Click here to switch to the map view.

The map label for this gene is glk

Identifier: 39996413

GI number: 39996413

Start: 1436894

End: 1438483

Strand: Reverse

Name: glk

Synonym: GSU1311

Alternate gene names: 39996413

Gene position: 1438483-1436894 (Counterclockwise)

Preceding gene: 39996414

Following gene: 39996412

Centisome position: 37.71

GC content: 65.97

Gene sequence:

>1590_bases
ATGAACGCCCATGAACTGTGGCAACGCTACCAGACCTATCTTCTTTTCGACGCGGACACGGGACTCATCCTTGATGTCAG
CAGAATGGCCTTCAGCGATGATTTCTTCGCCTCCATGGAGCCGGCCATGCAGCGCGCCTTCGACGCCATGGAACGGCTGG
AGGCGGGTGAGATCGCAAATCCGGACGAAAACCGGATGGTGGGGCACTATTGGCTCAGAAGTCCCGAACTGGCCCCCGAC
CCCGCTATCGCCGCCGCCATCAGGGAGACTGTTGATCGTGTAACGGCCTTTGCCGCTGATGTCCATAACGGGGTGGTGAC
GGCGCCCCGAGCCCGCCTCTTCCGCAACGTCCTGGTGATCGGCATCGGCGGCTCAGCCTTGGGGCCACAGTTCGTGGCAG
ATGCCCTGGGCGGCCACGGCGACCGGATGCGGCCCTTCTTCTTCGACAACACCGACCCTGACGGCATGGACCGGGTACTT
GAGACCCTCGGAGCGGATGGGCTGGCGGAAACCCTTGCCATCGTCATCTCCAAGAGCGGCGGCACCAAGGAAACGAGGAA
CGGCATGCTTGAGGCGGAGGCGGCCTACCGGCGTGCCGGGCTCGACTTTTCCCGTCATGCCGTGGCAGTCACCGGCGCCG
GCAGCGAGCTGGACCGGACCGCCGAGGCCGGCGGCTGGCTGTGCCGCTTCCCCATGTGGGACTGGGTCGGCGGCCGCACC
TCGGAGACCTCGGCCGTGGGACTCCTGCCGGCCGCGCTCCAGGGAATCCCCATCAGAGACTTCCTCGATGGCGCCCGGAC
CTGCGACACACTGACTCGCCGGCGCGAGACGCTCCGCAATCCGGCGGCCCTCCTGGCCCTCATGTGGCATCACGCCACCC
GGGGCAGCGGCTCCCGCGACATGGTGGTGCTCCCCTACAAGGATCGCCTGCTCCTCTTCTCCCGCTACCTCCAGCAACTC
ATCATGGAATCCATCGGCAAGGAGCTGGATCTGGACGGCACCGTGGTGAACCAGGGGCTCACGGTCTACGGCAACAAGGG
CTCCACGGATCAGCACGCCTACGTGCAGCAGTTGCGTGAGGGGACCAACAACTTCTTCGTCGCTTTCATCGAGGTGCTGA
AGGATCGCGAGGGGGCCTCCCTGGCGGTTGAGCCGGGCTTCACCAGCGGCGACTACCTGTCCGGCTTCCTTCAGGGGACC
CGCACCGCCCTGAGCGAAAAGGGACGCGAGTCACTCACCATCACCATTCCCGCCATAACCCCACGCACGGTGGGTGTCCT
GGTGGCCCTCTTCGAGCGGGCCGTGGGGCTCTATGCCTCCCTGGTCAACATCAACGCCTACCACCAGCCCGGCGTGGAGG
CGGGGAAAAAGGCGGCAGGCGGCGTCCTGGCCCTCACGGGCGAGGCACTGGCATTCCTGCGACGGGAAGGGGGCACCCTT
TCCGCCACGGAGATCGCCGCGGCACTGGGCAGGCCGGAAGAGGCGGAAACGATATTCAGAAGCCTCCTGCACGCCGCCGC
CAACCCGGACCACGGTGTCGTCATGGAAGCGGCATCCCCTCTTACCCGGAGCCGCTTTTCCGCCCGATGA

Upstream 100 bases:

>100_bases
GATTACTGTTATGCCTGCACCGCCGGTTCCGGTTTCACCTGAGGCGGCGCCATCGGAGCCCCGGAGGGGCCCGGAACACC
ATGAAGACCGGAGGAGTCCA

Downstream 100 bases:

>100_bases
ACGGCCGCGCCGCCCGGCACCTGATACTGGTAGGCGGAGGGCATGCCCATCTCCATACCCTCCGGCGCCTCCGGGAGCTT
ACCGGAGCGGGCATCGCCGT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MNAHELWQRYQTYLLFDADTGLILDVSRMAFSDDFFASMEPAMQRAFDAMERLEAGEIANPDENRMVGHYWLRSPELAPD
PAIAAAIRETVDRVTAFAADVHNGVVTAPRARLFRNVLVIGIGGSALGPQFVADALGGHGDRMRPFFFDNTDPDGMDRVL
ETLGADGLAETLAIVISKSGGTKETRNGMLEAEAAYRRAGLDFSRHAVAVTGAGSELDRTAEAGGWLCRFPMWDWVGGRT
SETSAVGLLPAALQGIPIRDFLDGARTCDTLTRRRETLRNPAALLALMWHHATRGSGSRDMVVLPYKDRLLLFSRYLQQL
IMESIGKELDLDGTVVNQGLTVYGNKGSTDQHAYVQQLREGTNNFFVAFIEVLKDREGASLAVEPGFTSGDYLSGFLQGT
RTALSEKGRESLTITIPAITPRTVGVLVALFERAVGLYASLVNINAYHQPGVEAGKKAAGGVLALTGEALAFLRREGGTL
SATEIAAALGRPEEAETIFRSLLHAAANPDHGVVMEAASPLTRSRFSAR

Sequences:

>Translated_529_residues
MNAHELWQRYQTYLLFDADTGLILDVSRMAFSDDFFASMEPAMQRAFDAMERLEAGEIANPDENRMVGHYWLRSPELAPD
PAIAAAIRETVDRVTAFAADVHNGVVTAPRARLFRNVLVIGIGGSALGPQFVADALGGHGDRMRPFFFDNTDPDGMDRVL
ETLGADGLAETLAIVISKSGGTKETRNGMLEAEAAYRRAGLDFSRHAVAVTGAGSELDRTAEAGGWLCRFPMWDWVGGRT
SETSAVGLLPAALQGIPIRDFLDGARTCDTLTRRRETLRNPAALLALMWHHATRGSGSRDMVVLPYKDRLLLFSRYLQQL
IMESIGKELDLDGTVVNQGLTVYGNKGSTDQHAYVQQLREGTNNFFVAFIEVLKDREGASLAVEPGFTSGDYLSGFLQGT
RTALSEKGRESLTITIPAITPRTVGVLVALFERAVGLYASLVNINAYHQPGVEAGKKAAGGVLALTGEALAFLRREGGTL
SATEIAAALGRPEEAETIFRSLLHAAANPDHGVVMEAASPLTRSRFSAR
>Mature_529_residues
MNAHELWQRYQTYLLFDADTGLILDVSRMAFSDDFFASMEPAMQRAFDAMERLEAGEIANPDENRMVGHYWLRSPELAPD
PAIAAAIRETVDRVTAFAADVHNGVVTAPRARLFRNVLVIGIGGSALGPQFVADALGGHGDRMRPFFFDNTDPDGMDRVL
ETLGADGLAETLAIVISKSGGTKETRNGMLEAEAAYRRAGLDFSRHAVAVTGAGSELDRTAEAGGWLCRFPMWDWVGGRT
SETSAVGLLPAALQGIPIRDFLDGARTCDTLTRRRETLRNPAALLALMWHHATRGSGSRDMVVLPYKDRLLLFSRYLQQL
IMESIGKELDLDGTVVNQGLTVYGNKGSTDQHAYVQQLREGTNNFFVAFIEVLKDREGASLAVEPGFTSGDYLSGFLQGT
RTALSEKGRESLTITIPAITPRTVGVLVALFERAVGLYASLVNINAYHQPGVEAGKKAAGGVLALTGEALAFLRREGGTL
SATEIAAALGRPEEAETIFRSLLHAAANPDHGVVMEAASPLTRSRFSAR

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=493, Percent_Identity=28.3975659229209, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI296080693, Length=493, Percent_Identity=26.369168356998, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1790457, Length=499, Percent_Identity=28.2565130260521, Blast_Score=142, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71996703, Length=487, Percent_Identity=27.3100616016427, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71996708, Length=487, Percent_Identity=27.3100616016427, Blast_Score=132, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6319673, Length=489, Percent_Identity=26.1758691206544, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24651916, Length=497, Percent_Identity=27.9678068410463, Blast_Score=147, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24651914, Length=497, Percent_Identity=27.9678068410463, Blast_Score=147, Evalue=3e-35,
Organism=Drosophila melanogaster, GI17737445, Length=497, Percent_Identity=27.9678068410463, Blast_Score=147, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_GEOSL (Q74DK5)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_952364.1
- ProteinModelPortal:   Q74DK5
- SMR:   Q74DK5
- GeneID:   2686480
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU1311
- NMPDR:   fig|243231.1.peg.1302
- TIGR:   GSU1311
- HOGENOM:   HBG285902
- OMA:   RTSITSA
- ProtClustDB:   PRK14096
- BioCyc:   GSUL243231:GSU_1311-MONOMER
- BRENDA:   5.3.1.9
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR018189
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 57260; Mature: 57260

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 323-323 ACT_SITE 352-352 ACT_SITE 456-456

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAHELWQRYQTYLLFDADTGLILDVSRMAFSDDFFASMEPAMQRAFDAMERLEAGEIAN
CCHHHHHHHHHEEEEEECCCCEEEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
PDENRMVGHYWLRSPELAPDPAIAAAIRETVDRVTAFAADVHNGVVTAPRARLFRNVLVI
CCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCEEEE
GIGGSALGPQFVADALGGHGDRMRPFFFDNTDPDGMDRVLETLGADGLAETLAIVISKSG
EECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHEECCC
GTKETRNGMLEAEAAYRRAGLDFSRHAVAVTGAGSELDRTAEAGGWLCRFPMWDWVGGRT
CCCHHHCCCHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHCCCCEEECCCHHCCCCCC
SETSAVGLLPAALQGIPIRDFLDGARTCDTLTRRRETLRNPAALLALMWHHATRGSGSRD
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCC
MVVLPYKDRLLLFSRYLQQLIMESIGKELDLDGTVVNQGLTVYGNKGSTDQHAYVQQLRE
EEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCEEEECCCCCCHHHHHHHHHHH
GTNNFFVAFIEVLKDREGASLAVEPGFTSGDYLSGFLQGTRTALSEKGRESLTITIPAIT
CCCHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
PRTVGVLVALFERAVGLYASLVNINAYHQPGVEAGKKAAGGVLALTGEALAFLRREGGTL
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCHHHCCCEEEEHHHHHHHHHHCCCCC
SATEIAAALGRPEEAETIFRSLLHAAANPDHGVVMEAASPLTRSRFSAR
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHCCCC
>Mature Secondary Structure
MNAHELWQRYQTYLLFDADTGLILDVSRMAFSDDFFASMEPAMQRAFDAMERLEAGEIAN
CCHHHHHHHHHEEEEEECCCCEEEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
PDENRMVGHYWLRSPELAPDPAIAAAIRETVDRVTAFAADVHNGVVTAPRARLFRNVLVI
CCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCEEEE
GIGGSALGPQFVADALGGHGDRMRPFFFDNTDPDGMDRVLETLGADGLAETLAIVISKSG
EECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHEECCC
GTKETRNGMLEAEAAYRRAGLDFSRHAVAVTGAGSELDRTAEAGGWLCRFPMWDWVGGRT
CCCHHHCCCHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHCCCCEEECCCHHCCCCCC
SETSAVGLLPAALQGIPIRDFLDGARTCDTLTRRRETLRNPAALLALMWHHATRGSGSRD
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCC
MVVLPYKDRLLLFSRYLQQLIMESIGKELDLDGTVVNQGLTVYGNKGSTDQHAYVQQLRE
EEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCEEEECCCCCCHHHHHHHHHHH
GTNNFFVAFIEVLKDREGASLAVEPGFTSGDYLSGFLQGTRTALSEKGRESLTITIPAIT
CCCHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
PRTVGVLVALFERAVGLYASLVNINAYHQPGVEAGKKAAGGVLALTGEALAFLRREGGTL
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCHHHCCCEEEEHHHHHHHHHHCCCCC
SATEIAAALGRPEEAETIFRSLLHAAANPDHGVVMEAASPLTRSRFSAR
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA