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The map label for this gene is mltD [H]

Identifier: 39996113

GI number: 39996113

Start: 1091283

End: 1092803

Strand: Direct

Name: mltD [H]

Synonym: GSU1010

Alternate gene names: 39996113

Gene position: 1091283-1092803 (Clockwise)

Preceding gene: 39996112

Following gene: 39996114

Centisome position: 28.61

GC content: 60.03

Gene sequence:

>1521_bases
ATGAATCGATCTTTTTTCCTGCTGGCCATAGTCCTGCTGTTTACACCCATTGCCCAGGCATCCGATCTTCACTTGAACCC
CCTGCGGGAGTTGACCTCCCTGGGGAGCGGTTCGCTGCAGGCCGATCTGTCGGGAGTTGTTCCCCGCGTGGGATCGGCGC
GGCCAAAGGCTGCCTCCCCTGCCGAGGGGCGCCGGGCGAATCCGCTGGAGCCGTCCATGGGAGAGCTCATCGTCGTGGAG
GACGAGACATCCCTTGAGGATGATTTCGAACTGCAGCTCCCCGGCCAGGACCTCCCCGAATCGGACATCCCGCTTGCCCT
CAACGGCAAGGTAGAGTACTTCATCTCCTATTTCCAGACCTCCGGCCGCAAGTCCTTTTCCCGCTGGCTTTCCCGCTCCG
AACGATACATTCCCATGATGCGCGAGGTTCTCAGGAAGGAAGGACTTCCCGAGGATCTGGTCTACCTGGCCATGATCGAG
AGCGGCTTTACGCCCCATGCGGTTTCCGTGGCGAGCGCCGTGGGCCCCTGGCAGTTCATCTCGGGCACGGGAAAACGTTA
CGACCTGAGGATCGACCAATGGATCGACGAACGGCGCGATCCGCTCAAGTCGACCGTTGCCGCCGCCATGTACCTGAAGG
AGCTTTACTCCCTCTTCAATCAGGATTGGTATCTGGCTGCGGCAGGCTATAACGCCGGCGAGAACAAGATCCTGCGCGCC
ATCGACAAATACAACACGCGGGACTTCTGGGAAATATCCAAGGGCTCGTATTTGAAGAGGGAGACCAAGGATTACGTGCC
GAAGCTCCTGGCCGCCGCCATCATCGCAAAGGAGCCGGCCCGCTACGGCTTCGCCGATGTGGCGTATCTTCCCCCCATCG
AGTTCGACTTAGTTGCCATTCCTTCGCGCACCGATCTGGACCTGGTGGCCAAACTCTGCGAGGTGGATGTCAAGGCCATC
AAGGAATTGAACCCGGAACTGCGCCGCTGGTGCACACCTCCCGACTACCCCGACTACGAGCTCAAAATCCCCAAGGGAAA
GCGCACGTCCTTCGAGGAGGCATACGCCCATCTCCCCGCGGACCAGCGCTACGTCGAGCGGATTGTCTACAGCCGCTACC
GGGTTAAGAAAAAGGATACCCTGCAGGCGATCGCGCGACGCTACGGCACCACTGCCGAGACCCTGGCCGAGGTTAACAAA
CTGAAGCCGACCTCGAAGCTCCGGGGCCGCACCCTGCTGGTGCCGGTGCCGGTCGCGACGGAGGATGCCGCGGAAAGGAC
CGTCGCCAAGGCGTCGCCGAAGAAGGACGAGTCCCGCGCATTCAACAAGTACTACACGGTCAAGAAAGGCGACACCGTCG
CCTCGCTGTCCAAGAAATTCAACATTTCCCAACGGATTCTGGCAGCATGGAATAATTTGAAGGGCAAAATGGCCCTTCAC
CCCGGCAAGCGGATCATCGTCGCCAAGTATGTGGAGAAAAAAGGGTCGATGGTGCCGGTCGACGGCGGGGAGAACAGCTA
G

Upstream 100 bases:

>100_bases
CTAATCTTGACAGTTTGGTGAAATGCGACTATACTGCCGCATCCGGCATGGCACCGGCTTCCCACATTATTCCCTCGCGA
AAGTGCGTGGAAGGGCTCCC

Downstream 100 bases:

>100_bases
CACGCTCTATTCTTCACTGCACTCACGAATGAAAGGACTTCATCCGCAATGTACAACTTCCTGATTTCCGGCGCGATCGC
CCTTGTCGCCATTGTCGTCA

Product: Slt family transglycosylase

Products: 1,6-Anhydrobond In The Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase D; Regulatory protein dniR [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MNRSFFLLAIVLLFTPIAQASDLHLNPLRELTSLGSGSLQADLSGVVPRVGSARPKAASPAEGRRANPLEPSMGELIVVE
DETSLEDDFELQLPGQDLPESDIPLALNGKVEYFISYFQTSGRKSFSRWLSRSERYIPMMREVLRKEGLPEDLVYLAMIE
SGFTPHAVSVASAVGPWQFISGTGKRYDLRIDQWIDERRDPLKSTVAAAMYLKELYSLFNQDWYLAAAGYNAGENKILRA
IDKYNTRDFWEISKGSYLKRETKDYVPKLLAAAIIAKEPARYGFADVAYLPPIEFDLVAIPSRTDLDLVAKLCEVDVKAI
KELNPELRRWCTPPDYPDYELKIPKGKRTSFEEAYAHLPADQRYVERIVYSRYRVKKKDTLQAIARRYGTTAETLAEVNK
LKPTSKLRGRTLLVPVPVATEDAAERTVAKASPKKDESRAFNKYYTVKKGDTVASLSKKFNISQRILAAWNNLKGKMALH
PGKRIIVAKYVEKKGSMVPVDGGENS

Sequences:

>Translated_506_residues
MNRSFFLLAIVLLFTPIAQASDLHLNPLRELTSLGSGSLQADLSGVVPRVGSARPKAASPAEGRRANPLEPSMGELIVVE
DETSLEDDFELQLPGQDLPESDIPLALNGKVEYFISYFQTSGRKSFSRWLSRSERYIPMMREVLRKEGLPEDLVYLAMIE
SGFTPHAVSVASAVGPWQFISGTGKRYDLRIDQWIDERRDPLKSTVAAAMYLKELYSLFNQDWYLAAAGYNAGENKILRA
IDKYNTRDFWEISKGSYLKRETKDYVPKLLAAAIIAKEPARYGFADVAYLPPIEFDLVAIPSRTDLDLVAKLCEVDVKAI
KELNPELRRWCTPPDYPDYELKIPKGKRTSFEEAYAHLPADQRYVERIVYSRYRVKKKDTLQAIARRYGTTAETLAEVNK
LKPTSKLRGRTLLVPVPVATEDAAERTVAKASPKKDESRAFNKYYTVKKGDTVASLSKKFNISQRILAAWNNLKGKMALH
PGKRIIVAKYVEKKGSMVPVDGGENS
>Mature_506_residues
MNRSFFLLAIVLLFTPIAQASDLHLNPLRELTSLGSGSLQADLSGVVPRVGSARPKAASPAEGRRANPLEPSMGELIVVE
DETSLEDDFELQLPGQDLPESDIPLALNGKVEYFISYFQTSGRKSFSRWLSRSERYIPMMREVLRKEGLPEDLVYLAMIE
SGFTPHAVSVASAVGPWQFISGTGKRYDLRIDQWIDERRDPLKSTVAAAMYLKELYSLFNQDWYLAAAGYNAGENKILRA
IDKYNTRDFWEISKGSYLKRETKDYVPKLLAAAIIAKEPARYGFADVAYLPPIEFDLVAIPSRTDLDLVAKLCEVDVKAI
KELNPELRRWCTPPDYPDYELKIPKGKRTSFEEAYAHLPADQRYVERIVYSRYRVKKKDTLQAIARRYGTTAETLAEVNK
LKPTSKLRGRTLLVPVPVATEDAAERTVAKASPKKDESRAFNKYYTVKKGDTVASLSKKFNISQRILAAWNNLKGKMALH
PGKRIIVAKYVEKKGSMVPVDGGENS

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 LysM repeats [H]

Homologues:

Organism=Escherichia coli, GI1786405, Length=373, Percent_Identity=30.0268096514745, Blast_Score=160, Evalue=2e-40,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008258
- InterPro:   IPR010511
- InterPro:   IPR018392
- InterPro:   IPR002482
- InterPro:   IPR000189 [H]

Pfam domain/function: PF01476 LysM; PF06474 MLTD_N; PF01464 SLT [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 56913; Mature: 56913

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRSFFLLAIVLLFTPIAQASDLHLNPLRELTSLGSGSLQADLSGVVPRVGSARPKAASP
CCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCC
AEGRRANPLEPSMGELIVVEDETSLEDDFELQLPGQDLPESDIPLALNGKVEYFISYFQT
CCCCCCCCCCCCCCCEEEEECCCCCCCCCEEECCCCCCCCCCCCEEECCHHHHHHHHHHH
SGRKSFSRWLSRSERYIPMMREVLRKEGLPEDLVYLAMIESGFTPHAVSVASAVGPWQFI
CCHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCHHHH
SGTGKRYDLRIDQWIDERRDPLKSTVAAAMYLKELYSLFNQDWYLAAAGYNAGENKILRA
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHH
IDKYNTRDFWEISKGSYLKRETKDYVPKLLAAAIIAKEPARYGFADVAYLPPIEFDLVAI
HHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCEEEEEC
PSRTDLDLVAKLCEVDVKAIKELNPELRRWCTPPDYPDYELKIPKGKRTSFEEAYAHLPA
CCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCEEECCCCCCCCHHHHHHHCCC
DQRYVERIVYSRYRVKKKDTLQAIARRYGTTAETLAEVNKLKPTSKLRGRTLLVPVPVAT
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHCCCEEEEECCCCC
EDAAERTVAKASPKKDESRAFNKYYTVKKGDTVASLSKKFNISQRILAAWNNLKGKMALH
CHHHHHHHHHCCCCCHHHHHHHHEEEEECCCHHHHHHHHCCHHHHHHHHHHCCCCCEEEC
PGKRIIVAKYVEKKGSMVPVDGGENS
CCCEEEEEEEHHHCCCEEECCCCCCC
>Mature Secondary Structure
MNRSFFLLAIVLLFTPIAQASDLHLNPLRELTSLGSGSLQADLSGVVPRVGSARPKAASP
CCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCC
AEGRRANPLEPSMGELIVVEDETSLEDDFELQLPGQDLPESDIPLALNGKVEYFISYFQT
CCCCCCCCCCCCCCCEEEEECCCCCCCCCEEECCCCCCCCCCCCEEECCHHHHHHHHHHH
SGRKSFSRWLSRSERYIPMMREVLRKEGLPEDLVYLAMIESGFTPHAVSVASAVGPWQFI
CCHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCHHHH
SGTGKRYDLRIDQWIDERRDPLKSTVAAAMYLKELYSLFNQDWYLAAAGYNAGENKILRA
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHH
IDKYNTRDFWEISKGSYLKRETKDYVPKLLAAAIIAKEPARYGFADVAYLPPIEFDLVAI
HHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCEEEEEC
PSRTDLDLVAKLCEVDVKAIKELNPELRRWCTPPDYPDYELKIPKGKRTSFEEAYAHLPA
CCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCEEECCCCCCCCHHHHHHHCCC
DQRYVERIVYSRYRVKKKDTLQAIARRYGTTAETLAEVNKLKPTSKLRGRTLLVPVPVAT
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHCCCEEEEECCCCC
EDAAERTVAKASPKKDESRAFNKYYTVKKGDTVASLSKKFNISQRILAAWNNLKGKMALH
CHHHHHHHHHCCCCCHHHHHHHHEEEEECCCHHHHHHHHCCHHHHHHHHHHCCCCCEEEC
PGKRIIVAKYVEKKGSMVPVDGGENS
CCCEEEEEEEHHHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]