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The map label for this gene is purE-1 [H]

Identifier: 39995718

GI number: 39995718

Start: 647453

End: 647962

Strand: Direct

Name: purE-1 [H]

Synonym: GSU0611

Alternate gene names: 39995718

Gene position: 647453-647962 (Clockwise)

Preceding gene: 39995717

Following gene: 39995719

Centisome position: 16.98

GC content: 63.73

Gene sequence:

>510_bases
ATGGAAAACCCGCAGGTACTCATCATTATGGGAAGTGATTCGGACGTTCCCGTCATGGAAGAAGCGGCAAAGGCCCTTGA
TGCTTTCGGCGTGACCTGGGAAATGCGAGTGGCGTCGGCCCACCGTTCGCCGAAAAAAGCGGCAGATCTCGCCTCGAACG
CGGCCGCGCGCGGCGTGAAGGCGATCATCGCCGGTGCCGGCGTGGCTGCCCACCTTGCGGGGGTCCTCGCCGCCGAGACT
ATTCTGCCGGTTATCGCGGTACCAATGCCGGGAGGGGCGCTCAACGGCGTTGATGCCCTGTACTCCATGGTGCAGATGCC
TGGCGGGATTCCGGTGGCTACTATGGCCATCGGCAAGGCAGGAGCCAAAAATGCCGGGCTGTTCGCGGTGCAGATCCTGG
CCCTCGGGGATGCCGCCATGGCCGGCAGGCTCGTGGAATACAAGGCGAGTATGGCGGAAGAGGTGGAGGCCAAGGATCGG
GCCCTTCAGGTCAAGTTGGGCCGCGCGTAG

Upstream 100 bases:

>100_bases
ATCGCGCCTACCGGGGCGTTGCGGCAATCTCATGGGACGGCGTCCACTACCGCAAAGACATCGGCGCCAAGGCGCTCACA
CGTTGACAGGGGAGGTCGCG

Downstream 100 bases:

>100_bases
CCCGGCTAGATTAACTTGCTGTAATCGTGCGGGTTTGACGCGGCTTCCGGCAGCTTTCCACTTGACAAAATCTGCATGTG
CTGTATAAAAGGTTGCGTTT

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 169; Mature: 169

Protein sequence:

>169_residues
MENPQVLIIMGSDSDVPVMEEAAKALDAFGVTWEMRVASAHRSPKKAADLASNAAARGVKAIIAGAGVAAHLAGVLAAET
ILPVIAVPMPGGALNGVDALYSMVQMPGGIPVATMAIGKAGAKNAGLFAVQILALGDAAMAGRLVEYKASMAEEVEAKDR
ALQVKLGRA

Sequences:

>Translated_169_residues
MENPQVLIIMGSDSDVPVMEEAAKALDAFGVTWEMRVASAHRSPKKAADLASNAAARGVKAIIAGAGVAAHLAGVLAAET
ILPVIAVPMPGGALNGVDALYSMVQMPGGIPVATMAIGKAGAKNAGLFAVQILALGDAAMAGRLVEYKASMAEEVEAKDR
ALQVKLGRA
>Mature_169_residues
MENPQVLIIMGSDSDVPVMEEAAKALDAFGVTWEMRVASAHRSPKKAADLASNAAARGVKAIIAGAGVAAHLAGVLAAET
ILPVIAVPMPGGALNGVDALYSMVQMPGGIPVATMAIGKAGAKNAGLFAVQILALGDAAMAGRLVEYKASMAEEVEAKDR
ALQVKLGRA

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Homo sapiens, GI119220559, Length=141, Percent_Identity=30.4964539007092, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI119220557, Length=141, Percent_Identity=30.4964539007092, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI5453539, Length=141, Percent_Identity=30.4964539007092, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1786734, Length=155, Percent_Identity=50.3225806451613, Blast_Score=114, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6324702, Length=164, Percent_Identity=48.780487804878, Blast_Score=149, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17087; Mature: 17087

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENPQVLIIMGSDSDVPVMEEAAKALDAFGVTWEMRVASAHRSPKKAADLASNAAARGVK
CCCCCEEEEECCCCCCCHHHHHHHHHHHHCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHH
AIIAGAGVAAHLAGVLAAETILPVIAVPMPGGALNGVDALYSMVQMPGGIPVATMAIGKA
HHHHCCCHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHCCC
GAKNAGLFAVQILALGDAAMAGRLVEYKASMAEEVEAKDRALQVKLGRA
CCCCCCHHEEHEEHHCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCC
>Mature Secondary Structure
MENPQVLIIMGSDSDVPVMEEAAKALDAFGVTWEMRVASAHRSPKKAADLASNAAARGVK
CCCCCEEEEECCCCCCCHHHHHHHHHHHHCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHH
AIIAGAGVAAHLAGVLAAETILPVIAVPMPGGALNGVDALYSMVQMPGGIPVATMAIGKA
HHHHCCCHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHCCC
GAKNAGLFAVQILALGDAAMAGRLVEYKASMAEEVEAKDRALQVKLGRA
CCCCCCHHEEHEEHHCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]