Click here to switch to the map view.

The map label for this gene is bioA [H]

Identifier: 39996682

GI number: 39996682

Start: 1734899

End: 1736260

Strand: Reverse

Name: bioA [H]

Synonym: GSU1582

Alternate gene names: 39996682

Gene position: 1736260-1734899 (Counterclockwise)

Preceding gene: 39996683

Following gene: 39996663

Centisome position: 45.52

GC content: 60.65

Gene sequence:

>1362_bases
GTGCCTGACTATGATACTCAGACCCTGAGAGACTGGGACCGTCGCCACATCTGGCACCCCTTCACCCAGATGAAGGAGTG
GGAGGAAAGCGAACCAGTGGTGATCGTTGAAGGGGAAGGCTCCTGGATCATCGATTCGGAAGGAAAACGCTACCTGGACG
GCGTGGCCGCTATCTGGACCAATGTGCACGGGCACTGCCGCCGGGAGATTAACGAGGCGCTCAAGGCCCAGGTGGACCGC
CTGGAGCATTCGACGCTCCTGGGGCTCACCAACGACAGGGCGGTTGTTCTGGCTAAACGCCTCGCTGAGATCGCTCCGCC
CGGACTGTGCAAGGTCTTTTACTCTGATAACGGCTCCACTGCCGTGGAAGTCGGCGTGAAGATGGCATTCCAGTTCTGGC
GCCATGAGGGCAAACCGGAAAAATCCCGGTTCATCTCCTTCACGAGCGCCTATCACGGCGACACCCTGGGTGCCGTGAGC
GTTGGAGGCATCGATCTGTTCCACGGCGTATTCCGCCCACTGCTCTTCCCGACTATCCAGGCGCCGGCGCCCTACTGCTA
CCGCTGCCCCATGGGCCGGGACACCCCTGCCGCCTGCGGCATGGAATGCCTGACGGAACTGGAGCGGATCATGGAAAGCC
ATGCCGGCGAGGTGGCGGGTCTCGTCATCGAGCCGCTGGTTCAGGGCGCGGGTGGAATGATCGTTCAGCCCGAAGGGTTT
TTAAAGGGGGTGCGGGAGCTCTGCGATCGACACGACATCCTGATGATCGCCGACGAAGTCGCTGTGGGCTTCGGCCGCAC
CGGTGCCATGTTCGCCTGTGGGCGCGAAGGGATCACTCCCGACATCATGGCACTCTCCAAGGGGATTACCGCAGGCTACA
TGCCCCTGGCCGCCACCCTGGCGACCCAGCAGGTCTATGATGCGTTCCTGGGCGAATACCGGGAGATGAAGACCTTTTTC
CACGGTCACACCTTCACGGGAAACCCCCTCGGCTGCGCCGTGGCCCTGGCAAGCCTCGACCTGTTCGAGAGCGACCGGCT
TCTCGGCAAACTACCAAACAAGATCAAGTTGTTACAAGAAAAACTTAAGGGACTGATTGAGCTTGAACACGTGGGAGATG
TACGGCAGTGCGGCATGATCGCCGCCGTGGAATTGGTGCGGGACCGGGCAACAAAAGAACCGTTCGACTGGGAAGAGCGA
GTGGGGGTCCGCGTCTGCCTGGAAGCACGCACGCACGGCGTCTTTTTGCGGCCCCTCGGCAATGTCATCGTTATTTTTCC
GCCCCTTGCCATCACTGCCGAGGAAATCGACTTCCTCGTTGACGGCTTGGAAAAGTCAATCCACACGGTCACCGGAGGGT
GA

Upstream 100 bases:

>100_bases
CCCCGCATCGAGGGAGCTGAAGGACGTGCCATGGTGGAACAGCTCGCGGCGCGCCTGGCAACCGAACCAACCACCAGGAT
ACTGGTAAGGGAGATTGGCT

Downstream 100 bases:

>100_bases
ACCACACACTGCGCCTGCGCTGGGCTCCGGCGATTGTCAGGCCGAATCCGCCAGACGCACGGCAATGCGCATCTCGTCGT
CGCGGGTTGCCGCTTCGCCG

Product: adenosylmethionine--8-amino-7-oxononanoate aminotransferase

Products: S-adenosyl-4-methylthio-2-oxobutanoate; 7,8-diaminononanoate

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA aminotransferase [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MPDYDTQTLRDWDRRHIWHPFTQMKEWEESEPVVIVEGEGSWIIDSEGKRYLDGVAAIWTNVHGHCRREINEALKAQVDR
LEHSTLLGLTNDRAVVLAKRLAEIAPPGLCKVFYSDNGSTAVEVGVKMAFQFWRHEGKPEKSRFISFTSAYHGDTLGAVS
VGGIDLFHGVFRPLLFPTIQAPAPYCYRCPMGRDTPAACGMECLTELERIMESHAGEVAGLVIEPLVQGAGGMIVQPEGF
LKGVRELCDRHDILMIADEVAVGFGRTGAMFACGREGITPDIMALSKGITAGYMPLAATLATQQVYDAFLGEYREMKTFF
HGHTFTGNPLGCAVALASLDLFESDRLLGKLPNKIKLLQEKLKGLIELEHVGDVRQCGMIAAVELVRDRATKEPFDWEER
VGVRVCLEARTHGVFLRPLGNVIVIFPPLAITAEEIDFLVDGLEKSIHTVTGG

Sequences:

>Translated_453_residues
MPDYDTQTLRDWDRRHIWHPFTQMKEWEESEPVVIVEGEGSWIIDSEGKRYLDGVAAIWTNVHGHCRREINEALKAQVDR
LEHSTLLGLTNDRAVVLAKRLAEIAPPGLCKVFYSDNGSTAVEVGVKMAFQFWRHEGKPEKSRFISFTSAYHGDTLGAVS
VGGIDLFHGVFRPLLFPTIQAPAPYCYRCPMGRDTPAACGMECLTELERIMESHAGEVAGLVIEPLVQGAGGMIVQPEGF
LKGVRELCDRHDILMIADEVAVGFGRTGAMFACGREGITPDIMALSKGITAGYMPLAATLATQQVYDAFLGEYREMKTFF
HGHTFTGNPLGCAVALASLDLFESDRLLGKLPNKIKLLQEKLKGLIELEHVGDVRQCGMIAAVELVRDRATKEPFDWEER
VGVRVCLEARTHGVFLRPLGNVIVIFPPLAITAEEIDFLVDGLEKSIHTVTGG
>Mature_452_residues
PDYDTQTLRDWDRRHIWHPFTQMKEWEESEPVVIVEGEGSWIIDSEGKRYLDGVAAIWTNVHGHCRREINEALKAQVDRL
EHSTLLGLTNDRAVVLAKRLAEIAPPGLCKVFYSDNGSTAVEVGVKMAFQFWRHEGKPEKSRFISFTSAYHGDTLGAVSV
GGIDLFHGVFRPLLFPTIQAPAPYCYRCPMGRDTPAACGMECLTELERIMESHAGEVAGLVIEPLVQGAGGMIVQPEGFL
KGVRELCDRHDILMIADEVAVGFGRTGAMFACGREGITPDIMALSKGITAGYMPLAATLATQQVYDAFLGEYREMKTFFH
GHTFTGNPLGCAVALASLDLFESDRLLGKLPNKIKLLQEKLKGLIELEHVGDVRQCGMIAAVELVRDRATKEPFDWEERV
GVRVCLEARTHGVFLRPLGNVIVIFPPLAITAEEIDFLVDGLEKSIHTVTGG

Specific function: Catalyzes the formation of the intermediate 7,8- diaminopelargonic acid (DAPA) from 7-keto-8-aminopelargonic acid (KAPA) with lysine as the amino donor. B.subtilis does not utilize S-adenosylmethionine (SAM), but instead utilizes only L-lysine as the amin

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=439, Percent_Identity=30.751708428246, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI13994255, Length=440, Percent_Identity=30.2272727272727, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI37574042, Length=425, Percent_Identity=29.6470588235294, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI226442705, Length=425, Percent_Identity=29.1764705882353, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI226442709, Length=390, Percent_Identity=29.7435897435897, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI24119277, Length=431, Percent_Identity=28.538283062645, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI284507298, Length=338, Percent_Identity=31.3609467455621, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI188536080, Length=436, Percent_Identity=22.4770642201835, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI38679950, Length=436, Percent_Identity=22.4770642201835, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI38679946, Length=436, Percent_Identity=22.4770642201835, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1786991, Length=443, Percent_Identity=38.1489841986456, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI145693181, Length=415, Percent_Identity=30.3614457831325, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1788044, Length=412, Percent_Identity=32.0388349514563, Blast_Score=175, Evalue=6e-45,
Organism=Escherichia coli, GI1789759, Length=417, Percent_Identity=30.9352517985612, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1789016, Length=421, Percent_Identity=30.4038004750594, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI1787560, Length=421, Percent_Identity=29.6912114014252, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1786349, Length=318, Percent_Identity=26.4150943396226, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI32564660, Length=449, Percent_Identity=30.0668151447661, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI25144271, Length=454, Percent_Identity=26.6519823788546, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI71992977, Length=446, Percent_Identity=25.1121076233184, Blast_Score=128, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI25144274, Length=232, Percent_Identity=31.8965517241379, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17541228, Length=447, Percent_Identity=23.7136465324385, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324386, Length=476, Percent_Identity=31.3025210084034, Blast_Score=213, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6323470, Length=461, Percent_Identity=27.3318872017354, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6324432, Length=442, Percent_Identity=27.3755656108597, Blast_Score=147, Evalue=3e-36,
Organism=Drosophila melanogaster, GI21357415, Length=447, Percent_Identity=29.3064876957494, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI161085790, Length=453, Percent_Identity=30.0220750551876, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI28574759, Length=453, Percent_Identity=30.4635761589404, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI21356575, Length=435, Percent_Identity=28.5057471264368, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI281366494, Length=287, Percent_Identity=25.7839721254355, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24667139, Length=287, Percent_Identity=25.7839721254355, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24667143, Length=287, Percent_Identity=25.7839721254355, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.62

Molecular weight: Translated: 50064; Mature: 49933

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDYDTQTLRDWDRRHIWHPFTQMKEWEESEPVVIVEGEGSWIIDSEGKRYLDGVAAIWT
CCCCCCHHHHHHHHHHCCCCHHHHHCCCCCCCEEEEECCCCEEECCCCCHHHHHHHHHHH
NVHGHCRREINEALKAQVDRLEHSTLLGLTNDRAVVLAKRLAEIAPPGLCKVFYSDNGST
HHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCC
AVEVGVKMAFQFWRHEGKPEKSRFISFTSAYHGDTLGAVSVGGIDLFHGVFRPLLFPTIQ
HHHHHHHHHHHHHHCCCCCCHHHHEEEHHHCCCCCCCCEEECHHHHHHHHHHHHHHCCCC
APAPYCYRCPMGRDTPAACGMECLTELERIMESHAGEVAGLVIEPLVQGAGGMIVQPEGF
CCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEECCHHH
LKGVRELCDRHDILMIADEVAVGFGRTGAMFACGREGITPDIMALSKGITAGYMPLAATL
HHHHHHHHCCCCEEEEEHHHHHCCCCCCCEEECCCCCCCHHHHHHHCCCCCCHHHHHHHH
ATQQVYDAFLGEYREMKTFFHGHTFTGNPLGCAVALASLDLFESDRLLGKLPNKIKLLQE
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHH
KLKGLIELEHVGDVRQCGMIAAVELVRDRATKEPFDWEERVGVRVCLEARTHGVFLRPLG
HHHHHEEHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEEECCCCCEEEEECC
NVIVIFPPLAITAEEIDFLVDGLEKSIHTVTGG
CEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PDYDTQTLRDWDRRHIWHPFTQMKEWEESEPVVIVEGEGSWIIDSEGKRYLDGVAAIWT
CCCCCHHHHHHHHHHCCCCHHHHHCCCCCCCEEEEECCCCEEECCCCCHHHHHHHHHHH
NVHGHCRREINEALKAQVDRLEHSTLLGLTNDRAVVLAKRLAEIAPPGLCKVFYSDNGST
HHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCC
AVEVGVKMAFQFWRHEGKPEKSRFISFTSAYHGDTLGAVSVGGIDLFHGVFRPLLFPTIQ
HHHHHHHHHHHHHHCCCCCCHHHHEEEHHHCCCCCCCCEEECHHHHHHHHHHHHHHCCCC
APAPYCYRCPMGRDTPAACGMECLTELERIMESHAGEVAGLVIEPLVQGAGGMIVQPEGF
CCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEECCHHH
LKGVRELCDRHDILMIADEVAVGFGRTGAMFACGREGITPDIMALSKGITAGYMPLAATL
HHHHHHHHCCCCEEEEEHHHHHCCCCCCCEEECCCCCCCHHHHHHHCCCCCCHHHHHHHH
ATQQVYDAFLGEYREMKTFFHGHTFTGNPLGCAVALASLDLFESDRLLGKLPNKIKLLQE
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHH
KLKGLIELEHVGDVRQCGMIAAVELVRDRATKEPFDWEERVGVRVCLEARTHGVFLRPLG
HHHHHEEHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEEECCCCCEEEEECC
NVIVIFPPLAITAEEIDFLVDGLEKSIHTVTGG
CEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-adenosyl-L-methionine; 8-amino-7-oxononanoate

Specific reaction: S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8763940; 9387221; 9384377 [H]