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The map label for this gene is atoC [H]

Identifier: 39995705

GI number: 39995705

Start: 628853

End: 630265

Strand: Direct

Name: atoC [H]

Synonym: GSU0598

Alternate gene names: 39995705

Gene position: 628853-630265 (Clockwise)

Preceding gene: 39995702

Following gene: 39995707

Centisome position: 16.49

GC content: 56.97

Gene sequence:

>1413_bases
ATGGAAAACATTGATGTACTTGTAGTTGACGATGAAGCGATTATCCGGGAGGGTCTGCGGAGGATCCTCGAAAAGGAGGG
CTACCATGTGGAGACCTCCGCCAGCGGACAGATTGCCCTGGAGAGACTGCAGGATGAGAACTACGGTCTGGTTATTACCG
ACCTTAAAATGCCCGGCATGAGCGGCATGGAAGTTCTCAAGGCCATCAAGGTCCTGCAGCCCGAAGTTCCCGTCATCATC
ATTACCGGATTCTCCACCGTCGATACCGCGGTCGAGGCTATGAAAAACGGCGCCTTCGACTATATTGCGAAACCTTTTAC
TCCGGACCAGATTACGGAGAAAGTGAGGAAAGCCCTCGAGCAGCGAGCAGTACTGCTCGAGAACATCTTTCTGAAAAAGG
AGCTGGGCGAGCACCACGGTTTCGATATCTTCGTGGGCGAGAGCAAAGAGATGCAGAAGGTTTATCGCCGCATCATCCAG
GTTGCTCCCACCGACAGCACCGTTCTCATTACCGGTGAAAGCGGGACCGGCAAAGAACTGGTGGCCCGGGCCGTCCACAA
CAACAGTCACCGTCGCGACAACCCCTTTGTGGCGGTGGACTGCACCTCCCTTGCTGAAAATCTTCTGGAAAGCGAGCTGT
TCGGCCACATCAAGGGCTCGTTCACCGGGGCCATCCAGACCAAAACCGGCTTGTTCAAGGTGGCCGACGGCGGCACGCTC
TTTTTGGACGAAATCTCCAACATCAGTCTCACCACTCAGGCAAAACTGCTGAGGGTGCTGCAGGAGCGGGAGATTACCCC
CATCGGCGGTACCCAGCCGATCCCCATCGACATCCGGCTCGTGGCCGCCACCAACAAGAATCTGCGCACTCTCGTCTCCC
AAGGGACGTTCCGGGAGGACCTCTTCTTCCGGCTCAACATCATTCCCATTGATCTGCCGCCCCTACGGGAGCGCAAGGGC
GATCTCCACCTCCTCATCGGGCATTTTCTCGCCACCTTTTCCGAGGAGATGGGGCGGGATATCCGCGGGCTAGCCCCTGA
TGCCCTGGCCCTTCTGGAAGACTATGCCTTCCCGGGCAACGTACGGGAGCTTGAGAACATCATTGAACGGGCCGTTGTTC
TCGCAGAGGGAGACCTGATTCAGAAGGAGGACCTGGAGCTTCGCGTCGCTACGGACTCCCAGGCCGGGGTTGGTGGCTAT
GTTCCCCAGAATGTGGAAGAGCTCAAGGAGACAAAGCGCCAGATACGGGAGCGGGCCGTGGAGCCCATAGAGAAGGCGTT
CGTGCTCCAGGCGCTCAAGCGCAACAACTGGAACATTACCAGGGCAGCCGAAGAGACGGGGATGTTGCGTCCCAACTTTC
AGGCATTGCTCAAAAAACTCCGGATTTCAGTACGTAACCAGATGACGAACTGA

Upstream 100 bases:

>100_bases
TTATTTGTCAGGGGGTTAATCTGTCTGGAACCATAGAGTTCAGTCGCTGTTCTCATGAATAAATGGGGTAGGGGCGGCAA
CGGAAAGGGGATGGTGGCGG

Downstream 100 bases:

>100_bases
ACATCTCGGCGTACCGGCTCAAATACAAAAAGGGGCACACGCGCGTGTGCCCCTTTTTGTATTTACGGCTGTCTTGATGT
CCGTACCGCAGTCGGATCAG

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MENIDVLVVDDEAIIREGLRRILEKEGYHVETSASGQIALERLQDENYGLVITDLKMPGMSGMEVLKAIKVLQPEVPVII
ITGFSTVDTAVEAMKNGAFDYIAKPFTPDQITEKVRKALEQRAVLLENIFLKKELGEHHGFDIFVGESKEMQKVYRRIIQ
VAPTDSTVLITGESGTGKELVARAVHNNSHRRDNPFVAVDCTSLAENLLESELFGHIKGSFTGAIQTKTGLFKVADGGTL
FLDEISNISLTTQAKLLRVLQEREITPIGGTQPIPIDIRLVAATNKNLRTLVSQGTFREDLFFRLNIIPIDLPPLRERKG
DLHLLIGHFLATFSEEMGRDIRGLAPDALALLEDYAFPGNVRELENIIERAVVLAEGDLIQKEDLELRVATDSQAGVGGY
VPQNVEELKETKRQIRERAVEPIEKAFVLQALKRNNWNITRAAEETGMLRPNFQALLKKLRISVRNQMTN

Sequences:

>Translated_470_residues
MENIDVLVVDDEAIIREGLRRILEKEGYHVETSASGQIALERLQDENYGLVITDLKMPGMSGMEVLKAIKVLQPEVPVII
ITGFSTVDTAVEAMKNGAFDYIAKPFTPDQITEKVRKALEQRAVLLENIFLKKELGEHHGFDIFVGESKEMQKVYRRIIQ
VAPTDSTVLITGESGTGKELVARAVHNNSHRRDNPFVAVDCTSLAENLLESELFGHIKGSFTGAIQTKTGLFKVADGGTL
FLDEISNISLTTQAKLLRVLQEREITPIGGTQPIPIDIRLVAATNKNLRTLVSQGTFREDLFFRLNIIPIDLPPLRERKG
DLHLLIGHFLATFSEEMGRDIRGLAPDALALLEDYAFPGNVRELENIIERAVVLAEGDLIQKEDLELRVATDSQAGVGGY
VPQNVEELKETKRQIRERAVEPIEKAFVLQALKRNNWNITRAAEETGMLRPNFQALLKKLRISVRNQMTN
>Mature_470_residues
MENIDVLVVDDEAIIREGLRRILEKEGYHVETSASGQIALERLQDENYGLVITDLKMPGMSGMEVLKAIKVLQPEVPVII
ITGFSTVDTAVEAMKNGAFDYIAKPFTPDQITEKVRKALEQRAVLLENIFLKKELGEHHGFDIFVGESKEMQKVYRRIIQ
VAPTDSTVLITGESGTGKELVARAVHNNSHRRDNPFVAVDCTSLAENLLESELFGHIKGSFTGAIQTKTGLFKVADGGTL
FLDEISNISLTTQAKLLRVLQEREITPIGGTQPIPIDIRLVAATNKNLRTLVSQGTFREDLFFRLNIIPIDLPPLRERKG
DLHLLIGHFLATFSEEMGRDIRGLAPDALALLEDYAFPGNVRELENIIERAVVLAEGDLIQKEDLELRVATDSQAGVGGY
VPQNVEELKETKRQIRERAVEPIEKAFVLQALKRNNWNITRAAEETGMLRPNFQALLKKLRISVRNQMTN

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=462, Percent_Identity=43.2900432900433, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1788550, Length=457, Percent_Identity=42.8884026258206, Blast_Score=364, Evalue=1e-102,
Organism=Escherichia coli, GI1790299, Length=387, Percent_Identity=43.4108527131783, Blast_Score=309, Evalue=3e-85,
Organism=Escherichia coli, GI1788905, Length=454, Percent_Identity=37.6651982378855, Blast_Score=295, Evalue=3e-81,
Organism=Escherichia coli, GI1789233, Length=310, Percent_Identity=45.1612903225806, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI87082117, Length=362, Percent_Identity=41.9889502762431, Blast_Score=268, Evalue=8e-73,
Organism=Escherichia coli, GI1789087, Length=343, Percent_Identity=40.8163265306122, Blast_Score=244, Evalue=7e-66,
Organism=Escherichia coli, GI87082152, Length=326, Percent_Identity=43.558282208589, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI87081872, Length=332, Percent_Identity=39.7590361445783, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI1786524, Length=331, Percent_Identity=39.8791540785499, Blast_Score=212, Evalue=5e-56,
Organism=Escherichia coli, GI1787583, Length=259, Percent_Identity=39.7683397683398, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI1789828, Length=216, Percent_Identity=35.1851851851852, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI87081858, Length=234, Percent_Identity=33.7606837606838, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI1788191, Length=118, Percent_Identity=37.2881355932203, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87082012, Length=120, Percent_Identity=30, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789809, Length=122, Percent_Identity=30.327868852459, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790860, Length=121, Percent_Identity=31.404958677686, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790552, Length=119, Percent_Identity=27.7310924369748, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786599, Length=118, Percent_Identity=29.6610169491525, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1790863, Length=121, Percent_Identity=31.404958677686, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789402, Length=117, Percent_Identity=31.6239316239316, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788222, Length=136, Percent_Identity=28.6764705882353, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786784, Length=126, Percent_Identity=26.984126984127, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=122, Percent_Identity=29.5081967213115, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 52506; Mature: 52506

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENIDVLVVDDEAIIREGLRRILEKEGYHVETSASGQIALERLQDENYGLVITDLKMPGM
CCCCEEEEECCHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHCCCCCCEEEEECCCCCC
SGMEVLKAIKVLQPEVPVIIITGFSTVDTAVEAMKNGAFDYIAKPFTPDQITEKVRKALE
CHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHH
QRAVLLENIFLKKELGEHHGFDIFVGESKEMQKVYRRIIQVAPTDSTVLITGESGTGKEL
HHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHH
VARAVHNNSHRRDNPFVAVDCTSLAENLLESELFGHIKGSFTGAIQTKTGLFKVADGGTL
HHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEECCCCEE
FLDEISNISLTTQAKLLRVLQEREITPIGGTQPIPIDIRLVAATNKNLRTLVSQGTFRED
EEECCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHCCCCCCC
LFFRLNIIPIDLPPLRERKGDLHLLIGHFLATFSEEMGRDIRGLAPDALALLEDYAFPGN
EEEEEEEEEECCCCHHHCCCCEEHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHCCCCCC
VRELENIIERAVVLAEGDLIQKEDLELRVATDSQAGVGGYVPQNVEELKETKRQIRERAV
HHHHHHHHHHHHHHCCCCCEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EPIEKAFVLQALKRNNWNITRAAEETGMLRPNFQALLKKLRISVRNQMTN
HHHHHHHHHHHHHCCCCCEEECHHHCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MENIDVLVVDDEAIIREGLRRILEKEGYHVETSASGQIALERLQDENYGLVITDLKMPGM
CCCCEEEEECCHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHCCCCCCEEEEECCCCCC
SGMEVLKAIKVLQPEVPVIIITGFSTVDTAVEAMKNGAFDYIAKPFTPDQITEKVRKALE
CHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHH
QRAVLLENIFLKKELGEHHGFDIFVGESKEMQKVYRRIIQVAPTDSTVLITGESGTGKEL
HHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHH
VARAVHNNSHRRDNPFVAVDCTSLAENLLESELFGHIKGSFTGAIQTKTGLFKVADGGTL
HHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEECCCCEE
FLDEISNISLTTQAKLLRVLQEREITPIGGTQPIPIDIRLVAATNKNLRTLVSQGTFRED
EEECCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHCCCCCCC
LFFRLNIIPIDLPPLRERKGDLHLLIGHFLATFSEEMGRDIRGLAPDALALLEDYAFPGN
EEEEEEEEEECCCCHHHCCCCEEHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHCCCCCC
VRELENIIERAVVLAEGDLIQKEDLELRVATDSQAGVGGYVPQNVEELKETKRQIRERAV
HHHHHHHHHHHHHHCCCCCEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EPIEKAFVLQALKRNNWNITRAAEETGMLRPNFQALLKKLRISVRNQMTN
HHHHHHHHHHHHHCCCCCEEECHHHCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]