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The map label for this gene is apt

Identifier: 39996626

GI number: 39996626

Start: 1672285

End: 1672800

Strand: Direct

Name: apt

Synonym: GSU1526

Alternate gene names: 39996626

Gene position: 1672285-1672800 (Clockwise)

Preceding gene: 39996625

Following gene: 39996627

Centisome position: 43.84

GC content: 57.95

Gene sequence:

>516_bases
ATGGATGAGCTGAAAAACATAATCCGCGACGTACCCGATTTCCCCAAAAAGGGGATCATCTTCAAGGACATTACCACGCT
ACTGGCGGACGCCCCGTCGTTCCAGCGTATGGTTGACCTGATCGCGCATCGCTATGTAGGGAAGAAGATCAGCAAGGTTG
TTGTGGTGGAAGCCCGCGGATTCGTCATCGGCGCCGCCCTGGCTTACAAGCTGGGTGCCGGCGTGGTCCTGGTGCGCAAG
CCGGGCAAACTCCCCTCAGAAACCTATAGCAAAACCTATCAGCTCGAATACGGCTCCGACACGCTGGAGATCCATACCGA
CGCCATTGCCAAGGGAGAGCGGGTGATCATCGCCGACGACATCCTCGCCACCGGCGGTACCATGGCGGCGGTGGTCGACA
TGGTCGAGGCGCTGGGGGGAGAGATTGTCGAGTGCTGTTTTATGGCCGAGCTCGAATTCCTCGGGGGCAGAAAGAGGTTG
CCCGAAGGAAAGGTTTACTCGCTTCTCACCTTCTAG

Upstream 100 bases:

>100_bases
GAGGCCAAGTCTCTGGAAAAATTGAGAAAGTATATTGAGGAAAGCGATGGCAACGCCATCGATTGAGCCGGCTTGATGCC
ATCACGGAGGGGGAAGAAGC

Downstream 100 bases:

>100_bases
CACCACCGGGGAAAGGGCTTGAAAATGCGCCCCGGATAGGCTATAAAAAATTCTCTTTTGTCCCCGTAGCTCAGCAGGAT
AGAGCACTTCCCTCCTAAGG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MDELKNIIRDVPDFPKKGIIFKDITTLLADAPSFQRMVDLIAHRYVGKKISKVVVVEARGFVIGAALAYKLGAGVVLVRK
PGKLPSETYSKTYQLEYGSDTLEIHTDAIAKGERVIIADDILATGGTMAAVVDMVEALGGEIVECCFMAELEFLGGRKRL
PEGKVYSLLTF

Sequences:

>Translated_171_residues
MDELKNIIRDVPDFPKKGIIFKDITTLLADAPSFQRMVDLIAHRYVGKKISKVVVVEARGFVIGAALAYKLGAGVVLVRK
PGKLPSETYSKTYQLEYGSDTLEIHTDAIAKGERVIIADDILATGGTMAAVVDMVEALGGEIVECCFMAELEFLGGRKRL
PEGKVYSLLTF
>Mature_171_residues
MDELKNIIRDVPDFPKKGIIFKDITTLLADAPSFQRMVDLIAHRYVGKKISKVVVVEARGFVIGAALAYKLGAGVVLVRK
PGKLPSETYSKTYQLEYGSDTLEIHTDAIAKGERVIIADDILATGGTMAAVVDMVEALGGEIVECCFMAELEFLGGRKRL
PEGKVYSLLTF

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=167, Percent_Identity=43.1137724550898, Blast_Score=144, Evalue=4e-35,
Organism=Homo sapiens, GI71773201, Length=121, Percent_Identity=45.4545454545455, Blast_Score=112, Evalue=1e-25,
Organism=Escherichia coli, GI1786675, Length=173, Percent_Identity=50.2890173410405, Blast_Score=175, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17509087, Length=171, Percent_Identity=39.766081871345, Blast_Score=123, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6323619, Length=173, Percent_Identity=42.7745664739884, Blast_Score=126, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320649, Length=171, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17136334, Length=173, Percent_Identity=39.8843930635838, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_GEOSL (Q74CZ3)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_952577.1
- ProteinModelPortal:   Q74CZ3
- SMR:   Q74CZ3
- GeneID:   2687684
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU1526
- NMPDR:   fig|243231.1.peg.1515
- TIGR:   GSU1526
- HOGENOM:   HBG703830
- OMA:   YVLVESH
- ProtClustDB:   PRK02304
- BioCyc:   GSUL243231:GSU_1526-MONOMER
- BRENDA:   2.4.2.7
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18652; Mature: 18652

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDELKNIIRDVPDFPKKGIIFKDITTLLADAPSFQRMVDLIAHRYVGKKISKVVVVEARG
CHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEEECCC
FVIGAALAYKLGAGVVLVRKPGKLPSETYSKTYQLEYGSDTLEIHTDAIAKGERVIIADD
EEHHHHHHHHHCCCEEEEECCCCCCCHHHCEEEEEEECCCEEEEEHHHHCCCCEEEEECC
ILATGGTMAAVVDMVEALGGEIVECCFMAELEFLGGRKRLPEGKVYSLLTF
HHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MDELKNIIRDVPDFPKKGIIFKDITTLLADAPSFQRMVDLIAHRYVGKKISKVVVVEARG
CHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEEECCC
FVIGAALAYKLGAGVVLVRKPGKLPSETYSKTYQLEYGSDTLEIHTDAIAKGERVIIADD
EEHHHHHHHHHCCCEEEEECCCCCCCHHHCEEEEEEECCCEEEEEHHHHCCCCEEEEECC
ILATGGTMAAVVDMVEALGGEIVECCFMAELEFLGGRKRLPEGKVYSLLTF
HHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA