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The map label for this gene is lpxC [H]

Identifier: 39995837

GI number: 39995837

Start: 777950

End: 778777

Strand: Direct

Name: lpxC [H]

Synonym: GSU0731

Alternate gene names: 39995837

Gene position: 777950-778777 (Clockwise)

Preceding gene: 39995834

Following gene: 39995839

Centisome position: 20.4

GC content: 60.75

Gene sequence:

>828_bases
ATGAACAAACGACAAACAACCATCAACCGGATTTTCAAGCTGAGCGGCATCGGTCTCCATACCGGCCGGGAAGTGACCCT
GGAGTTCATCCCCCGCCGGGAGTTCGGCATCGCCTTCGTCTATCAGGGACAGCTCATCCCTGCCCGCTACGACATGGTGG
CGGACACCCGGCTTTCGACCCAGATCGCGGCGGACGGGAAATCGGTCTCCACCATCGAGCACCTGATGGCGGCCTTCTAC
TACTCGGGGATCACCAACTGTCTCGTCTACATCGACGGCCCCGAGGTGCCGATCATGGACGGCTCGGCCTGGGAGTTCTA
CCACGAGATCTGGCGGGCCGGGGTCTACGAGTTTCCGGAGACGGGGGTCTACCTGAAGGTGCTCCGCCCCGTCGAGGTGA
GCCACAATGATGCCTGGGTGCGGGTAAAGCCCCTTAACACCCTCGACATCACCATGACCATCGAGTTCCGTCCCCCGGTC
GGGAAGCAGAGGAAGCGGCTCATGGACGTGGAGAACGCCGTCTCCATCATTAACTCGCGCACCTTCGTCCTCCACGAGGA
GATCGAGGCGATCCGCAAGGCGGGCCTCGCCAAGGGCGGGTCCCTGGACAACGCCGTTGTCATCGGCGGAGAGGAGATCC
TGAACCCCAACGGTCTCCGCTACAAAAAGGAGTTGGTGAACCACAAGATACTCGACCTCATCGGCGACCTCTTTACCTGC
GGCTACCGCATGCTGGGCAAGGTGGAGGCAAACAAGACCGGCCACTACCTGAACAACCGGCTGCTGCGCGAGATATTTGC
CGATCCCGACAATTACGCCATCTACTGA

Upstream 100 bases:

>100_bases
ATAATATATATTCAAAATAATATATTTTAAGACTGCAGTTGTTTTGCAGGAGTTCTTTTTTCTTTTTCCGGCGCAGGATT
TGTGATACGCACAAGGGACC

Downstream 100 bases:

>100_bases
CGGCGCCGGTTTGCGCGGCCCGGAAAATGAAAAAGCCCGCCGAATGCGGGCTTTTTTCGTACCGGGAACCAGGCGCGTGC
CGGCTACCGATGAAAATCCC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MNKRQTTINRIFKLSGIGLHTGREVTLEFIPRREFGIAFVYQGQLIPARYDMVADTRLSTQIAADGKSVSTIEHLMAAFY
YSGITNCLVYIDGPEVPIMDGSAWEFYHEIWRAGVYEFPETGVYLKVLRPVEVSHNDAWVRVKPLNTLDITMTIEFRPPV
GKQRKRLMDVENAVSIINSRTFVLHEEIEAIRKAGLAKGGSLDNAVVIGGEEILNPNGLRYKKELVNHKILDLIGDLFTC
GYRMLGKVEANKTGHYLNNRLLREIFADPDNYAIY

Sequences:

>Translated_275_residues
MNKRQTTINRIFKLSGIGLHTGREVTLEFIPRREFGIAFVYQGQLIPARYDMVADTRLSTQIAADGKSVSTIEHLMAAFY
YSGITNCLVYIDGPEVPIMDGSAWEFYHEIWRAGVYEFPETGVYLKVLRPVEVSHNDAWVRVKPLNTLDITMTIEFRPPV
GKQRKRLMDVENAVSIINSRTFVLHEEIEAIRKAGLAKGGSLDNAVVIGGEEILNPNGLRYKKELVNHKILDLIGDLFTC
GYRMLGKVEANKTGHYLNNRLLREIFADPDNYAIY
>Mature_275_residues
MNKRQTTINRIFKLSGIGLHTGREVTLEFIPRREFGIAFVYQGQLIPARYDMVADTRLSTQIAADGKSVSTIEHLMAAFY
YSGITNCLVYIDGPEVPIMDGSAWEFYHEIWRAGVYEFPETGVYLKVLRPVEVSHNDAWVRVKPLNTLDITMTIEFRPPV
GKQRKRLMDVENAVSIINSRTFVLHEEIEAIRKAGLAKGGSLDNAVVIGGEEILNPNGLRYKKELVNHKILDLIGDLFTC
GYRMLGKVEANKTGHYLNNRLLREIFADPDNYAIY

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=275, Percent_Identity=37.0909090909091, Blast_Score=178, Evalue=4e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 31211; Mature: 31211

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKRQTTINRIFKLSGIGLHTGREVTLEFIPRREFGIAFVYQGQLIPARYDMVADTRLST
CCCHHHHHHHHHHHCCCEECCCCEEEEEEECCCCCCEEEEEECEECCCHHHHEECCHHHE
QIAADGKSVSTIEHLMAAFYYSGITNCLVYIDGPEVPIMDGSAWEFYHEIWRAGVYEFPE
EEECCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEECCCHHHHHHHHHHCCCCCCCC
TGVYLKVLRPVEVSHNDAWVRVKPLNTLDITMTIEFRPPVGKQRKRLMDVENAVSIINSR
CCEEEEEEECEEECCCCCEEEEEECCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCC
TFVLHEEIEAIRKAGLAKGGSLDNAVVIGGEEILNPNGLRYKKELVNHKILDLIGDLFTC
EEEEHHHHHHHHHHCCCCCCCCCCEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
GYRMLGKVEANKTGHYLNNRLLREIFADPDNYAIY
HHHHHHEEECCCCCHHHHHHHHHHHHCCCCCEEEC
>Mature Secondary Structure
MNKRQTTINRIFKLSGIGLHTGREVTLEFIPRREFGIAFVYQGQLIPARYDMVADTRLST
CCCHHHHHHHHHHHCCCEECCCCEEEEEEECCCCCCEEEEEECEECCCHHHHEECCHHHE
QIAADGKSVSTIEHLMAAFYYSGITNCLVYIDGPEVPIMDGSAWEFYHEIWRAGVYEFPE
EEECCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEECCCHHHHHHHHHHCCCCCCCC
TGVYLKVLRPVEVSHNDAWVRVKPLNTLDITMTIEFRPPVGKQRKRLMDVENAVSIINSR
CCEEEEEEECEEECCCCCEEEEEECCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCC
TFVLHEEIEAIRKAGLAKGGSLDNAVVIGGEEILNPNGLRYKKELVNHKILDLIGDLFTC
EEEEHHHHHHHHHHCCCCCCCCCCEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
GYRMLGKVEANKTGHYLNNRLLREIFADPDNYAIY
HHHHHHEEECCCCCHHHHHHHHHHHHCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA