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The map label for this gene is pth

Identifier: 39995769

GI number: 39995769

Start: 699603

End: 700184

Strand: Direct

Name: pth

Synonym: GSU0663

Alternate gene names: 39995769

Gene position: 699603-700184 (Clockwise)

Preceding gene: 39995768

Following gene: 39995770

Centisome position: 18.34

GC content: 58.93

Gene sequence:

>582_bases
ATGGCAACAAAACTGATCGTCGGGCTGGGGAATCCCGGCCCGAAATACCTATGGACCCGCCACAACGCGGGTTTCATGGT
TTTAGACCGTCTTGCCCACGCCATCGGTGCGTCGGTTACCAGGAAGAGCTTTTCCGGTGTCTTCGGTGAGGGGGCTTGGC
ACGGCGAACGGCTTCTCCTTCTCAAGCCCCAGACCTACATGAATCTTTCCGGGCGCTCGGTGGCCGAGGCGCTCCGTTTT
CACAAGCTTCCGCTTTGCGACACCATCGTGATTCATGACGACCTCGACATTCCCTTCGGCCGTGTCAAGGTCAAGGAGGG
GGGCGGTCACGGCGGGCACAATGGTCTCCGCTCCCTTGTTCAGGAGCTTGGCGGAGCAGGCTTTGTCCGGGTGAGAGTCG
GGATCGGCAGGCCGGTCCATGGTGACGTGGTGAATTACGTTCTGACCAATTTCAGTCAGGACGAAATGGCGGATCTTGCC
CACCTGCTCGACGGAACCCTCGACCTCCTGGAGTCACTCCTGACAGCCGGACTCCCCAAGACCATGAGTCTGTATAACAA
CAAGGATCTTCTTGCCCCCTGA

Upstream 100 bases:

>100_bases
TGACCCCGAGACTCCCATCGTGAGCATCCACGGAAAGGCAAAGGAAGAAGCTCCTGCGGCGGAATAACCCCGCCGCACGG
CTTCACGCCGCGTCGACCAC

Downstream 100 bases:

>100_bases
CAACGAGGGGGGGCGGATATCTTCCTGAAGGAAGGATGCACATGGGTTTCAACTGCGGCATCGTGGGACTCCCCAACGTG
GGAAAGTCGACCATCTTCAA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MATKLIVGLGNPGPKYLWTRHNAGFMVLDRLAHAIGASVTRKSFSGVFGEGAWHGERLLLLKPQTYMNLSGRSVAEALRF
HKLPLCDTIVIHDDLDIPFGRVKVKEGGGHGGHNGLRSLVQELGGAGFVRVRVGIGRPVHGDVVNYVLTNFSQDEMADLA
HLLDGTLDLLESLLTAGLPKTMSLYNNKDLLAP

Sequences:

>Translated_193_residues
MATKLIVGLGNPGPKYLWTRHNAGFMVLDRLAHAIGASVTRKSFSGVFGEGAWHGERLLLLKPQTYMNLSGRSVAEALRF
HKLPLCDTIVIHDDLDIPFGRVKVKEGGGHGGHNGLRSLVQELGGAGFVRVRVGIGRPVHGDVVNYVLTNFSQDEMADLA
HLLDGTLDLLESLLTAGLPKTMSLYNNKDLLAP
>Mature_192_residues
ATKLIVGLGNPGPKYLWTRHNAGFMVLDRLAHAIGASVTRKSFSGVFGEGAWHGERLLLLKPQTYMNLSGRSVAEALRFH
KLPLCDTIVIHDDLDIPFGRVKVKEGGGHGGHNGLRSLVQELGGAGFVRVRVGIGRPVHGDVVNYVLTNFSQDEMADLAH
LLDGTLDLLESLLTAGLPKTMSLYNNKDLLAP

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=170, Percent_Identity=41.7647058823529, Blast_Score=106, Evalue=1e-23,
Organism=Escherichia coli, GI1787455, Length=188, Percent_Identity=41.4893617021277, Blast_Score=99, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321983, Length=168, Percent_Identity=31.547619047619, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_GEOSL (Q74FE6)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_951720.1
- ProteinModelPortal:   Q74FE6
- GeneID:   2685517
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU0663
- NMPDR:   fig|243231.1.peg.658
- TIGR:   GSU0663
- HOGENOM:   HBG610927
- OMA:   NESGRQV
- ProtClustDB:   PRK05426
- BioCyc:   GSUL243231:GSU_0663-MONOMER
- BRENDA:   3.1.1.29
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 20887; Mature: 20755

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATKLIVGLGNPGPKYLWTRHNAGFMVLDRLAHAIGASVTRKSFSGVFGEGAWHGERLLL
CCCEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
LKPQTYMNLSGRSVAEALRFHKLPLCDTIVIHDDLDIPFGRVKVKEGGGHGGHNGLRSLV
ECCCHHCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHH
QELGGAGFVRVRVGIGRPVHGDVVNYVLTNFSQDEMADLAHLLDGTLDLLESLLTAGLPK
HHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCH
TMSLYNNKDLLAP
HHHHHCCCCCCCC
>Mature Secondary Structure 
ATKLIVGLGNPGPKYLWTRHNAGFMVLDRLAHAIGASVTRKSFSGVFGEGAWHGERLLL
CCEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
LKPQTYMNLSGRSVAEALRFHKLPLCDTIVIHDDLDIPFGRVKVKEGGGHGGHNGLRSLV
ECCCHHCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHH
QELGGAGFVRVRVGIGRPVHGDVVNYVLTNFSQDEMADLAHLLDGTLDLLESLLTAGLPK
HHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCH
TMSLYNNKDLLAP
HHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA