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The map label for this gene is mtaP [H]

Identifier: 39996214

GI number: 39996214

Start: 1197837

End: 1198697

Strand: Direct

Name: mtaP [H]

Synonym: GSU1112

Alternate gene names: 39996214

Gene position: 1197837-1198697 (Clockwise)

Preceding gene: 39996213

Following gene: 39996215

Centisome position: 31.41

GC content: 60.05

Gene sequence:

>861_bases
ATGGAACAGGTAATCGGCGTTATCGGCGGGAGCGGGCTCTACGAGATGGAAGGGCTTCAGGACGTTCGGAGCATTGTTGT
TGAAACCCCCTTCGGCGCACCCTCGGATGAGTTTGTGACCGGCGTGCTGGATGGTGTGCGCATGGTGTTCCTTCCGCGCC
ACGGCCGGGGCCATCGGCTCCTGCCTACTGAGGTAAACTACCGGGCGAACATCTACGGCATGAAGAAGCTCGGCGTTACC
CGGATTATTTCCGTTTCCGCCGTGGGCAGCATGCGGGAGGAGATCGTGCCGGGGCATATTGTGATCCCGGACCAGTTCAT
CGACCGGACCAATGCCACCAGGGCAAATACGTTCTTCGGCAATGGGGTGGTTGCGCACATTCAATTTGCCGATCCGGTCT
GCGCCGACCTTTCCGCCGATCTCTATGCGGCGGCGCAGGAGGCGGGGGCAACGGTCCACCGGGGGGGGACCTATATCTGC
ATGGAAGGGCCGGCCTTTTCCACCCGGGCGGAGTCAAACCTCTACCGCTCTTTCGGTGTATCGGTCATCGGCATGACCAA
CATCCCCGAAGCAAAGCTGGCCCGTGAGGCGGAGATCTGCTACGGCGTTATCGCTCTTGCCACCGATTACGACTGCTGGC
ACGAGTCCCATGATGACGTGTCCGTGGACGCCATTATTGCCATCATCAAGCAGAATGTGGCCATGGCCAAGTCGATCATT
CGCAATGCGGTTCGCCGGATTGACCGGGAGCGGAATTGCCCCTGTGCATCGGCGCTCCGGTACGCCATCATTACCGACAA
GGCCGCGATTCCTGCCGAGACGAAGGAGCGGCTTGATCTCATCATCGGCTCGTACGTCTAA

Upstream 100 bases:

>100_bases
GCGGCCTGCGGTCAGCTCAAGGGCAAGCTGGACGCATTGAAGCCGTCCGGCGCGGGAAAGCAGATAGAGGTTTCAGACTC
CACTAACGAGGTGACATGAC

Downstream 100 bases:

>100_bases
GGAGGGATACATGGGTATTCTCGTTGTGGGTTCGGTTGCATTCGATTCGATTGAAACCCCTTTCGGCAGGGGAGAGCATG
TTCTGGGCGGCTCAGCCACC

Product: methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MEQVIGVIGGSGLYEMEGLQDVRSIVVETPFGAPSDEFVTGVLDGVRMVFLPRHGRGHRLLPTEVNYRANIYGMKKLGVT
RIISVSAVGSMREEIVPGHIVIPDQFIDRTNATRANTFFGNGVVAHIQFADPVCADLSADLYAAAQEAGATVHRGGTYIC
MEGPAFSTRAESNLYRSFGVSVIGMTNIPEAKLAREAEICYGVIALATDYDCWHESHDDVSVDAIIAIIKQNVAMAKSII
RNAVRRIDRERNCPCASALRYAIITDKAAIPAETKERLDLIIGSYV

Sequences:

>Translated_286_residues
MEQVIGVIGGSGLYEMEGLQDVRSIVVETPFGAPSDEFVTGVLDGVRMVFLPRHGRGHRLLPTEVNYRANIYGMKKLGVT
RIISVSAVGSMREEIVPGHIVIPDQFIDRTNATRANTFFGNGVVAHIQFADPVCADLSADLYAAAQEAGATVHRGGTYIC
MEGPAFSTRAESNLYRSFGVSVIGMTNIPEAKLAREAEICYGVIALATDYDCWHESHDDVSVDAIIAIIKQNVAMAKSII
RNAVRRIDRERNCPCASALRYAIITDKAAIPAETKERLDLIIGSYV
>Mature_286_residues
MEQVIGVIGGSGLYEMEGLQDVRSIVVETPFGAPSDEFVTGVLDGVRMVFLPRHGRGHRLLPTEVNYRANIYGMKKLGVT
RIISVSAVGSMREEIVPGHIVIPDQFIDRTNATRANTFFGNGVVAHIQFADPVCADLSADLYAAAQEAGATVHRGGTYIC
MEGPAFSTRAESNLYRSFGVSVIGMTNIPEAKLAREAEICYGVIALATDYDCWHESHDDVSVDAIIAIIKQNVAMAKSII
RNAVRRIDRERNCPCASALRYAIITDKAAIPAETKERLDLIIGSYV

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=248, Percent_Identity=45.9677419354839, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI71980569, Length=250, Percent_Identity=41.2, Blast_Score=200, Evalue=8e-52,
Organism=Saccharomyces cerevisiae, GI6323045, Length=303, Percent_Identity=35.3135313531353, Blast_Score=179, Evalue=4e-46,
Organism=Drosophila melanogaster, GI20130079, Length=273, Percent_Identity=40.2930402930403, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI221459247, Length=251, Percent_Identity=35.8565737051793, Blast_Score=178, Evalue=4e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 31105; Mature: 31105

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQVIGVIGGSGLYEMEGLQDVRSIVVETPFGAPSDEFVTGVLDGVRMVFLPRHGRGHRL
CCCEEEEECCCCCCHHHHHHHHHHHHEECCCCCCCHHHHHHHHHCEEEEEEECCCCCCCC
LPTEVNYRANIYGMKKLGVTRIISVSAVGSMREEIVPGHIVIPDQFIDRTNATRANTFFG
CCCCCCCEEEEEEEHHHCHHHEEHHHHHHHHHHHCCCCEEECCHHHHCCCCCCCCCEEEC
NGVVAHIQFADPVCADLSADLYAAAQEAGATVHRGGTYICMEGPAFSTRAESNLYRSFGV
CCEEEEEEECCCHHHHCCHHHHHHHHHCCCEEECCCEEEEECCCCCCCHHHHHHHHHHCC
SVIGMTNIPEAKLAREAEICYGVIALATDYDCWHESHDDVSVDAIIAIIKQNVAMAKSII
EEEEECCCCHHHHHHHHHHHHEEHHEECCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
RNAVRRIDRERNCPCASALRYAIITDKAAIPAETKERLDLIIGSYV
HHHHHHHHHHCCCCHHHHHEEHEEECCCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MEQVIGVIGGSGLYEMEGLQDVRSIVVETPFGAPSDEFVTGVLDGVRMVFLPRHGRGHRL
CCCEEEEECCCCCCHHHHHHHHHHHHEECCCCCCCHHHHHHHHHCEEEEEEECCCCCCCC
LPTEVNYRANIYGMKKLGVTRIISVSAVGSMREEIVPGHIVIPDQFIDRTNATRANTFFG
CCCCCCCEEEEEEEHHHCHHHEEHHHHHHHHHHHCCCCEEECCHHHHCCCCCCCCCEEEC
NGVVAHIQFADPVCADLSADLYAAAQEAGATVHRGGTYICMEGPAFSTRAESNLYRSFGV
CCEEEEEEECCCHHHHCCHHHHHHHHHCCCEEECCCEEEEECCCCCCCHHHHHHHHHHCC
SVIGMTNIPEAKLAREAEICYGVIALATDYDCWHESHDDVSVDAIIAIIKQNVAMAKSII
EEEEECCCCHHHHHHHHHHHHEEHHEECCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
RNAVRRIDRERNCPCASALRYAIITDKAAIPAETKERLDLIIGSYV
HHHHHHHHHHCCCCHHHHHEEHEEECCCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA