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The map label for this gene is gdh [H]

Identifier: 39996407

GI number: 39996407

Start: 1430144

End: 1431496

Strand: Reverse

Name: gdh [H]

Synonym: GSU1305

Alternate gene names: 39996407

Gene position: 1431496-1430144 (Counterclockwise)

Preceding gene: 39996412

Following gene: 39996390

Centisome position: 37.53

GC content: 61.64

Gene sequence:

>1353_bases
ATGTCACCGCATCAAGTCGACGAGAAACTTCAGGGCATCTATCAGGACGTTCTCAAGCGCAACCCGGGCGAAGTGGAATT
CCACCAGGCAGTGGCCGAGGTGCTCGAATCCCTCGGCCCCGTCGTCACCAAGCACCCCGAATACCTGGAGCGCAAGATCA
TCGAGCGGATCTGCGAACCCGAACGCCAGATCATCTTCCGGGTACCCTGGCAGGACGACAAAGGCCAAGTCCACATCAAC
CGCGGCTTCCGCGTGGAGTTCAACTCGGCCCTCGGTCCCTACAAGGGCGGCCTCCGCTTCCATCCGTCGGTCTACCTGGG
CATTATCAAGTTCCTGGGCTTCGAGCAGATCTTCAAGAACTCCCTCACCGGCATGCCCATCGGCGGCGGCAAGGGGGGTT
CCGACTTCGACCCCAAAGGAAGGTCCGATGATGAGATCATGCGTTTCTGCCAGAGCTTCATCACCGAGCTCTACCGCCAC
CTGGGCGAGCACACCGACGTTCCCGCCGGCGACATCGGCGTGGGCGGCCGCGAGATCGGCTACATGTTCGGCCAGTACAA
GCGGATCACCAACCGGTGGGAAGCGGGCGTGCTGACCGGCAAGGGGCTCAAGTGGGGCGGCTCCCTCGTGCGTACCGAGG
CCACCGGCTACGGCGCAACCTTCTTCATCAACGAGGCCCTCAAGGTCCGCAAGGATTCCTTTGACGGCAAGATCTGCACC
GTGTCCGGTTCCGGCAACGTGGCCATCTACACCATCGAGAAGATTCACCAACTGGGCGGCAAGTGCGTGGCCTGCTCCGA
CTCCAACGGCGTCATTTTCCACGAAAAAGGTCTCGACCTGGACCTCATCAAGCAGCTGAAGGAAGTGGAGCGTCGCCGCA
TTGAGGACTACGCCTCCTATCACAAGGATGCCAAGTACATCGCGGGCGGCAACATCTGGGACATCCCCTGCCAGGTAGCC
ATGCCGTCGGCAACCCAGAACGAGATCAACGGCAAGGATGCCAAGACCCTGGTGAAGAACGGCTGCATCGCCGTGGGCGA
AGGCGCCAACATGCCCACCACCCCCGAAGGGGTCAAGGTATTTCTCGACGCCAAGATTGCCTACGGCCCCGGCAAGGCTG
CCAACGCAGGCGGCGTCGCAACGTCGGCCCTGGAAATGCAGCAGAACGCCCAGCGCGATTCCTGGTCGTTCGAAGACACC
GAGAAGAAGCTTGAGAACATCATGAAGGGCATCCACCGTCTCTGCCACGAGACCGCCGAGGAATACGGCGCCACCGGCAA
CTACGTGCTCGGCGCCAACATCGCCGGCTTCACCAAGGTTGCCGATGCCATGGTGGCCCACGGCCTCGTCTAA

Upstream 100 bases:

>100_bases
TGGTGCAGTACGTGCATAAAATGCAGGCAATCTACTCAGAGAGACAGGACGCAATCTGTTCACACAGTTGACTGTCTACA
TTTTAATCAGGGGAGGAATC

Downstream 100 bases:

>100_bases
CAGCCTGGAAGCAACCAGGCAGCCCCATGCAAAAAGCCCGGTCCGGAGATGATCTCCGGGCCGGGCTTTTTCGTTCAGAC
GGCTGGCGCCCACGGTCCAT

Product: glutamate dehydrogenase

Products: NA

Alternate protein names: NADP-GDH [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MSPHQVDEKLQGIYQDVLKRNPGEVEFHQAVAEVLESLGPVVTKHPEYLERKIIERICEPERQIIFRVPWQDDKGQVHIN
RGFRVEFNSALGPYKGGLRFHPSVYLGIIKFLGFEQIFKNSLTGMPIGGGKGGSDFDPKGRSDDEIMRFCQSFITELYRH
LGEHTDVPAGDIGVGGREIGYMFGQYKRITNRWEAGVLTGKGLKWGGSLVRTEATGYGATFFINEALKVRKDSFDGKICT
VSGSGNVAIYTIEKIHQLGGKCVACSDSNGVIFHEKGLDLDLIKQLKEVERRRIEDYASYHKDAKYIAGGNIWDIPCQVA
MPSATQNEINGKDAKTLVKNGCIAVGEGANMPTTPEGVKVFLDAKIAYGPGKAANAGGVATSALEMQQNAQRDSWSFEDT
EKKLENIMKGIHRLCHETAEEYGATGNYVLGANIAGFTKVADAMVAHGLV

Sequences:

>Translated_450_residues
MSPHQVDEKLQGIYQDVLKRNPGEVEFHQAVAEVLESLGPVVTKHPEYLERKIIERICEPERQIIFRVPWQDDKGQVHIN
RGFRVEFNSALGPYKGGLRFHPSVYLGIIKFLGFEQIFKNSLTGMPIGGGKGGSDFDPKGRSDDEIMRFCQSFITELYRH
LGEHTDVPAGDIGVGGREIGYMFGQYKRITNRWEAGVLTGKGLKWGGSLVRTEATGYGATFFINEALKVRKDSFDGKICT
VSGSGNVAIYTIEKIHQLGGKCVACSDSNGVIFHEKGLDLDLIKQLKEVERRRIEDYASYHKDAKYIAGGNIWDIPCQVA
MPSATQNEINGKDAKTLVKNGCIAVGEGANMPTTPEGVKVFLDAKIAYGPGKAANAGGVATSALEMQQNAQRDSWSFEDT
EKKLENIMKGIHRLCHETAEEYGATGNYVLGANIAGFTKVADAMVAHGLV
>Mature_449_residues
SPHQVDEKLQGIYQDVLKRNPGEVEFHQAVAEVLESLGPVVTKHPEYLERKIIERICEPERQIIFRVPWQDDKGQVHINR
GFRVEFNSALGPYKGGLRFHPSVYLGIIKFLGFEQIFKNSLTGMPIGGGKGGSDFDPKGRSDDEIMRFCQSFITELYRHL
GEHTDVPAGDIGVGGREIGYMFGQYKRITNRWEAGVLTGKGLKWGGSLVRTEATGYGATFFINEALKVRKDSFDGKICTV
SGSGNVAIYTIEKIHQLGGKCVACSDSNGVIFHEKGLDLDLIKQLKEVERRRIEDYASYHKDAKYIAGGNIWDIPCQVAM
PSATQNEINGKDAKTLVKNGCIAVGEGANMPTTPEGVKVFLDAKIAYGPGKAANAGGVATSALEMQQNAQRDSWSFEDTE
KKLENIMKGIHRLCHETAEEYGATGNYVLGANIAGFTKVADAMVAHGLV

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=358, Percent_Identity=30.7262569832402, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI4885281, Length=358, Percent_Identity=30.7262569832402, Blast_Score=154, Evalue=1e-37,
Organism=Escherichia coli, GI1788059, Length=443, Percent_Identity=53.2731376975169, Blast_Score=479, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17544676, Length=361, Percent_Identity=26.3157894736842, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324951, Length=454, Percent_Identity=49.1189427312775, Blast_Score=401, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6319256, Length=456, Percent_Identity=48.2456140350877, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI45553475, Length=420, Percent_Identity=27.8571428571429, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI45549226, Length=420, Percent_Identity=27.8571428571429, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24649283, Length=449, Percent_Identity=27.6169265033408, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24649460, Length=320, Percent_Identity=28.75, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.4 [H]

Molecular weight: Translated: 49451; Mature: 49320

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPHQVDEKLQGIYQDVLKRNPGEVEFHQAVAEVLESLGPVVTKHPEYLERKIIERICEP
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHCCC
ERQIIFRVPWQDDKGQVHINRGFRVEFNSALGPYKGGLRFHPSVYLGIIKFLGFEQIFKN
CCEEEEECCCCCCCCEEEECCCEEEEECCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHC
SLTGMPIGGGKGGSDFDPKGRSDDEIMRFCQSFITELYRHLGEHTDVPAGDIGVGGREIG
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
YMFGQYKRITNRWEAGVLTGKGLKWGGSLVRTEATGYGATFFINEALKVRKDSFDGKICT
HHHHHHHHHHHHHHCCEEECCCCCCCCCEEEEECCCCCEEEEEHHHHHHHHCCCCCEEEE
VSGSGNVAIYTIEKIHQLGGKCVACSDSNGVIFHEKGLDLDLIKQLKEVERRRIEDYASY
EECCCCEEEEEHHHHHHHCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
HKDAKYIAGGNIWDIPCQVAMPSATQNEINGKDAKTLVKNGCIAVGEGANMPTTPEGVKV
HCCCCEECCCCEEECCCEEECCCCCCCCCCCHHHHHHHHCCCEEECCCCCCCCCCCCEEE
FLDAKIAYGPGKAANAGGVATSALEMQQNAQRDSWSFEDTEKKLENIMKGIHRLCHETAE
EEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EYGATGNYVLGANIAGFTKVADAMVAHGLV
HHCCCCCEEEECCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SPHQVDEKLQGIYQDVLKRNPGEVEFHQAVAEVLESLGPVVTKHPEYLERKIIERICEP
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHCCC
ERQIIFRVPWQDDKGQVHINRGFRVEFNSALGPYKGGLRFHPSVYLGIIKFLGFEQIFKN
CCEEEEECCCCCCCCEEEECCCEEEEECCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHC
SLTGMPIGGGKGGSDFDPKGRSDDEIMRFCQSFITELYRHLGEHTDVPAGDIGVGGREIG
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
YMFGQYKRITNRWEAGVLTGKGLKWGGSLVRTEATGYGATFFINEALKVRKDSFDGKICT
HHHHHHHHHHHHHHCCEEECCCCCCCCCEEEEECCCCCEEEEEHHHHHHHHCCCCCEEEE
VSGSGNVAIYTIEKIHQLGGKCVACSDSNGVIFHEKGLDLDLIKQLKEVERRRIEDYASY
EECCCCEEEEEHHHHHHHCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
HKDAKYIAGGNIWDIPCQVAMPSATQNEINGKDAKTLVKNGCIAVGEGANMPTTPEGVKV
HCCCCEECCCCEEECCCEEECCCCCCCCCCCHHHHHHHHCCCEEECCCCCCCCCCCCEEE
FLDAKIAYGPGKAANAGGVATSALEMQQNAQRDSWSFEDTEKKLENIMKGIHRLCHETAE
EEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EYGATGNYVLGANIAGFTKVADAMVAHGLV
HHCCCCCEEEECCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]