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The map label for this gene is serS

Identifier: 39995148

GI number: 39995148

Start: 47406

End: 48674

Strand: Direct

Name: serS

Synonym: GSU0037

Alternate gene names: 39995148

Gene position: 47406-48674 (Clockwise)

Preceding gene: 39995145

Following gene: 39995149

Centisome position: 1.24

GC content: 58.47

Gene sequence:

>1269_bases
ATGCTTGACGCCAAATATCTGCGGGAGAATCTGGAAGAGGTGGAGGCGCGGCTTGCCACCCGGGGCTCCGAGGTGAGTCT
CGGCCGGTTTCGCGAGTTGGACGAGCGTCGGCGCGCGCTCCTCACGGAGAGCGAATCACTCAAGGCGTTGAAAAACTCCG
TGTCCGAAGCCATCAGCAAGGTCAAGGACAAGAGCCAGATTCAGGATAAGATCGCCGAGATGCGTGAGGTGGGGGTAAGG
ATCAAGGGGCTCGACGACGAGTTGCGCGGCATCGAGGACGAGCTGCAGATGGTACTGCTGACGGTCCCCAATGTGCCGCA
TCCGACGGTACCCGTCGGAGCGTCGGAGGCGGACAATCGTCAGGTGCGGACATGGGGTGAGCCTCCCTGTTTTGCGTTTG
ACCCCAAGCCCCATTGGGAGATAGGCGAAGGGCTCGGCATTCTTGATTTTGAGCGGGGAGCGAAGCTTACCGGTGCCCGG
TTCACGCTCTATCGTGGTGCAGGTGCCCGATTGGAGCGCGCTCTCGTCAATTTCATGCTCGACCTGCACACCGAGCGGCA
CAATTATCTTGAAATGCTCCCGCCCTTCGTGGTAAACAGGGAAAGCATGACCGGAACCGGTCAGCTGCCCAAGTTTGAGG
ACGACCTCTTCCACCTGGAAGGGGTCGATTATTTCCTCATCCCCACGGCAGAGGTTCCCGTCACCAATATTCATCGCGCT
GAAATCCTCAAAGCTGCAGACCTGCCGCTCAGCTACACGGCCTACACTCCGTGCTTCCGCAAGGAGGCCGGCTCCTACGG
CAAGGACGTCCGCGGACTCATACGGCAACACCAGTTCAACAAGGTCGAGCTGGTGAAGTTTGTTCATCCCGCGACATCCT
ACGATGAGCTGGAAAAACTGCTCTCCAATGCCGAAGAGGTGTTGCGCCAGCTCGGACTGGCCTATCGGGTCGTTGAACTC
TGTACCGGCGATATGGGGTTTTCGGCTGCCAAGACATACGATATTGAAGTCTGGCTTCCCGGCCAGGAGACCTATCGGGA
AATTTCTTCGTGCAGCAACTTCGAGGATTTCCAGTCCCGGCGGGCCTCGATCCGGTTCCGGGAAGACGAAAAATCAAAGC
CTGAATTCGTCCACACGCTGAACGGTTCGGGGCTTGCAGTCGGTAGAACGCTGGTGGCCATCCTTGAGAATTACCAGCAG
GAAGACGGGTCGGTAGTAATCCCGGACGTGCTCCGGCCGTACATGGGGGGACTGCAGAAGATCGGCTAG

Upstream 100 bases:

>100_bases
GATGGTCATTTCTGCTCCGGAGGCACAAAAATATTGACTAATTCGCAGGTTAGTGCTAAACACTATAACTTTCATGTCGC
AAAAGTAAAGGCTTGAACCA

Downstream 100 bases:

>100_bases
GCTTTCGGAGGGATGGCCGAGTGGTTTAAGGCGGCGGTCTTGAAAACCGTTGAACGAAAGTTCCGTGGGTTCGAATCCTA
CTCCCTCCGCCATAATTAAT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MLDAKYLRENLEEVEARLATRGSEVSLGRFRELDERRRALLTESESLKALKNSVSEAISKVKDKSQIQDKIAEMREVGVR
IKGLDDELRGIEDELQMVLLTVPNVPHPTVPVGASEADNRQVRTWGEPPCFAFDPKPHWEIGEGLGILDFERGAKLTGAR
FTLYRGAGARLERALVNFMLDLHTERHNYLEMLPPFVVNRESMTGTGQLPKFEDDLFHLEGVDYFLIPTAEVPVTNIHRA
EILKAADLPLSYTAYTPCFRKEAGSYGKDVRGLIRQHQFNKVELVKFVHPATSYDELEKLLSNAEEVLRQLGLAYRVVEL
CTGDMGFSAAKTYDIEVWLPGQETYREISSCSNFEDFQSRRASIRFREDEKSKPEFVHTLNGSGLAVGRTLVAILENYQQ
EDGSVVIPDVLRPYMGGLQKIG

Sequences:

>Translated_422_residues
MLDAKYLRENLEEVEARLATRGSEVSLGRFRELDERRRALLTESESLKALKNSVSEAISKVKDKSQIQDKIAEMREVGVR
IKGLDDELRGIEDELQMVLLTVPNVPHPTVPVGASEADNRQVRTWGEPPCFAFDPKPHWEIGEGLGILDFERGAKLTGAR
FTLYRGAGARLERALVNFMLDLHTERHNYLEMLPPFVVNRESMTGTGQLPKFEDDLFHLEGVDYFLIPTAEVPVTNIHRA
EILKAADLPLSYTAYTPCFRKEAGSYGKDVRGLIRQHQFNKVELVKFVHPATSYDELEKLLSNAEEVLRQLGLAYRVVEL
CTGDMGFSAAKTYDIEVWLPGQETYREISSCSNFEDFQSRRASIRFREDEKSKPEFVHTLNGSGLAVGRTLVAILENYQQ
EDGSVVIPDVLRPYMGGLQKIG
>Mature_422_residues
MLDAKYLRENLEEVEARLATRGSEVSLGRFRELDERRRALLTESESLKALKNSVSEAISKVKDKSQIQDKIAEMREVGVR
IKGLDDELRGIEDELQMVLLTVPNVPHPTVPVGASEADNRQVRTWGEPPCFAFDPKPHWEIGEGLGILDFERGAKLTGAR
FTLYRGAGARLERALVNFMLDLHTERHNYLEMLPPFVVNRESMTGTGQLPKFEDDLFHLEGVDYFLIPTAEVPVTNIHRA
EILKAADLPLSYTAYTPCFRKEAGSYGKDVRGLIRQHQFNKVELVKFVHPATSYDELEKLLSNAEEVLRQLGLAYRVVEL
CTGDMGFSAAKTYDIEVWLPGQETYREISSCSNFEDFQSRRASIRFREDEKSKPEFVHTLNGSGLAVGRTLVAILENYQQ
EDGSVVIPDVLRPYMGGLQKIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=434, Percent_Identity=32.7188940092166, Blast_Score=224, Evalue=9e-59,
Organism=Homo sapiens, GI8923421, Length=397, Percent_Identity=34.2569269521411, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI225579074, Length=332, Percent_Identity=36.4457831325301, Blast_Score=204, Evalue=1e-52,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=50.9302325581395, Blast_Score=437, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17539260, Length=427, Percent_Identity=31.615925058548, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17542084, Length=366, Percent_Identity=29.5081967213115, Blast_Score=134, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6320226, Length=374, Percent_Identity=36.8983957219251, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6321799, Length=421, Percent_Identity=29.9287410926366, Blast_Score=203, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24581334, Length=334, Percent_Identity=35.6287425149701, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI17737985, Length=328, Percent_Identity=31.4024390243902, Blast_Score=156, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_GEOSL (Q74H55)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_951099.1
- ProteinModelPortal:   Q74H55
- SMR:   Q74H55
- GeneID:   2685629
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU0037
- NMPDR:   fig|243231.1.peg.37
- TIGR:   GSU0037
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- ProtClustDB:   PRK05431
- BioCyc:   GSUL243231:GSU_0037-MONOMER
- BRENDA:   6.1.1.11
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47692; Mature: 47692

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 283-283 BINDING 383-383

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDAKYLRENLEEVEARLATRGSEVSLGRFRELDERRRALLTESESLKALKNSVSEAISK
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VKDKSQIQDKIAEMREVGVRIKGLDDELRGIEDELQMVLLTVPNVPHPTVPVGASEADNR
HHHHHHHHHHHHHHHHHCCEEECCCHHHHCHHHHHHEEEEECCCCCCCCCCCCCCCCCCC
QVRTWGEPPCFAFDPKPHWEIGEGLGILDFERGAKLTGARFTLYRGAGARLERALVNFML
CEEECCCCCCEEECCCCCCCCCCCCCEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
DLHTERHNYLEMLPPFVVNRESMTGTGQLPKFEDDLFHLEGVDYFLIPTAEVPVTNIHRA
HHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCCCCCCHHH
EILKAADLPLSYTAYTPCFRKEAGSYGKDVRGLIRQHQFNKVELVKFVHPATSYDELEKL
HHHHHCCCCCCCHHCCCHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHH
LSNAEEVLRQLGLAYRVVELCTGDMGFSAAKTYDIEVWLPGQETYREISSCSNFEDFQSR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCHHHHHHHHCCCCHHHHHHH
RASIRFREDEKSKPEFVHTLNGSGLAVGRTLVAILENYQQEDGSVVIPDVLRPYMGGLQK
HHCEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHH
IG
CC
>Mature Secondary Structure
MLDAKYLRENLEEVEARLATRGSEVSLGRFRELDERRRALLTESESLKALKNSVSEAISK
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VKDKSQIQDKIAEMREVGVRIKGLDDELRGIEDELQMVLLTVPNVPHPTVPVGASEADNR
HHHHHHHHHHHHHHHHHCCEEECCCHHHHCHHHHHHEEEEECCCCCCCCCCCCCCCCCCC
QVRTWGEPPCFAFDPKPHWEIGEGLGILDFERGAKLTGARFTLYRGAGARLERALVNFML
CEEECCCCCCEEECCCCCCCCCCCCCEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
DLHTERHNYLEMLPPFVVNRESMTGTGQLPKFEDDLFHLEGVDYFLIPTAEVPVTNIHRA
HHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCCCCCCHHH
EILKAADLPLSYTAYTPCFRKEAGSYGKDVRGLIRQHQFNKVELVKFVHPATSYDELEKL
HHHHHCCCCCCCHHCCCHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHH
LSNAEEVLRQLGLAYRVVELCTGDMGFSAAKTYDIEVWLPGQETYREISSCSNFEDFQSR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCHHHHHHHHCCCCHHHHHHH
RASIRFREDEKSKPEFVHTLNGSGLAVGRTLVAILENYQQEDGSVVIPDVLRPYMGGLQK
HHCEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHH
IG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA