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The map label for this gene is fabI [H]

Identifier: 39996111

GI number: 39996111

Start: 1088641

End: 1089411

Strand: Direct

Name: fabI [H]

Synonym: GSU1008

Alternate gene names: 39996111

Gene position: 1088641-1089411 (Clockwise)

Preceding gene: 39996109

Following gene: 39996112

Centisome position: 28.54

GC content: 60.96

Gene sequence:

>771_bases
ATGGGTCTTTTGGAAGGCAAAAAGGCGGTCGTTTTCGGCATCGCCAACGAGAAAAGCATCGCGTGGGCCATTGCCCAGGC
GTTCAGGCGGGAAGGCGCCGATCTGGCGATCACCTATGCCAACGAAACCCTGGCCAAGCGGGTGATCCCGCTTGCCGAAA
GCATCGGGGCGAGCCTCATTCTCCCCTGCGACGTTCGCAACGACGACGACATTGCGGCAGTTTTCGCCCGGATTGAGCGT
TCGTGGGGAAGGCTCGACACCCTGGTTCATTCGGTGGCCTTTGCCAACAAGGACGAACTGAAGGGGTCCTTTCTCAATAC
CACCCGGGAAGGCTTTTCCCTCGCCATGGACATCAGCGCTTACTCCCTCATCGCCCTGGCCAAGGGGGCCCATCCCCTCC
TGAAGGAGCGGCAGGGGAGCATTATCACCCTTTCCTACTATGGCGGCCAGAAGGTTTTCCCGAGCTATAACGTCATGGGG
GTCGCCAAGGCGGCACTGGAGATGAGCGTCAGGTATCTTGCCGAGGCCGTCGGCCCCGACGGCATTCGCGTCAATGCCAT
CTCTGCCGGTCCACTGAAGACCCTCGCCGCAGCAGGCGTGGGCGGCTTCAACCAGATCGCCGGCCACGTGGCCGAGAAAG
CGCCTCTTCGCCGCAATATCAGCCAGGAGGAAGTGGCCGGCGCGGCTCTTTATCTGGCCAGCGATCTGTCGAGCGGGGTT
ACCGGGGAGGTGCACTTCGTCGACAGCGGGTATAATATCATAGGACTTTGA

Upstream 100 bases:

>100_bases
TTGCCAACGAGGGGGTTTTTTTGTATTACTATCCCCTCTGCGCCGAGCCGAAGTGAGTGCTCCGCGCAGGTGACAGCATC
CGGTAGGGAGGAGCGGATTC

Downstream 100 bases:

>100_bases
CAAACGAGGCTGCTGCCGGCCTCAAGGAGTTTTCAATCAAACAGCTGCACGGCAACCTCATGGGGCTCAAGCCGAGCCAG
GTGGCGGCCCTTGAACGGCT

Product: enoyl-ACP reductase

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase [H]

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MGLLEGKKAVVFGIANEKSIAWAIAQAFRREGADLAITYANETLAKRVIPLAESIGASLILPCDVRNDDDIAAVFARIER
SWGRLDTLVHSVAFANKDELKGSFLNTTREGFSLAMDISAYSLIALAKGAHPLLKERQGSIITLSYYGGQKVFPSYNVMG
VAKAALEMSVRYLAEAVGPDGIRVNAISAGPLKTLAAAGVGGFNQIAGHVAEKAPLRRNISQEEVAGAALYLASDLSSGV
TGEVHFVDSGYNIIGL

Sequences:

>Translated_256_residues
MGLLEGKKAVVFGIANEKSIAWAIAQAFRREGADLAITYANETLAKRVIPLAESIGASLILPCDVRNDDDIAAVFARIER
SWGRLDTLVHSVAFANKDELKGSFLNTTREGFSLAMDISAYSLIALAKGAHPLLKERQGSIITLSYYGGQKVFPSYNVMG
VAKAALEMSVRYLAEAVGPDGIRVNAISAGPLKTLAAAGVGGFNQIAGHVAEKAPLRRNISQEEVAGAALYLASDLSSGV
TGEVHFVDSGYNIIGL
>Mature_255_residues
GLLEGKKAVVFGIANEKSIAWAIAQAFRREGADLAITYANETLAKRVIPLAESIGASLILPCDVRNDDDIAAVFARIERS
WGRLDTLVHSVAFANKDELKGSFLNTTREGFSLAMDISAYSLIALAKGAHPLLKERQGSIITLSYYGGQKVFPSYNVMGV
AKAALEMSVRYLAEAVGPDGIRVNAISAGPLKTLAAAGVGGFNQIAGHVAEKAPLRRNISQEEVAGAALYLASDLSSGVT
GEVHFVDSGYNIIGL

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Homo sapiens, GI10190704, Length=259, Percent_Identity=27.7992277992278, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI5031737, Length=243, Percent_Identity=27.9835390946502, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI40254992, Length=249, Percent_Identity=27.3092369477912, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787545, Length=254, Percent_Identity=48.0314960629921, Blast_Score=254, Evalue=3e-69,
Organism=Escherichia coli, GI1789378, Length=255, Percent_Identity=31.3725490196078, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87082100, Length=261, Percent_Identity=28.3524904214559, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI2367365, Length=255, Percent_Identity=27.0588235294118, Blast_Score=61, Evalue=6e-11,
Organism=Escherichia coli, GI1787335, Length=258, Percent_Identity=27.906976744186, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=244, Percent_Identity=27.4590163934426, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71994604, Length=179, Percent_Identity=29.608938547486, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=260, Percent_Identity=27.6923076923077, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=262, Percent_Identity=30.1526717557252, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI23397609, Length=254, Percent_Identity=28.3464566929134, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357041, Length=198, Percent_Identity=31.3131313131313, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24644337, Length=242, Percent_Identity=29.7520661157025, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21355319, Length=246, Percent_Identity=28.0487804878049, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28571526, Length=197, Percent_Identity=29.4416243654822, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 27067; Mature: 26936

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLLEGKKAVVFGIANEKSIAWAIAQAFRREGADLAITYANETLAKRVIPLAESIGASLI
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCEEE
LPCDVRNDDDIAAVFARIERSWGRLDTLVHSVAFANKDELKGSFLNTTREGFSLAMDISA
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHCCCCCEEEEEEHHH
YSLIALAKGAHPLLKERQGSIITLSYYGGQKVFPSYNVMGVAKAALEMSVRYLAEAVGPD
HHHHHHHCCCCHHHHHCCCCEEEEEEECCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCC
GIRVNAISAGPLKTLAAAGVGGFNQIAGHVAEKAPLRRNISQEEVAGAALYLASDLSSGV
CEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHCHHHHCCCHHHHHHHHHEEHHHCCCCC
TGEVHFVDSGYNIIGL
CEEEEEEECCCEEECC
>Mature Secondary Structure 
GLLEGKKAVVFGIANEKSIAWAIAQAFRREGADLAITYANETLAKRVIPLAESIGASLI
CCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCEEE
LPCDVRNDDDIAAVFARIERSWGRLDTLVHSVAFANKDELKGSFLNTTREGFSLAMDISA
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHCCCCCEEEEEEHHH
YSLIALAKGAHPLLKERQGSIITLSYYGGQKVFPSYNVMGVAKAALEMSVRYLAEAVGPD
HHHHHHHCCCCHHHHHCCCCEEEEEEECCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCC
GIRVNAISAGPLKTLAAAGVGGFNQIAGHVAEKAPLRRNISQEEVAGAALYLASDLSSGV
CEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHCHHHHCCCHHHHHHHHHEEHHHCCCCC
TGEVHFVDSGYNIIGL
CEEEEEEECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]