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The map label for this gene is tlpC [H]

Identifier: 39996405

GI number: 39996405

Start: 1426553

End: 1428037

Strand: Direct

Name: tlpC [H]

Synonym: GSU1303

Alternate gene names: 39996405

Gene position: 1426553-1428037 (Clockwise)

Preceding gene: 39996404

Following gene: 39996406

Centisome position: 37.4

GC content: 60.74

Gene sequence:

>1485_bases
ATGGGATTGCGCAACATGACTATCCGGTGGAAGCTCATTGCCATGACCGCGATAATCGTTGTTCTGACGGCAACGGTGAT
CACAGCCATTTGCCTTGCGCGGTTCAAGGCCGATCTGATGAGGGTTGCCACGGTTTCCCAGGAAACGCGGCTCAAGACTC
TCTGGGAACTGCTCCGTCAGAAGGGAGCCAACGCCCGGATCGACAATGGCAGGCTCATGGTCGGCGAGTACGTGGTAAAC
GACAACTTTGAGATTCCCGACAAGGTGAAGGATCTTTGCGGCGGGACGGCAACCATCTTCATGGGCGACCTGCGGGTTTC
CACCAACGTCAAGAAGGAGGACGGCAGCCGCGCCATCGGCACAAAGCTCCAGGGGCCCGCCTATGATACAATTTTCAAGC
AAGGGAAACCTTACCGCGGCGAAGCGAATATTCTCGGCGTTCCCTACTTTACGTCCTATGATCCGCTCCGGGATGCGAGC
GGTGCGATCATCGGCGTGCTGTACGTCGGCGTAAAGAAAAGTGAGTTCTTCGAATCTTACGATCGCCTCAAGCTGATCAT
CGTCGGCAGCGCAGTGGGCACGGTTCTGCTGGCGTGTCTTGTGGCCGGGTTCGTGTCGGGACGGCTCGTGCGCCCGCTGC
GCGACGCAGTTGCCACCGTAGACCGGCTGGCCACGGGCGATCTTTCCGTTGCCGTTGAAGCAAAGGGGACGGATGAGATC
GGTCGCCTGCTTGCCGCCATGGGCAATATGGTGAGCAAGCTCAGGGAGGTAGTCACCAGTGTCAAGTCTGCTTCGGACAA
CGTGGCCGCCGGTGCCCGCGAGCTGTCCGTAAGCGCCGAGGAGATGAGCGAGGGGGCCACCGAGCAGGCGGCAGCGGCAG
AGCAGGCGTCCGGCAACATGGAGGAGATGAGCGGTTCTATCAGACACACTGCCGATAATGCGGTCCAGACCGAGAAAATT
GCCGGCAAGAGCGCCGCGGATGCCCGCGAGGGAGGGGAGGCGGTTGCCGAGACCGTATCGGCCATGAAGGTTATCGCCGG
CAAGATCGCGATCATTGAAGAGATCGCCCGCCAGACGAATCTGCTGGCCCTGAACGCGGCCATCGAGGCGGCCCGGGCCG
GCGAGCACGGCAAGGGGTTCGCGGTGGTGGCCTCCGAGGTGCGCAAGCTGGCCGAACGGAGTCAGAAAGCTGCGGGAGAG
ATCGGTGAGTTGTCCGCATCCAGCGTGCGAATCGCGGAGAAGGCTGGAGAGATGCTTGCCCGCATGATTCCCGATATTCA
GCGGACCGCAGAACTGGTGCAGGAGATCAGCGCGGCGTGCAAGGAGCAGGATTCCGGCGCGGACCAGATTAACAGGGCCA
TCCAGCAACTGGACAACGTGATCCAGCAGAACGCCTCCACCAGCGAGGAAATGGCGTCCACCAGCGAAGAACTGGCGAGT
CAGGCCGAACAGCTCCAGGCAACCATAGCCTTTTTTAACATCTGA

Upstream 100 bases:

>100_bases
ACTGCTGTTGGTTCGGCATGGCCGTTAAATCATCGTTAAAGATGGGTGGCGGGCCGTCGAAAGATATCTCTAGCACATTG
TGAATGTTCGGGAGGTATGC

Downstream 100 bases:

>100_bases
GAAATTCCCCTGATAGGTGAGGTGATAAACCGCGGCGAGTGCCGCGGTTTTTTTATTATCTGTAAGTGTCAGTTTGTCGT
GTTGTTAGACCAATTGTTTT

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MGLRNMTIRWKLIAMTAIIVVLTATVITAICLARFKADLMRVATVSQETRLKTLWELLRQKGANARIDNGRLMVGEYVVN
DNFEIPDKVKDLCGGTATIFMGDLRVSTNVKKEDGSRAIGTKLQGPAYDTIFKQGKPYRGEANILGVPYFTSYDPLRDAS
GAIIGVLYVGVKKSEFFESYDRLKLIIVGSAVGTVLLACLVAGFVSGRLVRPLRDAVATVDRLATGDLSVAVEAKGTDEI
GRLLAAMGNMVSKLREVVTSVKSASDNVAAGARELSVSAEEMSEGATEQAAAAEQASGNMEEMSGSIRHTADNAVQTEKI
AGKSAADAREGGEAVAETVSAMKVIAGKIAIIEEIARQTNLLALNAAIEAARAGEHGKGFAVVASEVRKLAERSQKAAGE
IGELSASSVRIAEKAGEMLARMIPDIQRTAELVQEISAACKEQDSGADQINRAIQQLDNVIQQNASTSEEMASTSEELAS
QAEQLQATIAFFNI

Sequences:

>Translated_494_residues
MGLRNMTIRWKLIAMTAIIVVLTATVITAICLARFKADLMRVATVSQETRLKTLWELLRQKGANARIDNGRLMVGEYVVN
DNFEIPDKVKDLCGGTATIFMGDLRVSTNVKKEDGSRAIGTKLQGPAYDTIFKQGKPYRGEANILGVPYFTSYDPLRDAS
GAIIGVLYVGVKKSEFFESYDRLKLIIVGSAVGTVLLACLVAGFVSGRLVRPLRDAVATVDRLATGDLSVAVEAKGTDEI
GRLLAAMGNMVSKLREVVTSVKSASDNVAAGARELSVSAEEMSEGATEQAAAAEQASGNMEEMSGSIRHTADNAVQTEKI
AGKSAADAREGGEAVAETVSAMKVIAGKIAIIEEIARQTNLLALNAAIEAARAGEHGKGFAVVASEVRKLAERSQKAAGE
IGELSASSVRIAEKAGEMLARMIPDIQRTAELVQEISAACKEQDSGADQINRAIQQLDNVIQQNASTSEEMASTSEELAS
QAEQLQATIAFFNI
>Mature_493_residues
GLRNMTIRWKLIAMTAIIVVLTATVITAICLARFKADLMRVATVSQETRLKTLWELLRQKGANARIDNGRLMVGEYVVND
NFEIPDKVKDLCGGTATIFMGDLRVSTNVKKEDGSRAIGTKLQGPAYDTIFKQGKPYRGEANILGVPYFTSYDPLRDASG
AIIGVLYVGVKKSEFFESYDRLKLIIVGSAVGTVLLACLVAGFVSGRLVRPLRDAVATVDRLATGDLSVAVEAKGTDEIG
RLLAAMGNMVSKLREVVTSVKSASDNVAAGARELSVSAEEMSEGATEQAAAAEQASGNMEEMSGSIRHTADNAVQTEKIA
GKSAADAREGGEAVAETVSAMKVIAGKIAIIEEIARQTNLLALNAAIEAARAGEHGKGFAVVASEVRKLAERSQKAAGEI
GELSASSVRIAEKAGEMLARMIPDIQRTAELVQEISAACKEQDSGADQINRAIQQLDNVIQQNASTSEEMASTSEELASQ
AEQLQATIAFFNI

Specific function: Mediates Taxis To The Sugars Ribose And Galactose VIa An Interaction With The Periplasmic Ribose- Or Galactose-Binding Proteins. Chemotactic-Signal Transducers Respond To Changes In The Concentration Of Attractants And Repellents In The Environment, Trans

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=325, Percent_Identity=37.8461538461538, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI2367378, Length=332, Percent_Identity=36.4457831325301, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1788195, Length=272, Percent_Identity=38.9705882352941, Blast_Score=175, Evalue=5e-45,
Organism=Escherichia coli, GI1788194, Length=300, Percent_Identity=36.6666666666667, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI1789453, Length=357, Percent_Identity=30.2521008403361, Blast_Score=148, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 52548; Mature: 52416

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLRNMTIRWKLIAMTAIIVVLTATVITAICLARFKADLMRVATVSQETRLKTLWELLRQ
CCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGANARIDNGRLMVGEYVVNDNFEIPDKVKDLCGGTATIFMGDLRVSTNVKKEDGSRAIG
CCCCCEECCCEEEEEEEEECCCCCCCHHHHHHHCCCEEEEEECEEEECCCCCCCCCCHHC
TKLQGPAYDTIFKQGKPYRGEANILGVPYFTSYDPLRDASGAIIGVLYVGVKKSEFFESY
CCCCCCHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCCCEEEHHEECCCHHHHHHHH
DRLKLIIVGSAVGTVLLACLVAGFVSGRLVRPLRDAVATVDRLATGDLSVAVEAKGTDEI
CCEEEEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHH
GRLLAAMGNMVSKLREVVTSVKSASDNVAAGARELSVSAEEMSEGATEQAAAAEQASGNM
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHCCCHHHHHCCCHHHHHHHHHHCCCH
EEMSGSIRHTADNAVQTEKIAGKSAADAREGGEAVAETVSAMKVIAGKIAIIEEIARQTN
HHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LLALNAAIEAARAGEHGKGFAVVASEVRKLAERSQKAAGEIGELSASSVRIAEKAGEMLA
EEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHH
RMIPDIQRTAELVQEISAACKEQDSGADQINRAIQQLDNVIQQNASTSEEMASTSEELAS
HHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
QAEQLQATIAFFNI
HHHHHHHHHHHHCC
>Mature Secondary Structure 
GLRNMTIRWKLIAMTAIIVVLTATVITAICLARFKADLMRVATVSQETRLKTLWELLRQ
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGANARIDNGRLMVGEYVVNDNFEIPDKVKDLCGGTATIFMGDLRVSTNVKKEDGSRAIG
CCCCCEECCCEEEEEEEEECCCCCCCHHHHHHHCCCEEEEEECEEEECCCCCCCCCCHHC
TKLQGPAYDTIFKQGKPYRGEANILGVPYFTSYDPLRDASGAIIGVLYVGVKKSEFFESY
CCCCCCHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCCCEEEHHEECCCHHHHHHHH
DRLKLIIVGSAVGTVLLACLVAGFVSGRLVRPLRDAVATVDRLATGDLSVAVEAKGTDEI
CCEEEEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHH
GRLLAAMGNMVSKLREVVTSVKSASDNVAAGARELSVSAEEMSEGATEQAAAAEQASGNM
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHCCCHHHHHCCCHHHHHHHHHHCCCH
EEMSGSIRHTADNAVQTEKIAGKSAADAREGGEAVAETVSAMKVIAGKIAIIEEIARQTN
HHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LLALNAAIEAARAGEHGKGFAVVASEVRKLAERSQKAAGEIGELSASSVRIAEKAGEMLA
EEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHH
RMIPDIQRTAELVQEISAACKEQDSGADQINRAIQQLDNVIQQNASTSEEMASTSEELAS
HHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
QAEQLQATIAFFNI
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7921238; 7704255; 8969502; 9384377 [H]