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The map label for this gene is moeZ [H]

Identifier: 39995760

GI number: 39995760

Start: 689939

End: 690685

Strand: Reverse

Name: moeZ [H]

Synonym: GSU0654

Alternate gene names: 39995760

Gene position: 690685-689939 (Counterclockwise)

Preceding gene: 39995761

Following gene: 39995745

Centisome position: 18.11

GC content: 56.09

Gene sequence:

>747_bases
ATGCTTACAAGTGATCAACAAGAGCGATATGCTCGCCACCTCATTCTTGAGGGAGTAGGCCCGGAAGGACAAGAAAAGCT
CCTTAACGGTAAAGTACTCGTAATCGGCGCCGGCGGTCTCGGCTCACCGGCAGCTTTTTACCTGGCAGCCGCCGGTGTTG
GAACCATCGGCATCGCCGACTCGGATCGAATCGAACTCTCAAATCTTCAACGCCAGATTATCCATTCCACTGCCGGCATC
GGCCGCCTCAAAGTCGAATCGGCACGTGAAGCGATGTGCGAACTGAACCCCGACGTCCAAGTCCGAACATACCCGGTGAG
AGTAGACGATGCTATCCTTCCGACCATACTCGCCGACTATGACTTCGTAATCGATGCCACCGACAATTTTGCCTCAAAGT
TCTTGATCAACGACGCGTGCGTCCGTGCGGGCAAATCATTTTCGCATGGGGGTATCTTGCGCTACGCAGGGCAGACCATG
ACAGTGCATCCCCACCGGTCGGCATGCTATCGATGCCTCTTTGAGGAAGAGCCTTCGTCGGAGATAGCAACCAGTTGTTC
GCGAGCAGGTGTAATGGGAGTATTACCGGGAGTGATAGGGTCGTTGCAGGCGACGGAGGCATTGAAGCACGTGATGGGAG
TAGGGGAGTTGCTGACGGGACGCATGCTGACGTACGACAGTTTAGCGCTGCGATTTCGGGAGGTAGCGGTAGGCCGGCGG
AGGGGCTGCGGAGCATGTGGACAGTAG

Upstream 100 bases:

>100_bases
CCATTATTGCAGAGACGCGACCGGTCTGACCATTTCGTCACACTCACGGCCCCACTCCTGAACGGGTGGGGCCTTTTTAC
ATTACACCCGAGGGAACCGC

Downstream 100 bases:

>100_bases
CGGTGGGTCGAATGTAAGAAACCCCCTGCTCCGGAAGGGAGCAGGGGGTTTGGAAAAAATCCCGGCGGCGACCTACTTTC
CCACACAGCTGCCCGTGCAG

Product: thiF family protein

Products: NA

Alternate protein names: Sulfur carrier protein CysO adenylyltransferase; Sulfur carrier protein CysO sulfurtransferase [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MLTSDQQERYARHLILEGVGPEGQEKLLNGKVLVIGAGGLGSPAAFYLAAAGVGTIGIADSDRIELSNLQRQIIHSTAGI
GRLKVESAREAMCELNPDVQVRTYPVRVDDAILPTILADYDFVIDATDNFASKFLINDACVRAGKSFSHGGILRYAGQTM
TVHPHRSACYRCLFEEEPSSEIATSCSRAGVMGVLPGVIGSLQATEALKHVMGVGELLTGRMLTYDSLALRFREVAVGRR
RGCGACGQ

Sequences:

>Translated_248_residues
MLTSDQQERYARHLILEGVGPEGQEKLLNGKVLVIGAGGLGSPAAFYLAAAGVGTIGIADSDRIELSNLQRQIIHSTAGI
GRLKVESAREAMCELNPDVQVRTYPVRVDDAILPTILADYDFVIDATDNFASKFLINDACVRAGKSFSHGGILRYAGQTM
TVHPHRSACYRCLFEEEPSSEIATSCSRAGVMGVLPGVIGSLQATEALKHVMGVGELLTGRMLTYDSLALRFREVAVGRR
RGCGACGQ
>Mature_248_residues
MLTSDQQERYARHLILEGVGPEGQEKLLNGKVLVIGAGGLGSPAAFYLAAAGVGTIGIADSDRIELSNLQRQIIHSTAGI
GRLKVESAREAMCELNPDVQVRTYPVRVDDAILPTILADYDFVIDATDNFASKFLINDACVRAGKSFSHGGILRYAGQTM
TVHPHRSACYRCLFEEEPSSEIATSCSRAGVMGVLPGVIGSLQATEALKHVMGVGELLTGRMLTYDSLALRFREVAVGRR
RGCGACGQ

Specific function: Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps:first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thioca

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=248, Percent_Identity=41.1290322580645, Blast_Score=166, Evalue=1e-41,
Organism=Homo sapiens, GI4885649, Length=163, Percent_Identity=30.6748466257669, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1787048, Length=247, Percent_Identity=43.7246963562753, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI87082356, Length=240, Percent_Identity=40.8333333333333, Blast_Score=171, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17540406, Length=241, Percent_Identity=38.5892116182573, Blast_Score=177, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI193203301, Length=157, Percent_Identity=29.2993630573248, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17508819, Length=218, Percent_Identity=24.7706422018349, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71984476, Length=172, Percent_Identity=30.2325581395349, Blast_Score=67, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6321903, Length=254, Percent_Identity=38.9763779527559, Blast_Score=177, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6322639, Length=179, Percent_Identity=27.9329608938547, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325323, Length=163, Percent_Identity=28.8343558282209, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320598, Length=163, Percent_Identity=26.3803680981595, Blast_Score=65, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24582879, Length=247, Percent_Identity=42.1052631578947, Blast_Score=199, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24660640, Length=157, Percent_Identity=33.1210191082803, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI28573937, Length=170, Percent_Identity=27.6470588235294, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR001763
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00581 Rhodanese; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 26540; Mature: 26540

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTSDQQERYARHLILEGVGPEGQEKLLNGKVLVIGAGGLGSPAAFYLAAAGVGTIGIAD
CCCCCHHHHHHHHHHHCCCCCCHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCEEECCC
SDRIELSNLQRQIIHSTAGIGRLKVESAREAMCELNPDVQVRTYPVRVDDAILPTILADY
CCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCEEEEEEEEECCHHHHHHHCCC
DFVIDATDNFASKFLINDACVRAGKSFSHGGILRYAGQTMTVHPHRSACYRCLFEEEPSS
CEEEECCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEEECCCHHHHHHHHHCCCCCH
EIATSCSRAGVMGVLPGVIGSLQATEALKHVMGVGELLTGRMLTYDSLALRFREVAVGRR
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
RGCGACGQ
CCCCCCCC
>Mature Secondary Structure
MLTSDQQERYARHLILEGVGPEGQEKLLNGKVLVIGAGGLGSPAAFYLAAAGVGTIGIAD
CCCCCHHHHHHHHHHHCCCCCCHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCEEECCC
SDRIELSNLQRQIIHSTAGIGRLKVESAREAMCELNPDVQVRTYPVRVDDAILPTILADY
CCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCEEEEEEEEECCHHHHHHHCCC
DFVIDATDNFASKFLINDACVRAGKSFSHGGILRYAGQTMTVHPHRSACYRCLFEEEPSS
CEEEECCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEEECCCHHHHHHHHHCCCCCH
EIATSCSRAGVMGVLPGVIGSLQATEALKHVMGVGELLTGRMLTYDSLALRFREVAVGRR
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
RGCGACGQ
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]