Click here to switch to the map view.

The map label for this gene is lpxA [H]

Identifier: 39996102

GI number: 39996102

Start: 1079182

End: 1079991

Strand: Direct

Name: lpxA [H]

Synonym: GSU0999

Alternate gene names: 39996102

Gene position: 1079182-1079991 (Clockwise)

Preceding gene: 39996101

Following gene: 39996103

Centisome position: 28.29

GC content: 60.12

Gene sequence:

>810_bases
ATGATTACTAACATTCATCCGACTGCCCACATAAGCCCCTCCGCCACCATTGCCGACGGCGCGGAAATCGGCCCCAACGT
CATCGTGGGAGATCACTCCTCCATCGGCGCCGGCACCAGGGTGATGGCCAACGCCGTTATCGGTCCCTGGACGCAGATCG
GCGAGAACAATGTCATTCACTTCGGCGCCATCGTCGGTCACGACCCCCAGGACTTCGGCTACAAGGGGGAGGAGAGCTGG
ACTATCGTCGGCAACGGCAACGTGATTCGCGAGTATGTCACCATTCACCGGGGTAACCGGCCGGGGACGAAAACGATGAT
CGGCAGCAATAACCTGTTCATGGCCCATTCCCACGTGGCCCACAACTGTGAGCTGGGGAGCAATATCATCCTGGTGAACG
GCGCCCTCCTGGCCGGACACGTGGTGGTGGAAGACCGGGTCATCATTTCCGGTAACAGTGTGGTGCACCAGTTCTGCCGC
ATCGGCACCTTTGCCATGATGCGGGGGCTGTCCCGCTCGTCCCGCGACGTGCCTCCCTTCTGCATCATGGACGACACCCA
TACGGTGAAGGCGCTGAACCTGGTTGGCCTCAAGCGCAACGGTTTCGACCAGTCCCGCATCCGGGCGCTCAAGAACGCCT
TCAAGCTCCTGTTCCTCTCGGGTCTCAACATGCAGAATGCCCTGGCAGAGGTGGAGCGCTCCCTCCACATCACCGATGAT
GTCCGCTACCTCATTGACTTCATCAAGTCGGCCAAGCGCGGCGTCTGTTTCGGTCGCGGCCTGATCGTGGATGTGGAGGA
TAAAGAGTAG

Upstream 100 bases:

>100_bases
GCCGAGATCATTATCGGCAAGCAGCGTAACGGCCCCATCGGCTCCGTCAACCTGCTGTTCAACGGCGAATTCACCAAGTT
CGAAAATATGGAGAAGCATC

Downstream 100 bases:

>100_bases
GGCGCCGCCTGCCCGGCTCATCCTCCGGAACCGACCGGCCCCGGCGGCTGGACGTCAGTACCCATTACGAATCGAGGAAT
CAATCATGACCACATACACT

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MITNIHPTAHISPSATIADGAEIGPNVIVGDHSSIGAGTRVMANAVIGPWTQIGENNVIHFGAIVGHDPQDFGYKGEESW
TIVGNGNVIREYVTIHRGNRPGTKTMIGSNNLFMAHSHVAHNCELGSNIILVNGALLAGHVVVEDRVIISGNSVVHQFCR
IGTFAMMRGLSRSSRDVPPFCIMDDTHTVKALNLVGLKRNGFDQSRIRALKNAFKLLFLSGLNMQNALAEVERSLHITDD
VRYLIDFIKSAKRGVCFGRGLIVDVEDKE

Sequences:

>Translated_269_residues
MITNIHPTAHISPSATIADGAEIGPNVIVGDHSSIGAGTRVMANAVIGPWTQIGENNVIHFGAIVGHDPQDFGYKGEESW
TIVGNGNVIREYVTIHRGNRPGTKTMIGSNNLFMAHSHVAHNCELGSNIILVNGALLAGHVVVEDRVIISGNSVVHQFCR
IGTFAMMRGLSRSSRDVPPFCIMDDTHTVKALNLVGLKRNGFDQSRIRALKNAFKLLFLSGLNMQNALAEVERSLHITDD
VRYLIDFIKSAKRGVCFGRGLIVDVEDKE
>Mature_269_residues
MITNIHPTAHISPSATIADGAEIGPNVIVGDHSSIGAGTRVMANAVIGPWTQIGENNVIHFGAIVGHDPQDFGYKGEESW
TIVGNGNVIREYVTIHRGNRPGTKTMIGSNNLFMAHSHVAHNCELGSNIILVNGALLAGHVVVEDRVIISGNSVVHQFCR
IGTFAMMRGLSRSSRDVPPFCIMDDTHTVKALNLVGLKRNGFDQSRIRALKNAFKLLFLSGLNMQNALAEVERSLHITDD
VRYLIDFIKSAKRGVCFGRGLIVDVEDKE

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=253, Percent_Identity=41.897233201581, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI1786376, Length=182, Percent_Identity=31.8681318681319, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 29214; Mature: 29214

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITNIHPTAHISPSATIADGAEIGPNVIVGDHSSIGAGTRVMANAVIGPWTQIGENNVIH
CCCCCCCCCCCCCCCEECCCCCCCCEEEEECCCCCCCCHHHHHHHHCCCHHHCCCCCEEE
FGAIVGHDPQDFGYKGEESWTIVGNGNVIREYVTIHRGNRPGTKTMIGSNNLFMAHSHVA
EEEEECCCCHHCCCCCCCCEEEEECCCEEEEEEEEECCCCCCCEEEECCCCEEEEECCHH
HNCELGSNIILVNGALLAGHVVVEDRVIISGNSVVHQFCRIGTFAMMRGLSRSSRDVPPF
CCCCCCCCEEEEECCEEEEEEEEECEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCE
CIMDDTHTVKALNLVGLKRNGFDQSRIRALKNAFKLLFLSGLNMQNALAEVERSLHITDD
EEECCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHH
VRYLIDFIKSAKRGVCFGRGLIVDVEDKE
HHHHHHHHHHHCCCEEECCEEEEEECCCC
>Mature Secondary Structure
MITNIHPTAHISPSATIADGAEIGPNVIVGDHSSIGAGTRVMANAVIGPWTQIGENNVIH
CCCCCCCCCCCCCCCEECCCCCCCCEEEEECCCCCCCCHHHHHHHHCCCHHHCCCCCEEE
FGAIVGHDPQDFGYKGEESWTIVGNGNVIREYVTIHRGNRPGTKTMIGSNNLFMAHSHVA
EEEEECCCCHHCCCCCCCCEEEEECCCEEEEEEEEECCCCCCCEEEECCCCEEEEECCHH
HNCELGSNIILVNGALLAGHVVVEDRVIISGNSVVHQFCRIGTFAMMRGLSRSSRDVPPF
CCCCCCCCEEEEECCEEEEEEEEECEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCE
CIMDDTHTVKALNLVGLKRNGFDQSRIRALKNAFKLLFLSGLNMQNALAEVERSLHITDD
EEECCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHH
VRYLIDFIKSAKRGVCFGRGLIVDVEDKE
HHHHHHHHHHHCCCEEECCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA