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The map label for this gene is yfhQ [H]

Identifier: 39996713

GI number: 39996713

Start: 1766767

End: 1767624

Strand: Reverse

Name: yfhQ [H]

Synonym: GSU1613

Alternate gene names: 39996713

Gene position: 1767624-1766767 (Counterclockwise)

Preceding gene: 39996714

Following gene: 39996684

Centisome position: 46.34

GC content: 60.72

Gene sequence:

>858_bases
TTGAACAGGGAACAGGAGCTGACACATCTCTTCCGCCGGGAGGGGCTCACGCCTGCAGTTGCGGACCTCTTCCGGCGGAT
CGTGTATGACTGGTATGCATCCCAGCGTCGCGAACTCCCCTGGCGGGAAACCTTTGATCCGTACGCCATCCTCGTGTCCG
AGATCATGCTCCAGCAGACGCAGGTGGAGCGCGTCAGGGAAAAGTACCCAACATTCCTGGCCGAGTTTCCGAACCTGAGG
GCCCTGGCTGCGGCGCCACTGGAACGGGTTCTTGCGGCATGGCAGGGGCTTGGCTACAACCGGCGCGCCGTGAACCTCAA
GCGCTGCGCCGAGGCGGTTGTCGCAAGTCTGGGAGGAGAGCTCCCCGCTGATCCGAACGAATTGGTCCGGCTGCCGGGCA
TTGGAACGTACACGTCCCGGGCAGTGGCCGCCTTTGCCTTCAACACCCCCCTGCCCTTCATCGAGACCAATATCCGCAGC
GTGTATATCCACCATTTCTTCGCGGACCAAAGCAGCATTCACGACCGCGATCTCATGCCTCTGATCGAACAGACCCTGGA
CCGTGACAATCCCCGCGAATGGTATTACGCTCTCATGGATTACGGATCGCACCTGAAGCGACTGCATGGCAATCCGTCGC
GCCGCAGTTCACATCATACGCGACAGACTCCGTTCAAGGGATCCAACCGGCAGGTGCGCAGCCGCATCCTCCGGGCCGTC
CTGGAAAATCCGGGGATCAGCCGCGATGCGCTTGAAAAGGCAGTGGGAGCGAGCAGCGAAATCGTGGGGAAAAACCTGGA
ACAGCTTGCCGCGGAAGGATTTATCGTGTCGCGGGGTCCAGGGTATCGCATCCTATAG

Upstream 100 bases:

>100_bases
GAGCCGAAAGCGACAAGGCGGTGGAGCTTTGCCGTCAAAACGGTATCACTGTCATCGCGGACGGGAGCTGCATTCTTGTT
GTCCTGGGGTACCGCGACCA

Downstream 100 bases:

>100_bases
CCCCTGACGCACACATACCTACCTCTTTACCTGATCCGCCACCGACTGGGTGGCCCGGGCAACCTCGTCAGGATCACCCA
GGTAATAGCTTCGTATGGGG

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MNREQELTHLFRREGLTPAVADLFRRIVYDWYASQRRELPWRETFDPYAILVSEIMLQQTQVERVREKYPTFLAEFPNLR
ALAAAPLERVLAAWQGLGYNRRAVNLKRCAEAVVASLGGELPADPNELVRLPGIGTYTSRAVAAFAFNTPLPFIETNIRS
VYIHHFFADQSSIHDRDLMPLIEQTLDRDNPREWYYALMDYGSHLKRLHGNPSRRSSHHTRQTPFKGSNRQVRSRILRAV
LENPGISRDALEKAVGASSEIVGKNLEQLAAEGFIVSRGPGYRIL

Sequences:

>Translated_285_residues
MNREQELTHLFRREGLTPAVADLFRRIVYDWYASQRRELPWRETFDPYAILVSEIMLQQTQVERVREKYPTFLAEFPNLR
ALAAAPLERVLAAWQGLGYNRRAVNLKRCAEAVVASLGGELPADPNELVRLPGIGTYTSRAVAAFAFNTPLPFIETNIRS
VYIHHFFADQSSIHDRDLMPLIEQTLDRDNPREWYYALMDYGSHLKRLHGNPSRRSSHHTRQTPFKGSNRQVRSRILRAV
LENPGISRDALEKAVGASSEIVGKNLEQLAAEGFIVSRGPGYRIL
>Mature_285_residues
MNREQELTHLFRREGLTPAVADLFRRIVYDWYASQRRELPWRETFDPYAILVSEIMLQQTQVERVREKYPTFLAEFPNLR
ALAAAPLERVLAAWQGLGYNRRAVNLKRCAEAVVASLGGELPADPNELVRLPGIGTYTSRAVAAFAFNTPLPFIETNIRS
VYIHHFFADQSSIHDRDLMPLIEQTLDRDNPREWYYALMDYGSHLKRLHGNPSRRSSHHTRQTPFKGSNRQVRSRILRAV
LENPGISRDALEKAVGASSEIVGKNLEQLAAEGFIVSRGPGYRIL

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298654, Length=207, Percent_Identity=36.231884057971, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI115298652, Length=207, Percent_Identity=36.231884057971, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI115298650, Length=207, Percent_Identity=36.231884057971, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI115298648, Length=207, Percent_Identity=36.231884057971, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI6912520, Length=207, Percent_Identity=36.231884057971, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI190358497, Length=207, Percent_Identity=36.231884057971, Blast_Score=114, Evalue=8e-26,
Organism=Escherichia coli, GI1789331, Length=190, Percent_Identity=34.7368421052632, Blast_Score=110, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 32598; Mature: 32598

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNREQELTHLFRREGLTPAVADLFRRIVYDWYASQRRELPWRETFDPYAILVSEIMLQQT
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
QVERVREKYPTFLAEFPNLRALAAAPLERVLAAWQGLGYNRRAVNLKRCAEAVVASLGGE
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
LPADPNELVRLPGIGTYTSRAVAAFAFNTPLPFIETNIRSVYIHHFFADQSSIHDRDLMP
CCCCHHHHEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LIEQTLDRDNPREWYYALMDYGSHLKRLHGNPSRRSSHHTRQTPFKGSNRQVRSRILRAV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LENPGISRDALEKAVGASSEIVGKNLEQLAAEGFIVSRGPGYRIL
HHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCEEEECCCCCCCC
>Mature Secondary Structure
MNREQELTHLFRREGLTPAVADLFRRIVYDWYASQRRELPWRETFDPYAILVSEIMLQQT
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
QVERVREKYPTFLAEFPNLRALAAAPLERVLAAWQGLGYNRRAVNLKRCAEAVVASLGGE
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
LPADPNELVRLPGIGTYTSRAVAAFAFNTPLPFIETNIRSVYIHHFFADQSSIHDRDLMP
CCCCHHHHEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LIEQTLDRDNPREWYYALMDYGSHLKRLHGNPSRRSSHHTRQTPFKGSNRQVRSRILRAV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LENPGISRDALEKAVGASSEIVGKNLEQLAAEGFIVSRGPGYRIL
HHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]