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The map label for this gene is atoC [H]

Identifier: 39996219

GI number: 39996219

Start: 1202241

End: 1202624

Strand: Direct

Name: atoC [H]

Synonym: GSU1117

Alternate gene names: 39996219

Gene position: 1202241-1202624 (Clockwise)

Preceding gene: 39996218

Following gene: 39996220

Centisome position: 31.52

GC content: 48.44

Gene sequence:

>384_bases
TTGGCCCAGCAGATAAAAAAGAAAATTCTGGTAGTTGATGACGAGGAGAATGCGCGGATCGGTCTGACCAAGCTCCTGGA
GCGGGAGGGATTCGAAGTCGCAAGCGTTTCCAACGGCTTTGAAGCGCTCAATTATCTTCAACAGCGGGAAGTCAACGTTA
TCGTTACCGATATCAATATGCCGGAAATGAACGGCATCACGTTCCTGAGAGAACTCAACAAGAGCTTCCCCCGCAGCAAT
GTAATCATGATTACCGCCTACGGGGGGGTTGAGTCCTACATCGAAGCCATGAATCTGGGGGCCTTCGAATACATCAACAA
GCCGGTAAAACTTGATGAACTCAAGTCGATCCTGACGAAGATCTTCAAGGAAAGCTGTCATTAA

Upstream 100 bases:

>100_bases
CGCTTCGTCCCGCAAGGCCGCTGAGGCATCTGCTTGACAGCAGGGGGCCCCATGCTAGACTCAATCAGAGATATGCACAT
ATTCCGGGGAGTTCACTTCT

Downstream 100 bases:

>100_bases
ACTCTTCAACGTCAAGGGGGATGAGATGAAGCCGTTCAGCACTATTGTATTTCCGACCGATTTTTCCGAGAACTCGGAGT
ATGCCTTTGACTATGCCCTT

Product: response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 127; Mature: 126

Protein sequence:

>127_residues
MAQQIKKKILVVDDEENARIGLTKLLEREGFEVASVSNGFEALNYLQQREVNVIVTDINMPEMNGITFLRELNKSFPRSN
VIMITAYGGVESYIEAMNLGAFEYINKPVKLDELKSILTKIFKESCH

Sequences:

>Translated_127_residues
MAQQIKKKILVVDDEENARIGLTKLLEREGFEVASVSNGFEALNYLQQREVNVIVTDINMPEMNGITFLRELNKSFPRSN
VIMITAYGGVESYIEAMNLGAFEYINKPVKLDELKSILTKIFKESCH
>Mature_126_residues
AQQIKKKILVVDDEENARIGLTKLLEREGFEVASVSNGFEALNYLQQREVNVIVTDINMPEMNGITFLRELNKSFPRSNV
IMITAYGGVESYIEAMNLGAFEYINKPVKLDELKSILTKIFKESCH

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=116, Percent_Identity=41.3793103448276, Blast_Score=99, Evalue=7e-23,
Organism=Escherichia coli, GI1790437, Length=112, Percent_Identity=36.6071428571429, Blast_Score=78, Evalue=2e-16,
Organism=Escherichia coli, GI1790299, Length=112, Percent_Identity=31.25, Blast_Score=75, Evalue=1e-15,
Organism=Escherichia coli, GI1788905, Length=117, Percent_Identity=30.7692307692308, Blast_Score=70, Evalue=4e-14,
Organism=Escherichia coli, GI1786784, Length=122, Percent_Identity=30.327868852459, Blast_Score=65, Evalue=1e-12,
Organism=Escherichia coli, GI145693157, Length=114, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=4e-12,
Organism=Escherichia coli, GI1789809, Length=120, Percent_Identity=30.8333333333333, Blast_Score=63, Evalue=5e-12,
Organism=Escherichia coli, GI1788191, Length=120, Percent_Identity=35.8333333333333, Blast_Score=62, Evalue=8e-12,
Organism=Escherichia coli, GI1788724, Length=116, Percent_Identity=31.0344827586207, Blast_Score=62, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 14445; Mature: 14314

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQQIKKKILVVDDEENARIGLTKLLEREGFEVASVSNGFEALNYLQQREVNVIVTDINM
CCCHHCCCEEEEECCCCCEEHHHHHHHHCCCCEEHHCCHHHHHHHHHHCCCEEEEEECCC
PEMNGITFLRELNKSFPRSNVIMITAYGGVESYIEAMNLGAFEYINKPVKLDELKSILTK
CCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHH
IFKESCH
HHHHHCC
>Mature Secondary Structure 
AQQIKKKILVVDDEENARIGLTKLLEREGFEVASVSNGFEALNYLQQREVNVIVTDINM
CCHHCCCEEEEECCCCCEEHHHHHHHHCCCCEEHHCCHHHHHHHHHHCCCEEEEEECCC
PEMNGITFLRELNKSFPRSNVIMITAYGGVESYIEAMNLGAFEYINKPVKLDELKSILTK
CCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHH
IFKESCH
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]