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The map label for this gene is adhA [H]

Identifier: 39995680

GI number: 39995680

Start: 601211

End: 602203

Strand: Direct

Name: adhA [H]

Synonym: GSU0573

Alternate gene names: 39995680

Gene position: 601211-602203 (Clockwise)

Preceding gene: 308513283

Following gene: 39995681

Centisome position: 15.76

GC content: 71.9

Gene sequence:

>993_bases
ATGCGCGCCATGCTGTTCGAGGAGGTGGGAAAACCGCTGCGGCCGGTCCGGGTGCCGGTCCCCGAACCGGGGCCGGGCGA
GGTGCTGCTCAAGGTTCACGCCTGCGGTATCTGCCGGACGGATGTTCACATCGTGGACGGCGAGCTGACGGAGCCCGCCC
TGCCGCTCATCCCCGGCCACCAGATCGTGGGGAGCGTGGCAAAGCTGGGGGAGGGGGTCGAGCGTTTCCGGGAGGGGACG
CGGGTGGGGGTCCCCTGGCTCGGCGCCACCTGCGGCGCCTGCCGCTACTGCCGGTCGGGACGGGAAAACCTGTGCGACCA
CGCCCGGTTCACCGGGTATCAGCGCGACGGCGGCTTTGCCGAGTTCACCGTTGCCGATGCCCGCTTCTGCTTTCCGATCC
CCGGGGGATACCCGGACCTCCAGGCGGCGCCGCTGCTCTGCGCCGGGCTCATCGGCTACCGCTCCCTGGTCATGGCCGGT
GAGGGGGAACGGCTGGGCATTTATGGCTTCGGCGCCGCGGCCCACATCGTGACCCAGGTGGCCCGCTTCCGGGGATGGCG
GGTCTACGCCTTCACCCGTCCCGACGACCGTGCCGGCCAGGCCTTTGCCCGGGAGATGGGAGCGGTCTGGGCCGGGGCCT
CCCACGAGCGGCCGCCCGAGGAGCTTGACGCCGCCATCATCTTCGCGCCCGCCGGAGAGCTGGTGCCGGCGGCGCTGCGG
GCGGTGGGCAAGGGGGGCGTCGTGGTCTGCGGCGGCATCCACATGAGCGACATCCCGCCGATCCCCTACGATATCCTCTG
GGGGGAGCGGAGCATCCGCTCCGTGGCCAACCTGACCCGGCGCGACGGGGAGGAATTCCTCGCCCTGGCGCCGAAGGTGC
CCGTCAGGACCGAGGTGACTGCCTATCCCCTCAGCGCGGCCAACGAAGCCCTCGACGACCTGCGGCGCGGGCGCCTGCGG
GGCGCCGGCGTCCTGGTGATCGACGAGGGATAA

Upstream 100 bases:

>100_bases
GCCAACGTGGTGCGGGCCGAAAGCCGGGGGATGCGGGGCATCCTGTTCGAGGACGAGCCACGGTTCGAGCGGGACCTGAA
ACGGTACACGGAGGTGTAGC

Downstream 100 bases:

>100_bases
TGTGCCGTGCTCCGGGAGGGTTGACACCCGGACCGCCGCCGTGCTATCGGTAGAGGCATGAATACGCTCAATTTTCTCAC
CGCAACTCCCCCTCCGGTCG

Product: alcohol dehydrogenase, zinc-containing

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MRAMLFEEVGKPLRPVRVPVPEPGPGEVLLKVHACGICRTDVHIVDGELTEPALPLIPGHQIVGSVAKLGEGVERFREGT
RVGVPWLGATCGACRYCRSGRENLCDHARFTGYQRDGGFAEFTVADARFCFPIPGGYPDLQAAPLLCAGLIGYRSLVMAG
EGERLGIYGFGAAAHIVTQVARFRGWRVYAFTRPDDRAGQAFAREMGAVWAGASHERPPEELDAAIIFAPAGELVPAALR
AVGKGGVVVCGGIHMSDIPPIPYDILWGERSIRSVANLTRRDGEEFLALAPKVPVRTEVTAYPLSAANEALDDLRRGRLR
GAGVLVIDEG

Sequences:

>Translated_330_residues
MRAMLFEEVGKPLRPVRVPVPEPGPGEVLLKVHACGICRTDVHIVDGELTEPALPLIPGHQIVGSVAKLGEGVERFREGT
RVGVPWLGATCGACRYCRSGRENLCDHARFTGYQRDGGFAEFTVADARFCFPIPGGYPDLQAAPLLCAGLIGYRSLVMAG
EGERLGIYGFGAAAHIVTQVARFRGWRVYAFTRPDDRAGQAFAREMGAVWAGASHERPPEELDAAIIFAPAGELVPAALR
AVGKGGVVVCGGIHMSDIPPIPYDILWGERSIRSVANLTRRDGEEFLALAPKVPVRTEVTAYPLSAANEALDDLRRGRLR
GAGVLVIDEG
>Mature_330_residues
MRAMLFEEVGKPLRPVRVPVPEPGPGEVLLKVHACGICRTDVHIVDGELTEPALPLIPGHQIVGSVAKLGEGVERFREGT
RVGVPWLGATCGACRYCRSGRENLCDHARFTGYQRDGGFAEFTVADARFCFPIPGGYPDLQAAPLLCAGLIGYRSLVMAG
EGERLGIYGFGAAAHIVTQVARFRGWRVYAFTRPDDRAGQAFAREMGAVWAGASHERPPEELDAAIIFAPAGELVPAALR
AVGKGGVVVCGGIHMSDIPPIPYDILWGERSIRSVANLTRRDGEEFLALAPKVPVRTEVTAYPLSAANEALDDLRRGRLR
GAGVLVIDEG

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=248, Percent_Identity=28.6290322580645, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI34577061, Length=248, Percent_Identity=28.6290322580645, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4501929, Length=248, Percent_Identity=27.8225806451613, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI156627571, Length=328, Percent_Identity=27.7439024390244, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI71743840, Length=226, Percent_Identity=26.5486725663717, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI262073058, Length=226, Percent_Identity=26.5486725663717, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI71565154, Length=110, Percent_Identity=35.4545454545455, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI71565152, Length=104, Percent_Identity=34.6153846153846, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87081918, Length=324, Percent_Identity=32.0987654320988, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI87082401, Length=339, Percent_Identity=27.7286135693215, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786518, Length=211, Percent_Identity=35.0710900473934, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787863, Length=228, Percent_Identity=31.5789473684211, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790045, Length=210, Percent_Identity=33.3333333333333, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI226510992, Length=128, Percent_Identity=35.15625, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788073, Length=239, Percent_Identity=27.6150627615063, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87082125, Length=182, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1786552, Length=197, Percent_Identity=31.9796954314721, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1788075, Length=185, Percent_Identity=25.4054054054054, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17562584, Length=333, Percent_Identity=28.2282282282282, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI71988145, Length=326, Percent_Identity=27.3006134969325, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17562582, Length=222, Percent_Identity=32.8828828828829, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17562876, Length=261, Percent_Identity=31.0344827586207, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17562878, Length=228, Percent_Identity=30.7017543859649, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25146526, Length=199, Percent_Identity=29.6482412060301, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=201, Percent_Identity=29.3532338308458, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323961, Length=192, Percent_Identity=38.0208333333333, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324486, Length=191, Percent_Identity=37.17277486911, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6323729, Length=335, Percent_Identity=28.0597014925373, Blast_Score=129, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6319621, Length=192, Percent_Identity=36.4583333333333, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6323980, Length=325, Percent_Identity=27.3846153846154, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6319949, Length=333, Percent_Identity=27.9279279279279, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=228, Percent_Identity=29.8245614035088, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320033, Length=238, Percent_Identity=26.890756302521, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17737897, Length=128, Percent_Identity=37.5, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI17137530, Length=126, Percent_Identity=36.5079365079365, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17737895, Length=110, Percent_Identity=35.4545454545455, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35402; Mature: 35402

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAMLFEEVGKPLRPVRVPVPEPGPGEVLLKVHACGICRTDVHIVDGELTEPALPLIPGH
CCCHHHHHCCCCCCCEECCCCCCCCCCEEEEEEECCEEECCCEEECCCCCCCCCCCCCCH
QIVGSVAKLGEGVERFREGTRVGVPWLGATCGACRYCRSGRENLCDHARFTGYQRDGGFA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCEECCCCEE
EFTVADARFCFPIPGGYPDLQAAPLLCAGLIGYRSLVMAGEGERLGIYGFGAAAHIVTQV
EEEEECCEEEEECCCCCCCCHHHHHHHHHHHHHHHEEEECCCCEEEEEECCHHHHHHHHH
ARFRGWRVYAFTRPDDRAGQAFAREMGAVWAGASHERPPEELDAAIIFAPAGELVPAALR
HHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCHHHHCEEEEEECCCHHHHHHHH
AVGKGGVVVCGGIHMSDIPPIPYDILWGERSIRSVANLTRRDGEEFLALAPKVPVRTEVT
HCCCCCEEEECCCCCCCCCCCCCEEECCCHHHHHHHHHHHCCCCHHEEECCCCCCCCCEE
AYPLSAANEALDDLRRGRLRGAGVLVIDEG
ECCCHHHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MRAMLFEEVGKPLRPVRVPVPEPGPGEVLLKVHACGICRTDVHIVDGELTEPALPLIPGH
CCCHHHHHCCCCCCCEECCCCCCCCCCEEEEEEECCEEECCCEEECCCCCCCCCCCCCCH
QIVGSVAKLGEGVERFREGTRVGVPWLGATCGACRYCRSGRENLCDHARFTGYQRDGGFA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCEECCCCEE
EFTVADARFCFPIPGGYPDLQAAPLLCAGLIGYRSLVMAGEGERLGIYGFGAAAHIVTQV
EEEEECCEEEEECCCCCCCCHHHHHHHHHHHHHHHEEEECCCCEEEEEECCHHHHHHHHH
ARFRGWRVYAFTRPDDRAGQAFAREMGAVWAGASHERPPEELDAAIIFAPAGELVPAALR
HHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCHHHHCEEEEEECCCHHHHHHHH
AVGKGGVVVCGGIHMSDIPPIPYDILWGERSIRSVANLTRRDGEEFLALAPKVPVRTEVT
HCCCCCEEEECCCCCCCCCCCCCEEECCCHHHHHHHHHHHCCCCHHEEECCCCCCCCCEE
AYPLSAANEALDDLRRGRLRGAGVLVIDEG
ECCCHHHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]