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The map label for this gene is bhbA [H]

Identifier: 39996678

GI number: 39996678

Start: 1729770

End: 1730174

Strand: Direct

Name: bhbA [H]

Synonym: GSU1578

Alternate gene names: 39996678

Gene position: 1729770-1730174 (Clockwise)

Preceding gene: 39996677

Following gene: 39996679

Centisome position: 45.35

GC content: 62.22

Gene sequence:

>405_bases
ATGACTGAAAGAACGCTGCGTATTCTCGTTGGCAAGCCGGGGCTCGACGGCCATGACAGGGGTGCCAAGGTAGTGGCCCG
GGCCTTCCGTGATGCCGGTTTCGAGGTGATCTATACCGGCCTCCACCAGACACCGGAGCAGATCGCGTCCTCCGCCATCC
AGGAAGACGTGGACGCCGTGGGGCTCTCGATCCTCTCTGGCGCCCACAATTCGCTTCTGCCGCGCGTCTGCCAGCTCCTC
AAGGAGAAGGGTGCCGACGATATCATCGTGTTCGGCGGCGGCGTGATCCCCGAAGATGATATTCCCGGATTGAAAGGAGC
GGGTGTCAGCGAGGTCTTCACCCCCGGTACCTCTACGGAGGATATCGTCAAATGGGTGCGGGAGAACGTGGCCCCGCGGG
CGTAA

Upstream 100 bases:

>100_bases
TCGCCGCCGCCGATCTGGTCACCGAGATGCGTGAGATCAAGCACTATTACCGTGCCGGCGTACCGGCACGTACGGGAATC
GAAAAATAAAGGAGATGGTC

Downstream 100 bases:

>100_bases
CCACCATTATTTCCGGCGTCGTGGCCGCCCTGCCGGGGTTCTGCCGCGCAGCCGACGTTGATTGATTTTCTGGAAGGAAC
CTGACGATGTCCCTGGCTTC

Product: B12-binding protein

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 134; Mature: 133

Protein sequence:

>134_residues
MTERTLRILVGKPGLDGHDRGAKVVARAFRDAGFEVIYTGLHQTPEQIASSAIQEDVDAVGLSILSGAHNSLLPRVCQLL
KEKGADDIIVFGGGVIPEDDIPGLKGAGVSEVFTPGTSTEDIVKWVRENVAPRA

Sequences:

>Translated_134_residues
MTERTLRILVGKPGLDGHDRGAKVVARAFRDAGFEVIYTGLHQTPEQIASSAIQEDVDAVGLSILSGAHNSLLPRVCQLL
KEKGADDIIVFGGGVIPEDDIPGLKGAGVSEVFTPGTSTEDIVKWVRENVAPRA
>Mature_133_residues
TERTLRILVGKPGLDGHDRGAKVVARAFRDAGFEVIYTGLHQTPEQIASSAIQEDVDAVGLSILSGAHNSLLPRVCQLLK
EKGADDIIVFGGGVIPEDDIPGLKGAGVSEVFTPGTSTEDIVKWVRENVAPRA

Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]

COG id: COG2185

COG function: function code I; Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=114, Percent_Identity=50, Blast_Score=106, Evalue=5e-24,
Organism=Escherichia coli, GI1789284, Length=121, Percent_Identity=46.2809917355372, Blast_Score=110, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI25144500, Length=114, Percent_Identity=49.1228070175439, Blast_Score=101, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 14201; Mature: 14070

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERTLRILVGKPGLDGHDRGAKVVARAFRDAGFEVIYTGLHQTPEQIASSAIQEDVDAV
CCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCHHEEHHCCCCCHHHHHHHHHHHHHHHH
GLSILSGAHNSLLPRVCQLLKEKGADDIIVFGGGVIPEDDIPGLKGAGVSEVFTPGTSTE
HHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCHHCCCCCCHH
DIVKWVRENVAPRA
HHHHHHHHHCCCCC
>Mature Secondary Structure 
TERTLRILVGKPGLDGHDRGAKVVARAFRDAGFEVIYTGLHQTPEQIASSAIQEDVDAV
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCHHEEHHCCCCCHHHHHHHHHHHHHHHH
GLSILSGAHNSLLPRVCQLLKEKGADDIIVFGGGVIPEDDIPGLKGAGVSEVFTPGTSTE
HHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCHHCCCCCCHH
DIVKWVRENVAPRA
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9889346; 11481431 [H]