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The map label for this gene is rnz [H]

Identifier: 39996151

GI number: 39996151

Start: 1136252

End: 1137259

Strand: Reverse

Name: rnz [H]

Synonym: GSU1049

Alternate gene names: 39996151

Gene position: 1137259-1136252 (Counterclockwise)

Preceding gene: 39996154

Following gene: 39996145

Centisome position: 29.82

GC content: 63.29

Gene sequence:

>1008_bases
ATGCCGCCACTCTTTCACCCTCATCTCGTGAACGGCCCTTTCGATGATCCGGGACTCTACGTCGATTTTCTGTTCGAGCG
GCGGGCGGTCCTGTTTGACCTGGGCGACACGGCTCCGCTGCCGCCCAGGAAGGTGCTCCGTCTCTCCCACATCTTCGTCT
CCCACACCCATGTGGACCACTTCATAGGCTTCGACCGGGTGGTAAGGCTCTGCCTCGGCCGGGAAAAACGGCTTCACCTG
CTCGGGCCGCCCGGATTCGTCGACCAAGTGGCCGCCCGACTGGCGGGATACACCTGGAACCTGGTGGAAACCTTCCCCAC
CGACTTCACCCTCGCTGCCGCCGAGCTTCATCCGGACGGAAGCGTTCACAGCGCGGAGTTTCATTGCCTTGCCGCGTTTT
CGAGGGACAACGAGCGGCGGGATCGCGCCGCCGGCGGAGTGCTTCTGGATGAAGAGGCATTCCGCGTCAGAAGCGTCTTC
CTCGATCACGGCATCCCCTGCCTCGCCTTTGCCCTGGAAGAAAAAAACCACGTGCACATTCTCAAGAACCGCCTGCGGGA
GGCGGGATTACCGACTGGGGCGTGGCTGGCGGAACTCAAACGGGCAATCCTGGGCGGCAGGGACGACGGGGAGCCCTTCA
GGGCATGGTGGCGGGACGGTGGAAAAGAATGCGAGGCGTGGTTCCCTCTCGGCGAACTGCGGGAGCGTTTTACCAAAACC
GTGGCCGGACAGAAAATTGTCTACGTCACGGACGCAGCACCGACCCCGGAAAACCGGCGTCTCATCGTGGAGCTGGCGGC
CGGTGCCGATTACCTCTTCATAGAGGCCCCCTTCCTGGATGAAGAGCGGGAGCGCGCCGGCGACCGATGTCATCTGACCG
CCCGCATTGCAGGCGAACTGGGCAGGGATGCGGGCGTTGCGCGGGTGGTCCCGTTCCACTTTTCCCCCCGTTACATGGGA
AGGGAATCGCTACTGCGGGATGAAGTGGAGCGGGCCTTCAGGGGGTGA

Upstream 100 bases:

>100_bases
ACAATCAAAAATCAAAATACGTTAATTTTTTAATGCAAAGACAATACCCACAACTCAAGACGCGATACACTTGCCAGCAA
AAGGCCACGGGAGGCTGATG

Downstream 100 bases:

>100_bases
CGGCGGAGCGGAAAAACGAACCGCGGCGCCGAAAGGGCGCCGCGGTCACGGTCAGACGGCGAACAAGGTCAGGCGCCGCA
ACACTTTTTGTACTTCTTGC

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MPPLFHPHLVNGPFDDPGLYVDFLFERRAVLFDLGDTAPLPPRKVLRLSHIFVSHTHVDHFIGFDRVVRLCLGREKRLHL
LGPPGFVDQVAARLAGYTWNLVETFPTDFTLAAAELHPDGSVHSAEFHCLAAFSRDNERRDRAAGGVLLDEEAFRVRSVF
LDHGIPCLAFALEEKNHVHILKNRLREAGLPTGAWLAELKRAILGGRDDGEPFRAWWRDGGKECEAWFPLGELRERFTKT
VAGQKIVYVTDAAPTPENRRLIVELAAGADYLFIEAPFLDEERERAGDRCHLTARIAGELGRDAGVARVVPFHFSPRYMG
RESLLRDEVERAFRG

Sequences:

>Translated_335_residues
MPPLFHPHLVNGPFDDPGLYVDFLFERRAVLFDLGDTAPLPPRKVLRLSHIFVSHTHVDHFIGFDRVVRLCLGREKRLHL
LGPPGFVDQVAARLAGYTWNLVETFPTDFTLAAAELHPDGSVHSAEFHCLAAFSRDNERRDRAAGGVLLDEEAFRVRSVF
LDHGIPCLAFALEEKNHVHILKNRLREAGLPTGAWLAELKRAILGGRDDGEPFRAWWRDGGKECEAWFPLGELRERFTKT
VAGQKIVYVTDAAPTPENRRLIVELAAGADYLFIEAPFLDEERERAGDRCHLTARIAGELGRDAGVARVVPFHFSPRYMG
RESLLRDEVERAFRG
>Mature_334_residues
PPLFHPHLVNGPFDDPGLYVDFLFERRAVLFDLGDTAPLPPRKVLRLSHIFVSHTHVDHFIGFDRVVRLCLGREKRLHLL
GPPGFVDQVAARLAGYTWNLVETFPTDFTLAAAELHPDGSVHSAEFHCLAAFSRDNERRDRAAGGVLLDEEAFRVRSVFL
DHGIPCLAFALEEKNHVHILKNRLREAGLPTGAWLAELKRAILGGRDDGEPFRAWWRDGGKECEAWFPLGELRERFTKTV
AGQKIVYVTDAAPTPENRRLIVELAAGADYLFIEAPFLDEERERAGDRCHLTARIAGELGRDAGVARVVPFHFSPRYMGR
ESLLRDEVERAFRG

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=315, Percent_Identity=25.3968253968254, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 37814; Mature: 37682

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPLFHPHLVNGPFDDPGLYVDFLFERRAVLFDLGDTAPLPPRKVLRLSHIFVSHTHVDH
CCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
FIGFDRVVRLCLGREKRLHLLGPPGFVDQVAARLAGYTWNLVETFPTDFTLAAAELHPDG
HHCHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCEEEHHHCCCCEEEEEEEECCCC
SVHSAEFHCLAAFSRDNERRDRAAGGVLLDEEAFRVRSVFLDHGIPCLAFALEEKNHVHI
CCCCCCEEEEEEHHCCCHHHHHHHCCEEECHHHHHHHHHHHHCCCCEEEEECCCCCCHHH
LKNRLREAGLPTGAWLAELKRAILGGRDDGEPFRAWWRDGGKECEAWFPLGELRERFTKT
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHCCCHHHHHHHHHHH
VAGQKIVYVTDAAPTPENRRLIVELAAGADYLFIEAPFLDEERERAGDRCHLTARIAGEL
HCCCEEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCCCHHHCCCCEEEEEEEHHHHC
GRDAGVARVVPFHFSPRYMGRESLLRDEVERAFRG
CCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PPLFHPHLVNGPFDDPGLYVDFLFERRAVLFDLGDTAPLPPRKVLRLSHIFVSHTHVDH
CCCCCCCCCCCCCCCCCHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
FIGFDRVVRLCLGREKRLHLLGPPGFVDQVAARLAGYTWNLVETFPTDFTLAAAELHPDG
HHCHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCEEEHHHCCCCEEEEEEEECCCC
SVHSAEFHCLAAFSRDNERRDRAAGGVLLDEEAFRVRSVFLDHGIPCLAFALEEKNHVHI
CCCCCCEEEEEEHHCCCHHHHHHHCCEEECHHHHHHHHHHHHCCCCEEEEECCCCCCHHH
LKNRLREAGLPTGAWLAELKRAILGGRDDGEPFRAWWRDGGKECEAWFPLGELRERFTKT
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHCCCHHHHHHHHHHH
VAGQKIVYVTDAAPTPENRRLIVELAAGADYLFIEAPFLDEERERAGDRCHLTARIAGEL
HCCCEEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCCCHHHCCCCEEEEEEEHHHHC
GRDAGVARVVPFHFSPRYMGRESLLRDEVERAFRG
CCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]