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The map label for this gene is gltA [H]

Identifier: 39996208

GI number: 39996208

Start: 1192192

End: 1193517

Strand: Direct

Name: gltA [H]

Synonym: GSU1106

Alternate gene names: 39996208

Gene position: 1192192-1193517 (Clockwise)

Preceding gene: 39996207

Following gene: 39996210

Centisome position: 31.26

GC content: 58.9

Gene sequence:

>1326_bases
ATGGCACTCAAGGAAACCCTAAAGCAAAAAATTGAGGAGCACCGTCCCCGCACCACCCGGCTCGTAAAGGAGTTCGGCAA
GGTCATTATCGACCAGGTGACCATTGATCAATGCATCGGCGGTGCCCGTGACATCCGCTGCCTGGTAACCGATATCTCCT
ATCTCGACCCGCAGGAAGGGATCCGGTTCCGTGGCAAGACCATTCCCGAGACCTTTGAGGCTCTCCCCAAGGCTGCCGGT
TCTGACTATCCGACCGTTGAATCCTTCTGGTACTTCCTCCTGACCGGCGAAGTCCCGACCCAGGCCCAGGTTGACGAAGT
GGTTGCCGAGTGGAAGGTACGTCAGGAAGTTCCCCAGTACGTGTTCGACGCCATCCGTGCACTGCCGCGTGATAGCCACC
CCATGGTCATGCTCTCCGTCGGTATCCTTGCCCTCCAAAAGGATTCCAAGTTCGCGGGCTTCTACAACTCGGGCAAGTTC
AACAAAATGACGGCTTGGGAATACGTCTACGAAGATGCCTATGATCTTGTAGCCCGTATCCCCGTCATCGCCGCATTCAT
CTACAACCTCAAGTACAAAGGCGACAAGCAGCTTCCCATCGATCCGAGTGCAGACTGCGGCGCCAACTTCGCCCGTATGA
TCGGCCAGTGCAAGGAGTACGAGGATGTTGCCCGGATGTACTTCATCCTTCACTCCGACCATGAGTCCGGCAACGTGTCG
GCCCACACCACTCACTTGGTGCACTCGGCCCTGTCCGACCCCTACTATGCCTACTCCGCCGGCCTGAACGGCCTCGCCGG
TCCGCTGCACGGCCTTGCCAACCAGGAAGTTCTCGACTGGACCATCAAGTTCCAGGAGAAGTACTGCAAGGACGTGGAGC
CCACCAAGGAGCTGGTCACCAAGGCCCTGTGGGATACCCTCAACGCCGGTCAGGTCGTTCCGGGATACGGCCACGCCGTT
CTCCGCAAGACCGACCCCCGGTATACCTCTCAGCGCGAGTTCTGCCTCAAGACTCCGGGGCTCAAGGATGATCCGCTGTT
CAAACTGGTTGCCATGATCTTTGAAACCGCTCCTGGCGTGCTCATGGAGCACGGTAAGGCCAAGAACCCCTGGCCGAACG
TCGATGCTCAGTCCGGCGTCATCCAGTGGTACTATGGCCTCCGTGAGTGGGACTTCTACACCGTCCTCTTCGGTGTGGGC
CGTGCGCTCGGCTGCATGGCGAACATCACCTGGGACCGTGGCCTCGGTTACGCCATCGAGCGTCCCAAGTCCGTTACCAC
TCCGATGCTTGAGAAGTGGGCGGAAGAAGGCGGCCGCAAGTTCTAG

Upstream 100 bases:

>100_bases
CGTGACACCACCAGTGGAAAGGAGGGGGAAGAAGGCAGGCGAGGTTGATAGTTTGTTTTTGTTTATTAAAACATCACAAC
TTGAAAGGAGAGCACGTAAC

Downstream 100 bases:

>100_bases
TCGTACATGTGCCGGGGGGCGTCATTCCCCGGCACTTCTGCTGTAAGTCAAATAGAAAATGGGGAGATGTCACCGCGTCT
CCCCATTTTTTCTATTCGTT

Product: type I citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MALKETLKQKIEEHRPRTTRLVKEFGKVIIDQVTIDQCIGGARDIRCLVTDISYLDPQEGIRFRGKTIPETFEALPKAAG
SDYPTVESFWYFLLTGEVPTQAQVDEVVAEWKVRQEVPQYVFDAIRALPRDSHPMVMLSVGILALQKDSKFAGFYNSGKF
NKMTAWEYVYEDAYDLVARIPVIAAFIYNLKYKGDKQLPIDPSADCGANFARMIGQCKEYEDVARMYFILHSDHESGNVS
AHTTHLVHSALSDPYYAYSAGLNGLAGPLHGLANQEVLDWTIKFQEKYCKDVEPTKELVTKALWDTLNAGQVVPGYGHAV
LRKTDPRYTSQREFCLKTPGLKDDPLFKLVAMIFETAPGVLMEHGKAKNPWPNVDAQSGVIQWYYGLREWDFYTVLFGVG
RALGCMANITWDRGLGYAIERPKSVTTPMLEKWAEEGGRKF

Sequences:

>Translated_441_residues
MALKETLKQKIEEHRPRTTRLVKEFGKVIIDQVTIDQCIGGARDIRCLVTDISYLDPQEGIRFRGKTIPETFEALPKAAG
SDYPTVESFWYFLLTGEVPTQAQVDEVVAEWKVRQEVPQYVFDAIRALPRDSHPMVMLSVGILALQKDSKFAGFYNSGKF
NKMTAWEYVYEDAYDLVARIPVIAAFIYNLKYKGDKQLPIDPSADCGANFARMIGQCKEYEDVARMYFILHSDHESGNVS
AHTTHLVHSALSDPYYAYSAGLNGLAGPLHGLANQEVLDWTIKFQEKYCKDVEPTKELVTKALWDTLNAGQVVPGYGHAV
LRKTDPRYTSQREFCLKTPGLKDDPLFKLVAMIFETAPGVLMEHGKAKNPWPNVDAQSGVIQWYYGLREWDFYTVLFGVG
RALGCMANITWDRGLGYAIERPKSVTTPMLEKWAEEGGRKF
>Mature_440_residues
ALKETLKQKIEEHRPRTTRLVKEFGKVIIDQVTIDQCIGGARDIRCLVTDISYLDPQEGIRFRGKTIPETFEALPKAAGS
DYPTVESFWYFLLTGEVPTQAQVDEVVAEWKVRQEVPQYVFDAIRALPRDSHPMVMLSVGILALQKDSKFAGFYNSGKFN
KMTAWEYVYEDAYDLVARIPVIAAFIYNLKYKGDKQLPIDPSADCGANFARMIGQCKEYEDVARMYFILHSDHESGNVSA
HTTHLVHSALSDPYYAYSAGLNGLAGPLHGLANQEVLDWTIKFQEKYCKDVEPTKELVTKALWDTLNAGQVVPGYGHAVL
RKTDPRYTSQREFCLKTPGLKDDPLFKLVAMIFETAPGVLMEHGKAKNPWPNVDAQSGVIQWYYGLREWDFYTVLFGVGR
ALGCMANITWDRGLGYAIERPKSVTTPMLEKWAEEGGRKF

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=436, Percent_Identity=49.3119266055046, Blast_Score=437, Evalue=1e-122,
Organism=Escherichia coli, GI1786939, Length=394, Percent_Identity=31.2182741116751, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1786527, Length=340, Percent_Identity=24.4117647058824, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17555174, Length=436, Percent_Identity=50, Blast_Score=434, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6324328, Length=439, Percent_Identity=53.3029612756264, Blast_Score=462, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6319850, Length=437, Percent_Identity=51.487414187643, Blast_Score=442, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6325257, Length=451, Percent_Identity=39.4678492239468, Blast_Score=330, Evalue=3e-91,
Organism=Drosophila melanogaster, GI24640124, Length=437, Percent_Identity=51.0297482837529, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24640126, Length=437, Percent_Identity=51.0297482837529, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI21356863, Length=439, Percent_Identity=43.2801822323462, Blast_Score=353, Evalue=1e-97,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 49882; Mature: 49750

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALKETLKQKIEEHRPRTTRLVKEFGKVIIDQVTIDQCIGGARDIRCLVTDISYLDPQEG
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHC
IRFRGKTIPETFEALPKAAGSDYPTVESFWYFLLTGEVPTQAQVDEVVAEWKVRQEVPQY
CEECCCCCHHHHHHHHHHCCCCCCCHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
VFDAIRALPRDSHPMVMLSVGILALQKDSKFAGFYNSGKFNKMTAWEYVYEDAYDLVARI
HHHHHHHCCCCCCCEEEEEHHHHEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
PVIAAFIYNLKYKGDKQLPIDPSADCGANFARMIGQCKEYEDVARMYFILHSDHESGNVS
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCC
AHTTHLVHSALSDPYYAYSAGLNGLAGPLHGLANQEVLDWTIKFQEKYCKDVEPTKELVT
HHHHHHHHHHHCCCCEEHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
KALWDTLNAGQVVPGYGHAVLRKTDPRYTSQREFCLKTPGLKDDPLFKLVAMIFETAPGV
HHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCCH
LMEHGKAKNPWPNVDAQSGVIQWYYGLREWDFYTVLFGVGRALGCMANITWDRGLGYAIE
HHHCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHC
RPKSVTTPMLEKWAEEGGRKF
CCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ALKETLKQKIEEHRPRTTRLVKEFGKVIIDQVTIDQCIGGARDIRCLVTDISYLDPQEG
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHC
IRFRGKTIPETFEALPKAAGSDYPTVESFWYFLLTGEVPTQAQVDEVVAEWKVRQEVPQY
CEECCCCCHHHHHHHHHHCCCCCCCHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
VFDAIRALPRDSHPMVMLSVGILALQKDSKFAGFYNSGKFNKMTAWEYVYEDAYDLVARI
HHHHHHHCCCCCCCEEEEEHHHHEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
PVIAAFIYNLKYKGDKQLPIDPSADCGANFARMIGQCKEYEDVARMYFILHSDHESGNVS
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCC
AHTTHLVHSALSDPYYAYSAGLNGLAGPLHGLANQEVLDWTIKFQEKYCKDVEPTKELVT
HHHHHHHHHHHCCCCEEHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
KALWDTLNAGQVVPGYGHAVLRKTDPRYTSQREFCLKTPGLKDDPLFKLVAMIFETAPGV
HHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCCH
LMEHGKAKNPWPNVDAQSGVIQWYYGLREWDFYTVLFGVGRALGCMANITWDRGLGYAIE
HHHCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHC
RPKSVTTPMLEKWAEEGGRKF
CCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7522844; 12948626 [H]