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The map label for this gene is zraR [H]

Identifier: 39996141

GI number: 39996141

Start: 1125639

End: 1127339

Strand: Direct

Name: zraR [H]

Synonym: GSU1039

Alternate gene names: 39996141

Gene position: 1125639-1127339 (Clockwise)

Preceding gene: 39996140

Following gene: 39996143

Centisome position: 29.51

GC content: 63.32

Gene sequence:

>1701_bases
ATGACATACAGCATTCTCGTGGTAGACGACGAGGAAAGCCTTCGCTACACCTTCCGCTGCTTCCTGGAGCATCAGGGCTA
TGAGGTAGCGATTGCGGCGAACTACGAAGAGGCCTTGGCGGCTCTGCCCGCCGGGTTCGATCTCGTTTTCGCCGATATCG
TCCTCGGCGGCTGGACCGGCGTCGATCTGCTGCGCGAGGCCCGTTTGCGCGGTTTCGACGTTCCCTTCGTCATGGTGACC
GGCTACCCCCACATCGATACCGCCTCTGAAGCGCTCAGGCTCGGCGCTTACGACTACATTCCCAAGCCGGTGAAGCAGGA
GACCATCGTCCGGGTTGCCCGCATGGCGATCCGTCACCACCTGGTCTCCAAGGAGAAAGATCAGTACCGCTCCAACCTGG
AGGCAATCTTCCGCAGCGTCAAGGATGCCATCGTCACTGTCGACCGGGGGATGCGGCTCATCGCCTGCAACGCTGCCGCC
ACCACGCTCTGCGGCATCACGAAGGACAGGGTCGAGGCTCAGGAGCTCTTCTGCCCCGAAGATTGCCAGCACCAGTGCCT
GAAGCTTCTGGAGGAGACCCTCGTCAAGCGTCAGCCCATCGAAGGGCAGCGGTTCGTCTGCCGCAGACAGGGACAGCCCG
ATCGCATAATCGCCGCAGCCACGTCGCCCTTGCTGGATCAACTGGAAGGTTTCGACGGAGCCGTCCTCGTGGCCCGGGAC
GAAACCCGTCTCGACCACCTGGAGCGCCGGGCTTCGGGGCGCCGTTCCCATCTGTCGCTGGTCGGCGGCAGCGCGGCGAT
GCAGCGGCTCTATTCGCTGCTGGAGGCGCTGTCGGAGGTGGATACCACCGTCCTCATCACCGGCGAGAGCGGAACCGGCA
AGGAGCTGGCCGCAGATGCCCTCCACCGGGGCGGACACCGTGCGGACAAGCCCTTTGTTGCGGTAAACTGCGCCGCTCTT
CCCGAAACCCTTTTGGAGAGCGAGTTGTTCGGCCATGTGAAGGGGGCGTTCACCGGCGCGCTCAGGGACAAGGAGGGGCG
CTTCCAGAAGGCCGATGGCGGAACGATTTTCCTGGACGAGATCGGGGATATATCCCCCGCCATGCAGCTGAGACTGCTGC
GGGTGCTTCAGGAGAAAGTGTTCGAGCGGGTAGGCGATGCGACGCCCATCCGGGTCGACGTGCGGATCGTGGCGGCCACC
AACCGCGACCTGGCGCAACTGGTCCGCGAAGGGCGGTTCCGGGAAGATCTCTATTACCGTCTTAAAGTCGTGCACCTGGA
ACTTCCTGCACTCCGGGAGCGCAAAGAGGATATCCCTTTGCTGGTGGAGCACTTTCTCGGGCGACTGACCGCCCGCTTCG
AGAGAAATCCGCTCACCATCTCCCAGGAGGCGCTGGACACGCTGATGTCCCACCCCTGGCCCGGCAACGTGCGCGAACTT
GAACACGTTCTGGAACATGCGGCGGTCATCTGCCGGGGGCACGTCATTCTGTCCGATCATCTGCCTGCCGACCTTGCTCC
TGCCGTGCCGGCTTCCGCGGCGCCGCGGACGGTCAGGGTAACGGACGAAGCAGCCCTGATCCGCGATGCCCTCGTCCGGG
CCGGCGGCAACAAGACCAAGGCGGCAAAGCTGCTCGGCATGAGCCGCCGGACTATTTATCGCAAGCTTGATGAACACGGC
ATCTTCGGTGACTTTAAGTAG

Upstream 100 bases:

>100_bases
GCCAGAACATCATCCGCGACCATGACGGCAACCTCTCCATCGAGAGCCGCGAGGGGGAATTCACCCTCGTGAGCATCGAC
CTTCCCGCCGAGGAGACGCC

Downstream 100 bases:

>100_bases
TTTTAAACACTTGTCCACGCATCGGGCCTCGAATGCCTACTGCCCAATTGACCCATCCGTTTTTTGTTTCTTAATTTATA
CTCAAGTATTTTCATGCAGT

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 566; Mature: 565

Protein sequence:

>566_residues
MTYSILVVDDEESLRYTFRCFLEHQGYEVAIAANYEEALAALPAGFDLVFADIVLGGWTGVDLLREARLRGFDVPFVMVT
GYPHIDTASEALRLGAYDYIPKPVKQETIVRVARMAIRHHLVSKEKDQYRSNLEAIFRSVKDAIVTVDRGMRLIACNAAA
TTLCGITKDRVEAQELFCPEDCQHQCLKLLEETLVKRQPIEGQRFVCRRQGQPDRIIAAATSPLLDQLEGFDGAVLVARD
ETRLDHLERRASGRRSHLSLVGGSAAMQRLYSLLEALSEVDTTVLITGESGTGKELAADALHRGGHRADKPFVAVNCAAL
PETLLESELFGHVKGAFTGALRDKEGRFQKADGGTIFLDEIGDISPAMQLRLLRVLQEKVFERVGDATPIRVDVRIVAAT
NRDLAQLVREGRFREDLYYRLKVVHLELPALRERKEDIPLLVEHFLGRLTARFERNPLTISQEALDTLMSHPWPGNVREL
EHVLEHAAVICRGHVILSDHLPADLAPAVPASAAPRTVRVTDEAALIRDALVRAGGNKTKAAKLLGMSRRTIYRKLDEHG
IFGDFK

Sequences:

>Translated_566_residues
MTYSILVVDDEESLRYTFRCFLEHQGYEVAIAANYEEALAALPAGFDLVFADIVLGGWTGVDLLREARLRGFDVPFVMVT
GYPHIDTASEALRLGAYDYIPKPVKQETIVRVARMAIRHHLVSKEKDQYRSNLEAIFRSVKDAIVTVDRGMRLIACNAAA
TTLCGITKDRVEAQELFCPEDCQHQCLKLLEETLVKRQPIEGQRFVCRRQGQPDRIIAAATSPLLDQLEGFDGAVLVARD
ETRLDHLERRASGRRSHLSLVGGSAAMQRLYSLLEALSEVDTTVLITGESGTGKELAADALHRGGHRADKPFVAVNCAAL
PETLLESELFGHVKGAFTGALRDKEGRFQKADGGTIFLDEIGDISPAMQLRLLRVLQEKVFERVGDATPIRVDVRIVAAT
NRDLAQLVREGRFREDLYYRLKVVHLELPALRERKEDIPLLVEHFLGRLTARFERNPLTISQEALDTLMSHPWPGNVREL
EHVLEHAAVICRGHVILSDHLPADLAPAVPASAAPRTVRVTDEAALIRDALVRAGGNKTKAAKLLGMSRRTIYRKLDEHG
IFGDFK
>Mature_565_residues
TYSILVVDDEESLRYTFRCFLEHQGYEVAIAANYEEALAALPAGFDLVFADIVLGGWTGVDLLREARLRGFDVPFVMVTG
YPHIDTASEALRLGAYDYIPKPVKQETIVRVARMAIRHHLVSKEKDQYRSNLEAIFRSVKDAIVTVDRGMRLIACNAAAT
TLCGITKDRVEAQELFCPEDCQHQCLKLLEETLVKRQPIEGQRFVCRRQGQPDRIIAAATSPLLDQLEGFDGAVLVARDE
TRLDHLERRASGRRSHLSLVGGSAAMQRLYSLLEALSEVDTTVLITGESGTGKELAADALHRGGHRADKPFVAVNCAALP
ETLLESELFGHVKGAFTGALRDKEGRFQKADGGTIFLDEIGDISPAMQLRLLRVLQEKVFERVGDATPIRVDVRIVAATN
RDLAQLVREGRFREDLYYRLKVVHLELPALRERKEDIPLLVEHFLGRLTARFERNPLTISQEALDTLMSHPWPGNVRELE
HVLEHAAVICRGHVILSDHLPADLAPAVPASAAPRTVRVTDEAALIRDALVRAGGNKTKAAKLLGMSRRTIYRKLDEHGI
FGDFK

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG3829

COG function: function code KT; Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=303, Percent_Identity=52.1452145214521, Blast_Score=302, Evalue=5e-83,
Organism=Escherichia coli, GI1788550, Length=326, Percent_Identity=45.7055214723926, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI1790299, Length=366, Percent_Identity=43.7158469945355, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI87082117, Length=320, Percent_Identity=46.5625, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1788905, Length=327, Percent_Identity=45.2599388379205, Blast_Score=258, Evalue=8e-70,
Organism=Escherichia coli, GI1789087, Length=308, Percent_Identity=46.4285714285714, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1789233, Length=321, Percent_Identity=42.6791277258567, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI87082152, Length=309, Percent_Identity=44.336569579288, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1786524, Length=315, Percent_Identity=42.2222222222222, Blast_Score=214, Evalue=2e-56,
Organism=Escherichia coli, GI87081872, Length=320, Percent_Identity=39.375, Blast_Score=205, Evalue=7e-54,
Organism=Escherichia coli, GI1787583, Length=341, Percent_Identity=38.7096774193548, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI87081858, Length=291, Percent_Identity=36.426116838488, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI1789828, Length=305, Percent_Identity=33.4426229508197, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1789809, Length=120, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 63009; Mature: 62878

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYSILVVDDEESLRYTFRCFLEHQGYEVAIAANYEEALAALPAGFDLVFADIVLGGWTG
CEEEEEEEECCHHHHHHHHHEEECCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHCCCHH
VDLLREARLRGFDVPFVMVTGYPHIDTASEALRLGAYDYIPKPVKQETIVRVARMAIRHH
HHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHH
LVSKEKDQYRSNLEAIFRSVKDAIVTVDRGMRLIACNAAATTLCGITKDRVEAQELFCPE
HHCCHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEECHHHHHHHCCCHHHHHHHHCCCCH
DCQHQCLKLLEETLVKRQPIEGQRFVCRRQGQPDRIIAAATSPLLDQLEGFDGAVLVARD
HHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEEEHHHHHHHHHCCCCCEEEEEEC
ETRLDHLERRASGRRSHLSLVGGSAAMQRLYSLLEALSEVDTTVLITGESGTGKELAADA
HHHHHHHHHHHCCCHHHHEEECCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHH
LHRGGHRADKPFVAVNCAALPETLLESELFGHVKGAFTGALRDKEGRFQKADGGTIFLDE
HHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECC
IGDISPAMQLRLLRVLQEKVFERVGDATPIRVDVRIVAATNRDLAQLVREGRFREDLYYR
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCHHHHHHHHCCCCHHHHHEE
LKVVHLELPALRERKEDIPLLVEHFLGRLTARFERNPLTISQEALDTLMSHPWPGNVREL
EEEEEEECHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHCCCCCCCHHHH
EHVLEHAAVICRGHVILSDHLPADLAPAVPASAAPRTVRVTDEAALIRDALVRAGGNKTK
HHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHCCCCHHH
AAKLLGMSRRTIYRKLDEHGIFGDFK
HHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TYSILVVDDEESLRYTFRCFLEHQGYEVAIAANYEEALAALPAGFDLVFADIVLGGWTG
EEEEEEEECCHHHHHHHHHEEECCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHCCCHH
VDLLREARLRGFDVPFVMVTGYPHIDTASEALRLGAYDYIPKPVKQETIVRVARMAIRHH
HHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHH
LVSKEKDQYRSNLEAIFRSVKDAIVTVDRGMRLIACNAAATTLCGITKDRVEAQELFCPE
HHCCHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEECHHHHHHHCCCHHHHHHHHCCCCH
DCQHQCLKLLEETLVKRQPIEGQRFVCRRQGQPDRIIAAATSPLLDQLEGFDGAVLVARD
HHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEEEHHHHHHHHHCCCCCEEEEEEC
ETRLDHLERRASGRRSHLSLVGGSAAMQRLYSLLEALSEVDTTVLITGESGTGKELAADA
HHHHHHHHHHHCCCHHHHEEECCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHH
LHRGGHRADKPFVAVNCAALPETLLESELFGHVKGAFTGALRDKEGRFQKADGGTIFLDE
HHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECC
IGDISPAMQLRLLRVLQEKVFERVGDATPIRVDVRIVAATNRDLAQLVREGRFREDLYYR
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCHHHHHHHHCCCCHHHHHEE
LKVVHLELPALRERKEDIPLLVEHFLGRLTARFERNPLTISQEALDTLMSHPWPGNVREL
EEEEEEECHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHCCCCCCCHHHH
EHVLEHAAVICRGHVILSDHLPADLAPAVPASAAPRTVRVTDEAALIRDALVRAGGNKTK
HHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHCCCCHHH
AAKLLGMSRRTIYRKLDEHGIFGDFK
HHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]