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The map label for this gene is ndk

Identifier: 39996212

GI number: 39996212

Start: 1196273

End: 1196686

Strand: Direct

Name: ndk

Synonym: GSU1110

Alternate gene names: 39996212

Gene position: 1196273-1196686 (Clockwise)

Preceding gene: 39996210

Following gene: 39996213

Centisome position: 31.36

GC content: 51.93

Gene sequence:

>414_bases
ATGGAAAGAACATTTGCGATTATTAAGCCTGATGCGGTGGAGCGTAACATCATCGGAAAGATACTTGAAAAAGTAGAAAC
GGCCGGCTTCCGAATTGTGGGCATGAAGAAGATCCTGCTTTCCAAGTGCGAGGCCGAAGGATTTTACTACGTGCACAAGG
AGCGGCCTTTCTTCAATGACCTTTGTTCCTTCATGTCGCGCAGCCCGGTGGTGGTTATGGTTCTTGAGCGTGAAAACGCC
ATCAATACCTGGCGCGAAGTGATGGGAGCAACAAATCCGGCCAACGCCGAAGCGGGAACCATCCGCAAGGATTTCGGCCT
GAGCATCGAGGAAAATTCCGTGCATGGCTCAGACTCCCCCGAATCGGCCGCTTACGAGATTCCGTATTTCTTCAGCCAGC
TCGAGCTGCTCTGA

Upstream 100 bases:

>100_bases
GTCCATGGGTCTTTTTTTGTCTGACAAAGAGATTGACTTCAAAGTCCGTACATGGTAAACGATACGGTCTTTTTATTTAC
AAGCGTAACTGGAGGTAGAG

Downstream 100 bases:

>100_bases
AGCTGAATGCGTGTGTGTCAGCAAAGCCCTTCTCTCGCGAAGGGCTTTTTTTTATAGTACGCTACCATGGATACAATGAT
TGACATTAAGGGGCTGAGCA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MERTFAIIKPDAVERNIIGKILEKVETAGFRIVGMKKILLSKCEAEGFYYVHKERPFFNDLCSFMSRSPVVVMVLERENA
INTWREVMGATNPANAEAGTIRKDFGLSIEENSVHGSDSPESAAYEIPYFFSQLELL

Sequences:

>Translated_137_residues
MERTFAIIKPDAVERNIIGKILEKVETAGFRIVGMKKILLSKCEAEGFYYVHKERPFFNDLCSFMSRSPVVVMVLERENA
INTWREVMGATNPANAEAGTIRKDFGLSIEENSVHGSDSPESAAYEIPYFFSQLELL
>Mature_137_residues
MERTFAIIKPDAVERNIIGKILEKVETAGFRIVGMKKILLSKCEAEGFYYVHKERPFFNDLCSFMSRSPVVVMVLERENA
INTWREVMGATNPANAEAGTIRKDFGLSIEENSVHGSDSPESAAYEIPYFFSQLELL

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=44.5255474452555, Blast_Score=123, Evalue=6e-29,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=44.5255474452555, Blast_Score=122, Evalue=7e-29,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=44.5255474452555, Blast_Score=122, Evalue=7e-29,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=44.5255474452555, Blast_Score=122, Evalue=7e-29,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=44.5255474452555, Blast_Score=122, Evalue=7e-29,
Organism=Homo sapiens, GI38045913, Length=136, Percent_Identity=45.5882352941176, Blast_Score=122, Evalue=7e-29,
Organism=Homo sapiens, GI4557797, Length=136, Percent_Identity=45.5882352941176, Blast_Score=122, Evalue=8e-29,
Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=43.3823529411765, Blast_Score=119, Evalue=8e-28,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=38.9705882352941, Blast_Score=107, Evalue=4e-24,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=39.8496240601504, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=39.8496240601504, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI5031951, Length=135, Percent_Identity=37.037037037037, Blast_Score=89, Evalue=9e-19,
Organism=Homo sapiens, GI4505413, Length=137, Percent_Identity=33.5766423357664, Blast_Score=79, Evalue=8e-16,
Organism=Homo sapiens, GI148839372, Length=129, Percent_Identity=35.6589147286822, Blast_Score=77, Evalue=3e-15,
Organism=Homo sapiens, GI30023828, Length=140, Percent_Identity=32.1428571428571, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1788866, Length=136, Percent_Identity=55.1470588235294, Blast_Score=158, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=42.2222222222222, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=38.9705882352941, Blast_Score=112, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=45.5882352941176, Blast_Score=126, Evalue=4e-30,
Organism=Drosophila melanogaster, GI18860097, Length=138, Percent_Identity=32.6086956521739, Blast_Score=83, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24645457, Length=140, Percent_Identity=27.1428571428571, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_GEOSL (Q74E54)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_952163.1
- ProteinModelPortal:   Q74E54
- SMR:   Q74E54
- GeneID:   2688549
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU1110
- NMPDR:   fig|243231.1.peg.1101
- TIGR:   GSU1110
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- BioCyc:   GSUL243231:GSU_1110-MONOMER
- BRENDA:   2.7.4.6
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15498; Mature: 15498

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTFAIIKPDAVERNIIGKILEKVETAGFRIVGMKKILLSKCEAEGFYYVHKERPFFND
CCCEEEEECCCHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHCCCCEEEEECCCCCHHH
LCSFMSRSPVVVMVLERENAINTWREVMGATNPANAEAGTIRKDFGLSIEENSVHGSDSP
HHHHHCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCHHHCCCEEECCCCCCCCCC
ESAAYEIPYFFSQLELL
CCCEEECHHHHHHHHCC
>Mature Secondary Structure
MERTFAIIKPDAVERNIIGKILEKVETAGFRIVGMKKILLSKCEAEGFYYVHKERPFFND
CCCEEEEECCCHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHCCCCEEEEECCCCCHHH
LCSFMSRSPVVVMVLERENAINTWREVMGATNPANAEAGTIRKDFGLSIEENSVHGSDSP
HHHHHCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCHHHCCCEEECCCCCCCCCC
ESAAYEIPYFFSQLELL
CCCEEECHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA