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The map label for this gene is rnr [H]

Identifier: 39996585

GI number: 39996585

Start: 1626769

End: 1629060

Strand: Direct

Name: rnr [H]

Synonym: GSU1485

Alternate gene names: 39996585

Gene position: 1626769-1629060 (Clockwise)

Preceding gene: 39996579

Following gene: 39996586

Centisome position: 42.65

GC content: 62.52

Gene sequence:

>2292_bases
ATGAAACGGAAACGGGAGGAAGTCCTCGCGTTCATCCGCGAGCAAGGGGGCAGCACCCCCTTCAGGGACATGATGCAGGC
CTTTGGCGTAACCAAGGCCAATCGGCTGGGATTCAAGCAGTTCGTGGACCAACTGGTGTCGGCGGGCGATCTGGTGAAAC
AGCGCGGCAACCGCTACGCCGTCCCGTCAGAGGAAACCGTCGTCCGGGGGCGTCTTGTCACTCATCGCGAGGGATACGGC
TTCGTGGTTCCCGAGGGGGGAGGAGACGACGTCTACGTCCCGGCCCGATACCTGGGGGGAAACCTCCACGGGGATGTGGT
TGAAGTCCGGGTTGAATCCTTTAAGCGTGGAGGGAAGAAGGAAGGGCGGATTATCCGGACCATCGAACGGGGGCTCAAGC
GGATCGTCGGCCGATTCGACACCGCCGGCGGGGTGGGGTTCGTCCAGCCGGACGACACCCGCATCACCCGGGATATCGCG
GTTCCCCAAAAAGCATGGGGGGGGGCCCGCAGCGGTCAGGTGGTAGTGGCGGAGCTTACGGCCTGGCCCACGGAGCGGAA
GAAGGCGGAGGGGCGCATCGTGGAAGTGTTGGGCTCTCCCGACGACCCCGAGGTTGAGGTCCTCACCATTATCCGCAAGC
ATGACCTTCCCTATGAATTTCCCGTAGACGTACTGACTGAGGCCCGTTCCACTCCGCAGGAGGTGCGCAGGGGGGACGTG
GCCAAACGGGTGGATCTGCGGGAGCGGCTTACCGTCACCATTGACGGCGAGACGGCCCGGGATTTCGATGACGCGGTATC
CGTGCAGCGGGAAAAGGGGGGCGACATCCGCCTCTGGGTCTCCATCGCCGATGTGTCCCACTACGTGAAACCGGGATCTG
CCCTGGACCGTGAAGCCTACCTGCGGGGAACCTCTGTCTATTTCCCCGATCGCTGTATCCCCATGCTGCCCGAGGAACTT
TCCAACGGCATCTGTTCGCTCAATCCCCAGGTGGAGCGCCTGACGCTCACGGCCGAGATGCTGTTCACCCGAAGCGGGGC
CATTAAGTCCTCGTCGTTCTATCCGAGCGTGATCAGGAGCGCCGCACGGCTCACCTATACGACGGTCCGCAAGGTGCTCG
TAGACGGCGATCCGGAGGCAATCAAGGCCAACCGTCACCTGGTAGACGACCTTGAAGTAATGAAGGAGTTGGCGCTGCGC
CTCATGGAGAAGCGGAAAAAACGCGGCAGCATCGACTTCGACCTGCCCGAGCCGCAGATCGTCCTGGATCTCCAGGGGGA
GATGGTGGATATCATCCGGTCCGAGCGCAACCTTGCCCACCGGATCATTGAAGAGTTCATGCTGGCGGCCAACGAGGCGG
TGGCGTCCCATATCGAGGAGCGGGGAATACCCTCTCTCTATCGGGTTCACGAACCGCCCGACCCGACCAAGCTGACCGAC
TTCCGGGAGTTCATTTTCAATTTCGGCTATGCCTTCCGGATGGATGGCGACCGGGTCGACCCCCACGAACTTCAGCGGCT
CATCGACGAAGCCGAGGGAAAGCCCGAGGAGCGGATGATCAACGAGGTGCTCCTGCGGTGCATGAAGCAGGCCCGCTACA
GCCACGAAAACTTGGGGCATTTCGGCCTGGCGGCCCGTTGCTACACCCATTTCACCTCCCCCATCCGCCGTTATCCCGAC
CTGGTTGTGCACCGCATTCTCAAGGACATTCTCGCCGGGGCCATGACTGAGAAGGAACAGGAGCGCCTGGCCGCCGCCCT
GCCGGAGACGGCCGAGCAGACGAGTCGCCGGGAGCGTCTCGCAATGGAGGCTGAACGGGAGATCGTGGCGCTCAAGAAGG
CCCAATTTATGAAGGAGCGGGTCGGCGAAACCTTTGAGGGCTATATCACCGGGGTAAGCTCCTTCGGCTTTTTCGTGGAG
CTGATCGATCTGTTTGTCGAGGGGATGGTTCATGTCTCTACCCTGGCCAATGACTTTTACCGTTACGAGGAGAAACGGCA
CTCGCTGGTGGGAGAACGGACAAAGGAGACCTTCAGGATCGGCGACAGGGTCAGCGTTCTGGTGGCTGCGGTGAGCATTG
AGCGGCGGCAGGTGGAGTTCGTTCTCGCGGGTCTCCACGAAGTCCGGCCGGGCTCGGCGGAAAGGACGTCGGCGACGGAG
GAGTATCCGCGGATACCGGTCAGGGGTAAGCGACCCAAGGCTCTTCAGGCACCCCGGGGCAAGGGGGGAGGGCGCGGCCG
TGGTTCCGGGGAGAAGCGTACGGGGGGCAAAGGTGGCCGCCCCAAACGGTGA

Upstream 100 bases:

>100_bases
GCAAAGGGTTTTTCAGTGATTGCGCCCGTATACGGATTGACTTTGCCGTGAAACTGCATGCATAGTAGCCGTGGCGTACA
GCCGGGAGAGGGGACGGATG

Downstream 100 bases:

>100_bases
CATTTGCCGGATACGCCATCCGTCCGCTTTACTCAAGTTGTCGCGCTGTGCTAATGTCTATCGGTTAAACCACGTACGTT
AAGGTAGAGGTGACATGTCA

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 763; Mature: 763

Protein sequence:

>763_residues
MKRKREEVLAFIREQGGSTPFRDMMQAFGVTKANRLGFKQFVDQLVSAGDLVKQRGNRYAVPSEETVVRGRLVTHREGYG
FVVPEGGGDDVYVPARYLGGNLHGDVVEVRVESFKRGGKKEGRIIRTIERGLKRIVGRFDTAGGVGFVQPDDTRITRDIA
VPQKAWGGARSGQVVVAELTAWPTERKKAEGRIVEVLGSPDDPEVEVLTIIRKHDLPYEFPVDVLTEARSTPQEVRRGDV
AKRVDLRERLTVTIDGETARDFDDAVSVQREKGGDIRLWVSIADVSHYVKPGSALDREAYLRGTSVYFPDRCIPMLPEEL
SNGICSLNPQVERLTLTAEMLFTRSGAIKSSSFYPSVIRSAARLTYTTVRKVLVDGDPEAIKANRHLVDDLEVMKELALR
LMEKRKKRGSIDFDLPEPQIVLDLQGEMVDIIRSERNLAHRIIEEFMLAANEAVASHIEERGIPSLYRVHEPPDPTKLTD
FREFIFNFGYAFRMDGDRVDPHELQRLIDEAEGKPEERMINEVLLRCMKQARYSHENLGHFGLAARCYTHFTSPIRRYPD
LVVHRILKDILAGAMTEKEQERLAAALPETAEQTSRRERLAMEAEREIVALKKAQFMKERVGETFEGYITGVSSFGFFVE
LIDLFVEGMVHVSTLANDFYRYEEKRHSLVGERTKETFRIGDRVSVLVAAVSIERRQVEFVLAGLHEVRPGSAERTSATE
EYPRIPVRGKRPKALQAPRGKGGGRGRGSGEKRTGGKGGRPKR

Sequences:

>Translated_763_residues
MKRKREEVLAFIREQGGSTPFRDMMQAFGVTKANRLGFKQFVDQLVSAGDLVKQRGNRYAVPSEETVVRGRLVTHREGYG
FVVPEGGGDDVYVPARYLGGNLHGDVVEVRVESFKRGGKKEGRIIRTIERGLKRIVGRFDTAGGVGFVQPDDTRITRDIA
VPQKAWGGARSGQVVVAELTAWPTERKKAEGRIVEVLGSPDDPEVEVLTIIRKHDLPYEFPVDVLTEARSTPQEVRRGDV
AKRVDLRERLTVTIDGETARDFDDAVSVQREKGGDIRLWVSIADVSHYVKPGSALDREAYLRGTSVYFPDRCIPMLPEEL
SNGICSLNPQVERLTLTAEMLFTRSGAIKSSSFYPSVIRSAARLTYTTVRKVLVDGDPEAIKANRHLVDDLEVMKELALR
LMEKRKKRGSIDFDLPEPQIVLDLQGEMVDIIRSERNLAHRIIEEFMLAANEAVASHIEERGIPSLYRVHEPPDPTKLTD
FREFIFNFGYAFRMDGDRVDPHELQRLIDEAEGKPEERMINEVLLRCMKQARYSHENLGHFGLAARCYTHFTSPIRRYPD
LVVHRILKDILAGAMTEKEQERLAAALPETAEQTSRRERLAMEAEREIVALKKAQFMKERVGETFEGYITGVSSFGFFVE
LIDLFVEGMVHVSTLANDFYRYEEKRHSLVGERTKETFRIGDRVSVLVAAVSIERRQVEFVLAGLHEVRPGSAERTSATE
EYPRIPVRGKRPKALQAPRGKGGGRGRGSGEKRTGGKGGRPKR
>Mature_763_residues
MKRKREEVLAFIREQGGSTPFRDMMQAFGVTKANRLGFKQFVDQLVSAGDLVKQRGNRYAVPSEETVVRGRLVTHREGYG
FVVPEGGGDDVYVPARYLGGNLHGDVVEVRVESFKRGGKKEGRIIRTIERGLKRIVGRFDTAGGVGFVQPDDTRITRDIA
VPQKAWGGARSGQVVVAELTAWPTERKKAEGRIVEVLGSPDDPEVEVLTIIRKHDLPYEFPVDVLTEARSTPQEVRRGDV
AKRVDLRERLTVTIDGETARDFDDAVSVQREKGGDIRLWVSIADVSHYVKPGSALDREAYLRGTSVYFPDRCIPMLPEEL
SNGICSLNPQVERLTLTAEMLFTRSGAIKSSSFYPSVIRSAARLTYTTVRKVLVDGDPEAIKANRHLVDDLEVMKELALR
LMEKRKKRGSIDFDLPEPQIVLDLQGEMVDIIRSERNLAHRIIEEFMLAANEAVASHIEERGIPSLYRVHEPPDPTKLTD
FREFIFNFGYAFRMDGDRVDPHELQRLIDEAEGKPEERMINEVLLRCMKQARYSHENLGHFGLAARCYTHFTSPIRRYPD
LVVHRILKDILAGAMTEKEQERLAAALPETAEQTSRRERLAMEAEREIVALKKAQFMKERVGETFEGYITGVSSFGFFVE
LIDLFVEGMVHVSTLANDFYRYEEKRHSLVGERTKETFRIGDRVSVLVAAVSIERRQVEFVLAGLHEVRPGSAERTSATE
EYPRIPVRGKRPKALQAPRGKGGGRGRGSGEKRTGGKGGRPKR

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=608, Percent_Identity=28.4539473684211, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI190014623, Length=608, Percent_Identity=28.6184210526316, Blast_Score=218, Evalue=2e-56,
Organism=Homo sapiens, GI134288890, Length=543, Percent_Identity=28.1767955801105, Blast_Score=176, Evalue=9e-44,
Organism=Homo sapiens, GI19115966, Length=576, Percent_Identity=28.125, Blast_Score=165, Evalue=2e-40,
Organism=Homo sapiens, GI219521928, Length=576, Percent_Identity=28.125, Blast_Score=165, Evalue=2e-40,
Organism=Homo sapiens, GI156105695, Length=359, Percent_Identity=26.4623955431755, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI156105693, Length=359, Percent_Identity=26.4623955431755, Blast_Score=83, Evalue=8e-16,
Organism=Escherichia coli, GI87082383, Length=661, Percent_Identity=43.5703479576399, Blast_Score=529, Evalue=1e-151,
Organism=Escherichia coli, GI1787542, Length=652, Percent_Identity=26.840490797546, Blast_Score=179, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI212645896, Length=504, Percent_Identity=30.5555555555556, Blast_Score=201, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI17553506, Length=526, Percent_Identity=29.6577946768061, Blast_Score=182, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6324552, Length=519, Percent_Identity=29.8651252408478, Blast_Score=197, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6320499, Length=525, Percent_Identity=25.3333333333333, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24649634, Length=562, Percent_Identity=30.0711743772242, Blast_Score=210, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24654592, Length=441, Percent_Identity=28.1179138321995, Blast_Score=153, Evalue=4e-37,
Organism=Drosophila melanogaster, GI19922976, Length=431, Percent_Identity=28.538283062645, Blast_Score=153, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24654597, Length=431, Percent_Identity=28.538283062645, Blast_Score=153, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 86023; Mature: 86023

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKREEVLAFIREQGGSTPFRDMMQAFGVTKANRLGFKQFVDQLVSAGDLVKQRGNRYA
CCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHCCCEEC
VPSEETVVRGRLVTHREGYGFVVPEGGGDDVYVPARYLGGNLHGDVVEVRVESFKRGGKK
CCCCCHHHHCEEEEEECCCEEEEECCCCCCEEECHHHHCCCCCCHHHHHHHHHHHCCCCC
EGRIIRTIERGLKRIVGRFDTAGGVGFVQPDDTRITRDIAVPQKAWGGARSGQVVVAELT
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHCCCHHHCCCCCCCCEEEEEEC
AWPTERKKAEGRIVEVLGSPDDPEVEVLTIIRKHDLPYEFPVDVLTEARSTPQEVRRGDV
CCCCHHHHCCCCEEEEECCCCCCCCHHEEEEHHCCCCCCCCHHHHHHCCCCHHHHHHCHH
AKRVDLRERLTVTIDGETARDFDDAVSVQREKGGDIRLWVSIADVSHYVKPGSALDREAY
HHHHCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEEEHHHHHCCCCCCCCHHHH
LRGTSVYFPDRCIPMLPEELSNGICSLNPQVERLTLTAEMLFTRSGAIKSSSFYPSVIRS
HCCCCEECCCCCCCCCCHHHCCCEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
AARLTYTTVRKVLVDGDPEAIKANRHLVDDLEVMKELALRLMEKRKKRGSIDFDLPEPQI
HHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
VLDLQGEMVDIIRSERNLAHRIIEEFMLAANEAVASHIEERGIPSLYRVHEPPDPTKLTD
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCHHHH
FREFIFNFGYAFRMDGDRVDPHELQRLIDEAEGKPEERMINEVLLRCMKQARYSHENLGH
HHHHHHHCCEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
FGLAARCYTHFTSPIRRYPDLVVHRILKDILAGAMTEKEQERLAAALPETAEQTSRRERL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHH
AMEAEREIVALKKAQFMKERVGETFEGYITGVSSFGFFVELIDLFVEGMVHVSTLANDFY
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RYEEKRHSLVGERTKETFRIGDRVSVLVAAVSIERRQVEFVLAGLHEVRPGSAERTSATE
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
EYPRIPVRGKRPKALQAPRGKGGGRGRGSGEKRTGGKGGRPKR
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKRKREEVLAFIREQGGSTPFRDMMQAFGVTKANRLGFKQFVDQLVSAGDLVKQRGNRYA
CCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHCCCEEC
VPSEETVVRGRLVTHREGYGFVVPEGGGDDVYVPARYLGGNLHGDVVEVRVESFKRGGKK
CCCCCHHHHCEEEEEECCCEEEEECCCCCCEEECHHHHCCCCCCHHHHHHHHHHHCCCCC
EGRIIRTIERGLKRIVGRFDTAGGVGFVQPDDTRITRDIAVPQKAWGGARSGQVVVAELT
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHCCCHHHCCCCCCCCEEEEEEC
AWPTERKKAEGRIVEVLGSPDDPEVEVLTIIRKHDLPYEFPVDVLTEARSTPQEVRRGDV
CCCCHHHHCCCCEEEEECCCCCCCCHHEEEEHHCCCCCCCCHHHHHHCCCCHHHHHHCHH
AKRVDLRERLTVTIDGETARDFDDAVSVQREKGGDIRLWVSIADVSHYVKPGSALDREAY
HHHHCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEEEHHHHHCCCCCCCCHHHH
LRGTSVYFPDRCIPMLPEELSNGICSLNPQVERLTLTAEMLFTRSGAIKSSSFYPSVIRS
HCCCCEECCCCCCCCCCHHHCCCEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
AARLTYTTVRKVLVDGDPEAIKANRHLVDDLEVMKELALRLMEKRKKRGSIDFDLPEPQI
HHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
VLDLQGEMVDIIRSERNLAHRIIEEFMLAANEAVASHIEERGIPSLYRVHEPPDPTKLTD
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCHHHH
FREFIFNFGYAFRMDGDRVDPHELQRLIDEAEGKPEERMINEVLLRCMKQARYSHENLGH
HHHHHHHCCEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
FGLAARCYTHFTSPIRRYPDLVVHRILKDILAGAMTEKEQERLAAALPETAEQTSRRERL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHH
AMEAEREIVALKKAQFMKERVGETFEGYITGVSSFGFFVELIDLFVEGMVHVSTLANDFY
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RYEEKRHSLVGERTKETFRIGDRVSVLVAAVSIERRQVEFVLAGLHEVRPGSAERTSATE
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
EYPRIPVRGKRPKALQAPRGKGGGRGRGSGEKRTGGKGGRPKR
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]