917, Blast_Score=132, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320925, Length=301, Percent_Identity=30.2325581395349, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322116, Length=301, Percent_Identity=29.5681063122924, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324055, Length=319, Percent_Identity=28.8401253918495, Blast_Score=115, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6324964, Length=321, Percent_Identity=29.9065420560748, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324980, Length=205, Percent_Identity=30.2439024390244, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24646446, Length=281, Percent_Identity=35.2313167259786, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24646448, Length=281, Percent_Identity=35.2313167259786, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24646452, Length=281, Percent_Identity=35.2313167259786, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24646450, Length=281, Percent_Identity=35.2313167259786, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI62472511, Length=281, Percent_Identity=35.2313167259786, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI28574286, Length=259, Percent_Identity=35.5212355212355, Blast_Score=141, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24585516, Length=255, Percent_Identity=31.3725490196078, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28571528, Length=280, Percent_Identity=32.8571428571429, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI45552429, Length=266, Percent_Identity=31.203007518797, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24585514, Length=266, Percent_Identity=31.203007518797, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI28574282, Length=266, Percent_Identity=31.203007518797, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI45551003, Length=266, Percent_Identity=31.203007518797, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI28574284, Length=266, Percent_Identity=31.203007518797, Blast_Score=121, Evalue=8e-28,
Organism=Drosophila melanogaster, GI19921140, Length=283, Percent_Identity=28.9752650176678, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: 1.1.1.29

Molecular weight: Translated: 34984; Mature: 34984

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQKPNIVILDGYTINPGDNPWTPLEKLGDCTIYDRTPPELRVERAKDADIVLTSKVKLD
CCCCCCEEEECCEEECCCCCCCCHHHHCCCEEEECCCCHHHHHCCCCCCCEEEEECEECC
EATLAALPKLRYISMLATGYNNVDVEAAGKRGIPVANIPAYSTESVVQTTFALLLELAVH
HHHHHHHCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VGIHDSAVKAREWVRSPDHSFWKTPIVELDGLTLGIVGYGTIGRAVARVGAAFGMKIMAY
CCCCHHHHHHHHHHCCCCCCHHCCCCEEECCEEEEEEECCHHHHHHHHHHHHHCCEEEEE
APRVPADLGPVPVRFVSLDELFAGSDVVSLNCPQTAENTGFVNSRLLSLMKPSAFFLNVA
CCCCCCCCCCCCEEEEEHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCHHEEEHH
RGGLVNEVDLAAALHSGKLAGAGLDVVAHEPMSPDNPLLGAPNCIFTPHLAWASLAARRR
CCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCEECCCHHHHHHHHHHH
LMGILAANVATFLAGEPQNVVNSRFLK
HHHHHHHHHHHHHCCCCHHHHHHHCCC
>Mature Secondary Structure
MIQKPNIVILDGYTINPGDNPWTPLEKLGDCTIYDRTPPELRVERAKDADIVLTSKVKLD
CCCCCCEEEECCEEECCCCCCCCHHHHCCCEEEECCCCHHHHHCCCCCCCEEEEECEECC
EATLAALPKLRYISMLATGYNNVDVEAAGKRGIPVANIPAYSTESVVQTTFALLLELAVH
HHHHHHHCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VGIHDSAVKAREWVRSPDHSFWKTPIVELDGLTLGIVGYGTIGRAVARVGAAFGMKIMAY
CCCCHHHHHHHHHHCCCCCCHHCCCCEEECCEEEEEEECCHHHHHHHHHHHHHCCEEEEE
APRVPADLGPVPVRFVSLDELFAGSDVVSLNCPQTAENTGFVNSRLLSLMKPSAFFLNVA
CCCCCCCCCCCCEEEEEHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCHHEEEHH
RGGLVNEVDLAAALHSGKLAGAGLDVVAHEPMSPDNPLLGAPNCIFTPHLAWASLAARRR
CCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCEECCCHHHHHHHHHHH
LMGILAANVATFLAGEPQNVVNSRFLK
HHHHHHHHHHHHHCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-glycerate; NAD+

Specific reaction: (R)-glycerate + NAD+ = hydroxypyruvate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]